Site-Selective γ-C(sp3)-H and γ-C(sp2)-H Arylation of Free Amino Esters Promoted by a Catalytic Transient Directing Group

The first selective Pd-II-catalysed gamma-C(sp(3))-H and gamma-C(sp(2))-H arylation of free amino esters using a commercially available catalytic transient directing group. A variety of free amino esters, including alpha-amino esters and beta-amino esters, amino monoesters and amino bis-esters, are shown to react with a diverse range of simple aryl and heteroaryl iodide reagents.