Iron-Catalyzed C(sp2)H and C(sp3)H Methylations of Amides and Anilides

Manganese-Catalyzed Synthesis ofcis-β-Amino Acid Esters through Organometallic CH Activation of Ketimines

(2015) Weiping Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Robust Ruthenium(II)-Catalyzed C–H Arylations: Carboxylate Assistance for the Efficient Synthesis of Angiotensin-II-Receptor Blockers

(2015) Lutz Ackermann   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Formal SN-Type Reactions in Rhodium(III)-Catalyzed CH Bond Activation

(2014) Nadine Kuhl et al.   ADVANCED SYNTHESIS & CATALYSIS

Catalysis for Total Synthesis: A Personal Account

(2014) Alois Fürstner   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iron-Catalyzed C(sp2)H and C(sp3)H Arylation by Triazole Assistance

(2014) Qing Gu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nickel-Catalyzed CH Alkylations: Direct Secondary Alkylations and Trifluoroethylations of Arenes

(2014) Weifeng Song et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cobalt-Catalyzed CH Cyanation of Arenes and Heteroarenes

(2014) Jie Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Triazole-Assisted Ruthenium-Catalyzed CH Arylation of Aromatic Amides

(2014) Hamad H. Al Mamari et al.   CHEMISTRY-A EUROPEAN JOURNAL

Cobalt-Catalyzed C–H Arylations, Benzylations, and Alkylations with Organic Electrophiles and Beyond

(2014) Lutz Ackermann   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Anthranilic Acid Derivatives through Iron-Catalyzed Ortho Amination of Aromatic Carboxamides with N-Chloroamines

(2014) Tatsuaki Matsubara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Unified Strategy for Iron-Catalyzed ortho-Alkylation of Carboxamides

(2014) Erin R. Fruchey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Convergent Synthesis of Diverse Tetrahydropyridines via Rh(I)-Catalyzed C–H Functionalization Sequences

(2014) Tehetena Mesganaw et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

The Cross-Dehydrogenative Coupling of C sp 3H Bonds: A Versatile Strategy for CC Bond Formations

(2013) Simon A. Girard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Profound Methyl Effects in Drug Discovery and a Call for New CH Methylation Reactions

(2013) Heike Schönherr et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iron-Catalyzed Oxidative Radical Cross-Coupling/Cyclization between Phenols and Olefins

(2013) Zhiliang Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhodium(I)-Catalyzed Redox-Economic Cross-Coupling of Carboxylic Acids with Arenes Directed by N-Containing Groups

(2013) Fei Pan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Functionalization of C(sp2)H and C(sp3)H Bonds by Using Bidentate Directing Groups

(2013) Guy Rouquet et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nickel-catalyzed alkyne annulation by anilines: versatile indole synthesis by C–H/N–H functionalization

(2013) Weifeng Song et al.   CHEMICAL COMMUNICATIONS

C–H nitrogenation and oxygenation by ruthenium catalysis

(2013) Vedhagiri S. Thirunavukkarasu et al.   CHEMICAL COMMUNICATIONS

Cobalt-Catalyzed CH Bond Functionalizations with Aryl and Alkyl Chlorides

(2013) Benudhar Punji et al.   CHEMISTRY-A EUROPEAN JOURNAL

Torsion Angle Preferences in Druglike Chemical Space: A Comprehensive Guide

(2013) Christin Schärfer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Iron-Catalyzed Ortho-Allylation of Aromatic Carboxamides with Allyl Ethers

(2013) Sobi Asako et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

C–H bond activation enables the rapid construction and late-stage diversification of functional molecules

(2013) Joanna Wencel-Delord et al.   Nature Chemistry

Mild Palladium-Catalyzed C–H Alkylation Using Potassium Alkyltrifluoroborates in Combination with MnF3

(2013) Sharon R. Neufeldt et al.   ORGANIC LETTERS

Programmed synthesis of arylthiazoles through sequential C–H couplings

(2013) Satoshi Tani et al.   Chemical Science

Palladium-Catalyzed CH Oxidation of Isoquinoline N-Oxides: Selective Alkylation with Dialkyl Sulfoxides and Halogenation with Dihalo sulfoxides

(2012) Bo Yao et al.   ADVANCED SYNTHESIS & CATALYSIS

Cobalt-Catalyzed Direct Arylation and Benzylation by CH/CO Cleavage with Sulfamates, Carbamates, and Phosphates

(2012) Weifeng Song et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Scaffold-hopping with zwitterionic CCR3 antagonists: Identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092

(2012) Ash Bahl et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Potent and Selective S1P1 Antagonist with Efficacy in Experimental Autoimmune Encephalomyelitis

(2012) Jean Quancard et al.   CHEMISTRY & BIOLOGY

Methyl Effects on Protein–Ligand Binding

(2012) Cheryl S. Leung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Iron-CatalyzedorthoMonoarylation of Benzamide Derivatives

(2012) Laurean Ilies et al.   Asian Journal of Organic Chemistry

Weak Coordination as a Powerful Means for Developing Broadly Useful C–H Functionalization Reactions

(2011) Keary M. Engle et al.   ACCOUNTS OF CHEMICAL RESEARCH

The Methylation Effect in Medicinal Chemistry

(2011) Eliezer J. Barreiro et al.   CHEMICAL REVIEWS

Catalytic Dehydrogenative Cross-Coupling: Forming Carbon−Carbon Bonds by Oxidizing Two Carbon−Hydrogen Bonds

(2011) Charles S. Yeung et al.   CHEMICAL REVIEWS

Transition metal-catalyzed arylation of unactivated C(sp3)–H bonds

(2011) Olivier Baudoin   CHEMICAL SOCIETY REVIEWS

Direct Arylation as a Synthetic Tool for the Synthesis of Thiophene-Based Organic Electronic Materials

(2011) Derek J. Schipper et al.   CHEMISTRY OF MATERIALS

Palladium-Catalyzed Coupling of Arene C–H Bonds with Methyl- and Arylboron Reagents Assisted by the Removable 2-Pyridylsulfinyl Group

(2011) José A. Romero-Revilla et al.   JOURNAL OF ORGANIC CHEMISTRY

Iron-Catalyzed Stereospecific Activation of Olefinic C–H Bonds with Grignard Reagent for Synthesis of Substituted Olefins

(2011) Laurean Ilies et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Divergent C–H Functionalizations Directed by Sulfonamide Pharmacophores: Late-Stage Diversification as a Tool for Drug Discovery

(2011) Hui-Xiong Dai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cobalt-Catalyzed Coupling of Alkyl Grignard Reagent with Benzamide and 2-Phenylpyridine Derivatives through Directed C–H Bond Activation under Air

(2011) Quan Chen et al.   ORGANIC LETTERS

Palladium-Catalyzed Alkylation ofortho-C(sp2)–H Bonds of Benzylamide Substrates with Alkyl Halides

(2011) Yingsheng Zhao et al.   ORGANIC LETTERS

Iron-Catalyzed Direct Arylation of Unactivated Arenes with Aryl Halides

(2010) Wei Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metal-catalyzed direct alkylations of (hetero)arenes via C–H bond cleavages with unactivated alkyl halides

(2010) Lutz Ackermann   CHEMICAL COMMUNICATIONS

Direct C−H Transformation via Iron Catalysis

(2010) Chang-Liang Sun et al.   CHEMICAL REVIEWS

Oxidative Coupling of Aromatic Substrates with Alkynes and Alkenes under Rhodium Catalysis

(2010) Tetsuya Satoh et al.   CHEMISTRY-A EUROPEAN JOURNAL

Cross-Coupling of C(sp3)-H Bonds with Organometallic Reagents via Pd(II)/Pd(0) Catalysis

(2010) Masayuki Wasa et al.   ISRAEL JOURNAL OF CHEMISTRY

Low-Valent Iron-Catalyzed C−C Bond Formation−Addition, Substitution, and C−H Bond Activation

(2010) Eiichi Nakamura et al.   JOURNAL OF ORGANIC CHEMISTRY

Regioselective syntheses of fully-substituted 1,2,3-triazoles: the CuAAC/C–H bond functionalization nexus

(2010) Lutz Ackermann et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Iron-Catalyzed Chemoselective ortho Arylation of Aryl Imines by Directed CH Bond Activation

(2009) Naohiko Yoshikai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cross Dehydrogenative Arylation (CDA) of a Benzylic CH Bond with Arenes by Iron Catalysis

(2009) Yi-Zhou Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transition-Metal-Catalyzed Direct Arylation of (Hetero)Arenes by CH Bond Cleavage

(2009) Lutz Ackermann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium(II)-Catalyzed CH Activation/CC Cross-Coupling Reactions: Versatility and Practicality

(2009) Xiao Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Aryl- and heteroaryl-substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitors

(2009) Markus Boehringer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Transition metal-catalyzed C–H activation reactions: diastereoselectivity and enantioselectivity

(2009) Ramesh Giri et al.   CHEMICAL SOCIETY REVIEWS

Direct palladium-catalyzed alkenylation, benzylation and alkylation of ethyl oxazole-4-carboxylate with alkenyl-, benzyl- and alkyl halides

(2009) Cécile Verrier et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The Promise and Challenge of Iron-Catalyzed Cross Coupling

(2008) Benjamin D. Sherry et al.   ACCOUNTS OF CHEMICAL RESEARCH

Sustainable Metal Catalysis with Iron: From Rust to a Rising Star?

(2008) Stephan Enthaler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iron-catalysed carbon–heteroatom and heteroatom–heteroatom bond forming processes

(2008) Arkaitz Correa et al.   CHEMICAL SOCIETY REVIEWS

Palladium-Catalyzed Methylation of Aryl C−H Bond by Using Peroxides

(2008) Yuhua Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iron-Catalyzed Direct Arylation through Directed C−H Bond Activation

(2008) Jakob Norinder et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

C−H Bond Activation of Heteroarenes Mediated by a Half-Sandwich Iron Complex of N-Heterocyclic Carbene

(2008) Yasuhiro Ohki et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Catalyzed “Click” Reaction/Direct Arylation Sequence: Modular Syntheses of 1,2,3-Triazoles

(2008) Lutz Ackermann et al.   ORGANIC LETTERS