CH Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals

Synthesis of C-Glycoside Analogues of α-Galactosylceramide via Linear Allylic C–H Oxidation and Allyl Cyanate to Isocyanate Rearrangement

(2012) Zheng Liu et al.   ORGANIC LETTERS

Total Synthesis of (−)-Kaitocephalin Based on a Rh-Catalyzed C–H Amination

(2012) Keisuke Takahashi et al.   ORGANIC LETTERS

Borylation and Silylation of C–H Bonds: A Platform for Diverse C–H Bond Functionalizations

(2011) John F. Hartwig   ACCOUNTS OF CHEMICAL RESEARCH

Oxidative Biaryl Coupling of Thiophenes and Thiazoles with Arylboronic Acids through Palladium Catalysis: Otherwise Difficult C4-Selective CH Arylation Enabled by Boronic Acids

(2011) Sylvia Kirchberg et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Practical Strategy for the Structural Diversification of Aliphatic Scaffolds through the Palladium-Catalyzed Picolinamide-Directed Remote Functionalization of Unactivated C(sp3)H Bonds

(2011) Gang He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

One-Pot Formation of CC and CN Bonds through Palladium-Catalyzed Dual CH Activation: Synthesis of Phenanthridinones

(2011) Guan-Wu Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Total Syntheses of Communesins A and B

(2011) Zhiwei Zuo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bond Formations between Two Nucleophiles: Transition Metal Catalyzed Oxidative Cross-Coupling Reactions

(2011) Chao Liu et al.   CHEMICAL REVIEWS

Catalytic Dehydrogenative Cross-Coupling: Forming Carbon−Carbon Bonds by Oxidizing Two Carbon−Hydrogen Bonds

(2011) Charles S. Yeung et al.   CHEMICAL REVIEWS

C–H functionalization logic in total synthesis

(2011) Will R. Gutekunst et al.   CHEMICAL SOCIETY REVIEWS

Catalytic C–H amination: the stereoselectivity issue

(2011) Florence Collet et al.   CHEMICAL SOCIETY REVIEWS

Recent developments in natural product synthesis using metal-catalysed C–H bond functionalisation

(2011) Lindsay McMurray et al.   CHEMICAL SOCIETY REVIEWS

Regioselectivity of the borylation of alkanes and arenes

(2011) John F. Hartwig   CHEMICAL SOCIETY REVIEWS

Recent advances in transition metal-catalyzed sp3C–H amination adjacent to double bonds and carbonyl groups

(2011) Thomas A. Ramirez et al.   CHEMICAL SOCIETY REVIEWS

Oxidative C–H/C–H Coupling of Azine and Indole/Pyrrole Nuclei: Palladium Catalysis and Synthesis of Eudistomin U

(2011) Atsushi D. Yamaguchi et al.   CHEMISTRY LETTERS

Nickel-Catalyzed CH Arylation of Azoles with Haloarenes: Scope, Mechanism, and Applications to the Synthesis of Bioactive Molecules

(2011) Takuya Yamamoto et al.   CHEMISTRY-A EUROPEAN JOURNAL

Aliphatic C−H to C−C Conversion: Synthesis of (−)-Cameroonan-7α-ol

(2011) Douglass F. Taber et al.   JOURNAL OF ORGANIC CHEMISTRY

Direct Arylation of Simple Azoles Catalyzed by 1,10-Phenanthroline Containing Palladium Complexes: An Investigation of C4 Arylation of Azoles and the Synthesis of Triarylated Azoles by Sequential Arylation

(2011) Fumitoshi Shibahara et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Angiotensin II Receptor Blockers by Means of a Catalytic System for C–H Activation

(2011) Masahiko Seki et al.   JOURNAL OF ORGANIC CHEMISTRY

Preparative Scale Synthesis of the Biaryl Core of Anacetrapib via a Ruthenium-Catalyzed Direct Arylation Reaction: Unexpected Effect of Solvent Impurity on the Arylation Reaction†

(2011) Stéphane G. Ouellet et al.   JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of Cortistatins A and J

(2011) Shuji Yamashita et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Dragmacidin D via Direct C–H Couplings

(2011) Debashis Mandal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed C–H/C–O Coupling of Azoles with Phenol Derivatives

(2011) Kei Muto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Total Synthesis of (−)-Kibdelone C

(2011) John R. Butler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthetic Versatility in C–H Oxidation: A Rapid Approach to Differentiated Diols and Pyrans from Simple Olefins

(2011) Paul E. Gormisky et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Scalable, Stereocontrolled Total Syntheses of (±)-Axinellamines A and B

(2011) Shun Su et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Total Syntheses of (−)-Taiwaniaquinone H and (−)-Taiwaniaquinol B by Iridium-Catalyzed Borylation and Palladium-Catalyzed Asymmetric α-Arylation

(2011) Xuebin Liao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Intermolecular Directed C−H Amidation of Aromatic Ketones

(2011) Bin Xiao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

C–H Arylation of Pyridines: High Regioselectivity as a Consequence of the Electronic Character of C–H Bonds and Heteroarene Ring

(2011) Pengfei Guo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Practical C−H Functionalization of Quinones with Boronic Acids

(2011) Yuta Fujiwara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis and Structural Revision of the Piperarborenines via Sequential Cyclobutane C–H Arylation

(2011) Will R. Gutekunst et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Scalable Synthesis of Cortistatin A and Related Structures

(2011) Jun Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Convergent Total Synthesis of (+)-Lithospermic Acid via a Late-Stage Intermolecular C−H Olefination

(2011) Dong-Hui Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Total Syntheses of (−)-Palau’amine, (−)-Axinellamines, and (−)-Massadines

(2011) Ian B. Seiple et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ligand-Promoted C3-Selective Arylation of Pyridines with Pd Catalysts: Gram-Scale Synthesis of (±)-Preclamol

(2011) Mengchun Ye et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Divergent C–H Functionalizations Directed by Sulfonamide Pharmacophores: Late-Stage Diversification as a Tool for Drug Discovery

(2011) Hui-Xiong Dai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of (−)-N-Methylwelwitindolinone C Isothiocyanate

(2011) Alexander D. Huters et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of Oxidized Welwitindolinones and (−)-N-Methylwelwitindolinone C Isonitrile

(2011) Kyle W. Quasdorf et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereocontrolled Synthesis of (+)-Methoxyphenylkainic Acid and (+)-Phenylkainic Acid

(2011) Takumi Higashi et al.   ORGANIC LETTERS

Enantioselective Total Synthesis of Aperidine

(2011) Toshiyuki Wakimoto et al.   ORGANIC LETTERS

Synthesis ofl-epi-Capreomycidine Derivatives via C–H Amination

(2011) Tetsuya Tanino et al.   ORGANIC LETTERS

Studies toward the Synthesis of Maoecrystal V

(2011) Zhenhua Gu et al.   ORGANIC LETTERS

Total Synthesis of (±)-Kainic Acid: A Photochemical C–H Carbamoylation Approach

(2011) Takuma Kamon et al.   ORGANIC LETTERS

Ruthenium-Catalyzed γ-Carbolinium Ion Formation from Aryl Azides; Synthesis of Dimebolin

(2011) Huijun Dong et al.   ORGANIC LETTERS

Pd-Catalyzed Intramolecular Oxidative C–H Amination: Synthesis of Carbazoles

(2011) So Won Youn et al.   ORGANIC LETTERS

Formal Synthesis of Nitidine and NK109 via Palladium-Catalyzed Domino Direct Arylation/N-Arylation of Aryl Triflates

(2011) Mathieu Blanchot et al.   ORGANIC LETTERS

A novel three-step synthesis of Celecoxib via palladium-catalyzed direct arylation

(2011) Steven M. Gaulier et al.   TETRAHEDRON LETTERS

Total Syntheses and Cytotoxicity of (R)- and (S)-Boehmeriasin A

(2011) Matthew W. Leighty et al.   ACS Medicinal Chemistry Letters

Highly Efficient Catalytic System for C–H Activation: A Practical Approach to Angiotensin II Receptor Blockers

(2011) Masahiko Seki   ACS Catalysis

Constructing Multiply Substituted Arenes Using Sequential Palladium(II)-Catalyzed CH Olefination

(2010) Keary M. Engle et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pd0/PR3-Catalyzed Arylation of Nicotinic and Isonicotinic Acid Derivatives

(2010) Masayuki Wasa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A General Catalyst for the β-Selective C-H Bond Arylation of Thiophenes with Iodoarenes

(2010) Kirika Ueda et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of Dictyodendrin A and B

(2010) Kentaro Okano et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct multiple C–H bond arylation reaction of heteroarenes catalyzed by cationic palladium complex bearing 1,10-phenanthroline

(2010) Fumitoshi Shibahara et al.   CHEMICAL COMMUNICATIONS

Metal-catalyzed direct alkylations of (hetero)arenes via C–H bond cleavages with unactivated alkyl halides

(2010) Lutz Ackermann   CHEMICAL COMMUNICATIONS

Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions

(2010) Thomas W. Lyons et al.   CHEMICAL REVIEWS

Atroposelective Total Synthesis of Axially Chiral Biaryl Natural Products

(2010) Gerhard Bringmann et al.   CHEMICAL REVIEWS

Diastereotopos-differentiating C–H activation reactions at methylene groups

(2010) Pavel Herrmann et al.   CHEMICAL SOCIETY REVIEWS

Overview of the Mechanistic Work on the Concerted Metallation–Deprotonation Pathway

(2010) David Lapointe et al.   CHEMISTRY LETTERS

Syntheses of Fumagillin and Ovalicin

(2010) Junichiro Yamaguchi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Total Synthesis of (−)-Morphine

(2010) Hifumi Koizumi et al.   Chemistry-An Asian Journal

Transition-Metal-Catalyzed Direct C-H Alkenylation, Alkynylation, Benzylation, and Alkylation of (Hetero)arenes

(2010) Samir Messaoudi et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Graphislactone H

(2010) Hitoshi Abe et al.   HETEROCYCLES

Total Synthesis of (−)-Muraymycin D2 and Its Epimer

(2010) Tetsuya Tanino et al.   JOURNAL OF ORGANIC CHEMISTRY

Mechanistic Analysis of AzineN-Oxide Direct Arylation: Evidence for a Critical Role of Acetate in the Pd(OAc)2Precatalyst

(2010) Ho-Yan Sun et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Complex Allylic Esters via C−H Oxidation vs C−C Bond Formation

(2010) Nicolaas A. Vermeulen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of (+)-Complanadine A Using an Iridium-Catalyzed Pyridine C−H Functionalization

(2010) Daniel F. Fischer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of (±)- and (−)-Actinophyllic Acid

(2010) Connor L. Martin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ruthenium-Catalyzed Hydroxylation of Unactivated Tertiary C−H Bonds

(2010) Eric McNeill et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ligand-Accelerated C−H Activation Reactions: Evidence for a Switch of Mechanism

(2010) Keary M. Engle et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iridium-Catalyzed, Silyl-Directed Borylation of Nitrogen-Containing Heterocycles

(2010) Daniel W. Robbins et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rhodium(III)-Catalyzed Arene and Alkene C−H Bond Functionalization Leading to Indoles and Pyrroles

(2010) David R. Stuart et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Auxiliary-Assisted Palladium-Catalyzed Arylation and Alkylation of sp2and sp3Carbon−Hydrogen Bonds

(2010) Dmitry Shabashov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of cortistatins A, J, K and L

(2010) Alec N. Flyer et al.   Nature Chemistry

Expedient Drug Synthesis and Diversification via ortho-C−H Iodination using Recyclable PdI2as the Precatalyst

(2010) Tian-Sheng Mei et al.   ORGANIC LETTERS

First C−H Activation Route to Oxindoles using Copper Catalysis

(2010) Johannes E. M. N. Klein et al.   ORGANIC LETTERS

Total Synthesis of Diptoindonesin G via a Highly Efficient Domino Cyclodehydration/Intramolecular Friedel−Crafts Acylation/Regioselective Demethylation Sequence

(2010) Kyungsun Kim et al.   ORGANIC LETTERS

Functionalization of Aromatic Amino Acids via Direct C−H Activation: Generation of Versatile Building Blocks for Accessing Novel Peptide Space

(2010) Falco-Magnus Meyer et al.   ORGANIC LETTERS

Mechanistic Insight into Direct Arylations with Ruthenium(II) Carboxylate Catalysts

(2010) Lutz Ackermann et al.   ORGANIC LETTERS

Formal total synthesis of (±)-cortistatin A

(2010) Eric M. Simmons et al.   TETRAHEDRON

The organocatalytic three-step total synthesis of (+)-frondosin B

(2010) Maud Reiter et al.   Chemical Science

Total Synthesis of Celogentin C

(2009) Bing Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Oxindole Synthesis by Direct Coupling of C sp 2H and C sp 3H Centers

(2009) Yi-Xia Jia et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iron-Catalyzed Chemoselective ortho Arylation of Aryl Imines by Directed CH Bond Activation

(2009) Naohiko Yoshikai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Cyclopamine Using a Biomimetic and Diastereoselective Approach

(2009) Athanassios Giannis et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of Celogentin C by Stereoselective CH Activation

(2009) Yiqing Feng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transition-Metal-Catalyzed Direct Arylation of (Hetero)Arenes by CH Bond Cleavage

(2009) Lutz Ackermann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium(II)-Catalyzed CH Activation/CC Cross-Coupling Reactions: Versatility and Practicality

(2009) Xiao Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed C3 or C4 Direct Arylation of Heteroaromatic Compounds with Aryl Halides by CH Bond Activation

(2009) Julien Roger et al.   ChemCatChem

Catalytic C–H amination: recent progress and future directions

(2009) Florence Collet et al.   CHEMICAL COMMUNICATIONS

The key intermediate in the amination of saturated C–H bonds: synthesis, X-ray characterization and catalytic activity of Ru(TPP)(NAr)2 (Ar = 3,5-(CF3)2C6H3)

(2009) Simone Fantauzzi et al.   CHEMICAL COMMUNICATIONS

Oxindole synthesis by direct C–H, Ar–H coupling

(2009) Alexis Perry et al.   CHEMICAL COMMUNICATIONS

Catalytic Carbene Insertion into C−H Bonds

(2009) Michael P. Doyle et al.   CHEMICAL REVIEWS

C−H Activation for the Construction of C−B Bonds

(2009) Ibraheem A. I. Mkhalid et al.   CHEMICAL REVIEWS

Intermolecular oxidative cross-coupling of arenes

(2009) James A. Ashenhurst   CHEMICAL SOCIETY REVIEWS

Fe-Catalyzed Oxidative Coupling of Heteroarenes and Methylamines

(2009) Masaki Ohta et al.   Chemistry-An Asian Journal

Acid-Free Synthesis of Carbazoles and Carbazolequinones by Intramolecular Pd-Catalyzed, Microwave-Assisted Oxidative Biaryl Coupling Reactions - Efficient Syntheses of Murrayafoline A, 2-Methoxy-3-methylcarbazole, and Glycozolidine

(2009) Vellaisamy Sridharan et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of (±)-Morphine

(2009) Tohru Fukuyama et al.   HETEROCYCLES

Nonracemic Bicyclic Lactam Lactones via Regio- andcis-Diastereocontrolled C−H Insertion. Asymmetric Synthesis of (8S,8aS)-Octahydroindolizidin-8-ol and (1S,8aS)-Octahydroindolizidin-1-ol

(2009) Andrew G. H. Wee et al.   JOURNAL OF ORGANIC CHEMISTRY

Palladium-Catalyzed Direct Synthesis of Carbazoles via One-PotN-Arylation and Oxidative Biaryl Coupling: Synthesis and Mechanistic Study

(2009) Toshiaki Watanabe et al.   JOURNAL OF ORGANIC CHEMISTRY

Establishment of Broadly Applicable Reaction Conditions for the Palladium-Catalyzed Direct Arylation of Heteroatom-Containing Aromatic Compounds

(2009) Benoît Liégault et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of (+)-CP-99,994 via Pd(0)-Catalyzed Asymmetric Allylic and Homoallylic C−H Diamination of Terminal Olefin

(2009) Renzhong Fu et al.   JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of (±)-Rhazinal Using Novel Palladium-Catalyzed Cyclizations

(2009) Alfred L. Bowie et al.   JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Synthesis of Neolignans (−)-epi-Conocarpan and (+)-Conocarpan via Rh(II)-Catalyzed C−H Insertion Process and Revision of the Absolute Configuration of (−)-epi-Conocarpan

(2009) Yoshihiro Natori et al.   JOURNAL OF ORGANIC CHEMISTRY

Highly Efficient, Enantioselective Syntheses of (S)-(+)- and (R)-(−)-Dapoxetine Starting with 3-Phenyl-1-propanol

(2009) Soyeong Kang et al.   JOURNAL OF ORGANIC CHEMISTRY

Concise Syntheses of (−)-Galanthamine and (±)-Codeine via Intramolecular Alkylation of a Phenol Derivative

(2009) Philip Magnus et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Aromatic C−H Halogenation with Hydrogen Halides by Means of Electrochemical Oxidation

(2009) Fumitoshi Kakiuchi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Direct Arylation of Azine and AzoleN-Oxides: Reaction Development, Scope and Applications in Synthesis

(2009) Louis-Charles Campeau et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereoelectronic Effect for the Selectivity in C−H Insertion of Alkylidene Carbenes and Its Application to the Synthesis of Platensimycin

(2009) Sang Young Yun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of (+)-Lyconadin A and Related Compounds via Oxidative C−N Bond Formation

(2009) Scott P. West et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Allylic C−H Amination for the Preparation ofsyn-1,3-Amino Alcohol Motifs

(2009) Grant T. Rice et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regiospecific and Stereoselective Syntheses of (±) Morphine, Codeine, and Thebaine via a Highly Stereocontrolled Intramolecular 4 + 2 Cycloaddition Leading to a Phenanthrofuran System

(2009) Gilbert Stork et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Synthesis of SM-130686 Based on the Development of Asymmetric Cu(I)F Catalysis To Access 2-Oxindoles Containing a Tetrasubstituted Carbon

(2009) Daisuke Tomita et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Synthesis of (+)-Cephalostatin 1

(2009) Kevin C. Fortner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total synthesis of eudesmane terpenes by site-selective C–H oxidations

(2009) Ke Chen et al.   NATURE

Total synthesis and study of 6-deoxyerythronolide B by late-stage C–H oxidation

(2009) Erik M. Stang et al.   Nature Chemistry

Highly Efficient Borylation Suzuki Coupling Process for 4-Bromo-2-ketothiazoles: Straightforward Access to Micrococcinate and Saramycetate Esters

(2009) Thibaut Martin et al.   ORGANIC LETTERS

Nickel-Catalyzed Biaryl Coupling of Heteroarenes and Aryl Halides/Triflates

(2009) Jérôme Canivet et al.   ORGANIC LETTERS

Ruthenium-Catalyzed Intramolecular Amination Reactions of Aryl- and Vinylazides

(2009) Wang Ge Shou et al.   ORGANOMETALLICS

Total Synthesis of (+)-11,11'-Dideoxyverticillin A

(2009) J. Kim et al.   SCIENCE

Ligand-Enabled Reactivity and Selectivity in a Synthetically Versatile Aryl C-H Olefination

(2009) D.-H. Wang et al.   SCIENCE

Chemoenzymatic enantiodivergent total syntheses of (+)- and (−)-codeine

(2009) Hannes Leisch et al.   TETRAHEDRON

Direct arylation of azine N-oxides with aryl triflates

(2009) Derek J. Schipper et al.   TETRAHEDRON

Recent advances in the synthesis of (hetero)aryl-substituted heteroarenes via transition metal-catalysed direct (hetero)arylation of heteroarene C–H bonds with aryl halides or pseudohalides, diaryliodonium salts, and potassium aryltrifluoroborates

(2009) Fabio Bellina et al.   TETRAHEDRON

Direct Functionalization of Nitrogen Heterocycles via Rh-Catalyzed C−H Bond Activation

(2008) Jared C. Lewis et al.   ACCOUNTS OF CHEMICAL RESEARCH

Cross-Dehydrogenative Coupling (CDC): Exploring C−C Bond Formations beyond Functional Group Transformations

(2008) Chao-Jun Li   ACCOUNTS OF CHEMICAL RESEARCH

PdII-Catalyzed Enantioselective Activation of C(sp2)H and C(sp3)H Bonds Using Monoprotected Amino Acids as Chiral Ligands

(2008) Bing-Feng Shi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of (+)-Cortistatin A

(2008) K. C. Nicolaou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of 3,4-Dihydroisoquinolines by a C(sp3)H Activation/Electrocyclization Strategy: Total Synthesis of Coralydine

(2008) Manon Chaumontet et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Synthesis of (+)-Monobromophakellin and (+)-Phakellin: A Concise Phakellin Annulation Strategy Applicable to Palau'amine

(2008) Shaohui Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Rhazinicine by a Metal-Catalyzed CH Bond Functionalization Strategy

(2008) Elizabeth M. Beck et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of 1,9-Dideoxy-pre-axinellamine

(2008) Junichiro Yamaguchi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of (±)-Axinellamines A and B

(2008) Daniel P. O'Malley et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Isolation, Structure Elucidation, and Biomimetic Total Synthesis of Versicolamide B, and the Isolation of Antipodal (−)-Stephacidin A and (+)-Notoamide B fromAspergillus versicolor NRRL 35600

(2008) Thomas J. Greshock et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective CH Amination Using Cationic Ruthenium(II)-pybox Catalysts

(2008) Erika Milczek et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct arylations on water: synthesis of 2,5-disubstituted oxazoles balsoxin and texaline

(2008) Stephan A. Ohnmacht et al.   CHEMICAL COMMUNICATIONS

Diastereoselective Total Synthesis of (±)-Codeine

(2008) Marie Varin et al.   CHEMISTRY-A EUROPEAN JOURNAL

Vinylic CH Borylation of Cyclic Vinyl Ethers with Bis(pinacolato)diboron Catalyzed by an Iridium(I)-dtbpy Complex

(2008) Takao Kikuchi et al.   Chemistry-An Asian Journal

Synthesis of (−)-Hamigeran B

(2008) Douglass F. Taber et al.   JOURNAL OF ORGANIC CHEMISTRY

Palladium-Catalyzed Direct (Hetero)arylation of Ethyl Oxazole-4-carboxylate: An Efficient Access to (Hetero)aryloxazoles

(2008) Cécile Verrier et al.   JOURNAL OF ORGANIC CHEMISTRY

Ligandless Microwave-Assisted Pd/Cu-Catalyzed Direct Arylation of Oxazoles

(2008) François Besselièvre et al.   JOURNAL OF ORGANIC CHEMISTRY

Intramolecular Pd(II)-Catalyzed Oxidative Biaryl Synthesis Under Air: Reaction Development and Scope

(2008) Benoît Liégault et al.   JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Synthesis of (−)-Incarvillateine Employing an Intramolecular Alkylation via Rh-Catalyzed Olefinic C−H Bond Activation

(2008) Andy S. Tsai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A General Method for Copper-Catalyzed Arylation of Arene C−H Bonds

(2008) Hien-Quang Do et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of (±)-Actinophyllic Acid

(2008) Connor L. Martin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of (−)-Serotobenine

(2008) Yasuaki Koizumi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Syntheses of (±)-Massadine and Massadine Chloride

(2008) Shun Su et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Intermolecular Linear Allylic C−H Amination via Heterobimetallic Catalysis

(2008) Sean A. Reed et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Chiral Rhodium Carboxamidate Catalyst for Enantioselective C−H Amination

(2008) David N. Zalatan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of (+)-Cortistatin A

(2008) Ryan A. Shenvi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iron-Catalyzed Direct Arylation through Directed C−H Bond Activation

(2008) Jakob Norinder et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rh(I)-Catalyzed Direct Arylation of Pyridines and Quinolines

(2008) Ashley M. Berman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Synthesis of (+)-Cortistatin A, a Potent and Selective Inhibitor of Endothelial Cell Proliferation

(2008) Hong Myung Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium(II)-Catalyzed Direct Arylation of Enaminones Using Organotrifluoroborates

(2008) Haibo Ge et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

1,3-Diol Synthesis via Controlled, Radical-Mediated C−H Functionalization

(2008) Ke Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Asymmetric Allylic and Homoallylic Diamination of Terminal Olefins via Formal C−H Activation

(2008) Haifeng Du et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantiospecific Total Synthesis of the Hapalindoles, Fischerindoles, and Welwitindolinonesviaa Redox Economic Approach

(2008) Jeremy M. Richter et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Benzocyclobutenes by Palladium-Catalyzed C−H Activation of Methyl Groups: Method and Mechanistic Study

(2008) Manon Chaumontet et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic C–H functionalization by metal carbenoid and nitrenoid insertion

(2008) Huw M. L. Davies et al.   NATURE

First total synthesis of clausine L and pityriazole, a metabolite of the human pathogenic yeast Malassezia furfur

(2008) Ronny Forke et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Palladium-catalyzed total synthesis of euchrestifoline using a one-pot Wacker oxidation and double aromatic C–H bond activation

(2008) Konstanze K. Gruner et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Palladium-Catalyzed Direct Arylation of Nitro-Substituted Aromatics with Aryl Halides

(2008) Laurence Caron et al.   ORGANIC LETTERS

Stereoselective Direct Copper-Catalyzed Alkenylation of Oxazoles with Bromoalkenes

(2008) François Besselièvre et al.   ORGANIC LETTERS

Transition-Metal-Catalyzed Carbon-Carbon Bond Formation via Carbon-Hydrogen Bond Cleavage

(2008) Fumitoshi Kakiuchi et al.   SYNTHESIS-STUTTGART

Asymmetric formal synthesis of (−)-pancracine via catalytic enantioselective C–H amination process

(2008) Masahiro Anada et al.   TETRAHEDRON

An intramolecular Schmidt reaction strategy for the synthesis of a methyl analogue of crispine A

(2008) Ponminor Senthil Kumar et al.   TETRAHEDRON LETTERS

Copper-mediated direct arylation of benzoazoles with aryl iodides

(2008) Tomoki Yoshizumi et al.   TETRAHEDRON LETTERS

Palladium-Catalyzed Direct C−H Arylation ofN-Iminopyridinium Ylides:  Application to the Synthesis of (±)-Anabasine

(2007) Alexandre Larivée et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Formal synthesis of (−)-morphine from d-glucal based on the cascade Claisen rearrangement

(2007) Hiroki Tanimoto et al.   TETRAHEDRON LETTERS