Lipids and Lipid Derivatives for RNA Delivery

Design of SARS-CoV-2 hFc-Conjugated Receptor-Binding Domain mRNA Vaccine Delivered via Lipid Nanoparticles

(2021) Uri Elia et al.   ACS Nano

Lumasiran: First Approval

(2021) Lesley J. Scott et al.   DRUGS

First Drug Approved for Rare Genetic Disorder Affecting Kidneys

(2021) Mary Chris Jaklevic   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis

(2021) Christina Krienke et al.   SCIENCE

Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR–Cas gene editing

(2021) Shuai Liu et al.   NATURE MATERIALS

Neutralizing Activity of BNT162b2-Elicited Serum

(2021) Yang Liu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3

(2021) Min Qiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability

(2021) Linde Schoenmaker et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

A single dose of self-transcribing and replicating RNA-based SARS-CoV-2 vaccine produces protective adaptive immunity in mice

(2021) Ruklanthi de Alwis et al.   MOLECULAR THERAPY

A Combinatorial Library of Lipid Nanoparticles for RNA Delivery to Leukocytes

(2020) Srinivas Ramishetti et al.   ADVANCED MATERIALS

Combinatorial Synthesis of a Lipidoid Library by Thiolactone Chemistry: In Vitro Screening and In Vivo Validation for siRNA Delivery

(2020) Mijanur R. Molla et al.   BIOCONJUGATE CHEMISTRY

Givosiran: First Approval

(2020) Lesley J. Scott   DRUGS

Sugar-Nanocapsules Imprinted with Microbial Molecular Patterns for mRNA Vaccination

(2020) Sejin Son et al.   NANO LETTERS

Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering

(2020) Margaret M. Billingsley et al.   NANO LETTERS

Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis

(2020) Xucheng Hou et al.   Nature Nanotechnology

An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors

(2020) Katharina Reinhard et al.   SCIENCE

Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA

(2020) Siddharth Patel et al.   Nature Communications

Lipid‐Modified Aminoglycosides for mRNA Delivery to the Liver

(2020) Xueliang Yu et al.   Advanced Healthcare Materials

Efficient Delivery of Antisense Oligonucleotides Using Bioreducible Lipid Nanoparticles In Vitro and In Vivo

(2020) Liu Yang et al.   Molecular Therapy-Nucleic Acids

In Vitro and In Vivo Study of Amphotericin B Formulation with Quaternized Bioreducible Lipidoids

(2020) Fang Liu et al.   ACS Biomaterials-Science & Engineering

Tailored Lipoprotein‐Like miRNA Delivery Nanostructure Suppresses Glioma Stemness and Drug Resistance through Receptor‐Stimulated Macropinocytosis

(2020) Gan Jiang et al.   Advanced Science

Artificial Platelets for Efficient siRNA Delivery to Clear “Bad Cholesterol”

(2020) Yanfen Zhang et al.   ACS Applied Materials & Interfaces

Protein and mRNA Delivery Enabled by Cholesteryl‐Based Biodegradable Lipidoid Nanoparticles

(2020) Yamin Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Lipid Nanoparticles for Cell-Specific in Vivo Targeted Delivery of Nucleic Acids

(2020) Ikramy A. Khalil et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

RNA-based pharmacotherapy for tumors: From bench to clinic and back

(2020) Xiangping Liang et al.   BIOMEDICINE & PHARMACOTHERAPY

Naturally Derived Membrane Lipids Impact Nanoparticle-Based Messenger RNA Delivery

(2020) Jeonghwan Kim et al.   Cellular and Molecular Bioengineering

Charge-reversible Lipid Derivative: A Novel Type of pH-responsive Lipid for Nanoparticle-mediated siRNA Delivery

(2020) Yusuke Hirai et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Targeted delivery of celastrol to renal interstitial myofibroblasts using fibronectin-binding liposomes attenuates renal fibrosis and reduces systemic toxicity

(2020) Rui Li et al.   JOURNAL OF CONTROLLED RELEASE

Hyperbranched lipoid-based lipid nanoparticles for bidirectional regulation of collagen accumulation in liver fibrosis

(2020) Jian-Bin Qiao et al.   JOURNAL OF CONTROLLED RELEASE

Deconvoluting Lipid Nanoparticle Structure for Messenger RNA Delivery

(2020) Yulia Eygeris et al.   NANO LETTERS

Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing

(2020) Qiang Cheng et al.   Nature Nanotechnology

RNA delivery by extracellular vesicles in mammalian cells and its applications

(2020) Killian O’Brien et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol

(2020) Kausik K. Ray et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inclisiran for the Treatment of Heterozygous Familial Hypercholesterolemia

(2020) Frederick J. Raal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver

(2020) Lei Miao et al.   Nature Communications

Targeted gene silencing in vivo by platelet membrane–coated metal-organic framework nanoparticles

(2020) Jia Zhuang et al.   Science Advances

Biocompatible Nanovector of siRNA Consisting of Arginine-Based Cationic Lipid for Gene Knockdown in Cancer Cells

(2020) Natalia Sánchez-Arribas et al.   ACS Applied Materials & Interfaces

Surface-Functionalized PEGylated Nanoparticles Deliver Messenger RNA to Pulmonary Immune Cells

(2020) Xiyu Ke et al.   ACS Applied Materials & Interfaces

Development of lipid-like materials for RNA delivery based on intracellular environment-responsive membrane destabilization and spontaneous collapse

(2020) Hiroki Tanaka et al.   ADVANCED DRUG DELIVERY REVIEWS

Lipoprotein-based drug delivery

(2020) Sara Busatto et al.   ADVANCED DRUG DELIVERY REVIEWS

Lipid nanoparticle technology for therapeutic gene regulation in the liver

(2020) Dominik Witzigmann et al.   ADVANCED DRUG DELIVERY REVIEWS

Self‐Degradable Lipid‐Like Materials Based on “Hydrolysis accelerated by the intra‐Particle Enrichment of Reactant (HyPER)” for Messenger RNA Delivery

(2020) Hiroki Tanaka et al.   ADVANCED FUNCTIONAL MATERIALS

Imidazole‐based Synthetic Lipidoids for In Vivo mRNA Delivery into Primary T Lymphocytes

(2020) Xuewei Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Thermostable mRNA Vaccine against COVID-19

(2020) Na-Na Zhang et al.   CELL

A novel receptor-binding domain (RBD)-based mRNA vaccine against SARS-CoV-2

(2020) Wanbo Tai et al.   CELL RESEARCH

DNA Functional Materials Assembled from Branched DNA: Design, Synthesis, and Applications

(2020) Yuhang Dong et al.   CHEMICAL REVIEWS

Magnetofection: Magic magnetic nanoparticles for efficient gene delivery

(2020) Qunjie Bi et al.   CHINESE CHEMICAL LETTERS

Recent advances in mRNA vaccine technology

(2020) Norbert Pardi et al.   CURRENT OPINION IN IMMUNOLOGY

A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice

(2020) Dorottya Laczkó et al.   IMMUNITY

Nucleic acid-based drug delivery strategies

(2020) Xuyu Tan et al.   JOURNAL OF CONTROLLED RELEASE

Lipid and Polymer-Based Nanoparticle siRNA Delivery Systems for Cancer Therapy

(2020) Francesco Mainini et al.   MOLECULES

Role of Lipid-Based and Polymer-Based Non-Viral Vectors in Nucleic Acid Delivery for Next-Generation Gene Therapy

(2020) Aniket Wahane et al.   MOLECULES

A Potent Branched-Tail Lipid Nanoparticle Enables Multiplexed mRNA Delivery and Gene Editing In Vivo

(2020) Khalid A. Hajj et al.   NANO LETTERS

An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma

(2020) Ugur Sahin et al.   NATURE

Advances in oligonucleotide drug delivery

(2020) Thomas C. Roberts et al.   NATURE REVIEWS DRUG DISCOVERY

Phase 3 Trial of RNAi Therapeutic Givosiran for Acute Intermittent Porphyria

(2020) Manisha Balwani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice

(2020) Paul F. McKay et al.   Nature Communications

Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing

(2020) Tuo Wei et al.   Nature Communications

Polymeric Nanocarriers with Controlled Chain Flexibility Boost mRNA Delivery In Vivo through Enhanced Structural Fastening

(2020) Takuya Miyazaki et al.   Advanced Healthcare Materials

Characterizing Extracellular Vesicles and Their Diverse RNA Contents

(2020) Eren M. Veziroglu et al.   Frontiers in Genetics

Co-delivery of IKBKE siRNA and cabazitaxel by hybrid nanocomplex inhibits invasiveness and growth of triple-negative breast cancer

(2020) Zhen Zhao et al.   Science Advances

Neurotransmitter-derived lipidoids (NT-lipidoids) for enhanced brain delivery through intravenous injection

(2020) Feihe Ma et al.   Science Advances

A Comprehensive Review of Cancer MicroRNA Therapeutic Delivery Strategies

(2020) Alexis Forterre et al.   Cancers

The Role of RNA and DNA Aptamers in Glioblastoma Diagnosis and Therapy: A Systematic Review of the Literature

(2020) Silvia Nuzzo et al.   Cancers

Nanoparticles containing constrained phospholipids deliver mRNA to liver immune cells in vivo without targeting ligands

(2020) Zubao Gan et al.   Bioengineering & Translational Medicine

Leveraging mRNA Sequences and Nanoparticles to Deliver SARS‐CoV‐2 Antigens In Vivo

(2020) Chunxi Zeng et al.   ADVANCED MATERIALS

A COVID-19 mRNA vaccine encoding SARS-CoV-2 virus-like particles induces a strong antiviral-like immune response in mice

(2020) Jing Lu et al.   CELL RESEARCH

PEG shedding-rate-dependent blood clearance of PEGylated lipid nanoparticles in mice: Faster PEG shedding attenuates anti-PEG IgM production

(2020) Takuya Suzuki et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Triton X-100-Modified Adenosine Triphosphate-Responsive siRNA Delivery Agent for Antitumor Therapy

(2020) Xinli Fan et al.   MOLECULAR PHARMACEUTICS

Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates

(2020) Edward E. Walsh et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults

(2020) Evan J. Anderson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gene Therapy Based on Nucleic Acid Nanostructure

(2020) Xiaohui Wu et al.   Advanced Healthcare Materials

Functionalized lipid-like nanoparticles for in vivo mRNA delivery and base editing

(2020) Xinfu Zhang et al.   Science Advances

Adjuvant-pulsed mRNA vaccine nanoparticle for immunoprophylactic and therapeutic tumor suppression in mice

(2020) Mohammad Ariful Islam et al.   BIOMATERIALS

Bundling of mRNA strands inside polyion complexes improves mRNA delivery efficiency in vitro and in vivo

(2020) Kyoko Koji et al.   BIOMATERIALS

COVID-19: A review of therapeutic strategies and vaccine candidates

(2020) Vladislav Izda et al.   CLINICAL IMMUNOLOGY

Addressing the Cold Reality of mRNA Vaccine Stability

(2020) Daan J.A. Crommelin et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Engineering precision nanoparticles for drug delivery

(2020) Michael J. Mitchell et al.   NATURE REVIEWS DRUG DISCOVERY

Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination

(2020) Alicia T. Widge et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vaccine formulations in clinical development for the prevention of severe acute respiratory syndrome coronavirus 2 infection

(2020) Cole J. Batty et al.   ADVANCED DRUG DELIVERY REVIEWS

Engineered histidine-enriched facial lipopeptides for enhanced intracellular delivery of functional siRNA to triple negative breast cancer cells.

(2019) Abhijit Biswas et al.   ACS Applied Materials & Interfaces

Bioconjugated oligonucleotides: recent developments and therapeutic applications

(2019) sebastien benizri et al.   BIOCONJUGATE CHEMISTRY

Branched-Tail Lipid Nanoparticles Potently Deliver mRNA In Vivo due to Enhanced Ionization at Endosomal pH

(2019) Khalid A. Hajj et al.   Small

Cationic Niosomes as Non-Viral Vehicles for Nucleic Acids: Challenges and Opportunities in Gene Delivery

(2019) Santiago Grijalvo et al.   Pharmaceutics

Chemotherapy drugs derived nanoparticles encapsulating mRNA encoding tumor suppressor proteins to treat triple-negative breast cancer

(2019) Chengxiang Zhang et al.   Nano Research

Improved Efficacy in a Fabry Disease Model Using a Systemic mRNA Liver Depot System as Compared to Enzyme Replacement Therapy

(2019) Frank DeRosa et al.   MOLECULAR THERAPY

Lipid-polymer hybrid nanoparticles: Synthesis strategies and biomedical applications

(2019) Vivek Dave et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Understanding structure-activity relationships of pH-sensitive cationic lipids facilitates the rational identification of promising lipid nanoparticles for delivering siRNAs in vivo

(2019) Yusuke Sato et al.   JOURNAL OF CONTROLLED RELEASE

Lipid–polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives

(2019) Anubhab Mukherjee et al.   International Journal of Nanomedicine

Systemic Delivery of Tumor-Targeting siRNA Nanoparticles against an Oncogenic LncRNA Facilitates Effective Triple-Negative Breast Cancer Therapy

(2019) Amita M Vaidya et al.   BIOCONJUGATE CHEMISTRY

Nanoparticles Containing Oxidized Cholesterol Deliver mRNA to the Liver Microenvironment at Clinically Relevant Doses

(2019) Kalina Paunovska et al.   ADVANCED MATERIALS

A minimalist's approach for DNA nanoconstructions

(2019) Hua Zuo et al.   ADVANCED DRUG DELIVERY REVIEWS

Radiation-Induced Targeted Nanoparticle-Based Gene Delivery for Brain Tumor Therapy

(2019) Gulsah Erel-Akbaba et al.   ACS Nano

Lipid-mRNA Nanoparticle Designed to Enhance Intracellular Delivery Mediated by Shock Waves

(2019) Jing Zhang et al.   ACS Applied Materials & Interfaces

Small interfering RNAs (siRNAs) in cancer therapy: a nano-based approach

(2019) Ghanbar Mahmoodi Chalbatani et al.   International Journal of Nanomedicine

Oligo(serine ester) Charge-Altering Releasable Transporters: Organocatalytic Ring-Opening Polymerization and their Use for in Vitro and in Vivo mRNA Delivery

(2019) Nancy L. Benner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Advances in therapeutic applications of extracellular vesicles

(2019) Oscar P. B. Wiklander et al.   Science Translational Medicine

mRNA vaccines against H10N8 and H7N9 influenza viruses of pandemic potential are immunogenic and well tolerated in healthy adults in phase 1 randomized clinical trials

(2019) Robert A. Feldman et al.   VACCINE

Formulation of Biocompatible Targeted ECO/siRNA Nanoparticles with Long-Term Stability for Clinical Translation of RNAi

(2019) Nadia R. Ayat et al.   Nucleic Acid Therapeutics

Intriguing circles: Conflicts and controversies in circular RNA research

(2019) Hui‐Min Li et al.   Wiley Interdisciplinary Reviews-RNA

Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines

(2019) Kimberly J. Hassett et al.   Molecular Therapy-Nucleic Acids

Fast and Efficient CRISPR/Cas9 Genome Editing In Vivo Enabled by Bioreducible Lipid and Messenger RNA Nanoparticles

(2019) Ji Liu et al.   ADVANCED MATERIALS

Nucleic‐Acid Structures as Intracellular Probes for Live Cells

(2019) Devleena Samanta et al.   ADVANCED MATERIALS

Introduction: Nucleic Acid Nanotechnology

(2019) Yamuna Krishnan et al.   CHEMICAL REVIEWS

Lipid-Based Vectors for Therapeutic mRNA-Based Anti-Cancer Vaccines

(2019) Maria L Guevara et al.   CURRENT PHARMACEUTICAL DESIGN

Lipid nanoparticles for delivery of messenger RNA to the back of the eye

(2019) Siddharth Patel et al.   JOURNAL OF CONTROLLED RELEASE

Extracellular vesicles: a new communication paradigm?

(2019) Graça Raposo et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mannosylation of LNP Results in Improved Potency for Self-Amplifying RNA (SAM) Vaccines

(2019) Roshan Goswami et al.   ACS Infectious Diseases

Constrained Nanoparticles Deliver siRNA and sgRNA to T Cells In Vivo without Targeting Ligands

(2019) Melissa P. Lokugamage et al.   ADVANCED MATERIALS

Development of a lipoplex-type mRNA carrier composed of an ionizable lipid with a vitamin E scaffold and the KALA peptide for use as an ex vivo dendritic cell-based cancer vaccine

(2019) Naho Tateshita et al.   JOURNAL OF CONTROLLED RELEASE

Strategies for the use of Extracellular Vesicles for the Delivery of Therapeutics

(2019) Susmita Sil et al.   Journal of Neuroimmune Pharmacology

A Multifunctional Lipid-Based Nanodevice for the Highly Specific Codelivery of Sorafenib and Midkine siRNA to Hepatic Cancer Cells

(2019) Mahmoud A. Younis et al.   MOLECULAR PHARMACEUTICS

Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation

(2019) Lei Miao et al.   NATURE BIOTECHNOLOGY

Lipid nanoparticle-targeted mRNA therapy as a treatment for the inherited metabolic liver disorder arginase deficiency

(2019) Brian Truong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted Delivery of siRNA Lipoplexes to Cancer Cells Using Macrophage Transient Horizontal Gene Transfer

(2019) Elizabeth C. Wayne et al.   Advanced Science

Cell-Selective Messenger RNA Delivery and CRISPR/Cas9 Genome Editing by Modulating the Interface of Phenylboronic Acid-Derived Lipid Nanoparticles and Cellular Surface Sialic Acid

(2019) Qiao Tang et al.   ACS Applied Materials & Interfaces

Hydrophobic scaffolds of pH-sensitive cationic lipids contribute to miscibility with phospholipids and improve the efficiency of delivering short interfering RNA by small-sized lipid nanoparticles

(2019) Yusuke Sato et al.   Acta Biomaterialia

Mild Innate Immune Activation Overrides Efficient Nanoparticle‐Mediated RNA Delivery

(2019) Melissa P. Lokugamage et al.   ADVANCED MATERIALS

Quantitative analysis of cholesterol oxidation products and desmosterol in parenteral liposomal pharmaceutical formulations

(2019) Changguang Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Key determinants of siRNA delivery mediated by unique pH-responsive lipid-based liposomes

(2019) Mariko Sako et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Pharmacokinetics of Patisiran, the First Approved RNA Interference Therapy in Patients With Hereditary Transthyretin‐Mediated Amyloidosis

(2019) Xiaoping Zhang et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Aptamers: A Review of Their Chemical Properties and Modifications for Therapeutic Application

(2019) Adachi et al.   MOLECULES

Therapeutic Prospects of mRNA-Based Gene Therapy for Glioblastoma

(2019) Xiangjun Tang et al.   Frontiers in Oncology

Extracellular vesicle (ECV)-modified polyethylenimine (PEI) complexes for enhanced siRNA delivery in vitro and in vivo

(2019) Petro Zhupanyn et al.   JOURNAL OF CONTROLLED RELEASE

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

(2019) Akin Akinc et al.   Nature Nanotechnology

Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient cancers to mTOR inhibition

(2019) Na Kong et al.   Science Translational Medicine

Strategies for the CRISPR-Based Therapeutics

(2019) Bin Li et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Circular RNA: biogenesis, degradation, functions and potential roles in mediating resistance to anticarcinogens

(2019) Xiuchao Geng et al.   Epigenomics

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation

(2019) Zhaogang Yang et al.   Nature Biomedical Engineering

On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA

(2018) Jayesh A. Kulkarni et al.   ACS Nano

Analyzing 2000 in Vivo Drug Delivery Data Points Reveals Cholesterol Structure Impacts Nanoparticle Delivery

(2018) Kalina Paunovska et al.   ACS Nano

Advances in microfluidics for lipid nanoparticles and extracellular vesicles and applications in drug delivery systems

(2018) Masatoshi Maeki et al.   ADVANCED DRUG DELIVERY REVIEWS

One-Pot Parallel Synthesis of Lipid Library via Thiolactone Ring Opening and Screening for Gene Delivery

(2018) Mijanur R. Molla et al.   BIOCONJUGATE CHEMISTRY

A novel Lipidoid-MicroRNA formulation promotes calvarial bone regeneration

(2018) Lei Sui et al.   BIOMATERIALS

Combinatorial library of chalcogen-containing lipidoids for intracellular delivery of genome-editing proteins

(2018) Yamin Li et al.   BIOMATERIALS

Noncovalent tagging of siRNA with steroids for transmembrane delivery

(2018) Wanyi Tai et al.   BIOMATERIALS

Paranemic Crossover DNA: There and Back Again

(2018) Xing Wang et al.   CHEMICAL REVIEWS

Safety, tolerability, and pharmacokinetics of BMS-986263/ND-L02-s0201, a novel targeted lipid nanoparticle delivering HSP47 siRNA, in healthy participants: A randomised, placebo-controlled, double-blind, phase 1 study

(2018) B. Soule et al.   JOURNAL OF HEPATOLOGY

Evaluation of GalNAc-siRNA Conjugate Activity in Pre-clinical Animal Models with Reduced Asialoglycoprotein Receptor Expression

(2018) Jennifer L.S. Willoughby et al.   MOLECULAR THERAPY

Exosome-Mediated Small RNA Delivery: A Novel Therapeutic Approach for Inflammatory Lung Responses

(2018) Duo Zhang et al.   MOLECULAR THERAPY

A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates

(2018) Staci Sabnis et al.   MOLECULAR THERAPY

Lipid-Based Liquid Crystalline Nanoparticles Facilitate Cytosolic Delivery of siRNA via Structural Transformation

(2018) Shufang He et al.   NANO LETTERS

Lipid Nanoparticle Formulations for Enhanced Co-delivery of siRNA and mRNA

(2018) Rebecca L. Ball et al.   NANO LETTERS

Multifunctional nucleic acid nanostructures for gene therapies

(2018) Jianbing Liu et al.   Nano Research

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis

(2018) David Adams et al.   NEW ENGLAND JOURNAL OF MEDICINE

Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles

(2018) Marianna Yanez Arteta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A review on current status of antiviral siRNA

(2018) Abid Qureshi et al.   REVIEWS IN MEDICAL VIROLOGY

Multi-antigenic human cytomegalovirus mRNA vaccines that elicit potent humoral and cell-mediated immunity

(2018) Shinu John et al.   VACCINE

Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection

(2018) Alvaro Baeza Garcia et al.   Nature Communications

Efficient RNA drug delivery using red blood cell extracellular vesicles

(2018) Waqas Muhammad Usman et al.   Nature Communications

Journey of siRNA: Clinical Developments and Targeted Delivery

(2018) Rahul R. Nikam et al.   Nucleic Acid Therapeutics

Lipid Nanoparticles Enabling Gene Therapies: From Concepts to Clinical Utility

(2018) Jayesh A. Kulkarni et al.   Nucleic Acid Therapeutics

DNA Nanostructure-Based Systems for Intelligent Delivery of Therapeutic Oligonucleotides

(2018) Qinqin Hu et al.   Advanced Healthcare Materials

A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing

(2018) Jonathan D. Finn et al.   Cell Reports

Synthetic High-Density Lipoprotein-Mediated Targeted Delivery of Liver X Receptors Agonist Promotes Atherosclerosis Regression

(2018) Yanhong Guo et al.   EBioMedicine

Exosome-based small RNA delivery: Progress and prospects

(2018) Mei Lu et al.   Asian Journal of Pharmaceutical Sciences

Customizable Lipid Nanoparticle Materials for the Delivery of siRNAs and mRNAs

(2018) Owen S. Fenton et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PEGylated DC-Chol/DOPE cationic liposomes containing KSP siRNA as a systemic siRNA delivery Carrier for ovarian cancer therapy

(2018) Jinju Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Immune lipoprotein nanostructures inspired relay drug delivery for amplifying antitumor efficiency

(2018) Yue Han et al.   BIOMATERIALS

Optimization of siRNA delivery to target sites: issues and future directions

(2018) Ikramy A. Khalil et al.   Expert Opinion on Drug Delivery

Transfection reagent Lipofectamine triggers type I interferon signaling activation in macrophages

(2018) Xiaomin Guo et al.   IMMUNOLOGY AND CELL BIOLOGY

Tryptamine-Induced Tryptophanyl-tRNAtrp Deficiency in Neurodifferentiation and Neurodegeneration Interplay: Progenitor Activation with Neurite Growth Terminated in Alzheimer's Disease Neuronal Vesicularization and Fragmentation

(2018) Elena L. Paley   JOURNAL OF ALZHEIMERS DISEASE

Nanoparticles Based on Poly (β-Amino Ester) and HPV16-Targeting CRISPR/shRNA as Potential Drugs for HPV16-Related Cervical Malignancy

(2018) Da Zhu et al.   MOLECULAR THERAPY

Biomedical applications of mRNA nanomedicine

(2018) Qingqing Xiong et al.   Nano Research

Alnylam launches era of RNAi drugs

(2018) Ken Garber   NATURE BIOTECHNOLOGY

FDA approves landmark RNAi drug

(2018) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

mRNA vaccination with charge-altering releasable transporters elicits human T cell responses and cures established tumors in mice

(2018) Ole A. W. Haabeth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sugar Functionalized Synergistic Dendrimers for Biocompatible Delivery of Nucleic Acid Therapeutics

(2018) Shuqin Han et al.   Polymers

RNA Interference as a Prospective Tool for the Control of Human Viral Infections

(2018) Alesia Levanova et al.   Frontiers in Microbiology

Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA

(2018) Mohammad Ariful Islam et al.   Nature Biomedical Engineering

Synthetic materials at the forefront of gene delivery

(2018) Irene Lostalé-Seijo et al.   Nature Reviews Chemistry

Dendrimer-Based Lipid Nanoparticles Deliver Therapeutic FAH mRNA to Normalize Liver Function and Extend Survival in a Mouse Model of Hepatorenal Tyrosinemia Type I

(2018) Qiang Cheng et al.   ADVANCED MATERIALS

Exosomes: natural nanoparticles as bio shuttles for RNAi delivery

(2018) Saber Ghazizadeh Darband et al.   JOURNAL OF CONTROLLED RELEASE

Light-Controlled Lipid Interaction and Membrane Organization in Photolipid Bilayer Vesicles

(2018) Patrick Urban et al.   LANGMUIR

A Review on Electroporation-Based Intracellular Delivery

(2018) Junfeng Shi et al.   MOLECULES

High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing

(2018) Cory D. Sago et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell engineering with microfluidic squeezing preserves functionality of primary immune cells in vivo

(2018) Tia DiTommaso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted delivery of antisense oligonucleotides to pancreatic β-cells

(2018) C. Ämmälä et al.   Science Advances

Rigorous control of vesicle-forming lipid pKa by fluorine-conjugated bioisosteres for gene-silencing with siRNA

(2018) Ayaka Okamoto et al.   JOURNAL OF CONTROLLED RELEASE

Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes

(2017) Shuaijian Ni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biodegradable lipid nanoparticles induce a prolonged RNA interference-mediated protein knockdown and show rapid hepatic clearance in mice and nonhuman primates

(2017) Yuta Suzuki et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Exosomes: Nanoparticulate tools for RNA interference and drug delivery

(2017) Fahimeh Shahabipour et al.   JOURNAL OF CELLULAR PHYSIOLOGY

pH-labile PEGylation of siRNA-loaded lipid nanoparticle improves active targeting and gene silencing activity in hepatocytes

(2017) Kazuki Hashiba et al.   JOURNAL OF CONTROLLED RELEASE

Retinal gene delivery enhancement by lycopene incorporation into cationic niosomes based on DOTMA and polysorbate 60

(2017) Mohamed Mashal et al.   JOURNAL OF CONTROLLED RELEASE

The Delivery of Small Interfering RNA to Hepatic Stellate Cells Using a Lipid Nanoparticle Composed of a Vitamin A-Scaffold Lipid-Like Material

(2017) Naoyuki Toriyabe et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

PEGylation of the GALA Peptide Enhances the Lung-Targeting Activity of Nanocarriers That Contain Encapsulated siRNA

(2017) Sarochin Santiwarangkool et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Systemic delivery of complexes of melanoma RNA with mannosylated liposomes activates highly efficient murine melanoma-specific cytotoxic T cells in vivo

(2017) O. V. Markov et al.   MOLECULAR BIOLOGY

Efficient Targeting and Activation of Antigen-Presenting Cells In Vivo after Modified mRNA Vaccine Administration in Rhesus Macaques

(2017) Frank Liang et al.   MOLECULAR THERAPY

Development and Mechanism of Small Activating RNA Targeting CEBPA, a Novel Therapeutic in Clinical Trials for Liver Cancer

(2017) Jon Voutila et al.   MOLECULAR THERAPY

Lipid Nanoparticle Systems for Enabling Gene Therapies

(2017) Pieter R. Cullis et al.   MOLECULAR THERAPY

Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses

(2017) Kapil Bahl et al.   MOLECULAR THERAPY

Adamantane in Drug Delivery Systems and Surface Recognition

(2017) Adela Štimac et al.   MOLECULES

Cell membrane-derived nanoparticles: emerging clinical opportunities for targeted drug delivery

(2017) Svetlana T Yurkin et al.   Nanomedicine

Cationic switchable lipids: pH-triggered molecular switch for siRNA delivery

(2017) W. Viricel et al.   Nanoscale

Microfluidic self-assembly of folate-targeted monomolecular siRNA-lipid nanoparticles

(2017) R. Krzysztoń et al.   Nanoscale

Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides

(2017) Naoki Iwamoto et al.   NATURE BIOTECHNOLOGY

Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing

(2017) Hao Yin et al.   NATURE BIOTECHNOLOGY

Inclisiran in Patients at High Cardiovascular Risk with Elevated LDL Cholesterol

(2017) Kausik K. Ray et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs

(2017) Xiulong Shen et al.   NUCLEIC ACIDS RESEARCH

Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics

(2017) James E. Dahlman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Charge-altering releasable transporters (CARTs) for the delivery and release of mRNA in living animals

(2017) Colin J. McKinlay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systemic delivery of factor IX messenger RNA for protein replacement therapy

(2017) Suvasini Ramaswamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunogenicity and protective efficacy induced by self-amplifying mRNA vaccines encoding bacterial antigens

(2017) Giulietta Maruggi et al.   VACCINE

Nanoescapology: progress toward understanding the endosomal escape of polymeric nanoparticles

(2017) Laura I. Selby et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis

(2017) Jia-Lin Huang et al.   Nature Communications

Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge

(2017) Norbert Pardi et al.   Nature Communications

Molecular Mechanisms of Antisense Oligonucleotides

(2017) Stanley T. Crooke   Nucleic Acid Therapeutics

Surface De-PEGylation Controls Nanoparticle-Mediated siRNA Delivery In Vitro and In Vivo

(2017) Xi Zhu et al.   Theranostics

RNA in extracellular vesicles

(2017) Kyoung Mi Kim et al.   Wiley Interdisciplinary Reviews-RNA

Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo

(2017) X. Luo et al.   Biomaterials Science

Cationic Nanoliposomes Meet mRNA: Efficient Delivery of Modified mRNA Using Hemocompatible and Stable Vectors for Therapeutic Applications

(2017) Tatjana Michel et al.   Molecular Therapy-Nucleic Acids

Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing

(2017) Yu Cao et al.   Frontiers of Chemical Science and Engineering

DNA nanotechnology

(2017) Nadrian C. Seeman et al.   Nature Reviews Materials

High-throughput nuclear delivery and rapid expression of DNA via mechanical and electrical cell-membrane disruption

(2017) Xiaoyun Ding et al.   Nature Biomedical Engineering

Understanding the formation mechanism of lipid nanoparticles in microfluidic devices with chaotic micromixers

(2017) Masatoshi Maeki et al.   PLoS One

Tumor-targeted delivery of siRNA using fatty acyl-CGKRK peptide conjugates

(2017) Meenakshi Sharma et al.   Scientific Reports

Role of Cell Membrane–Vector Interactions in Successful Gene Delivery

(2016) Sriram Vaidyanathan et al.   ACCOUNTS OF CHEMICAL RESEARCH

Design of Highly Potent Lipid-Functionalized Peptidomimetics for Efficient in Vivo siRNA Delivery

(2016) Hai Xiao et al.   ACS Applied Materials & Interfaces

Efficient Cellular Knockdown Mediated by siRNA Nanovectors of Gemini Cationic Lipids Having Delocalizable Headgroups and Oligo-Oxyethylene Spacers

(2016) María Martínez-Negro et al.   ACS Applied Materials & Interfaces

High-Density Lipoproteins: Nature’s Multifunctional Nanoparticles

(2016) Rui Kuai et al.   ACS Nano

The role of helper lipids in lipid nanoparticles (LNPs) designed for oligonucleotide delivery

(2016) Xinwei Cheng et al.   ADVANCED DRUG DELIVERY REVIEWS

Properties of Native High-Density Lipoproteins Inspire Synthesis of Actively Targeted In Vivo siRNA Delivery Vehicles

(2016) Kaylin M. McMahon et al.   ADVANCED FUNCTIONAL MATERIALS

PGMA-Based Star-Like Polycations with Plentiful Hydroxyl Groups Act as Highly Efficient miRNA Delivery Nanovectors for Effective Applications in Heart Diseases

(2016) Rui-Quan Li et al.   ADVANCED MATERIALS

Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery

(2016) Owen S. Fenton et al.   ADVANCED MATERIALS

Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA

(2016) Jason B. Miller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Coordinative Amphiphiles as Tunable siRNA Transporters

(2016) Jin Bum Kim et al.   BIOCONJUGATE CHEMISTRY

Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype

(2016) Mariana Conceição et al.   BIOMATERIALS

Comparative Study of the Condensing Effects of Ergosterol and Cholesterol

(2016) Wei-Chin Hung et al.   BIOPHYSICAL JOURNAL

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

Lipidoid Tail Structure Strongly Influences siRNA Delivery Activity

(2016) Christopher M. Knapp et al.   Cellular and Molecular Bioengineering

Structural studies of the formation of lipoplexes between siRNA and selected bis-imidazolium gemini surfactants

(2016) W. Andrzejewska et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Synthesis and evaluation of novel lipopeptide as a vehicle for efficient gene delivery and gene silencing

(2016) O.O. Koloskova et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Therapeutic efficacy in a hemophilia B model using a biosynthetic mRNA liver depot system

(2016) F DeRosa et al.   GENE THERAPY

Anti-EphA10 antibody-conjugated pH-sensitive liposomes for specific intracellular delivery of siRNA

(2016) Xinlong Zang et al.   International Journal of Nanomedicine

Nanomedicine engulfed by macrophages for targeted tumor therapy

(2016) Yueqing Gu et al.   International Journal of Nanomedicine

Efficient delivery of Notch1 siRNA to SKOV3 cells by cationic cholesterol derivative-based liposome

(2016) Yunchun Zhao et al.   International Journal of Nanomedicine

Achieving long-term stability of lipid nanoparticles: examining the effect of pH, temperature, and lyophilization

(2016) Rebecca Ball et al.   International Journal of Nanomedicine

Structure, activity and uptake mechanism of siRNA-lipid nanoparticles with an asymmetric ionizable lipid

(2016) Yuta Suzuki et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The role of helper lipids in the intracellular disposition and transfection efficiency of niosome formulations for gene delivery to retinal pigment epithelial cells

(2016) Edilberto Ojeda et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Effect of particle size on their accumulation in an inflammatory lesion in a dextran sulfate sodium (DSS)-induced colitis model

(2016) Ayaka Watanabe et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Extracellular vesicles: masters of intercellular communication and potential clinical interventions

(2016) Jonathan M. Pitt et al.   JOURNAL OF CLINICAL INVESTIGATION

A phase Ib/IIa study of combination therapy with gemcitabine and Atu027 in patients with locally advanced or metastatic pancreatic adenocarcinoma.

(2016) Beate Schultheis et al.   JOURNAL OF CLINICAL ONCOLOGY

A lipid nanoparticle for the efficient delivery of siRNA to dendritic cells

(2016) Shota Warashina et al.   JOURNAL OF CONTROLLED RELEASE

Delivery of siRNA targeting tumor metabolism using non-covalent PEGylated chitosan nanoparticles: Identification of an optimal combination of ligand structure, linker and grafting method

(2016) Cyril Corbet et al.   JOURNAL OF CONTROLLED RELEASE

Functional exosome-mimic for delivery of siRNA to cancer: in vitro and in vivo evaluation

(2016) Zhaogang Yang et al.   JOURNAL OF CONTROLLED RELEASE

Materials for non-viral intracellular delivery of messenger RNA therapeutics

(2016) Kevin J. Kauffman et al.   JOURNAL OF CONTROLLED RELEASE

Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA

(2016) Sam Chen et al.   JOURNAL OF CONTROLLED RELEASE

The role of disulfide-bridge on the activities of H-shape gemini-like cationic lipid based siRNA delivery

(2016) Xiao-Fei Ma et al.   JOURNAL OF CONTROLLED RELEASE

Novel pH-sensitive multifunctional envelope-type nanodevice for siRNA-based treatments for chronic HBV infection

(2016) Naoki Yamamoto et al.   JOURNAL OF HEPATOLOGY

Design of Ionizable Lipids To Overcome the Limiting Step of Endosomal Escape: Application in the Intracellular Delivery of mRNA, DNA, and siRNA

(2016) Damien Habrant et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effects of HMGA2 siRNA and doxorubicin dual delivery by chitosan nanoparticles on cytotoxicity and gene expression of HT-29 colorectal cancer cell line

(2016) Homayoon Siahmansouri et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Novel Targeted Therapy for Precursor B-Cell Acute Lymphoblastic Leukemia: Anti-CD22 Antibody-MXD3 Antisense Oligonucleotide Conjugate

(2016) Noriko Satake et al.   MOLECULAR MEDICINE

Delivery of siRNA Complexed with Palmitoylated α-Peptide/β-Peptoid Cell-Penetrating Peptidomimetics: Membrane Interaction and Structural Characterization of a Lipid-Based Nanocarrier System

(2016) Xiaona Jing et al.   MOLECULAR PHARMACEUTICS

Myocardial Delivery of Lipidoid Nanoparticle Carrying modRNA Induces Rapid and Transient Expression

(2016) Irene C Turnbull et al.   MOLECULAR THERAPY

Relationship Between the Physicochemical Properties of Lipid Nanoparticles and the Quality of siRNA Delivery to Liver Cells

(2016) Yusuke Sato et al.   MOLECULAR THERAPY

Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo

(2016) Yizhou Dong et al.   NANO LETTERS

Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy

(2016) Matthias A. Oberli et al.   NANO LETTERS

Biodistribution and pharmacokinetics ofMad2siRNA-loaded EGFR-targeted chitosan nanoparticles in cisplatin sensitive and resistant lung cancer models

(2016) Ana Vanessa Nascimento et al.   Nanomedicine

Polyethylenimine-based polyplex delivery of self-replicating RNA vaccines

(2016) Thomas Démoulins et al.   Nanomedicine-Nanotechnology Biology and Medicine

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

(2016) Lena M. Kranz et al.   NATURE

A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice

(2016) Yang Yang et al.   NATURE BIOTECHNOLOGY

Lipid Nanoparticles Loaded with an Antisense Oligonucleotide Gapmer Against Bcl-2 for Treatment of Lung Cancer

(2016) Xinwei Cheng et al.   PHARMACEUTICAL RESEARCH

Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, andToxoplasma gondiichallenges with a single dose

(2016) Jasdave S. Chahal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles

(2016) Ming Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional polyesters enable selective siRNA delivery to lung cancer over matched normal cells

(2016) Yunfeng Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model

(2016) Kejin Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Looking Beyond Structure: Membrane Phospholipids of Skeletal Muscle Mitochondria

(2016) Timothy D. Heden et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Intrathecal delivery of frataxin mRNA encapsulated in lipid nanoparticles to dorsal root ganglia as a potential therapeutic for Friedreich’s ataxia

(2016) Joseph F. Nabhan et al.   Scientific Reports

Mono-arginine Cholesterol-based Small Lipid Nanoparticles as a Systemic siRNA Delivery Platform for Effective Cancer Therapy

(2016) Jinju Lee et al.   Theranostics

Targeted Dual pH-Sensitive Lipid ECO/siRNA Self-Assembly Nanoparticles Facilitate In Vivo Cytosolic sieIF4E Delivery and Overcome Paclitaxel Resistance in Breast Cancer Therapy

(2016) Maneesh Gujrati et al.   Advanced Healthcare Materials

Exosome-mediated small RNA delivery for gene therapy

(2016) Yu Zhou et al.   Wiley Interdisciplinary Reviews-RNA

Enhanced siRNA delivery of a cyclododecylated dendrimer compared to its linear derivative

(2016) Wanwan Shen et al.   Journal of Materials Chemistry B

Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges

(2016) Dinh Ha et al.   Acta Pharmaceutica Sinica B

Effects of local structural transformation of lipid-like compounds on delivery of messenger RNA

(2016) Bin Li et al.   Scientific Reports

siRNA Conjugates Carrying Sequentially Assembled Trivalent N-Acetylgalactosamine Linked Through Nucleosides Elicit Robust Gene Silencing In Vivo in Hepatocytes

(2015) Shigeo Matsuda et al.   ACS Chemical Biology

Stealth monoolein-based nanocarriers for delivery of siRNA to cancer cells

(2015) Ana C.N. Oliveira et al.   Acta Biomaterialia

In vivo delivery of miRNAs for cancer therapy: Challenges and strategies

(2015) Yunching Chen et al.   ADVANCED DRUG DELIVERY REVIEWS

Preclinical and clinical development of siRNA-based therapeutics

(2015) Gulnihal Ozcan et al.   ADVANCED DRUG DELIVERY REVIEWS

Antisense oligonucleotides in therapy for neurodegenerative disorders

(2015) Melvin M. Evers et al.   ADVANCED DRUG DELIVERY REVIEWS

Switchable Lipids: Conformational Change for Fast pH-Triggered Cytoplasmic Delivery

(2015) Warren Viricel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biodegradable Stearylated Peptide with Internal Disulfide Bonds for Efficient Delivery of siRNA In Vitro and In Vivo

(2015) Zongguang Tai et al.   BIOMACROMOLECULES

Silencing β3 Integrin by Targeted ECO/siRNA Nanoparticles Inhibits EMT and Metastasis of Triple-Negative Breast Cancer

(2015) Jenny G. Parvani et al.   CANCER RESEARCH

pH-Cleavable Nucleoside Lipids: A New Paradigm for Controlling the Stability of Lipid-Based Delivery Systems

(2015) Khalid Oumzil et al.   ChemMedChem

Lipid-Based Nanocarriers for RNA Delivery

(2015) Hui Xue et al.   CURRENT PHARMACEUTICAL DESIGN

Fatty acid modified octa-arginine for delivery of siRNA

(2015) Yuhuan Li et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Multicomponent mannose-containing liposomes efficiently deliver RNA in murine immature dendritic cells and provide productive anti-tumour response in murine melanoma model

(2015) Oleg V. Markov et al.   JOURNAL OF CONTROLLED RELEASE

A neutral lipid envelope-type nanoparticle composed of a pH-activated and vitamin E-scaffold lipid-like material as a platform for a gene carrier targeting renal cell carcinoma

(2015) Hidetaka Akita et al.   JOURNAL OF CONTROLLED RELEASE

siRNA-lipid nanoparticles with long-term storage stability facilitate potent gene-silencing in vivo

(2015) Y. Suzuki et al.   JOURNAL OF CONTROLLED RELEASE

siRNA delivery to lung-metastasized tumor by systemic injection with cationic liposomes

(2015) Yoshiyuki Hattori et al.   JOURNAL OF LIPOSOME RESEARCH

Rapid Synthesis of a Lipocationic Polyester Library via Ring-Opening Polymerization of Functional Valerolactones for Efficacious siRNA Delivery

(2015) Jing Hao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Induction of Broad-Based Immunity and Protective Efficacy by Self-amplifying mRNA Vaccines Encoding Influenza Virus Hemagglutinin

(2015) Michela Brazzoli et al.   JOURNAL OF VIROLOGY

Lipid–PEG Conjugates Sterically Stabilize and Reduce the Toxicity of Phytantriol-Based Lyotropic Liquid Crystalline Nanoparticles

(2015) Jiali Zhai et al.   LANGMUIR

mRNA: Fulfilling the Promise of Gene Therapy

(2015) Drew Weissman et al.   MOLECULAR THERAPY

Dendrimer-Inspired Nanomaterials for the in Vivo Delivery of siRNA to Lung Vasculature

(2015) Omar F. Khan et al.   NANO LETTERS

An Orthogonal Array Optimization of Lipid-like Nanoparticles for mRNA Delivery in Vivo

(2015) Bin Li et al.   NANO LETTERS

Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs

(2015) Kevin J. Kauffman et al.   NANO LETTERS

Combinatorial library strategies for synthesis of cationic lipid-like nanoparticles and their potential medical applications

(2015) Sarah Altınoglu et al.   Nanomedicine

Nanoparticle biointerfacing by platelet membrane cloaking

(2015) Che-Ming J. Hu et al.   NATURE

Gene therapy returns to centre stage

(2015) Luigi Naldini   NATURE

Therapeutic genome editing: prospects and challenges

(2015) David Benjamin Turitz Cox et al.   NATURE MEDICINE

Clinical experiences with systemically administered siRNA-based therapeutics in cancer

(2015) Jonathan E. Zuckerman et al.   NATURE REVIEWS DRUG DISCOVERY

Knocking down disease: a progress report on siRNA therapeutics

(2015) Anders Wittrup et al.   NATURE REVIEWS GENETICS

Programmable materials and the nature of the DNA bond

(2015) M. R. Jones et al.   SCIENCE

Postnatal genome editing partially restores dystrophin expression in a mouse model of muscular dystrophy

(2015) C. Long et al.   SCIENCE

Supramolecularly engineered phospholipids constructed by nucleobase molecular recognition: upgraded generation of phospholipids for drug delivery

(2015) Dali Wang et al.   Chemical Science

Turning Squalene into Cationic Lipid Allows a Delivery of siRNA in Cultured Cells

(2015) Jean-Rémi Bertrand et al.   Nucleic Acid Therapeutics

Cell or Cell Membrane-Based Drug Delivery Systems

(2015) Songwei Tan et al.   Theranostics

Synthesis, Physicochemical Characterization, and Interaction with DNA of Long-Alkyl-Chain Gemini Pyridinium Surfactants

(2015) Nadia Barbero et al.   ChemPlusChem

Recombinant messenger RNA technology and its application in cancer immunotherapy, transcript replacement therapies, pluripotent stem cell induction, and beyond

(2015) Britta Vallazza et al.   Wiley Interdisciplinary Reviews-RNA

Chimeric Antisense Oligonucleotide Conjugated to α-Tocopherol

(2015) Tomoko Nishina et al.   Molecular Therapy-Nucleic Acids

Molecular Tuning of a Vitamin E-Scaffold pH-Sensitive and Reductive Cleavable Lipid-like Material for Accelerated in Vivo Hepatic siRNA Delivery

(2015) Hidetaka Akita et al.   ACS Biomaterials-Science & Engineering

Influence of cholesterol on liposome stability and on in vitro drug release

(2015) Maria-Lucia Briuglia et al.   Drug Delivery and Translational Research

Molecular Tuning of a Vitamin E-Scaffold pH-Sensitive and Reductive Cleavable Lipid-like Material for Accelerated in Vivo Hepatic siRNA Delivery

(2015) Hidetaka Akita et al.   ACS Biomaterials Science & Engineering

CRISPR-Cas9 delivery to hard-to-transfect cells via membrane deformation

(2015) X. Han et al.   Science Advances

Cell-Type–Specific Aptamer and Aptamer-Small Interfering RNA Conjugates for Targeted Human Immunodeficiency Virus Type 1 Therapy

(2015) Jiehua Zhou et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Lipidoid Nanoparticles for siRNA Delivery to the Intestinal Epithelium: In Vitro Investigations in a Caco-2 Model

(2015) Rebecca L. Ball et al.   PLoS One

Gemini Surfactants Based on Bis-Imidazolium Alkoxy Derivatives as Effective Agents for Delivery of Nucleic Acids: A Structural and Spectroscopic Study

(2015) Zuzanna Pietralik et al.   PLoS One

Dioctadecyldimethylammonium:Monoolein Nanocarriers for Efficient in Vitro Gene Silencing

(2014) Ana Cristina Norberto Oliveira et al.   ACS Applied Materials & Interfaces

Triggering of RNA Interference with RNA–RNA, RNA–DNA, and DNA–RNA Nanoparticles

(2014) Kirill A. Afonin et al.   ACS Nano

Liposomal siRNA nanocarriers for cancer therapy

(2014) Bulent Ozpolat et al.   ADVANCED DRUG DELIVERY REVIEWS

Ionizable Amphiphilic Dendrimer-Based Nanomaterials with Alkyl-Chain-Substituted Amines for Tunable siRNA Delivery to the Liver Endothelium In Vivo

(2014) Omar F. Khan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Combinatorially Designed Lipid-like Nanoparticles for Intracellular Delivery of Cytotoxic Protein for Cancer Therapy

(2014) Ming Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Electroporation-Based Technologies for Medicine: Principles, Applications, and Challenges

(2014) Martin L. Yarmush et al.   Annual Review of Biomedical Engineering

Biosynthetic preparation of selectively deuterated phosphatidylcholine in genetically modified Escherichia coli

(2014) Selma Maric et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Isocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics

(2014) Gijs Koopmanschap et al.   Beilstein Journal of Organic Chemistry

Structural dynamics and physicochemical properties of pDNA/DODAB:MO lipoplexes: Effect of pH and anionic lipids in inverted non-lamellar phases versus lamellar phases

(2014) J.P. Neves Silva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A comprehensive overview of exosomes as drug delivery vehicles — Endogenous nanocarriers for targeted cancer therapy

(2014) Kasper Bendix Johnsen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Direct cytosolic siRNA delivery by reconstituted high density lipoprotein for target-specific therapy of tumor angiogenesis

(2014) Yang Ding et al.   BIOMATERIALS

Low-density lipoprotein-coupled N-succinyl chitosan nanoparticles co-delivering siRNA and doxorubicin for hepatocyte-targeted therapy

(2014) Qiao-ling Zhu et al.   BIOMATERIALS

Sialic Acids Sweeten a Tumor's Life

(2014) C. Bull et al.   CANCER RESEARCH

Permanent Alteration of PCSK9 With In Vivo CRISPR-Cas9 Genome Editing

(2014) Qiurong Ding et al.   CIRCULATION RESEARCH

Lipid-based mRNA vaccine delivery systems

(2014) Patrick Midoux et al.   Expert Review of Vaccines

VCAM-1 specific PEGylated SAINT-based lipoplexes deliver siRNA to activated endothelium in vivo but do not attenuate target gene expression

(2014) Niek G.J. Leus et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

First-in-Human Phase I Study of the Liposomal RNA Interference Therapeutic Atu027 in Patients With Advanced Solid Tumors

(2014) Beate Schultheis et al.   JOURNAL OF CLINICAL ONCOLOGY

How does spacer length of imidazolium gemini surfactants control the fabrication of 2D-Langmuir films of silver-nanoparticles at the air–water interface?

(2014) Sougata Datta et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Designer lipids for drug delivery: From heads to tails

(2014) Aditya G. Kohli et al.   JOURNAL OF CONTROLLED RELEASE

Anti-VCAM-1 SAINT-O-Somes enable endothelial-specific delivery of siRNA and downregulation of inflammatory genes in activated endothelium in vivo

(2014) Piotr S. Kowalski et al.   JOURNAL OF CONTROLLED RELEASE

Target-specific delivery of siRNA by stabilized calcium phosphate nanoparticles using dopa–hyaluronic acid conjugate

(2014) Min Sang Lee et al.   JOURNAL OF CONTROLLED RELEASE

Potent Immune Responses in Rhesus Macaques Induced by Nonviral Delivery of a Self-amplifying RNA Vaccine Expressing HIV Type 1 Envelope With a Cationic Nanoemulsion

(2014) W. M. Bogers et al.   JOURNAL OF INFECTIOUS DISEASES

Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

(2014) Jayaprakash K. Nair et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lies and deception in bacterial gene regulation: the roles of nucleic acid decoys

(2014) Yvonne Göpel et al.   MOLECULAR MICROBIOLOGY

Stabilization of Ostwald Ripening in Low Molecular Weight Amino Lipid Nanoparticles for Systemic Delivery of siRNA Therapeutics

(2014) Marian E. Gindy et al.   MOLECULAR PHARMACEUTICS

Multifunctional Cationic Lipid-Based Nanoparticles Facilitate Endosomal Escape and Reduction-Triggered Cytosolic siRNA Release

(2014) Maneesh Gujrati et al.   MOLECULAR PHARMACEUTICS

A Cationic Nanoemulsion for the Delivery of Next-generation RNA Vaccines

(2014) Luis A Brito et al.   MOLECULAR THERAPY

Intracellular delivery of nanomaterials: How to catch endosomal escape in the act

(2014) Thomas F. Martens et al.   Nano Today

Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype

(2014) Hao Yin et al.   NATURE BIOTECHNOLOGY

In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight

(2014) James E. Dahlman et al.   Nature Nanotechnology

mRNA-based therapeutics — developing a new class of drugs

(2014) Ugur Sahin et al.   NATURE REVIEWS DRUG DISCOVERY

Non-viral vectors for gene-based therapy

(2014) Hao Yin et al.   NATURE REVIEWS GENETICS

Antisense Oligonucleotides Capable of Promoting Specific Target mRNA Reduction via Competing RNase H1-Dependent and Independent Mechanisms

(2014) Timothy A. Vickers et al.   PLoS One

Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates

(2014) Y. Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineered red blood cells as carriers for systemic delivery of a wide array of functional probes

(2014) J. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity

(2014) Kathryn A. Whitehead et al.   Nature Communications

Phosphorothioates, Essential Components of Therapeutic Oligonucleotides

(2014) Fritz Eckstein   Nucleic Acid Therapeutics

In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus.

(2014) Tsunamasa Watanabe et al.   Scientific Reports

Enhanced Intracellular siRNA Delivery using Bioreducible Lipid-Like Nanoparticles

(2014) Ming Wang et al.   Advanced Healthcare Materials

Neutralized Nanoparticle Composed of SS-Cleavable and pH-Activated Lipid-Like Material as a Long-Lasting and Liver-Specific Gene Delivery System

(2014) Masami Ukawa et al.   Advanced Healthcare Materials

Lipid-Like Nanomaterials for Simultaneous Gene Expression and Silencing In Vivo

(2014) Yizhou Dong et al.   Advanced Healthcare Materials

Tamoxifen embedded in lipid bilayer improves the oncotarget of liposomal daunorubicin in vivo

(2014) M. H. Li et al.   Journal of Materials Chemistry B

Cationic gemini lipids containing polyoxyethylene spacers as improved transfecting agents of plasmid DNA in cancer cells

(2014) Ana L. Barrán-Berdón et al.   Journal of Materials Chemistry B

Mechanism of Polyplex- and Lipoplex-Mediated Delivery of Nucleic Acids: Real-Time Visualization of Transient Membrane Destabilization without Endosomal Lysis

(2013) Zia ur Rehman et al.   ACS Nano

Stable RNA nanoparticles as potential new generation drugs for cancer therapy

(2013) Yi Shu et al.   ADVANCED DRUG DELIVERY REVIEWS

Lipid-Modified Aminoglycoside Derivatives for In Vivo siRNA Delivery

(2013) Yunlong Zhang et al.   ADVANCED MATERIALS

The Headgroup Evolution of Cationic Lipids for Gene Delivery

(2013) Defu Zhi et al.   BIOCONJUGATE CHEMISTRY

The Polyethyleneglycol Dilemma: Advantage and Disadvantage of PEGylation of Liposomes for Systemic Genes and Nucleic Acids Delivery to Tumors

(2013) Hiroto Hatakeyama et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Combinational delivery of c-myc siRNA and nucleoside analogs in a single, synthetic nanocarrier for targeted cancer therapy

(2013) Yuan Zhang et al.   BIOMATERIALS

Interfacial engineering of pyridinium gemini surfactants for the generation of synthetic transfection systems

(2013) Vishnu D. Sharma et al.   BIOMATERIALS

Core-Shell type lipid/rPAA-Chol polymer hybrid nanoparticles for in vivo siRNA delivery

(2013) Ling-Yan Gao et al.   BIOMATERIALS

Gene therapy for cardiovascular disease mediated by ultrasound and microbubbles

(2013) Zhi-Yi Chen et al.   Cardiovascular Ultrasound

One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering

(2013) Haoyi Wang et al.   CELL

Phospholipid-Detergent Conjugates as Novel Tools for siRNA Delivery

(2013) Philippe Pierrat et al.   CHEMISTRY-A EUROPEAN JOURNAL

In-Vivo Gene Delivery by Sonoporation: Recent Progress and Prospects

(2013) Jean-Michel Escoffre et al.   CURRENT GENE THERAPY

Cholesterol precursors

(2013) Andrew J. Brown et al.   CURRENT OPINION IN LIPIDOLOGY

An efficient method for long-term room temperature storage of RNA

(2013) Anne-Lise Fabre et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Lipopolyplexes comprising imidazole/imidazolium lipophosphoramidate, histidinylated polyethyleneimine and siRNA as efficient formulation for siRNA transfection

(2013) Cristine Gonçalves et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Enhanced hepatic delivery of siRNA and microRNA using oleic acid based lipid nanoparticle formulations

(2013) Xinmei Wang et al.   JOURNAL OF CONTROLLED RELEASE

Nanostructured lipid carriers as multifunctional nanomedicine platform for pulmonary co-delivery of anticancer drugs and siRNA

(2013) Oleh Taratula et al.   JOURNAL OF CONTROLLED RELEASE

Design and evaluation of new pH-sensitive amphiphilic cationic lipids for siRNA delivery

(2013) Anthony S. Malamas et al.   JOURNAL OF CONTROLLED RELEASE

Efficient delivery of therapeutic small nucleic acids to prostate cancer cells using ketal nucleoside lipid nanoparticles

(2013) Delphine Luvino et al.   JOURNAL OF CONTROLLED RELEASE

A novel cationic niosome formulation for gene delivery to the retina

(2013) G. Puras et al.   JOURNAL OF CONTROLLED RELEASE

Dual-Responsive Surfaces Modified with Phenylboronic Acid-Containing Polymer Brush To Reversibly Capture and Release Cancer Cells

(2013) Hongliang Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Developing Lipid Nanoparticle-Based siRNA Therapeutics for Hepatocellular Carcinoma Using an Integrated Approach

(2013) Leiming Li et al.   MOLECULAR CANCER THERAPEUTICS

Anti-VCAM-1 and Anti-E-selectin SAINT-O-Somes for Selective Delivery of siRNA into Inflammation-Activated Primary Endothelial Cells

(2013) Piotr S. Kowalski et al.   MOLECULAR PHARMACEUTICS

Stabilization of Distearoylphosphatidylcholine Lamellar Phases in Propylene Glycol Using Cholesterol

(2013) Richard D. Harvey et al.   MOLECULAR PHARMACEUTICS

Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics

(2013) Martin A Maier et al.   MOLECULAR THERAPY

Gene Silencing via RNAi and siRNA Quantification in Tumor Tissue Using MEND, a Liposomal siRNA Delivery System

(2013) Yu Sakurai et al.   MOLECULAR THERAPY

Cationic lipid nanoparticles for therapeutic delivery of siRNA and miRNA to murine liver tumor

(2013) Shu-hao Hsu et al.   Nanomedicine-Nanotechnology Biology and Medicine

Phospholipid-modified polyethylenimine-based nanopreparations for siRNA–mediated gene silencing: Implications for transfection and the role of lipid components

(2013) Gemma Navarro et al.   Nanomedicine-Nanotechnology Biology and Medicine

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

(2013) Jerome Gilleron et al.   NATURE BIOTECHNOLOGY

Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction

(2013) Lior Zangi et al.   NATURE BIOTECHNOLOGY

Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

(2013) Gaurav Sahay et al.   NATURE BIOTECHNOLOGY

Delivery materials for siRNA therapeutics

(2013) Rosemary Kanasty et al.   NATURE MATERIALS

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

Rat Brain-Uptake Index for Phenylethylamine and Various Monomethylated Derivatives

(2013) Aron D. Mosnaim et al.   NEUROCHEMICAL RESEARCH

Structure–transfection activity relationships in a series of novel cationic lipids with heterocyclic head-groups

(2013) Ekaterina A. Ivanova et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Bioresponsive Deciduous-Charge Amphiphiles for Liposomal Delivery of DNA and siRNA

(2013) Philippe Pierrat et al.   PHARMACEUTICAL RESEARCH

Transfection and structural properties of phytanyl substituted gemini surfactant-based vectors for gene delivery

(2013) Haitang Wang et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Multiparametric approach for the evaluation of lipid nanoparticles for siRNA delivery

(2013) C. A. Alabi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug

(2013) X. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A vector-free microfluidic platform for intracellular delivery

(2013) A. Sharei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA-Based Tools for Nuclear Reprogramming and Lineage-Conversion: Towards Clinical Applications

(2013) Juan A. Bernal   Journal of Cardiovascular Translational Research

A Neutral Envelope-Type Nanoparticle Containing pH-Responsive and SS-Cleavable Lipid-Like Material as a Carrier for Plasmid DNA

(2013) Hidetaka Akita et al.   Advanced Healthcare Materials

Delivery of RNA and Its Intracellular Translation into Protein Mediated by SDS-CTAB Vesicles: Potential Use in Nanobiotechnology

(2013) Laura Russo et al.   Biomed Research International

Magnetofection: A Reproducible Method for Gene Delivery to Melanoma Cells

(2013) Lara Prosen et al.   Biomed Research International

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform

(2013) Armon Sharei et al.   Jove-Journal of Visualized Experiments

Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

(2013) Barbara L Mui et al.   Molecular Therapy-Nucleic Acids

Lipid Nanoparticle Delivery of siRNA to Silence Neuronal Gene Expression in the Brain

(2013) Ravi L Rungta et al.   Molecular Therapy-Nucleic Acids

Lipid nanoparticle delivery systems for siRNA-based therapeutics

(2013) C. Wan et al.   Drug Delivery and Translational Research

Advances in Lipid Nanoparticles for siRNA Delivery

(2013) Yuen Tam et al.   Pharmaceutics

Safety profile of RNAi nanomedicines

(2012) Scott A. Barros et al.   ADVANCED DRUG DELIVERY REVIEWS

Cationic lipids activate intracellular signaling pathways

(2012) Caroline Lonez et al.   ADVANCED DRUG DELIVERY REVIEWS

Liposomal drug delivery systems: From concept to clinical applications

(2012) Theresa M. Allen et al.   ADVANCED DRUG DELIVERY REVIEWS

Exosomes for targeted siRNA delivery across biological barriers

(2012) Samir EL Andaloussi et al.   ADVANCED DRUG DELIVERY REVIEWS

Mesoporous Silica Nanoparticles: Synthesis, Biocompatibility and Drug Delivery

(2012) Fangqiong Tang et al.   ADVANCED MATERIALS

An Amphiphilic Dendrimer for Effective Delivery of Small Interfering RNA and Gene Silencing In Vitro and In Vivo

(2012) Tianzhu Yu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

(2012) Muthusamy Jayaraman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transfection efficiency boost of cholesterol-containing lipoplexes

(2012) Daniela Pozzi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The role of the helper lipid dioleoylphosphatidylethanolamine (DOPE) for DNA transfection cooperating with a cationic lipid bearing ethylenediamine

(2012) Shinichi Mochizuki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Synthesis, Characterization, and Evaluation of Ionizable Lysine-Based Lipids for siRNA Delivery

(2012) Colin L. Walsh et al.   BIOCONJUGATE CHEMISTRY

How Does the Spacer Length of Cationic Gemini Lipids Influence the Lipoplex Formation with Plasmid DNA? Physicochemical and Biochemical Characterizations and their Relevance in Gene Therapy

(2012) Mónica Muñoz-Úbeda et al.   BIOMACROMOLECULES

A biomimetic lipid library for gene delivery through thiol-yne click chemistry

(2012) Linxian Li et al.   BIOMATERIALS

Lipid nanoparticles for hepatic delivery of small interfering RNA

(2012) Bo Yu et al.   BIOMATERIALS

Synthesis and characterization of novel zwitterionic lipids with pH-responsive biophysical properties

(2012) Colin L. Walsh et al.   CHEMICAL COMMUNICATIONS

Efficient and safe delivery of siRNA using anionic lipids: Formulation optimization studies

(2012) Mamta Kapoor et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo

(2012) Yusuke Sato et al.   JOURNAL OF CONTROLLED RELEASE

Doxil® — The first FDA-approved nano-drug: Lessons learned

(2012) Yechezkel (Chezy) Barenholz   JOURNAL OF CONTROLLED RELEASE

How cationic lipids transfer nucleic acids into cells and across cellular membranes: Recent advances

(2012) Zia ur Rehman et al.   JOURNAL OF CONTROLLED RELEASE

The mannose receptor

(2012) Luisa Martinez-Pomares   JOURNAL OF LEUKOCYTE BIOLOGY

Small-Angle Neutron-Scattering Studies of Mixed Micellar Structures Made of Dimeric Surfactants Having Imidazolium and Ammonium Headgroups

(2012) Asish Pal et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Rapid Discovery of Potent siRNA-Containing Lipid Nanoparticles Enabled by Controlled Microfluidic Formulation

(2012) Delai Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pendant Polymer:Amino-β-Cyclodextrin:siRNA Guest:Host Nanoparticles as Efficient Vectors for Gene Silencing

(2012) Aditya Kulkarni et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Gemini Imidazolium Surfactants: Synthesis and Their Biophysiochemical Study

(2012) Raman Kamboj et al.   LANGMUIR

Heterocyclic Cationic Gemini Surfactants: A Comparative Overview of Their Synthesis, Self-assembling, Physicochemical, and Biological Properties

(2012) Vishnu Dutt Sharma et al.   MEDICINAL RESEARCH REVIEWS

Asymmetrical N4,N9-Diacyl Spermines: SAR Studies of Nonviral Lipopolyamine Vectors for Efficient siRNA Delivery with Silencing of EGFP Reporter Gene

(2012) Ian S. Blagbrough et al.   MOLECULAR PHARMACEUTICS

Glycerol Monooleate-Based Nanocarriers for siRNA Delivery in Vitro

(2012) Guoliang Zhen et al.   MOLECULAR PHARMACEUTICS

Synthesis and Preliminary Investigations of the siRNA Delivery Potential of Novel, Single-Chain Rigid Cationic Carotenoid Lipids

(2012) Michael D. Pungente et al.   MOLECULES

Influence of cationic lipid composition on uptake and intracellular processing of lipid nanoparticle formulations of siRNA

(2012) Paulo J.C. Lin et al.   Nanomedicine-Nanotechnology Biology and Medicine

RNA therapeutics: beyond RNA interference and antisense oligonucleotides

(2012) Ryszard Kole et al.   NATURE REVIEWS DRUG DISCOVERY

Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes

(2012) Jessica Wahlgren et al.   NUCLEIC ACIDS RESEARCH

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Exploiting cell surface thiols to enhance cellular uptake

(2012) Adrian G. Torres et al.   TRENDS IN BIOTECHNOLOGY

DODAB:monoolein-based lipoplexes as non-viral vectors for transfection of mammalian cells

(2011) J.P. Neves Silva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A Molecular Umbrella Approach to the Intracellular Delivery of Small Interfering RNA

(2011) Lauren L. Cline et al.   BIOCONJUGATE CHEMISTRY

Dicetyl Phosphate-Tetraethylenepentamine-Based Liposomes for Systemic siRNA Delivery

(2011) Tomohiro Asai et al.   BIOCONJUGATE CHEMISTRY

Mechanistic Insights into LDL Nanoparticle-Mediated siRNA Delivery

(2011) Honglin Jin et al.   BIOCONJUGATE CHEMISTRY

Galactose-Modified Cationic Liposomes as a Liver-Targeting Delivery System for Small Interfering RNA

(2011) Satoru Sonoke et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Cationic drug-derived nanoparticles for multifunctional delivery of anticancer siRNA

(2011) Rae Sung Chang et al.   BIOMATERIALS

The many faces of the adamantyl group in drug design

(2011) Joe Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

MicroRNA therapeutics

(2011) J A Broderick et al.   GENE THERAPY

Lipid nanoparticle siRNA systems for silencing the androgen receptor in human prostate cancer in vivo

(2011) Justin B. Lee et al.   INTERNATIONAL JOURNAL OF CANCER

Novel RGD-lipid conjugate-modified liposomes for enhancing siRNA delivery in human retinal pigment epithelial cells

(2011) Cheng-Wei Chen et al.   International Journal of Nanomedicine

Design of multifunctional non-viral gene vectors to overcome physiological barriers: Dilemmas and strategies

(2011) Tao Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Calcium phosphate nanoparticles with an asymmetric lipid bilayer coating for siRNA delivery to the tumor

(2011) Jun Li et al.   JOURNAL OF CONTROLLED RELEASE

Interaction of Cholesterol-Conjugated Ionizable Amino Lipids with Biomembranes: Lipid Polymorphism, Structure–Activity Relationship, and Implications for siRNA Delivery

(2011) Jingtao Zhang et al.   LANGMUIR

Nanogyroids Incorporating Multivalent Lipids: Enhanced Membrane Charge Density and Pore Forming Ability for Gene Silencing

(2011) Cecília Leal et al.   LANGMUIR

Ionization Behavior of Amino Lipids for siRNA Delivery: Determination of Ionization Constants, SAR, and the Impact of Lipid pKaon Cationic Lipid−Biomembrane Interactions

(2011) Jingtao Zhang et al.   LANGMUIR

SPANosomes as Delivery Vehicles for Small Interfering RNA (siRNA)

(2011) Chenguang Zhou et al.   MOLECULAR PHARMACEUTICS

Mannose-Functionalized “Pathogen-like” Polyanhydride Nanoparticles Target C-Type Lectin Receptors on Dendritic Cells

(2011) Brenda Carrillo-Conde et al.   MOLECULAR PHARMACEUTICS

In Vitroandin VivomRNA Delivery Using Lipid-Enveloped pH-Responsive Polymer Nanoparticles

(2011) Xingfang Su et al.   MOLECULAR PHARMACEUTICS

Efficient Silencing of EGFP Reporter Gene with siRNA Delivered by Asymmetrical N4,N9-Diacyl Spermines

(2011) Abdelkader A. Metwally et al.   MOLECULAR PHARMACEUTICS

Influence of Cationic Lipid Composition on Gene Silencing Properties of Lipid Nanoparticle Formulations of siRNA in Antigen-Presenting Cells

(2011) Genc Basha et al.   MOLECULAR THERAPY

An Amino Acid-based Amphoteric Liposomal Delivery System for Systemic Administration of siRNA

(2011) Roger C Adami et al.   MOLECULAR THERAPY

Systemic Delivery of Tumor Suppressor microRNA Mimics Using a Neutral Lipid Emulsion Inhibits Lung Tumors in Mice

(2011) Phong Trang et al.   MOLECULAR THERAPY

Enhancement of dendritic cells transfection in vivo and of vaccination against B16F10 melanoma with mannosylated histidylated lipopolyplexes loaded with tumor antigen messenger RNA

(2011) Federico Perche et al.   Nanomedicine-Nanotechnology Biology and Medicine

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Photoporation of Biomolecules into Single Cells in Living Vertebrate Embryos Induced by a Femtosecond Laser Amplifier

(2011) Yoichiroh Hosokawa et al.   PLoS One

Efficient Cytosolic Delivery of siRNA Using HDL-Mimicking Nanoparticles

(2011) Mi Yang et al.   Small

Cellular Uptake, Intracellular Trafficking, and Cytotoxicity of Nanomaterials

(2011) Feng Zhao et al.   Small

Enhanced Chemotherapy Efficacy by Sequential Delivery of siRNA and Anticancer Drugs Using PEI-Grafted Graphene Oxide

(2011) Liming Zhang et al.   Small

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

(2011) María Mittelbrunn et al.   Nature Communications

Polymers in Small-Interfering RNA Delivery

(2011) Kaushik Singha et al.   Nucleic Acid Therapeutics

Efficient Gene Silencing by Self-Assembled Complexes of siRNA and Symmetrical Fatty Acid Amides of Spermine

(2011) Abdelkader A. Metwally et al.   Pharmaceutics

Self-Assembled Lipoplexes of Short Interfering RNA (siRNA) Using Spermine-Based Fatty Acid Amide Guanidines: Effect on Gene Silencing Efficiency

(2011) Abdelkader A. Metwally et al.   Pharmaceutics

Superparamagnetic iron oxide nanoparticles (SPIONs): Development, surface modification and applications in chemotherapy

(2010) Morteza Mahmoudi et al.   ADVANCED DRUG DELIVERY REVIEWS

Assessment of Tumor Metastasis by the Direct Determination of Cell-Membrane Sialic Acid Expression

(2010) Akira Matsumoto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Thiol-Yne Chemistry: A Powerful Tool for Creating Highly Functional Materials

(2010) Richard Hoogenboom   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform

(2010) C. Frank Bennett et al.   Annual Review of Pharmacology and Toxicology

Plant pentacyclic triterpenic acids as modulators of lipid membrane physical properties

(2010) Jesús Prades et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Combinatorial Approach to Determine Functional Group Effects on Lipidoid-Mediated siRNA Delivery

(2010) Kerry P. Mahon et al.   BIOCONJUGATE CHEMISTRY

Transfection Efficiency of Cationic Lipids with Different Hydrophobic Domains in Gene Delivery

(2010) DeFu Zhi et al.   BIOCONJUGATE CHEMISTRY

Cationic Nucleoside Lipids Derived from Universal Bases: A Rational Approach for siRNA Transfection

(2010) Claire Ceballos et al.   BIOCONJUGATE CHEMISTRY

The systemic toxicity of positively charged lipid nanoparticles and the role of Toll-like receptor 4 in immune activation

(2010) Ranit Kedmi et al.   BIOMATERIALS

Mechanisms of nucleotide trafficking during siRNA delivery to endothelial cells using perfluorocarbon nanoemulsions

(2010) Megan M. Kaneda et al.   BIOMATERIALS

Development of a Lung Cancer Therapeutic Based on the Tumor Suppressor MicroRNA-34

(2010) J. F. Wiggins et al.   CANCER RESEARCH

Synthesis and delivery activity of new cationic cholesteryl glucosides

(2010) Mikhail A. Maslov et al.   CARBOHYDRATE RESEARCH

Atu027 Prevents Pulmonary Metastasis in Experimental and Spontaneous Mouse Metastasis Models

(2010) A. Santel et al.   CLINICAL CANCER RESEARCH

Gene delivery by lipoplexes and polyplexes

(2010) Conchita Tros de Ilarduya et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

DC-Chol/DOPE cationic liposomes: A comparative study of the influence factors on plasmid pDNA and siRNA gene delivery

(2010) Yang Zhang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Multifunctional Nanoparticles Delivering Small Interfering RNA and Doxorubicin Overcome Drug Resistance in Cancer

(2010) Yunching Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endosomal escape pathways for delivery of biologicals

(2010) Amir K. Varkouhi et al.   JOURNAL OF CONTROLLED RELEASE

Glioma-initiating cells: A predominant role in microglia/macrophages tropism to glioma

(2010) Liang Yi et al.   JOURNAL OF NEUROIMMUNOLOGY

Highly Efficient Gene Silencing Activity of siRNA Embedded in a Nanostructured Gyroid Cubic Lipid Matrix

(2010) Cecília Leal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tailoring Lipoplex Composition to the Lipid Composition of Plasma Membrane: A Trojan Horse for Cell Entry?

(2010) Cristina Marchini et al.   LANGMUIR

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

(2010) Akin Akinc et al.   MOLECULAR THERAPY

Noninvasive Imaging of Lipid Nanoparticle–Mediated Systemic Delivery of Small-Interfering RNA to the Liver

(2010) Weikang Tao et al.   MOLECULAR THERAPY

Mechanistically Probing Lipid-siRNA Nanoparticle-associated Toxicities Identifies Jak Inhibitors Effective in Mitigating Multifaceted Toxic Responses

(2010) Weikang Tao et al.   MOLECULAR THERAPY

Polymer- and lipid-based nanoparticle therapeutics for the treatment of liver diseases

(2010) Lanjuan Li et al.   Nano Today

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

The emerging field of RNA nanotechnology

(2010) Peixuan Guo   Nature Nanotechnology

Aptamers as therapeutics

(2010) Anthony D. Keefe et al.   NATURE REVIEWS DRUG DISCOVERY

Lipid-like materials for low-dose, in vivo gene silencing

(2010) K. T. Love et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional delivery of viral miRNAs via exosomes

(2010) D. M. Pegtel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Locked nucleic acid as a novel class of therapeutic agents

(2010) Rakesh N. Veedu et al.   RNA Biology

Platelet-derived microparticles – an updated perspective

(2010) Pia R.M. Siljander   THROMBOSIS RESEARCH

Nanotoxicity of pure silica mediated through oxidant generation rather than glutathione depletion in human lung epithelial cells

(2010) Mohd Javed Akhtar et al.   TOXICOLOGY

Laser-Activated Gene Silencing via Gold Nanoshell−siRNA Conjugates

(2009) Gary B. Braun et al.   ACS Nano

Polyethyleneimine Coating Enhances the Cellular Uptake of Mesoporous Silica Nanoparticles and Allows Safe Delivery of siRNA and DNA Constructs

(2009) Tian Xia et al.   ACS Nano

Lipid-Like Nanoparticles for Small Interfering RNA Delivery to Endothelial Cells

(2009) Seung-Woo Cho et al.   ADVANCED FUNCTIONAL MATERIALS

All-in-One Target-Cell-Specific Magnetic Nanoparticles for Simultaneous Molecular Imaging and siRNA Delivery

(2009) Jae-Hyun Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ligand-Targeted Delivery of Small Interfering RNAs to Malignant Cells and Tissues

(2009) Mini Thomas et al.   Annals of the New York Academy of Sciences

Cationic Nucleoside Lipids Based on a 3-Nitropyrrole Universal Base for siRNA Delivery

(2009) Claire Ceballos et al.   BIOCONJUGATE CHEMISTRY

Addressing the problem of cationic lipid-mediated toxicity: The magnetoliposome model

(2009) Stefaan J.H. Soenen et al.   BIOMATERIALS

A novel in vivo siRNA delivery system specifically targeting dendritic cells and silencing CD40 genes for immunomodulation

(2009) X. Zheng et al.   BLOOD

A modified protocol for efficient DNA encapsulation into pegylated immunoliposomes (PILs)

(2009) Tina Skjørringe et al.   JOURNAL OF CONTROLLED RELEASE

Anionic amino acid-derived cationic lipid for siRNA delivery

(2009) Min Sung Suh et al.   JOURNAL OF CONTROLLED RELEASE

DODAG; a versatile new cationic lipid that mediates efficient delivery of pDNA and siRNA

(2009) Mathieu Mével et al.   JOURNAL OF CONTROLLED RELEASE

Noninvasive Sialic Acid Detection at Cell Membrane by Using Phenylboronic Acid Modified Self-Assembled Monolayer Gold Electrode

(2009) Akira Matsumoto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mesomorphic Imidazolium Salts: New Vectors for Efficient siRNA Transfection

(2009) William Dobbs et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Gene Regulation with Polyvalent siRNA−Nanoparticle Conjugates

(2009) David A. Giljohann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Novel Gemini Pyridinium Surfactants: Synthesis and Study of Their Surface Activity, DNA Binding, and Cytotoxicity

(2009) Avinash Bhadani et al.   LANGMUIR

Novel Cationic Lipid That Delivers siRNA and Enhances Therapeutic Effect in Lung Cancer Cells

(2009) Yunching Chen et al.   MOLECULAR PHARMACEUTICS

A Novel Mechanism Is Involved in Cationic Lipid-Mediated Functional siRNA Delivery

(2009) James J. Lu et al.   MOLECULAR PHARMACEUTICS

Drug Delivery–mediated Control of RNA Immunostimulation

(2009) David N. Nguyen et al.   MOLECULAR THERAPY

Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver

(2009) Akin Akinc et al.   MOLECULAR THERAPY

Evaluation of Efficacy, Biodistribution, and Inflammation for a Potent siRNA Nanoparticle: Effect of Dexamethasone Co-treatment

(2009) Marc T Abrams et al.   MOLECULAR THERAPY

Efficient siRNA delivery into primary cells by a peptide transduction domain–dsRNA binding domain fusion protein

(2009) Akiko Eguchi et al.   NATURE BIOTECHNOLOGY

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Sensors and regulators of intracellular pH

(2009) Joseph R. Casey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transfer of MicroRNAs by Embryonic Stem Cell Microvesicles

(2009) Alex Yuan et al.   PLoS One

Self-Assembled Lipid−Polymer Hybrid Nanoparticles: A Robust Drug Delivery Platform

(2008) Liangfang Zhang et al.   ACS Nano

Gold nanoparticles in delivery applications☆

(2008) P GHOSH et al.   ADVANCED DRUG DELIVERY REVIEWS

Catalytic Three-Component Ugi Reaction

(2008) Subhas Chandra Pan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Focusing on clathrin-mediated endocytosis

(2008) Joshua Z. Rappoport   BIOCHEMICAL JOURNAL

Cellular Internalization and Distribution of Arginine-Rich Peptides as a Function of Extracellular Peptide Concentration, Serum, and Plasma Membrane Associated Proteoglycans

(2008) Michie Kosuge et al.   BIOCONJUGATE CHEMISTRY

Evaluation of Cationic Assemblies Constructed with Amino Acid Based Lipids for Plasmid DNA Delivery

(2008) Yosuke Obata et al.   BIOCONJUGATE CHEMISTRY

Tumor Regression in Mice by Delivery of Bcl-2 Small Interfering RNA with Pegylated Cationic Liposomes

(2008) Satoru Sonoke et al.   CANCER RESEARCH

Atu027, a Liposomal Small Interfering RNA Formulation Targeting Protein Kinase N3, Inhibits Cancer Progression

(2008) M. Aleku et al.   CANCER RESEARCH

Nonviral Vectors for Gene Delivery

(2008) Meredith A. Mintzer et al.   CHEMICAL REVIEWS

Microinjection as a tool of mechanical delivery

(2008) Yan Zhang et al.   CURRENT OPINION IN BIOTECHNOLOGY

Electroporation as an efficient method of gene transfer

(2008) Noritaka Odani et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Mannose-targeted systems for the delivery of therapeutics

(2008) Juan M Irache et al.   Expert Opinion on Drug Delivery

Stability of luciferase plasmid entrapped in cationic bilayer vesicles

(2008) A. Manosroi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Two-dimensional self-assembly and complementary base-pairing between amphiphile nucleotides on graphite

(2008) Isabelle Bestel et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Synergistic antitumoral effect of vinblastine and HSV-Tk/GCV gene therapy mediated by albumin-associated cationic liposomes

(2008) H. Faneca et al.   JOURNAL OF CONTROLLED RELEASE

Coating didodecyldimethylammonium bromide onto Au nanoparticles increases the stability of its complex with DNA

(2008) Peicai Li et al.   JOURNAL OF CONTROLLED RELEASE

Bioactive sphingolipids: metabolism and function

(2008) Nana Bartke et al.   JOURNAL OF LIPID RESEARCH

Sterol-Modified Phospholipids: Cholesterol and Phospholipid Chimeras with Improved Biomembrane Properties

(2008) Zhaohua Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thiol−Yne Photopolymerizations: Novel Mechanism, Kinetics, and Step-Growth Formation of Highly Cross-Linked Networks

(2008) Benjamin D. Fairbanks et al.   MACROMOLECULES

Formulation and Delivery of siRNA by Oleic Acid and Stearic Acid Modified Polyethylenimine

(2008) Aws Alshamsan et al.   MOLECULAR PHARMACEUTICS

Assessing siRNA Pharmacodynamics in a Luciferase-expressing Mouse

(2008) Robert U Svensson et al.   MOLECULAR THERAPY

Efficient In Vivo Delivery of siRNA to the Liver by Conjugation of α-Tocopherol

(2008) Kazutaka Nishina et al.   MOLECULAR THERAPY

Microfluidic Platform for Controlled Synthesis of Polymeric Nanoparticles

(2008) Rohit Karnik et al.   NANO LETTERS

The effect of cetyl palmitate crystallinity on physical properties of gamma-oryzanol encapsulated in solid lipid nanoparticles

(2008) Uracha Ruktanonchai et al.   NANOTECHNOLOGY

Resolution of liver cirrhosis using vitamin A–coupled liposomes to deliver siRNA against a collagen-specific chaperone

(2008) Yasushi Sato et al.   NATURE BIOTECHNOLOGY

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

(2008) Akin Akinc et al.   NATURE BIOTECHNOLOGY

Cellular cholesterol trafficking and compartmentalization

(2008) Elina Ikonen   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Very Long Chain N 4 ,N 9 -Diacyl Spermines: Non-Viral Lipopolyamine Vectors for Efficient Plasmid DNA and siRNA Delivery

(2008) Hassan M. Ghonaim et al.   PHARMACEUTICAL RESEARCH

NPC1/NPC2 function as a tag team duo to mobilize cholesterol

(2008) K. Subramanian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

(2008) M. Frank-Kamenetsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A multifunctional and reversibly polymerizable carrier for efficient siRNA delivery

(2007) Xu-Li Wang et al.   BIOMATERIALS

Efficient gene silencing in metastatic tumor by siRNA formulated in surface-modified nanoparticles

(2007) Shyh-Dar Li et al.   JOURNAL OF CONTROLLED RELEASE

Efficient targeting to alveolar macrophages by intratracheal administration of mannosylated liposomes in rats

(2007) Wassana Wijagkanalan et al.   JOURNAL OF CONTROLLED RELEASE

Protein therapeutics: a summary and pharmacological classification

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