Modular, stereocontrolled Cβ–H/Cα–C activation of alkyl carboxylic acids

Transition-Metal-Catalyzed Selective Functionalization of C(sp3 )−H Bonds in Natural Products

(2018) Rashad R. Karimov et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pd(II)-Catalyzed Enantioselective C(sp3)–H Arylation of Free Carboxylic Acids

(2018) Peng-Xiang Shen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organic synthesis provides opportunities to transform drug discovery

(2018) David C. Blakemore et al.   Nature Chemistry

Regio- and Stereoselective Palladium-Catalyzed C(sp3)–H Arylation of Pyrrolidines and Piperidines with C(3) Directing Groups

(2018) Daniele Antermite et al.   ORGANIC LETTERS

Enantioselective C–H Arylation and Vinylation of Cyclobutyl Carboxylic Amides

(2018) Qing-Feng Wu et al.   ACS Catalysis

Radical Retrosynthesis

(2018) Joel M. Smith et al.   ACCOUNTS OF CHEMICAL RESEARCH

Building C(sp3)-rich complexity by combining cycloaddition and C–C cross-coupling reactions

(2018) Tie–Gen Chen et al.   NATURE

Cu-Catalyzed Decarboxylative Borylation

(2018) Jie Wang et al.   ACS Catalysis

A Survey of the Structures of US FDA Approved Combination Drugs

(2018) Pradipta Das et al.   JOURNAL OF MEDICINAL CHEMISTRY

Decarboxylative alkenylation

(2017) Jacob T. Edwards et al.   NATURE

Decarboxylative borylation

(2017) Chao Li et al.   SCIENCE

Nickel-Catalyzed Barton Decarboxylation and Giese Reactions: A Practical Take on Classic Transforms

(2016) Tian Qin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nickel-Catalyzed Cross-Coupling of Redox-Active Esters with Boronic Acids

(2016) Jie Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed Transformations of Alkyl C–H Bonds

(2016) Jian He et al.   CHEMICAL REVIEWS

Practical Ni-Catalyzed Aryl–Alkyl Cross-Coupling of Secondary Redox-Active Esters

(2016) Josep Cornella et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

(2016) Nobutaka Kato et al.   NATURE

Enantioselective amine α-functionalization via palladium-catalysed C–H arylation of thioamides

(2016) Pankaj Jain et al.   Nature Chemistry

Ligand-accelerated enantioselective methylene C(sp3)–H bond activation

(2016) Gang Chen et al.   SCIENCE

A general alkyl-alkyl cross-coupling enabled by redox-active esters and alkylzinc reagents

(2016) T. Qin et al.   SCIENCE

UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genes

(2016) Michelle Yi-Xiu Lim et al.   Nature Microbiology

Transition metal-catalyzed ketone-directed or mediated C–H functionalization

(2015) Zhongxing Huang et al.   CHEMICAL SOCIETY REVIEWS

Transition metal-catalyzed C–H bond functionalizations by the use of diverse directing groups

(2015) Zhengkai Chen et al.   Organic Chemistry Frontiers

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

(2014) Edon Vitaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Saturated N-Heterocycles

(2014) Cam-Van T. Vo et al.   JOURNAL OF ORGANIC CHEMISTRY

Regio- and Stereospecific Synthesis of C-3 Functionalized Proline Derivatives by Palladium Catalyzed Directed C(sp3)–H Arylation

(2014) Dominic P. Affron et al.   ORGANIC LETTERS

Ruthenium(II)-Catalyzed C(sp3)–H α-Alkylation of Pyrrolidines

(2014) Marvin Schinkel et al.   ORGANIC LETTERS

Palladium-catalyzed trifluoroacetate-promoted mono-arylation of the β-methyl group of alanine at room temperature: synthesis of β-arylated α-amino acids through sequential C–H functionalization

(2014) Bo Wang et al.   Chemical Science

Class D β-Lactamases: A Reappraisal after Five Decades

(2013) David A. Leonard et al.   ACCOUNTS OF CHEMICAL RESEARCH

Carboxylate-Assisted Ruthenium-Catalyzed Alkyne Annulations by C–H/Het–H Bond Functionalizations

(2013) Lutz Ackermann   ACCOUNTS OF CHEMICAL RESEARCH

Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor

(2013) Grigory Veinberg et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Targeting Plasmodium PI(4)K to eliminate malaria

(2013) Case W. McNamara et al.   NATURE

Antimalarial drug discovery — approaches and progress towards new medicines

(2013) Erika L. Flannery et al.   NATURE REVIEWS MICROBIOLOGY

CH Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals

(2012) Junichiro Yamaguchi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and Profiling of a Diverse Collection of Azetidine-Based Scaffolds for the Development of CNS-Focused Lead-like Libraries

(2012) Jason T. Lowe et al.   JOURNAL OF ORGANIC CHEMISTRY

Recent Developments in Palladium-Catalyzed Alkene Aminoarylation Reactions for the Synthesis of Nitrogen Heterocycles

(2012) John Wolfe et al.   SYNTHESIS-STUTTGART

Innate and Guided C–H Functionalization Logic

(2011) Tobias Brückl et al.   ACCOUNTS OF CHEMICAL RESEARCH

Weak Coordination as a Powerful Means for Developing Broadly Useful C–H Functionalization Reactions

(2011) Keary M. Engle et al.   ACCOUNTS OF CHEMICAL RESEARCH

Synergistic Palladium-Catalyzed C(sp3)H Activation/C(sp3)O Bond Formation: A Direct, Step-Economical Route to Benzolactones

(2011) Petr Novák et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

C–H functionalization logic in total synthesis

(2011) Will R. Gutekunst et al.   CHEMICAL SOCIETY REVIEWS

Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions

(2010) Thomas W. Lyons et al.   CHEMICAL REVIEWS

C-2 Arylation of Piperidines through Directed Transition-Metal-Catalyzed sp3CH Activation

(2010) Hana Prokopcová et al.   CHEMISTRY-A EUROPEAN JOURNAL

Functionalization of Organic Molecules by Transition-Metal-Catalyzed C(sp3)H Activation

(2010) Rodolphe Jazzar et al.   CHEMISTRY-A EUROPEAN JOURNAL

Three Decades of  -Lactamase Inhibitors

(2010) S. M. Drawz et al.   CLINICAL MICROBIOLOGY REVIEWS

Palladium- and Copper-Catalyzed Arylation of Carbon−Hydrogen Bonds

(2009) Olafs Daugulis et al.   ACCOUNTS OF CHEMICAL RESEARCH

Palladium(II)-Catalyzed CH Activation/CC Cross-Coupling Reactions: Versatility and Practicality

(2009) Xiao Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY

Carboxylic Acids as Substrates in Homogeneous Catalysis

(2008) Lukas J. Gooßen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Towards the Optimal Screening Collection: A Synthesis Strategy

(2007) Thomas E. Nielsen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION