Nickel-Catalyzed Site-Selective Amidation of Unactivated C(sp3)H Bonds

Copper-Catalyzed Intramolecular C(sp3)H and C(sp2)H Amidation by Oxidative Cyclization

(2014) Zhen Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Catalyzed Site-Selective Intramolecular Amidation of Unactivated C(sp3)H Bonds

(2014) Xuesong Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nickel-Catalyzed CH Alkylations: Direct Secondary Alkylations and Trifluoroethylations of Arenes

(2014) Weifeng Song et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nickel-catalyzed chelation-assisted direct arylation of unactivated C(sp3)–H bonds with aryl halides

(2014) Mingliang Li et al.   CHEMICAL COMMUNICATIONS

Timing Is Everything: Unifying Codon Translation Rates and Nascent Proteome Behavior

(2014) Daniel A. Nissley et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Class D β-Lactamases: A Reappraisal after Five Decades

(2013) David A. Leonard et al.   ACCOUNTS OF CHEMICAL RESEARCH

Stereoselective Synthesis of Chiral α-Amino-β-Lactams through Palladium(II)-Catalyzed Sequential Monoarylation/Amidation of C(sp3)H Bonds

(2013) Qi Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

CH Alkenylation of Azoles with Enols and Esters by Nickel Catalysis

(2013) Lingkui Meng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Use of a Readily Removable Auxiliary Group for the Synthesis of Pyrrolidones by the Palladium-Catalyzed Intramolecular Amination of Unactivated γ C(sp3)H Bonds

(2013) Gang He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Functionalization of C(sp2)H and C(sp3)H Bonds by Using Bidentate Directing Groups

(2013) Guy Rouquet et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nickel-catalyzed alkyne annulation by anilines: versatile indole synthesis by C–H/N–H functionalization

(2013) Weifeng Song et al.   CHEMICAL COMMUNICATIONS

Origins of the β-lactam rings in natural products

(2013) Kapil Tahlan et al.   JOURNAL OF ANTIBIOTICS

Developing Ligands for Palladium(II)-Catalyzed C–H Functionalization: Intimate Dialogue between Ligand and Substrate

(2013) Keary M. Engle et al.   JOURNAL OF ORGANIC CHEMISTRY

Bimetallic Oxidative Addition Involving Radical Intermediates in Nickel-Catalyzed Alkyl–Alkyl Kumada Coupling Reactions

(2013) Jan Breitenfeld et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Isolation, Structure, and Reactivity of an Arylnickel(II) Pivalate Complex in Catalytic C–H/C–O Biaryl Coupling

(2013) Kei Muto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

β-Arylation of Carboxamides via Iron-Catalyzed C(sp3)–H Bond Activation

(2013) Rui Shang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanism and Selectivity in Nickel-Catalyzed Cross-Electrophile Coupling of Aryl Halides with Alkyl Halides

(2013) Soumik Biswas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Picolinamide-Directed Alkylation of Unactivated C(sp3)–H Bonds with Alkyl Iodides

(2013) Shu-Yu Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Direct Alkylation of C–H Bonds in Benzamides and Acrylamides with Functionalized Alkyl Halides via Bidentate-Chelation Assistance

(2013) Yoshinori Aihara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Direct Arylation of C(sp3)–H Bonds in Aliphatic Amides via Bidentate-Chelation Assistance

(2013) Yoshinori Aihara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

β-Lactamase Inhibitors: An Update

(2013) Jiao Chen et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

A robustness screen for the rapid assessment of chemical reactions

(2013) Karl D. Collins et al.   Nature Chemistry

Tandem Isomerization and C–H Activation: Regioselective Hydroheteroarylation of Allylarenes

(2013) Wei-Chih Lee et al.   ORGANIC LETTERS

Palladium-Catalyzed Unactivated C(sp3)–H Bond Activation and Intramolecular Amination of Carboxamides: A New Approach to β-Lactams

(2013) Wen-Wu Sun et al.   ORGANIC LETTERS

Carbon–Hydrogen Bond Stannylation and Alkylation Catalyzed by Nitrogen-Donor-Supported Nickel Complexes: Intermediates with Ni–Sn Bonds and Catalytic Carbostannylation of Ethylene with Organostannanes

(2013) Meghan E. Doster et al.   ORGANOMETALLICS

3,3-gem-Difluorinated-β-lactams: synthesis pathways and applications

(2013) Thomas Orbegozo et al.   TETRAHEDRON

Pd(ii)-catalyzed alkylation of unactivated C(sp3)–H bonds: efficient synthesis of optically active unnatural α-amino acids

(2013) Kai Chen et al.   Chemical Science

Alkylation of Pyridone Derivatives By Nickel/Lewis Acid Catalysis

(2012) Ryuichi Tamura et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

CH Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals

(2012) Junichiro Yamaguchi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nonnatural Amino Acid Synthesis by Using Carbon-Hydrogen Bond Functionalization Methodology

(2012) Ly Dieu Tran et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nickel(0)/NaHMDS adduct-mediated intramolecular alkylation of unactivated arenes via a homolytic aromatic substitution mechanism

(2012) Louis-Philippe B. Beaulieu et al.   CHEMICAL COMMUNICATIONS

Ruthenium(II)-Catalyzed C–H Bond Activation and Functionalization

(2012) Percia Beatrice Arockiam et al.   CHEMICAL REVIEWS

Catalytic Arylation of a CH Bond in Pyridine and Related Six-Membered N-Heteroarenes Using Organozinc Reagents

(2012) Isao Hyodo et al.   Chemistry-An Asian Journal

Anticancer Drug Design Using Scaffolds of β-Lactams, Sulfonamides, Quinoline, Quinoxaline and Natural Products. Drugs Advances in Clinical Trials

(2012) I. Balderas-Renteria et al.   CURRENT MEDICINAL CHEMISTRY

Reappraising the use of β-lactams to treat tuberculosis

(2012) Sebastian G Kurz et al.   Expert Review of Anti-Infective Therapy

Decarbonylative C–H Coupling of Azoles and Aryl Esters: Unprecedented Nickel Catalysis and Application to the Synthesis of Muscoride A

(2012) Kazuma Amaike et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pd(II)-Catalyzed Primary-C(sp3)–H Acyloxylation at Room Temperature

(2012) Raja K. Rit et al.   ORGANIC LETTERS

The Regioselective Switch for Amino-NHC Mediated C–H Activation of Benzimidazole via Ni–Al Synergistic Catalysis

(2012) Wei-Chun Shih et al.   ORGANIC LETTERS

Ni-Catalyzed Alkenylation of Triazolopyridines: Synthesis of 2,6-Disubstituted Pyridines

(2012) Sheng Liu et al.   ORGANIC LETTERS

Mechanistic Origin of Regioselectivity in Nickel-Catalyzed Olefin Hydroheteroarylation through C–H Activation

(2012) Yuan-Ye Jiang et al.   ORGANOMETALLICS

Adding Aliphatic C-H Bond Oxidations to Synthesis

(2012) M. C. White   SCIENCE

Advances in the chemistry of ?-lactam and its medicinal applications

(2012) Anushree Kamath et al.   TETRAHEDRON

Palladium-catalyzed N-(2-pyridyl)sulfonyl-directed C(sp3)–H γ-arylation of amino acid derivatives

(2012) Nuria Rodríguez et al.   Chemical Science

Rhodium Catalyzed Chelation-Assisted C–H Bond Functionalization Reactions

(2011) Denise A. Colby et al.   ACCOUNTS OF CHEMICAL RESEARCH

Nickel- and Cobalt-Catalyzed Direct Alkylation of Azoles with N-Tosylhydrazones Bearing Unactivated Alkyl Groups

(2011) Tomoyuki Yao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nickel-Catalyzed Three-Component Coupling between Aryl Aldehydes, Norbornenes, and Silanes Leading to Indanols through Aromatic CH Bond Activation of Aryl Aldehydes

(2011) Kenichi Ogata et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Practical Strategy for the Structural Diversification of Aliphatic Scaffolds through the Palladium-Catalyzed Picolinamide-Directed Remote Functionalization of Unactivated C(sp3)H Bonds

(2011) Gang He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

If CH Bonds Could Talk: Selective CH Bond Oxidation

(2011) Timothy Newhouse et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nickel-catalyzed sp2 C–H bonds arylation of N-aromatic heterocycles with Grignard reagents at room temperature

(2011) Gui-Rong Qu et al.   CHEMICAL COMMUNICATIONS

Regioselective C–H bond functionalizations of acridines using organozinc reagents

(2011) Isao Hyodo et al.   CHEMICAL COMMUNICATIONS

Catalytic Dehydrogenative Cross-Coupling: Forming Carbon−Carbon Bonds by Oxidizing Two Carbon−Hydrogen Bonds

(2011) Charles S. Yeung et al.   CHEMICAL REVIEWS

Carboxylate-Assisted Transition-Metal-Catalyzed C−H Bond Functionalizations: Mechanism and Scope

(2011) Lutz Ackermann   CHEMICAL REVIEWS

C–H Functionalization in organic synthesis

(2011) Huw M. L. Davies et al.   CHEMICAL SOCIETY REVIEWS

C–H functionalization logic in total synthesis

(2011) Will R. Gutekunst et al.   CHEMICAL SOCIETY REVIEWS

Transition metal-catalyzed arylation of unactivated C(sp3)–H bonds

(2011) Olivier Baudoin   CHEMICAL SOCIETY REVIEWS

Regioselectivity of the borylation of alkanes and arenes

(2011) John F. Hartwig   CHEMICAL SOCIETY REVIEWS

Nickel-Catalyzed CH Arylation of Azoles with Haloarenes: Scope, Mechanism, and Applications to the Synthesis of Bioactive Molecules

(2011) Takuya Yamamoto et al.   CHEMISTRY-A EUROPEAN JOURNAL

Monocyclic β-Lactams: New Structures for New Biological Activities

(2011) P. Galletti et al.   CURRENT MEDICINAL CHEMISTRY

Revisiting Beta-lactams – PK/PD improves dosing of old antibiotics

(2011) Alasdair MacGowan   CURRENT OPINION IN PHARMACOLOGY

Nickel-Catalyzed C–H/C–O Coupling of Azoles with Phenol Derivatives

(2011) Kei Muto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Direct Ethynylation of C(sp3)–H Bonds in Aliphatic Carboxylic Acid Derivatives

(2011) Yusuke Ano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Heterocycle Synthesis via Direct C–H/N–H Coupling

(2011) Enrico T. Nadres et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Efficient Syntheses of Azetidines, Pyrrolidines, and Indolines via Palladium Catalyzed Intramolecular Amination of C(sp3)–H and C(sp2)–H Bonds at γ and δ Positions

(2011) Gang He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dehydrogenative [4 + 2] Cycloaddition of Formamides with Alkynes through Double C−H Activation

(2011) Yoshiaki Nakao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Chelation-Assisted Transformations Involving Ortho C–H Bond Activation: Regioselective Oxidative Cycloaddition of Aromatic Amides to Alkynes

(2011) Hirotaka Shiota et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel(0)-Catalyzed Cyclization ofN-Benzoylaminals for Isoindolinone Synthesis

(2011) Danielle M. Shacklady-McAtee et al.   ORGANIC LETTERS

Palladium-Catalyzed Direct ortho-Alkynylation of Aromatic Carboxylic Acid Derivatives

(2011) Yusuke Ano et al.   ORGANIC LETTERS

Hydrofluoroarylation of Alkynes with Ni Catalysts. C–H Activation via Ligand-to-Ligand Hydrogen Transfer, an Alternative to Oxidative Addition

(2011) Julie Guihaumé et al.   ORGANOMETALLICS

Cobalt-Catalyzed, Chelation-Assisted C-H Bond Functionalization

(2011) Naohiko Yoshikai   SYNLETT

Synthesis and reactivity of spiro-fused β-lactams

(2011) Girija S. Singh et al.   TETRAHEDRON

Challenge and progress: palladium-catalyzed sp3 C–H activation

(2011) Hu Li et al.   Catalysis Science & Technology

Nickel-Catalyzed Hydroheteroarylation of Vinylarenes

(2010) Yoshiaki Nakao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Nickel/Copper-Catalyzed Direct Alkylation of Heterocyclic CH Bonds

(2010) Oleg Vechorkin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nickel-Catalyzed Direct CH Arylation and Alkenylation of Heteroarenes with Organosilicon Reagents

(2010) Hitoshi Hachiya et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Oxidative Nickel-Air Catalysis in CH Arylation: Direct Cross-Coupling of Azoles with Arylboronic Acids using Air as Sole Oxidant

(2010) Hitoshi Hachiya et al.   ChemCatChem

Metal-catalyzed direct alkylations of (hetero)arenes via C–H bond cleavages with unactivated alkyl halides

(2010) Lutz Ackermann   CHEMICAL COMMUNICATIONS

Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions

(2010) Thomas W. Lyons et al.   CHEMICAL REVIEWS

Palladium- and Nickel-Catalyzed Direct Alkylation of Azoles with Unactivated Alkyl Bromides and Chlorides

(2010) Tomoyuki Yao et al.   CHEMISTRY-A EUROPEAN JOURNAL

Functionalization of Organic Molecules by Transition-Metal-Catalyzed C(sp3)H Activation

(2010) Rodolphe Jazzar et al.   CHEMISTRY-A EUROPEAN JOURNAL

Hydrofluoroarylation of alkynes with fluoroarenes

(2010) Kyalo Stephen Kanyiva et al.   DALTON TRANSACTIONS

Cross-Coupling of C(sp3)-H Bonds with Organometallic Reagents via Pd(II)/Pd(0) Catalysis

(2010) Masayuki Wasa et al.   ISRAEL JOURNAL OF CHEMISTRY

Selective C-4 Alkylation of Pyridine by Nickel/Lewis Acid Catalysis

(2010) Yoshiaki Nakao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bimetallic Nickel Aluminun MediatedPara-Selective Alkenylation of Pyridine: Direct Observation of η2,η1-Pyridine Ni(0)−Al(III) Intermediates Prior to C−H Bond Activation

(2010) Chung-Chih Tsai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic C−H Bond Stannylation: A New Regioselective Pathway to C−Sn Bonds via C−H Bond Functionalization

(2010) Meghan E. Doster et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Auxiliary-Assisted Palladium-Catalyzed Arylation and Alkylation of sp2and sp3Carbon−Hydrogen Bonds

(2010) Dmitry Shabashov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel- and Copper-Catalyzed Direct Alkynylation of Azoles and Polyfluoroarenes with Terminal Alkynes under O2or Atmospheric Conditions

(2010) Naoto Matsuyama et al.   ORGANIC LETTERS

Nickel, Manganese, Cobalt, and Iron-Catalyzed Deprotonative Arene Dimerization

(2010) Thanh Truong et al.   ORGANIC LETTERS

Synthesis and Reactivity of NiII(Phpy)2(Phpy = 2-Phenylpyridine)†

(2010) Andrew T. Higgs et al.   ORGANOMETALLICS

Carbon−Hydrogen Bond Oxidative Addition of Partially Fluorinated Aromatics to a Ni(PiPr3)2Synthon: The Influence of Steric Bulk on the Thermodynamics and Kinetics of C−H Bond Activation

(2010) Jillian A. Hatnean et al.   ORGANOMETALLICS

Palladium- and Copper-Catalyzed Arylation of Carbon−Hydrogen Bonds

(2009) Olafs Daugulis et al.   ACCOUNTS OF CHEMICAL RESEARCH

Palladium(II)-Catalyzed CH Activation/CC Cross-Coupling Reactions: Versatility and Practicality

(2009) Xiao Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhodium-Catalyzed C−C Bond Formation via Heteroatom-Directed C−H Bond Activation

(2009) Denise A. Colby et al.   CHEMICAL REVIEWS

Nickel-Catalyzed C−H Alkenylation and Alkylation of 1,3,4-Oxadiazoles with Alkynes and Styrenes

(2009) Tomoya Mukai et al.   JOURNAL OF ORGANIC CHEMISTRY

Nickel-Catalyzed Reaction of Arylzinc Reagents with N-Aromatic Heterocycles: A Straightforward Approach to C−H Bond Arylation of Electron-Deficient Heteroaromatic Compounds

(2009) Mamoru Tobisu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Alkenylation and Alkylation of Pyridone Derivatives by Ni/AlMe3Catalysis

(2009) Yoshiaki Nakao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Direct Alkynylation of Azoles with Alkynyl Bromides

(2009) Naoto Matsuyama et al.   ORGANIC LETTERS

Nickel-Catalyzed Direct Arylation of Azoles with Aryl Bromides

(2009) Hitoshi Hachiya et al.   ORGANIC LETTERS

Nickel-Catalyzed Biaryl Coupling of Heteroarenes and Aryl Halides/Triflates

(2009) Jérôme Canivet et al.   ORGANIC LETTERS

Oxidatively Induced Carbon−Halogen Bond-Forming Reactions at Nickel

(2009) Andrew T. Higgs et al.   ORGANOMETALLICS

Regioselective alkenylation of imidazoles by nickel/Lewis acid catalysis

(2009) Kyalo Stephen Kanyiva et al.   TETRAHEDRON LETTERS

Cross-Coupling Reaction of Alkyl Halides with Grignard Reagents Catalyzed by Ni, Pd, or Cu Complexes with π-Carbon Ligand(s)

(2008) Jun Terao et al.   ACCOUNTS OF CHEMICAL RESEARCH

Nickel-Catalyzed Alkenylation and Alkylation of Fluoroarenes via Activation of C−H Bond over C−F Bond

(2008) Yoshiaki Nakao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Strategy for C−H Activation of Pyridines:  Direct C-2 Selective Alkenylation of Pyridines by Nickel/Lewis Acid Catalysis

(2008) Yoshiaki Nakao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dehydrogenation of Inert Alkyl Groups via Remote C−H Activation: Converting a Propyl Group into a π-Allylic Complex

(2008) Ramesh Giri et al.   ORGANOMETALLICS