Leveraging mRNA Sequences and Nanoparticles to Deliver SARS‐CoV‐2 Antigens In Vivo

Rational Design of Small Molecules to Enhance Genome Editing Efficiency by Selectively Targeting Distinct Functional States of CRISPR-Cas12a

(2020) Wenqing Li et al.   BIOCONJUGATE CHEMISTRY

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

(2020) Roujian Lu et al.   LANCET

The promise of mRNA vaccines: a biotech and industrial perspective

(2020) Nicholas A. C. Jackson et al.   npj Vaccines

The COVID-19 vaccine development landscape

(2020) Tung Thanh Le et al.   NATURE REVIEWS DRUG DISCOVERY

mRNA as a Transformative Technology for Vaccine Development to Control Infectious Diseases

(2019) Giulietta Maruggi et al.   MOLECULAR THERAPY

Coronavirus envelope protein: current knowledge

(2019) Dewald Schoeman et al.   Virology Journal

Human 5′ UTR design and variant effect prediction from a massively parallel translation assay

(2019) Paul J. Sample et al.   NATURE BIOTECHNOLOGY

miRDB: an online database for prediction of functional microRNA targets

(2019) Yuhao Chen et al.   NUCLEIC ACIDS RESEARCH

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

(2019) Akin Akinc et al.   Nature Nanotechnology

Design and assessment of engineered CRISPR–Cpf1 and its use for genome editing

(2018) Bin Li et al.   Nature Protocols

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

A brave new world of RNA-binding proteins

(2018) Matthias W. Hentze et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Maximizing the translational yield of mRNA therapeutics by minimizing 5'-UTRs

(2018) Zeljka Trepotec et al.   TISSUE ENGINEERING PART A

mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell–derived hematopoietic progenitors

(2017) Jungmin Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

IntaRNA 2.0: enhanced and customizable prediction of RNA–RNA interactions

(2017) Martin Mann et al.   NUCLEIC ACIDS RESEARCH

Structural Insights into the Mechanism of Scanning and Start Codon Recognition in Eukaryotic Translation Initiation

(2017) Alan G. Hinnebusch   TRENDS IN BIOCHEMICAL SCIENCES

Translation of Angiotensin-Converting Enzyme 2 upon Liver- and Lung-Targeted Delivery of Optimized Chemically Modified mRNA

(2017) Eva Schrom et al.   Molecular Therapy-Nucleic Acids

The coming of age of de novo protein design

(2016) Po-Ssu Huang et al.   NATURE

The STAR protein QKI-7 recruits PAPD4 to regulate post-transcriptional polyadenylation of target mRNAs

(2016) Ryota Yamagishi et al.   NUCLEIC ACIDS RESEARCH

Translational control by 5'-untranslated regions of eukaryotic mRNAs

(2016) A. G. Hinnebusch et al.   SCIENCE

Plasma Proteome Profiling to Assess Human Health and Disease

(2016) Philipp E. Geyer et al.   Cell Systems

Human cellular CYBA UTR sequences increase mRNA translation without affecting the half-life of recombinant RNA transcripts

(2016) Mehrije Ferizi et al.   Scientific Reports

Effect of vaccine administration modality on immunogenicity and efficacy

(2015) Lu Zhang et al.   Expert Review of Vaccines

An Orthogonal Array Optimization of Lipid-like Nanoparticles for mRNA Delivery in Vivo

(2015) Bin Li et al.   NANO LETTERS

A Deeper Look into Translation Initiation

(2014) Andrei A. Korostelev   CELL

Hepatitis C virus 3′UTR regulates viral translation through direct interactions with the host translation machinery

(2013) Yun Bai et al.   NUCLEIC ACIDS RESEARCH

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

(2012) Muthusamy Jayaraman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A novel mechanism of eukaryotic translation initiation that is neither m7G-cap-, nor IRES-dependent

(2012) Ilya M. Terenin et al.   NUCLEIC ACIDS RESEARCH

miRNA repression of translation in vitro takes place during 43S ribosomal scanning

(2012) Emiliano P. Ricci et al.   NUCLEIC ACIDS RESEARCH

Degradation of mRNAs that lack a stop codon: a decade of nonstop progress

(2012) A. Alejandra Klauer et al.   Wiley Interdisciplinary Reviews-RNA

Global quantification of mammalian gene expression control

(2011) Björn Schwanhäusser et al.   NATURE

Structural basis for the biological relevance of the invariant apical stem in IRES-mediated translation

(2011) Noemí Fernández et al.   NUCLEIC ACIDS RESEARCH

Quaking Regulates Hnrnpa1 Expression through Its 3′ UTR in Oligodendrocyte Precursor Cells

(2011) N. Ruth Zearfoss et al.   PLoS Genetics

Sindbis Virus Usurps the Cellular HuR Protein to Stabilize Its Transcripts and Promote Productive Infections in Mammalian and Mosquito Cells

(2010) Kevin J. Sokoloski et al.   Cell Host & Microbe

Role of 5′- and 3′-untranslated regions of mRNAs in human diseases

(2009) Sangeeta Chatterjee et al.   BIOLOGY OF THE CELL

RNA Folding: Conformational Statistics, Folding Kinetics, and Ion Electrostatics

(2008) Shi-Jie Chen   Annual Review of Biophysics

Stability of Eukaryotic Translation Initiation Factor 4E mRNA Is Regulated by HuR, and This Activity Is Dysregulated in Cancer

(2008) I. Topisirovic et al.   MOLECULAR AND CELLULAR BIOLOGY

Comprehensive detection of human terminal oligo-pyrimidine (TOP) genes and analysis of their characteristics

(2008) Riu Yamashita et al.   NUCLEIC ACIDS RESEARCH