From Reactivity and Regioselectivity to Stereoselectivity: An Odyssey of Designing PIP Amine and Related Directing Groups for C—H Activation

Enantioselective Synthesis of Atropisomers Featuring Pentatomic Heteroaromatics by Pd-Catalyzed C–H Alkynylation

(2019) Shuo Zhang et al.   ACS Catalysis

Palladium-Catalyzed Electrochemical C–H Bromination Using NH4Br as the Brominating Reagent

(2019) Qi-Liang Yang et al.   ORGANIC LETTERS

Pd(II)-Catalyzed Enantioselective Alkynylation of Unbiased Methylene C(sp3)–H Bonds Using 3,3′-Fluorinated-BINOL as a Chiral Ligand

(2019) Ye-Qiang Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium(II)-Catalyzed Enantioselective Arylation of Unbiased Methylene C(sp3 )−H Bonds Enabled by a 2-Pyridinylisopropyl Auxiliary and Chiral Phosphoric Acids

(2018) Sheng-Yi Yan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Late-Stage Peptide Diversification by Position-Selective C-H Activation

(2018) Wei Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Scalable, Stereocontrolled Formal Syntheses of (+)-Isoschizandrin and (+)-Steganone: Development and Applications of Palladium(II)-Catalyzed Atroposelective C−H Alkynylation

(2018) Gang Liao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Comparison of the Reactivities and Selectivities of Group 9 [Cp*MIII ] Catalysts in C−H Functionalization Reactions

(2018) Juhyeon Park et al.   Chemistry-An Asian Journal

Visible Light Promoted β-C-H Alkylation of β-Ketocarbonyls via a β-Enaminyl Radical Intermediate

(2018) Dehong Wang et al.   CHINESE JOURNAL OF CHEMISTRY

Recent Advances in Organic Electrochemical C-H Functionalization

(2018) Qi-Liang Yang et al.   CHINESE JOURNAL OF CHEMISTRY

Rh-catalyzed Transient Directing Group Promoted C-H Amidation of Benzaldehydes Utilizing Dioxazolones

(2018) Xiaoyang Wang et al.   CHINESE JOURNAL OF CHEMISTRY

Controlling Pd(iv) reductive elimination pathways enables Pd(ii)-catalysed enantioselective C(sp3)−H fluorination

(2018) Hojoon Park et al.   Nature Chemistry

Enantioselective C(sp3)‒H bond activation by chiral transition metal catalysts

(2018) Tyler G. Saint-Denis et al.   SCIENCE

Stereoselective construction of sterically hindered oxaspirocycles via chiral bidentate directing group-mediated C(sp3)–O bond formation

(2018) Yechan Kim et al.   Chemical Science

Remote C−H Functionalization of 8-Aminoquinolinamides

(2018) Bhuttu Khan et al.   Asian Journal of Organic Chemistry

Transient Directing Groups for Transformative C–H Activation by Synergistic Metal Catalysis

(2018) Parthasarathy Gandeepan et al.   Chem

A comprehensive overview of directing groups applied in metal-catalysed C–H functionalisation chemistry

(2018) Carlo Sambiagio et al.   CHEMICAL SOCIETY REVIEWS

Understanding Ni(II)-Mediated C(sp3)–H Activation: Tertiary Ureas as Model Substrates

(2018) D. Dawson Beattie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Macrocyclic peptide construction through C–H activation strategy

(2018) Kai Chen et al.   Science Bulletin

Pd-Catalyzed Atroposelective C−H Allylation through β-O Elimination: Diverse Synthesis of Axially Chiral Biaryls

(2018) Gang Liao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

3d Transition Metals for C–H Activation

(2018) Parthasarathy Gandeepan et al.   CHEMICAL REVIEWS

Cobalt-Catalyzed Cross-Dehydrogenative Coupling Reaction between Unactivated C(sp2)–H and C(sp3)–H Bonds

(2017) Qun Li et al.   ORGANIC LETTERS

Directed Iron-Catalyzed ortho-Alkylation and Arylation: Toward the Stereoselective Catalytic Synthesis of 1,2-Disubstituted Planar-Chiral Ferrocene Derivatives

(2017) David Schmiel et al.   ORGANOMETALLICS

Palladium-Catalyzed Direct Intermolecular Amination of Unactivated Methylene C(sp3)–H Bonds with Azodiformates via Bidentate-Chelation Assistance

(2017) He-Yuan Bai et al.   ACS Catalysis

Syntheses and Transformations of α-Amino Acids via Palladium-Catalyzed Auxiliary-Directed sp3 C–H Functionalization

(2016) Gang He et al.   ACCOUNTS OF CHEMICAL RESEARCH

Nickel-catalyzed ortho-halogenation of unactivated (hetero)aryl C–H bonds with lithium halides using a removable auxiliary

(2016) Bei-Bei Zhan et al.   CHEMICAL COMMUNICATIONS

Palladium-Catalyzed Transformations of Alkyl C–H Bonds

(2016) Jian He et al.   CHEMICAL REVIEWS

Cobalt-Catalyzed C(sp2)−H Methylation by using Dicumyl Peroxide as both the Methylating Reagent and Hydrogen Acceptor

(2016) Qun Li et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of unnatural amino acids through palladium-catalyzed C(sp3)H functionalization

(2016) Xi Lu et al.   CHINESE CHEMICAL LETTERS

Nickel-Catalyzed Ortho-Arylation of Unactivated (Hetero)aryl C–H Bonds with Arylsilanes Using a Removable Auxiliary

(2016) Sheng Zhao et al.   ORGANIC LETTERS

Functionalization of C(sp3)-H bonds using a transient directing group

(2016) F.-L. Zhang et al.   SCIENCE

γ-Lactone Synthesis via Palladium(II)-Catalyzed Lactonization of Unactivated Methylene C(sp3)–H Bonds

(2016) Bing-Feng Shi et al.   SYNLETT

Recent Progress on Copper-Mediated Directing-Group-Assisted C(sp2)–H Activation

(2016) Hui-Xiong Dai et al.   SYNTHESIS-STUTTGART

A unified synthesis of cyclic ethers or lactones via Pd-catalyzed intramolecular O -functionalization of sp 3 C H bonds

(2016) Haifeng Wang et al.   TETRAHEDRON LETTERS

Recent advances in copper-mediated chelation-assisted functionalization of unactivated C–H bonds

(2016) Wei-Hao Rao et al.   Organic Chemistry Frontiers

Nickel(ii)-catalyzed direct arylation of aryl C–H bonds with aryl-boron reagents directed by a removable bidentate auxiliary

(2016) Bin Liu et al.   Organic Chemistry Frontiers

Bidentate, Monoanionic Auxiliary-Directed Functionalization of Carbon–Hydrogen Bonds

(2015) Olafs Daugulis et al.   ACCOUNTS OF CHEMICAL RESEARCH

Recent Advances on Transition-Metal-Catalyzed Halogenation of Unactivated C-H Bonds

(2015) Gang Liao et al.   ACTA CHIMICA SINICA

A General and Scalable Synthesis of Aeruginosin Marine Natural Products Based on Two Strategic C(sp3)H Activation Reactions

(2015) David Dailler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-catalyzed ortho-halogenation of arenes and heteroarenes directed by a removable auxiliary

(2015) Bo Li et al.   CHEMICAL COMMUNICATIONS

Nickel-catalyzed thiolation of unactivated aryl C–H bonds: efficient access to diverse aryl sulfides

(2015) Sheng-Yi Yan et al.   CHEMICAL COMMUNICATIONS

Copper-catalyzed oxidative C–H/C–H cross-coupling of benzamides and thiophenes

(2015) Sheng Zhao et al.   CHEMICAL COMMUNICATIONS

Nickel-catalyzed and benzoic acid-promoted direct sulfenylation of unactivated arenes

(2015) Ke Yang et al.   CHEMICAL COMMUNICATIONS

Ni(ii)-catalyzed dehydrative alkynylation of unactivated (hetero)aryl C–H bonds using oxygen: a user-friendly approach

(2015) Yan-Hua Liu et al.   CHEMICAL COMMUNICATIONS

A sustainable and simple catalytic system for direct alkynylation of C(sp2)–H bonds with low nickel loadings

(2015) Yue-Jin Liu et al.   CHEMICAL COMMUNICATIONS

Nickel Catalysts/N,N′-Bidentate Directing Groups: An Excellent Partnership in Directed C–H Activation Reactions

(2015) Luis C. Misal Castro et al.   CHEMISTRY LETTERS

Divergent Synthesis of Aeruginosins Based on a C(sp3)H Activation Strategy

(2015) David Dailler et al.   CHEMISTRY-A EUROPEAN JOURNAL

Palladium-Catalyzed Arylation of Unactivated γ-Methylene C(sp3)H and δ-CH Bonds with an Oxazoline-Carboxylate Auxiliary

(2015) Peng-Xiang Ling et al.   CHEMISTRY-A EUROPEAN JOURNAL

Development of Modifiable Bidentate Amino Oxazoline Directing Group for Pd-Catalyzed Arylation of Secondary CH Bonds

(2015) Kang Chen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Stereoselective Synthesis of Chiral β-Fluoro α-Amino Acids via Pd(II)-Catalyzed Fluorination of Unactivated Methylene C(sp3)–H Bonds: Scope and Mechanistic Studies

(2015) Qi Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-/Silver-Mediated Arylation of C(sp2)–H Bonds with 2-Thiophenecarboxylic Acids

(2015) Sheng Zhao et al.   ORGANIC LETTERS

Palladium-Catalyzed Site-Selective Fluorination of Unactivated C(sp3)–H Bonds

(2015) Jinmin Miao et al.   ORGANIC LETTERS

Copper(II)-Catalyzed Direct Sulfonylation of C(sp2)–H Bonds with Sodium Sulfinates

(2015) Wei-Hao Rao et al.   ORGANIC LETTERS

Palladium-Catalyzed Asymmetric Arylation of C(sp3)–H Bonds of Aliphatic Amides: Controlling Enantioselectivity Using Chiral Phosphoric Amides/Acids

(2015) Shao-Bai Yan et al.   ORGANIC LETTERS

Copper-catalyzed direct acyloxylation of C(sp2)-H bonds with Benzoic acids

(2015) Sheng Zhao et al.   Science China-Chemistry

Cobalt-Catalyzed C–H Activation

(2015) Marc Moselage et al.   ACS Catalysis

Copper(ii)-catalyzed methoxylation of unactivated (hetero)aryl C–H bonds using a removable bidentate auxiliary

(2015) Xue-Song Yin et al.   Organic Chemistry Frontiers

Transition metal-catalyzed C–H bond functionalizations by the use of diverse directing groups

(2015) Zhengkai Chen et al.   Organic Chemistry Frontiers

Transition-Metal-Catalyzed Arylation of Unactivated C(sp3)—H Bonds Assisted by Bidentate Directing Groups

(2015) Bo Zhang et al.   CHINESE JOURNAL OF ORGANIC CHEMISTRY

Cobalt-Catalyzed, Aminoquinoline-Directed C(sp2)H Bond Alkenylation by Alkynes

(2014) Liene Grigorjeva et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pd(ii)-Catalyzed arylation of unactivated methylene C(sp3)–H bonds with aryl halides using a removable auxiliary

(2014) Qi Zhang et al.   CHEMICAL COMMUNICATIONS

C–H Functionalization in the Synthesis of Amino Acids and Peptides

(2014) Anaïs F. M. Noisier et al.   CHEMICAL REVIEWS

Copper/Silver-Mediated Directortho-Ethynylation of Unactivated (Hetero)aryl CH Bonds with Terminal Alkyne

(2014) Yue-Jin Liu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Cu(II)-Mediated C–S/N–S Bond Formation via C–H Activation: Access to Benzoisothiazolones Using Elemental Sulfur

(2014) Fa-Jie Chen et al.   ORGANIC LETTERS

Copper-Mediated Hydroxylation of Arenes and Heteroarenes Directed by a Removable Bidentate Auxiliary

(2014) Xin Li et al.   ORGANIC LETTERS

Recent Progress in the Synthesis of Functionalized β-Lactams through Transition-Metal-Catalyzed C(sp3)–H Amidation

(2014) Bing-Feng Shi et al.   SYNLETT

Palladium-catalyzed trifluoroacetate-promoted mono-arylation of the β-methyl group of alanine at room temperature: synthesis of β-arylated α-amino acids through sequential C–H functionalization

(2014) Bo Wang et al.   Chemical Science

Recent advances in directed C–H functionalizations using monodentate nitrogen-based directing groups

(2014) Min Zhang et al.   Organic Chemistry Frontiers

Regio-selective Dehydrogenation on the D or E Rings of Oleanolic Acid by Pd-Promoted C—H Activation

(2013) Yuyong Ma et al.   ACTA CHIMICA SINICA

Stereoselective Synthesis of Chiral α-Amino-β-Lactams through Palladium(II)-Catalyzed Sequential Monoarylation/Amidation of C(sp3)H Bonds

(2013) Qi Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Functionalization of C(sp2)H and C(sp3)H Bonds by Using Bidentate Directing Groups

(2013) Guy Rouquet et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Developing Ligands for Palladium(II)-Catalyzed C–H Functionalization: Intimate Dialogue between Ligand and Substrate

(2013) Keary M. Engle et al.   JOURNAL OF ORGANIC CHEMISTRY

Divergence between Organometallic and Single-Electron-Transfer Mechanisms in Copper(II)-Mediated Aerobic C–H Oxidation

(2013) Alison M. Suess et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Direct Alkylation of C–H Bonds in Benzamides and Acrylamides with Functionalized Alkyl Halides via Bidentate-Chelation Assistance

(2013) Yoshinori Aihara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereoselective Synthesis of β-Alkylated α-Amino Acids via Palladium-Catalyzed Alkylation of Unactivated Methylene C(sp3)–H Bonds with Primary Alkyl Halides

(2013) Shu-Yu Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pd(ii)-catalyzed alkoxylation of unactivated C(sp3)–H and C(sp2)–H bonds using a removable directing group: efficient synthesis of alkyl ethers

(2013) Fa-Jie Chen et al.   Chemical Science

Recent development of direct asymmetric functionalization of inert C–H bonds

(2013) Chao Zheng et al.   RSC Advances

CH Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals

(2012) Junichiro Yamaguchi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nonnatural Amino Acid Synthesis by Using Carbon-Hydrogen Bond Functionalization Methodology

(2012) Ly Dieu Tran et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

C–C, C–O and C–N bond formation via rhodium(iii)-catalyzed oxidative C–H activation

(2012) Guoyong Song et al.   CHEMICAL SOCIETY REVIEWS

Ligand-Enabled Methylene C(sp3)–H Bond Activation with a Pd(II) Catalyst

(2012) Masayuki Wasa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Promoted Sulfenylation of sp2 C–H Bonds

(2012) Ly Dieu Tran et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

C–H functionalization logic in total synthesis

(2011) Will R. Gutekunst et al.   CHEMICAL SOCIETY REVIEWS

Recent developments in natural product synthesis using metal-catalysed C–H bond functionalisation

(2011) Lindsay McMurray et al.   CHEMICAL SOCIETY REVIEWS

Recent Advances in the Synthesis of Fluorinated Amino Acids

(2011) Xiao-Long Qiu et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Palladium-Catalyzed Direct Ethynylation of C(sp3)–H Bonds in Aliphatic Carboxylic Acid Derivatives

(2011) Yusuke Ano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Challenge and progress: palladium-catalyzed sp3 C–H activation

(2011) Hu Li et al.   Catalysis Science & Technology

Synthesis of the Leu–Trp Component of the Celogentin Family of Cyclic Peptides Through a C–H Activation–Cross-Coupling Strategy

(2010) Barbara T. Y. Li et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions

(2010) Thomas W. Lyons et al.   CHEMICAL REVIEWS

Auxiliary-Assisted Palladium-Catalyzed Arylation and Alkylation of sp2and sp3Carbon−Hydrogen Bonds

(2010) Dmitry Shabashov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Facile Benzo-Ring Construction via Palladium-Catalyzed Functionalization of Unactivated sp3C−H Bonds under Mild Reaction Conditions

(2010) Yiqing Feng et al.   ORGANIC LETTERS

Palladium- and Copper-Catalyzed Arylation of Carbon−Hydrogen Bonds

(2009) Olafs Daugulis et al.   ACCOUNTS OF CHEMICAL RESEARCH

Total Synthesis of Celogentin C by Stereoselective CH Activation

(2009) Yiqing Feng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium(II)-Catalyzed CH Activation/CC Cross-Coupling Reactions: Versatility and Practicality

(2009) Xiao Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and Reactivity of a Mono-σ-Aryl Palladium(IV) Fluoride Complex

(2009) Nicholas D. Ball et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evolution of the Total Syntheses of Ustiloxin Natural Products and Their Analogues

(2008) Pixu Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY