Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 17, Pages 5633-5638Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201900479
Keywords
arylation; BODIPY labeling; density functional calculations; mechanistic studies; natural products
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Funding
- SERB, India [CRG/2018/003951]
- NPDF [PDF/2015/000127]
- UGC India
- CSIR, India
- A*STAR Singapore
- EPSRC Centre for Doctoral Training in Theory and Modelling in Chemical Sciences [EP/L015722/1]
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Directed C-H functionalization has been realized as a complementary tool to the traditional approaches for a straightforward access of non-proteinogenic amino acids; albeit such a process is restricted mostly up to the gamma-position. In the present work, we demonstrate the diverse (hetero) arylation of amino acids and analogous aliphatic amines selectively at the remote delta-position by tuning the reactivity controlled by ligands. An organopalladium delta-C(sp(3))-H activated intermediate has been isolated and crystallographically characterized. Mechanistic investigations carried out experimentally in conjunction with computational studies shed light on the difference in the mechanistic picture depending on the substrate structure.
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