Catalytic C(sp3)−H Arylation of Free Primary Amines with anexoDirecting Group Generated In Situ

Syntheses and Transformations of α-Amino Acids via Palladium-Catalyzed Auxiliary-Directed sp3 C–H Functionalization

(2016) Gang He et al.   ACCOUNTS OF CHEMICAL RESEARCH

A Hydrazone-Based exo -Directing-Group Strategy for β C−H Oxidation of Aliphatic Amines

(2016) Zhongxing Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthetic approaches to the 2010–2014 new agrochemicals

(2016) Stephane Jeanmart et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Auxiliary-assisted palladium-catalyzed halogenation of unactivated C(sp3)–H bonds at room temperature

(2016) Xinglin Yang et al.   CHEMICAL COMMUNICATIONS

Ligand-Enabled γ-C(sp3)–H Olefination of Amines: En Route to Pyrrolidines

(2016) Heng Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-catalysed transannular C–H functionalization of alicyclic amines

(2016) Joseph J. Topczewski et al.   NATURE

Direct Observation of C–H Cyclopalladation at Tertiary Positions Enabled by an Exo-Directing Group

(2016) Zhi Ren et al.   ORGANOMETALLICS

Functionalization of C(sp3)-H bonds using a transient directing group

(2016) F.-L. Zhang et al.   SCIENCE

Apology: Readily Removable Directing Group Assisted Chemo- and Regioselective C(sp3)H Activation by Palladium Catalysis

(2015) Yun-Fei Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ligand-Enabled Catalytic CH Arylation of Aliphatic Amines by a Four-Membered-Ring Cyclopalladation Pathway

(2015) Chuan He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed Arylation of Unactivated γ-Methylene C(sp3)H and δ-CH Bonds with an Oxazoline-Carboxylate Auxiliary

(2015) Peng-Xiang Ling et al.   CHEMISTRY-A EUROPEAN JOURNAL

Palladium(II)-Catalyzed Directed Trifluoromethylthiolation of Unactivated C(sp3)–H Bonds

(2015) Heng-Ying Xiong et al.   JOURNAL OF ORGANIC CHEMISTRY

Palladium(II)-Catalyzed Highly Enantioselective C–H Arylation of Cyclopropylmethylamines

(2015) Kelvin S. L. Chan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanistic Insights into the Palladium-Catalyzed Aziridination of Aliphatic Amines by C–H Activation

(2015) Adam P. Smalley et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Platinum-Catalyzed, Terminal-Selective C(sp3)–H Oxidation of Aliphatic Amines

(2015) Melissa Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cyclic Ether Synthesis via Palladium-Catalyzed Directed Dehydrogenative Annulation at Unactivated Terminal Positions

(2015) Samuel J. Thompson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diverse sp3 C−H functionalization through alcohol β-sulfonyloxylation

(2015) Yan Xu et al.   Nature Chemistry

Catalytic Ortho-Acetoxylation of Masked Benzyl Alcohols via an Exo-Directing Mode

(2015) Zhi Ren et al.   ORGANIC LETTERS

Direct Borylation of Primary CH Bonds in Functionalized Molecules by Palladium Catalysis

(2014) Li-Sheng Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Practical Aerobic Oxidations of Alcohols and Amines with Homogeneous Copper/TEMPO and Related Catalyst Systems

(2014) Bradford L. Ryland et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

(2014) Edon Vitaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

Palladium-catalysed C–H activation of aliphatic amines to give strained nitrogen heterocycles

(2014) Andrew McNally et al.   NATURE

Ligand-enabled cross-coupling of C(sp3)–H bonds with arylboron reagents via Pd(II)/Pd(0) catalysis

(2014) Kelvin S. L. Chan et al.   Nature Chemistry

Palladium-Catalyzed Stereoretentive Olefination of Unactivated C(sp3)–H Bonds with Vinyl Iodides at Room Temperature: Synthesis of β-Vinyl α-Amino Acids

(2014) Bo Wang et al.   ORGANIC LETTERS

Regioselective ketone  -alkylation with simple olefins via dual activation

(2014) F. Mo et al.   SCIENCE

Room-temperature enantioselective C–H iodination via kinetic resolution

(2014) Ling Chu et al.   SCIENCE

Silver-catalysed direct amination of unactivated C–H bonds of functionalized molecules

(2014) Mingyu Yang et al.   Nature Communications

Aerobic Synthesis of Pyrroles and Dihydropyrroles from Imines: Palladium(II)-Catalyzed Intramolecular CH Dehydrogenative Cyclization

(2013) Zhuangzhi Shi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed Direct Functionalization of 2-Aminobutanoic Acid Derivatives: Application of a Convenient and Versatile Auxiliary

(2013) Mengyang Fan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed Picolinamide-Directed Alkylation of Unactivated C(sp3)–H Bonds with Alkyl Iodides

(2013) Shu-Yu Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Direct Arylation of C(sp3)–H Bonds in Aliphatic Amides via Bidentate-Chelation Assistance

(2013) Yoshinori Aihara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Arylation of Primary and Secondary sp3 C–H Bonds with Diarylhyperiodonium Salts via Pd Catalysis

(2013) Fei Pan et al.   ORGANIC LETTERS

1,2,3-Triazoles as versatile directing group for selective sp2 and sp3 C–H activation: cyclization vs substitution

(2013) Xiaohan Ye et al.   Chemical Science

Metal-Catalyzed Nitrogen-Atom Transfer Methods for the Oxidation of Aliphatic C–H Bonds

(2012) Jennifer L. Roizen et al.   ACCOUNTS OF CHEMICAL RESEARCH

CH Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals

(2012) Junichiro Yamaguchi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficient Alkyl Ether Synthesis via Palladium-Catalyzed, Picolinamide-Directed Alkoxylation of Unactivated C(sp3)–H and C(sp2)–H Bonds at Remote Positions

(2012) Shu-Yu Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pd(II)-Catalyzed Primary-C(sp3)–H Acyloxylation at Room Temperature

(2012) Raja K. Rit et al.   ORGANIC LETTERS

Palladium-catalyzed N-(2-pyridyl)sulfonyl-directed C(sp3)–H γ-arylation of amino acid derivatives

(2012) Nuria Rodríguez et al.   Chemical Science

A Practical Strategy for the Structural Diversification of Aliphatic Scaffolds through the Palladium-Catalyzed Picolinamide-Directed Remote Functionalization of Unactivated C(sp3)H Bonds

(2011) Gang He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

C–H Functionalization in organic synthesis

(2011) Huw M. L. Davies et al.   CHEMICAL SOCIETY REVIEWS

C–H functionalization logic in total synthesis

(2011) Will R. Gutekunst et al.   CHEMICAL SOCIETY REVIEWS

Recent developments in natural product synthesis using metal-catalysed C–H bond functionalisation

(2011) Lindsay McMurray et al.   CHEMICAL SOCIETY REVIEWS

Highly Regioselective Carbonylation of Unactivated C(sp3)–H Bonds by Ruthenium Carbonyl

(2011) Nao Hasegawa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Heterocycle Synthesis via Direct C–H/N–H Coupling

(2011) Enrico T. Nadres et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Efficient Syntheses of Azetidines, Pyrrolidines, and Indolines via Palladium Catalyzed Intramolecular Amination of C(sp3)–H and C(sp2)–H Bonds at γ and δ Positions

(2011) Gang He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions

(2010) Thomas W. Lyons et al.   CHEMICAL REVIEWS

Auxiliary-Assisted Palladium-Catalyzed Arylation and Alkylation of sp2and sp3Carbon−Hydrogen Bonds

(2010) Dmitry Shabashov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium- and Copper-Catalyzed Arylation of Carbon−Hydrogen Bonds

(2009) Olafs Daugulis et al.   ACCOUNTS OF CHEMICAL RESEARCH

Palladium-Catalyzed Amidation of Unactivated C(sp3)H Bonds: from Anilines to Indolines

(2009) Julia J. Neumann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY