Exosome-mediated small RNA delivery for gene therapy

RNA Interference (RNAi)-Based Therapeutics: Delivering on the Promise?

(2016) Maggie L. Bobbin et al.   Annual Review of Pharmacology and Toxicology

Preclinical and clinical development of siRNA-based therapeutics

(2015) Gulnihal Ozcan et al.   ADVANCED DRUG DELIVERY REVIEWS

Synthetic RNAi triggers and their use in chronic hepatitis B therapies with curative intent

(2015) Robert G. Gish et al.   ANTIVIRAL RESEARCH

Exosomes: Natural Carriers for siRNA Delivery

(2015) Lalit Kumar et al.   CURRENT PHARMACEUTICAL DESIGN

Quantitative Analysis of Tissue Distribution of the B16BL6-Derived Exosomes Using a Streptavidin-Lactadherin Fusion Protein and Iodine-125-Labeled Biotin Derivative After Intravenous Injection in Mice

(2015) Masaki Morishita et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Are RNAi and miRNA therapeutics truly dead?

(2015) João Conde et al.   TRENDS IN BIOTECHNOLOGY

RNAi therapy targeting KRAS in combination with chemotherapy for locally advanced pancreatic cancer patients

(2015) Talia Golan et al.   Oncotarget

Targeted exosome-mediated delivery of opioid receptor Mu siRNA for the treatment of morphine relapse

(2015) Yuchen Liu et al.   Scientific Reports

Combinatorial RNA Interference Therapy Prevents Selection of Pre-existing HBV Variants in Human Liver Chimeric Mice

(2015) Yao-Ming Shih et al.   Scientific Reports

Role of Exosomal Noncoding RNAs in Lung Carcinogenesis

(2015) Tao Sun et al.   Biomed Research International

Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter

(2014) Charles P. Lai et al.   ACS Nano

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Microvesicle-mediated delivery of transforming growth factor β1 siRNA for the suppression of tumor growth in mice

(2014) Yaqin Zhang et al.   BIOMATERIALS

Exosomal miR-221/222 enhances tamoxifen resistance in recipient ER-positive breast cancer cells

(2014) Yifang Wei et al.   BREAST CANCER RESEARCH AND TREATMENT

Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis

(2014) Weiying Zhou et al.   CANCER CELL

Abstract LB-289: A phase I dose escalation study of TKM-080301, a RNAi therapeutic directed against PLK1, in patients with advanced solid tumors.

(2014) Ramesh K. Ramanathan et al.   CANCER RESEARCH

Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth

(2014) Yuan Yin et al.   CELL RESEARCH

Biogenesis and secretion of exosomes

(2014) Joanna Kowal et al.   CURRENT OPINION IN CELL BIOLOGY

Exosomes in diagnostic and therapeutic applications: biomarker, vaccine and RNA interference delivery vehicle

(2014) Cecilia Lässer   EXPERT OPINION ON BIOLOGICAL THERAPY

Pharmacokinetic evaluation of pegaptanib octasodium for the treatment of diabetic edema

(2014) Rupal Morjaria et al.   Expert Opinion on Drug Metabolism & Toxicology

First-in-Human Phase I Study of the Liposomal RNA Interference Therapeutic Atu027 in Patients With Advanced Solid Tumors

(2014) Beate Schultheis et al.   JOURNAL OF CLINICAL ONCOLOGY

Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice

(2014) J. Mark Cooper et al.   MOVEMENT DISORDERS

Correlating animal and human phase Ia/Ib clinical data with CALAA-01, a targeted, polymer-based nanoparticle containing siRNA

(2014) J. E. Zuckerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toxicological and Pharmacokinetic Properties of QPI-1007, a Chemically Modified Synthetic siRNA Targeting Caspase 2 mRNA, Following Intravitreal Injection

(2014) Elisabeth C.R. Solano et al.   Nucleic Acid Therapeutics

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

(2013) Yanhua Tian et al.   BIOMATERIALS

Exosomes are natural carriers of exogenous siRNA to human cells in vitro

(2013) Tatyana A Shtam et al.   Cell Communication and Signaling

Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection

(2013) Yuki Takahashi et al.   JOURNAL OF BIOTECHNOLOGY

Phase I First-in-Humans Trial of ALN-TTRsc, a Novel RNA Interference Therapeutic for the Treatment of Familial Amyloidotic Cardiomyopathy (FAC)

(2013) Tracy Zimmermann et al.   JOURNAL OF CARDIAC FAILURE

Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles

(2013) Sander A.A. Kooijmans et al.   JOURNAL OF CONTROLLED RELEASE

Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial

(2013) Kevin Fitzgerald et al.   LANCET

In Vitro and In Vivo Efficacy of SYL040012, a Novel siRNA Compound for Treatment of Glaucoma

