Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

(2012) Muthusamy Jayaraman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Macropinocytosis of the PDGF β-receptor promotes fibroblast transformation by H-RasG12V

(2012) C. Schmees et al.   MOLECULAR BIOLOGY OF THE CELL

Rab5 is necessary for the biogenesis of the endolysosomal system in vivo

(2012) Anja Zeigerer et al.   NATURE

Effective siRNA delivery and target mRNA degradation using an amphipathic peptide to facilitate pH-dependent endosomal escape

(2011) René Bartz et al.   BIOCHEMICAL JOURNAL

Endosomal escape and the knockdown efficiency of liposomal-siRNA by the fusogenic peptide shGALA

(2011) Yu Sakurai et al.   BIOMATERIALS

Non-viral vectors for the mediation of RNAi

(2011) Shubiao Zhang et al.   BIOORGANIC CHEMISTRY

RNA-Induced Silencing Complex-Bound Small Interfering RNA Is a Determinant of RNA Interference-Mediated Gene Silencing in Mice

(2011) J. Wei et al.   MOLECULAR PHARMACOLOGY

Influence of Cationic Lipid Composition on Gene Silencing Properties of Lipid Nanoparticle Formulations of siRNA in Antigen-Presenting Cells

(2011) Genc Basha et al.   MOLECULAR THERAPY

Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo

(2011) Samir EL Andaloussi et al.   NUCLEIC ACIDS RESEARCH

Identification of the Switch in Early-to-Late Endosome Transition

(2010) Dmitry Poteryaev et al.   CELL

Efficient and targeted delivery of siRNA in vivo

(2010) Min Suk Shim et al.   FEBS Journal

Breaking down the barriers: siRNA delivery and endosome escape

(2010) M. Dominska et al.   JOURNAL OF CELL SCIENCE

Nanoparticles for ex vivo siRNA delivery to dendritic cells for cancer vaccines: Programmed endosomal escape and dissociation☆

(2010) Hidetaka Akita et al.   JOURNAL OF CONTROLLED RELEASE

Murine Cytomegalovirus Perturbs Endosomal Trafficking of Major Histocompatibility Complex Class I Molecules in the Early Phase of Infection

(2010) M. I. Tomas et al.   JOURNAL OF VIROLOGY

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

(2010) Akin Akinc et al.   MOLECULAR THERAPY

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

Small RNA sorting: matchmaking for Argonautes

(2010) Benjamin Czech et al.   NATURE REVIEWS GENETICS

Modulation of thermal stability can enhance the potency of siRNA

(2010) H. Addepalli et al.   NUCLEIC ACIDS RESEARCH

Novel siRNA Delivery System to Target Podocytes In Vivo

(2010) Peter V. Hauser et al.   PLoS One

Lipid-like materials for low-dose, in vivo gene silencing

(2010) K. T. Love et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative evaluation of siRNA delivery in vivo

(2010) Y. Pei et al.   RNA

Selective gene silencing by viral delivery of short hairpin RNA

(2010) Katja Sliva et al.   Virology Journal

Mechanisms of Endocytosis

(2009) Gary J. Doherty et al.   Annual Review of Biochemistry

Enhanced Cytoplasmic Delivery of siRNA Using a Stabilized Polyion Complex Based on PEGylated Nanogels with a Cross-Linked Polyamine Structure

(2009) Atsushi Tamura et al.   BIOMACROMOLECULES

Reconstitution of Rab- and SNARE-dependent membrane fusion by synthetic endosomes

(2009) Takeshi Ohya et al.   NATURE

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

(2009) Jesper B. Bramsen et al.   NUCLEIC ACIDS RESEARCH

In vivo silencing of alpha-synuclein using naked siRNA

(2008) Jada Lewis et al.   Molecular Neurodegeneration

Antibody-Mediated Targeting of siRNA via the Human Insulin Receptor Using Avidin−Biotin Technology

(2008) Chun-Fang Xia et al.   MOLECULAR PHARMACEUTICS

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

(2008) Akin Akinc et al.   NATURE BIOTECHNOLOGY

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

(2008) M. Frank-Kamenetsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thermally sensitive cationic polymer nanocapsules for specific cytosolic delivery and efficient gene silencing of siRNA: Swelling induced physical disruption of endosome by cold shock

(2007) Soo Hyeon Lee et al.   JOURNAL OF CONTROLLED RELEASE