Site-Selective δ-C(sp3 )−H Alkylation of Amino Acids and Peptides with Maleimides via a Six-Membered Palladacycle

sp3 C–H activation via exo-type directing groups

(2018) Yan Xu et al.   Chemical Science

Catalytic Coupling between Unactivated Aliphatic C–H Bonds and Alkynes via a Metal–Hydride Pathway

(2017) Yan Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

C–H Alkylations of (Hetero)Arenes by Maleimides and Maleate Esters through Cobalt(III) Catalysis

(2017) Zhao Zhang et al.   ORGANIC LETTERS

Rh(I)-Catalyzed Alkylation of ortho-C–H Bonds in Aromatic Amides with Maleimides

(2017) Qiyuan He et al.   ORGANIC LETTERS

An Approach to 3-(Indol-2-yl)succinimide Derivatives by Manganese-Catalyzed C–H Activation

(2017) Shuang-Liang Liu et al.   ORGANIC LETTERS

Late stage modification of peptides via C H activation reactions

(2017) Saumitra Sengupta et al.   TETRAHEDRON LETTERS

Syntheses and Transformations of α-Amino Acids via Palladium-Catalyzed Auxiliary-Directed sp3 C–H Functionalization

(2016) Gang He et al.   ACCOUNTS OF CHEMICAL RESEARCH

Stapled Peptides by Late-Stage C(sp3 )−H Activation

(2016) Anaïs F. M. Noisier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Divergent and Stereoselective Synthesis of β-Silyl-α-Amino Acids through Palladium-Catalyzed Intermolecular Silylation of Unactivated Primary and Secondary C−H Bonds

(2016) Yue-Jin Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Silicon-Containing Amino Acids: Synthetic Aspects, Conformational Studies, and Applications to Bioactive Peptides

(2016) Emmanuelle Rémond et al.   CHEMICAL REVIEWS

Palladium-Catalyzed Transformations of Alkyl C–H Bonds

(2016) Jian He et al.   CHEMICAL REVIEWS

Synthesis of unnatural amino acids through palladium-catalyzed C(sp3)H functionalization

(2016) Xi Lu et al.   CHINESE CHEMICAL LETTERS

Site-Selective Alkenylation of δ-C(sp3)–H Bonds with Alkynes via a Six-Membered Palladacycle

(2016) Jing-Wen Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rhodium(III)-Catalyzed C(sp3)–H Alkylation of 8-Methylquinolines with Maleimides

(2016) Sangil Han et al.   ORGANIC LETTERS

The reductive cleavage of picolinic amides

(2016) Daniel H. O’ Donovan et al.   TETRAHEDRON LETTERS

Stereoselective alkoxycarbonylation of unactivated C(sp3)–H bonds with alkyl chloroformates via Pd(II)/Pd(IV) catalysis

(2016) Gang Liao et al.   Nature Communications

Palladium-Catalyzed Carbonylative Cyclization of Amines via γ-C(sp3)–H Activation: Late-Stage Diversification of Amino Acids and Peptides

(2016) Elier Hernando et al.   ACS Catalysis

Undirected, Homogeneous C–H Bond Functionalization: Challenges and Opportunities

(2016) John F. Hartwig et al.   ACS Central Science

Bidentate, Monoanionic Auxiliary-Directed Functionalization of Carbon–Hydrogen Bonds

(2015) Olafs Daugulis et al.   ACCOUNTS OF CHEMICAL RESEARCH

Nickel-Catalyzed Insertion of Alkynes and Electron-Deficient Olefins into Unactivated sp3CH Bonds

(2015) Soham Maity et al.   CHEMISTRY-A EUROPEAN JOURNAL

Peptide therapeutics: current status and future directions

(2015) Keld Fosgerau et al.   DRUG DISCOVERY TODAY

Stereoselective Synthesis of Chiral β-Fluoro α-Amino Acids via Pd(II)-Catalyzed Fluorination of Unactivated Methylene C(sp3)–H Bonds: Scope and Mechanistic Studies

(2015) Qi Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ru (II)-Catalyzed C–H Activation: Ketone-Directed Novel 1,4-Addition of Ortho C–H Bond to Maleimides

(2015) Kiran R. Bettadapur et al.   ORGANIC LETTERS

Nickel-Catalyzed Addition-Type Alkenylation of Unactivated, Aliphatic C–H Bonds with Alkynes: A Concise Route to Polysubstituted γ-Butyrolactones

(2015) Mingliang Li et al.   ORGANIC LETTERS

Copper-Mediated Oxidative Coupling of Benzamides with Maleimides via Directed C–H Cleavage

(2015) Wataru Miura et al.   ORGANIC LETTERS

Reusable directing groups [8-aminoquinoline, picolinamide, sulfoximine] in C(sp3)–H bond activation: present and future

(2015) Raja K. Rit et al.   TETRAHEDRON

Sulfonamide-Promoted Palladium(II)-Catalyzed Alkylation of Unactivated Methylene C(sp3)H Bonds with Alkyl Iodides

(2014) Kai Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of azobenzenealkylmaleimide probes to photocontrol the enzyme activity of a bacterial histone deacetylase-like amidohydrolase

(2014) Benjamin Horstmann et al.   BIOORGANIC CHEMISTRY

C–H Functionalization in the Synthesis of Amino Acids and Peptides

(2014) Anaïs F. M. Noisier et al.   CHEMICAL REVIEWS

Site-Selective C(sp3)–H Functionalization of Di-, Tri-, and Tetrapeptides at the N-Terminus

(2014) Wei Gong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Remote C(sp3)–H Arylation of 3-Pinanamine

(2014) Wei Cui et al.   ORGANIC LETTERS

Stereoselective Synthesis of Chiral α-Amino-β-Lactams through Palladium(II)-Catalyzed Sequential Monoarylation/Amidation of C(sp3)H Bonds

(2013) Qi Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Functionalization of C(sp2)H and C(sp3)H Bonds by Using Bidentate Directing Groups

(2013) Guy Rouquet et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Genetic Incorporation of Multiple Unnatural Amino Acids into Proteins in Mammalian Cells

(2013) Han Xiao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed Picolinamide-Directed Alkylation of Unactivated C(sp3)–H Bonds with Alkyl Iodides

(2013) Shu-Yu Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Therapeutic peptides

(2012) Fernando Albericio et al.   Future Medicinal Chemistry

Efficient Alkyl Ether Synthesis via Palladium-Catalyzed, Picolinamide-Directed Alkoxylation of Unactivated C(sp3)–H and C(sp2)–H Bonds at Remote Positions

(2012) Shu-Yu Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-catalyzed N-(2-pyridyl)sulfonyl-directed C(sp3)–H γ-arylation of amino acid derivatives

(2012) Nuria Rodríguez et al.   Chemical Science

Transition metal-catalyzed arylation of unactivated C(sp3)–H bonds

(2011) Olivier Baudoin   CHEMICAL SOCIETY REVIEWS

Regioselectivity of the borylation of alkanes and arenes

(2011) John F. Hartwig   CHEMICAL SOCIETY REVIEWS

Heterocycle Synthesis via Direct C–H/N–H Coupling

(2011) Enrico T. Nadres et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Efficient Syntheses of Azetidines, Pyrrolidines, and Indolines via Palladium Catalyzed Intramolecular Amination of C(sp3)–H and C(sp2)–H Bonds at γ and δ Positions

(2011) Gang He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Challenge and progress: palladium-catalyzed sp3 C–H activation

(2011) Hu Li et al.   Catalysis Science & Technology

Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions

(2010) Thomas W. Lyons et al.   CHEMICAL REVIEWS

Functionalization of Organic Molecules by Transition-Metal-Catalyzed C(sp3)H Activation

(2010) Rodolphe Jazzar et al.   CHEMISTRY-A EUROPEAN JOURNAL

Palladium- and Copper-Catalyzed Arylation of Carbon−Hydrogen Bonds

(2009) Olafs Daugulis et al.   ACCOUNTS OF CHEMICAL RESEARCH

Palladium(II)-Catalyzed CH Activation/CC Cross-Coupling Reactions: Versatility and Practicality

(2009) Xiao Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transition-Metal-Catalyzed Carbon-Carbon Bond Formation via Carbon-Hydrogen Bond Cleavage

(2008) Fumitoshi Kakiuchi et al.   SYNTHESIS-STUTTGART