(2013) Tamara Martínez et al.   MOLECULAR THERAPY

Safety and Efficacy of RNAi Therapy for Transthyretin Amyloidosis

(2013) Teresa Coelho et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

HCV-Induced miR-21 Contributes to Evasion of Host Immune System by Targeting MyD88 and IRAK1

(2013) Yanni Chen et al.   PLoS Pathogens

The origin, function, and diagnostic potential of extracellular microRNAs in human body fluids

(2013) Hongwei Liang et al.   Wiley Interdisciplinary Reviews-RNA

A paradigm shift for extracellular vesicles as small RNA carriers: from cellular waste elimination to therapeutic applications

(2013) Keitaro Hagiwara et al.   Drug Delivery and Translational Research

Extracellular circulating viral microRNAs: current knowledge and perspectives

(2013) Alessandro Laganà et al.   Frontiers in Genetics

Virus-modified exosomes for targeted RNA delivery; A new approach in nanomedicine

(2012) Danijela Koppers-Lalic et al.   ADVANCED DRUG DELIVERY REVIEWS

Exosomes for targeted siRNA delivery across biological barriers

(2012) Samir EL Andaloussi et al.   ADVANCED DRUG DELIVERY REVIEWS

Functional transfer of microRNA by exosomes

(2012) W. Stoorvogel   BLOOD

Phase 1 dose-escalation study of a siRNA targeting the RTP801 gene in age-related macular degeneration patients

(2012) Q D Nguyen et al.   EYE

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration

(2012) Sabrina M Lehmann et al.   NATURE NEUROSCIENCE

Exosome-mediated delivery of siRNA in vitro and in vivo

(2012) Samir El-Andaloussi et al.   Nature Protocols

Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes

(2012) Jessica Wahlgren et al.   NUCLEIC ACIDS RESEARCH

Evaluation of the siRNA PF-04523655 versus Ranibizumab for the Treatment of Neovascular Age-related Macular Degeneration (MONET Study)

(2012) Quan Dong Nguyen et al.   OPHTHALMOLOGY

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

(2012) M. Fabbri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secreted microRNAs: a new form of intercellular communication

(2012) Xi Chen et al.   TRENDS IN CELL BIOLOGY

Strategies for ocular siRNA delivery: Potential and limitations of non-viral nanocarriers

(2012) Ajit Thakur et al.   Journal of Biological Engineering

Multivesicular Body Morphogenesis

(2011) Phyllis I. Hanson et al.   Annual Review of Cell and Developmental Biology

Hepatic cell-to-cell transmission of small silencing RNA can extend the therapeutic reach of RNA interference (RNAi)

(2011) Qiuwei Pan et al.   GUT

Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs

(2011) Tian Chen et al.   Journal of Translational Medicine

Examination of mesenchymal stem cell-mediated RNAi transfer to Huntington's disease affected neuronal cells for reduction of huntingtin

(2011) Scott D. Olson et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

SiRNA delivery with exosome nanoparticles

(2011) Jasper G van den Boorn et al.   NATURE BIOTECHNOLOGY

RNA Interference and Cancer Therapy

(2011) Zhaohui Wang et al.   PHARMACEUTICAL RESEARCH

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

(2011) María Mittelbrunn et al.   Nature Communications

Current Status of Vascular Endothelial Growth Factor Inhibition in Age-Related Macular Degeneration

(2010) Shaker A. Mousa et al.   BIODRUGS

Potential clinical applications of siRNA technique: benefits and limitations

(2010) Shao-Hua Chen et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells

(2010) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosomes Containing Glycoprotein 350 Released by EBV-Transformed B Cells Selectively Target B Cells through CD21 and Block EBV Infection In Vitro

(2010) H. Vallhov et al.   JOURNAL OF IMMUNOLOGY

Exosomes: Extracellular organelles important in intercellular communication

(2010) Suresh Mathivanan et al.   Journal of Proteomics

Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell Migration

(2010) Yujing Zhang et al.   MOLECULAR CELL

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Functional delivery of viral miRNAs via exosomes

(2010) D. M. Pegtel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomes – vesicular carriers for intercellular communication

(2009) Mikael Simons et al.   CURRENT OPINION IN CELL BIOLOGY

First-in-human Mutation-targeted siRNA Phase Ib Trial of an Inherited Skin Disorder

(2009) Sancy A Leachman et al.   MOLECULAR THERAPY

Preclinical Studies To Understand Nanoparticle Interaction with the Immune System and Its Potential Effects on Nanoparticle Biodistribution

(2008) Marina A. Dobrovolskaia et al.   MOLECULAR PHARMACEUTICS

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE