Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 80, Pages 14929-14932Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc04952k
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Funding
- National '973' grant from the Ministry of Science and Technology [2011CB965300]
- National Natural Science Foundation of China [21302106, 21290194, 21221002, 21473215]
- Tsinghua University Initiative Scientific Research Program
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A novel palladium catalyzed hydroxylation of unactivated aliphatic C(sp(3))-H bonds was successfully developed. Different from conventional methods, water serves as the hydroxyl group source in the reaction. This new reaction demonstrates good reactivity and broad functional group tolerance. The C-H hydroxylated products can be readily transformed into various highly valuable chemicals via known transformations. Based on experimental and theoretical studies, a mechanism involving the Pd(II)/(IV) pathway is proposed for this hydroxylation reaction.
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