Synthetic materials at the forefront of gene delivery

Synthetic Genomics: From DNA Synthesis to Genome Design

(2018) Lianrong Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Different-Length Hydrazone Activated Polymers for Plasmid DNA Condensation and Cellular Transfection

(2018) Juan M. Priegue et al.   BIOMACROMOLECULES

The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer

(2018) Elissa D. Pastuzyn et al.   CELL

DNA nanoclew templated spherical nucleic acids for siRNA delivery

(2018) Weimin Ruan et al.   CHEMICAL COMMUNICATIONS

Polydiacetylenic nanofibers as new siRNA vehicles for in vitro and in vivo delivery

(2018) P. Neuberg et al.   Nanoscale

Reversal of siRNA-mediated gene silencing in vivo

(2018) Ivan Zlatev et al.   NATURE BIOTECHNOLOGY

Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis

(2018) David Adams et al.   NEW ENGLAND JOURNAL OF MEDICINE

Acute hepatotoxicity of 2′ fluoro-modified 5–10–5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins

(2018) Wen Shen et al.   NUCLEIC ACIDS RESEARCH

Molecular spherical nucleic acids

(2018) Hui Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene therapy comes of age

(2018) Cynthia E. Dunbar et al.   SCIENCE

Current Status of Messenger RNA Delivery Systems

(2018) Matthew G. Stanton   Nucleic Acid Therapeutics

Rolling circle transcription-based polymeric siRNA nanoparticles for tumor-targeted delivery

(2017) Jae Hyeop Lee et al.   JOURNAL OF CONTROLLED RELEASE

siRNA-cell-penetrating peptides complexes as a combinatorial therapy against chronic myeloid leukemia using BV173 cell line as model

(2017) João Miguel Freire et al.   JOURNAL OF CONTROLLED RELEASE

Self-aggregating 1.8 kDa polyethylenimines with dissolution switch at endosomal acidic pH are delivery carriers for plasmid DNA, mRNA, siRNA and exon-skipping oligonucleotides

(2017) Manuela Chiper et al.   JOURNAL OF CONTROLLED RELEASE

Cationic microbubbles and antibiotic-free miniplasmid for sustained ultrasound–mediated transgene expression in liver

(2017) Simona Manta et al.   JOURNAL OF CONTROLLED RELEASE

Bioreducible Zinc(II)-Coordinative Polyethylenimine with Low Molecular Weight for Robust Gene Delivery of Primary and Stem Cells

(2017) Shuai Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Polymer Structure and Conformation Alter the Antigenicity of Virus-like Particle–Polymer Conjugates

(2017) Parker W. Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Polyplex Micelles with Phenylboronate/Gluconamide Cross-Linking in the Core Exerting Promoted Gene Transfection through Spatiotemporal Responsivity to Intracellular pH and ATP Concentration

(2017) Naoto Yoshinaga et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Depth-Profiling the Nuclease Stability and the Gene Silencing Efficacy of Brush-Architectured Poly(ethylene glycol)–DNA Conjugates

(2017) Fei Jia et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65 -mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial

(2017) Stephen Russell et al.   LANCET

Enhanced Intracellular Delivery of siRNA by Controlling ATP-Responsivity of Phenylboronic Acid-Functionalized Polyion Complex Micelles

(2017) Mitsuru Naito et al.   MACROMOLECULAR BIOSCIENCE

Functional Delivery of Lipid-Conjugated siRNA by Extracellular Vesicles

(2017) Aisling J. O’Loughlin et al.   MOLECULAR THERAPY

Fatty Acid-Modified Gapmer Antisense Oligonucleotide and Serum Albumin Constructs for Pharmacokinetic Modulation

(2017) Michael Lykke Hvam et al.   MOLECULAR THERAPY

FDA-Approved Oligonucleotide Therapies in 2017

(2017) Cy A. Stein et al.   MOLECULAR THERAPY

Cationic switchable lipids: pH-triggered molecular switch for siRNA delivery

(2017) W. Viricel et al.   Nanoscale

Multi-step encapsulation of chemotherapy and gene silencing agents in functionalized mesoporous silica nanoparticles

(2017) Jianliang Shen et al.   Nanoscale

After Glybera's withdrawal, what's next for gene therapy?

(2017) Melanie Senior   NATURE BIOTECHNOLOGY

The chemical evolution of oligonucleotide therapies of clinical utility

(2017) Anastasia Khvorova et al.   NATURE BIOTECHNOLOGY

In situ programming of leukaemia-specific T cells using synthetic DNA nanocarriers

(2017) Tyrel T. Smith et al.   Nature Nanotechnology

Cytosolic delivery of siRNA by ultra-high affinity dsRNA binding proteins

(2017) Nicole J. Yang et al.   NUCLEIC ACIDS RESEARCH

Asialoglycoprotein receptor 1 mediates productive uptake of N-acetylgalactosamine-conjugated and unconjugated phosphorothioate antisense oligonucleotides into liver hepatocytes

(2017) Michael Tanowitz et al.   NUCLEIC ACIDS RESEARCH

Characterizing the effect of GalNAc and phosphorothioate backbone on binding of antisense oligonucleotides to the asialoglycoprotein receptor

(2017) Karsten Schmidt et al.   NUCLEIC ACIDS RESEARCH

Charge-altering releasable transporters (CARTs) for the delivery and release of mRNA in living animals

(2017) Colin J. McKinlay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipophilic siRNA targets albumin in situ and promotes bioavailability, tumor penetration, and carrier-free gene silencing

(2017) Samantha M. Sarett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of systemic multiexon skipping with peptide-conjugated morpholinos in the heart of a dog model of Duchenne muscular dystrophy

(2017) Yusuke Echigoya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual bioluminescence and near-infrared fluorescence monitoring to evaluate spherical nucleic acid nanoconjugate activity in vivo

(2017) Timothy L. Sita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A second chance

(2017) Jocelyn Kaiser   SCIENCE

Peptide/Cas9 nanostructures for ribonucleoprotein cell membrane transport and gene edition

(2017) Irene Lostalé-Seijo et al.   Chemical Science

Nuclear-targeted siRNA delivery for long-term gene silencing

(2017) Na Li et al.   Chemical Science

Arginine-Rich Peptide-Based mRNA Nanocomplexes Efficiently Instigate Cytotoxic T Cell Immunity Dependent on the Amphipathic Organization of the Peptide

(2017) Vimal K. Udhayakumar et al.   Advanced Healthcare Materials

Advances in the delivery of RNA therapeutics: from concept to clinical reality

(2017) James C. Kaczmarek et al.   Genome Medicine

Hydrazone-modulated peptides for efficient gene transfection

(2017) Iria Louzao et al.   Journal of Materials Chemistry B

Preclinical and Clinical Advances of GalNAc-Decorated Nucleic Acid Therapeutics

(2017) Yuanyu Huang   Molecular Therapy-Nucleic Acids

Bio-Orthogonal Mediated Nucleic Acid Transfection of Cells via Cell Surface Engineering

(2017) Paul J. O’Brien et al.   ACS Central Science

Tools for translation: non-viral materials for therapeutic mRNA delivery

(2017) Khalid A. Hajj et al.   Nature Reviews Materials

High-throughput nuclear delivery and rapid expression of DNA via mechanical and electrical cell-membrane disruption

(2017) Xiaoyun Ding et al.   Nature Biomedical Engineering

pH-Responsive Nanometric Polydiacetylenic Micelles Allow for Efficient Intracellular siRNA Delivery

(2016) Manon Ripoll et al.   ACS Applied Materials & Interfaces

Cellular Engineering with Membrane Fusogenic Liposomes to Produce Functionalized Extracellular Vesicles

(2016) Junsung Lee et al.   ACS Applied Materials & Interfaces

Artificial Virus Delivers CRISPR-Cas9 System for Genome Editing of Cells in Mice

(2016) Ling Li et al.   ACS Nano

Spatial Control of Gene Expression by Nanocarriers Using Heparin Masking and Ultrasound-Targeted Microbubble Destruction

(2016) Beata Chertok et al.   ACS Nano

Peptides for nucleic acid delivery

(2016) Taavi Lehto et al.   ADVANCED DRUG DELIVERY REVIEWS

An Intrinsically Disordered Peptide Facilitates Non-Endosomal Cell Entry

(2016) Scott H. Medina et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Virus-Inspired Polymer for Efficient In Vitro and In Vivo Gene Delivery

(2016) Yilong Cheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In Situ Functionalized Polymers for siRNA Delivery

(2016) Juan M. Priegue et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ultra-pH-Responsive and Tumor-Penetrating Nanoplatform for Targeted siRNA Delivery with Robust Anti-Cancer Efficacy

(2016) Xiaoding Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Polymer-Lipid Nanoparticles for Systemic Delivery of mRNA to the Lungs

(2016) James C. Kaczmarek et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Viral vectors for gene therapy and gene modification approaches

(2016) Otto-Wilhelm Merten et al.   BIOCHEMICAL ENGINEERING JOURNAL

Focused Library Approach to Discover Discrete Dipeptide Bolaamphiphiles for siRNA Delivery

(2016) Alexander C. Eldredge et al.   BIOMACROMOLECULES

RNA-targeted therapeutics in cancer clinical trials: Current status and future directions

(2016) Pedro Barata et al.   CANCER TREATMENT REVIEWS

Ultrasound-targeted hepatic delivery of factor IX in hemophiliac mice

(2016) C D Anderson et al.   GENE THERAPY

Targeted systemic delivery of siRNA to cervical cancer model using cyclic RGD-installed unimer polyion complex-assembled gold nanoparticles

(2016) Yu Yi et al.   JOURNAL OF CONTROLLED RELEASE

An albumin-mediated cholesterol design-based strategy for tuning siRNA pharmacokinetics and gene silencing

(2016) Konrad Bienk et al.   JOURNAL OF CONTROLLED RELEASE

Effective Antisense Gene Regulation via Noncationic, Polyethylene Glycol Brushes

(2016) Xueguang Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing

(2016) Marie-Cécile Didiot et al.   MOLECULAR THERAPY

Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo

(2016) Yizhou Dong et al.   NANO LETTERS

pH-Sensitive Nanomicelles for High-Efficiency siRNA Delivery in Vitro and in Vivo: An Insight into the Design of Polycations with Robust Cytosolic Release

(2016) Junhui Zhou et al.   NANO LETTERS

Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy

(2016) Matthias A. Oberli et al.   NANO LETTERS

Coiled coil interactions for the targeting of liposomes for nucleic acid delivery

(2016) Erik E. Oude Blenke et al.   Nanoscale

Supramolecular cyclodextrin nanocarriers for chemo- and gene therapy towards the effective treatment of drug resistant cancers

(2016) Xiaohong Chen et al.   Nanoscale

Highly efficient siRNA delivery from core–shell mesoporous silica nanoparticles with multifunctional polymer caps

(2016) Karin Möller et al.   Nanoscale

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

(2016) Lena M. Kranz et al.   NATURE

In vitro and ex vivo strategies for intracellular delivery

(2016) Martin P. Stewart et al.   NATURE

Local triple-combination therapy results in tumour regression and prevents recurrence in a colon cancer model

(2016) João Conde et al.   NATURE MATERIALS

Driving CAR T-cells forward

(2016) Hollie J. Jackson et al.   Nature Reviews Clinical Oncology

The delivery of therapeutic oligonucleotides

(2016) Rudolph L. Juliano   NUCLEIC ACIDS RESEARCH

Systemic peptide-mediated oligonucleotide therapy improves long-term survival in spinal muscular atrophy

(2016) Suzan M. Hammond et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, andToxoplasma gondiichallenges with a single dose

(2016) Jasdave S. Chahal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional polyesters enable selective siRNA delivery to lung cancer over matched normal cells

(2016) Yunfeng Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overcoming Gene-Delivery Hurdles: Physiological Considerations for Nonviral Vectors

(2016) Andrew B. Hill et al.   TRENDS IN BIOTECHNOLOGY

Drug Delivery via Cell Membrane Fusion Using Lipopeptide Modified Liposomes

(2016) Jian Yang et al.   ACS Central Science

Clinical development of gene therapy: results and lessons from recent successes

(2016) Sandeep RP Kumar et al.   Molecular Therapy-Methods & Clinical Development

Efficient delivery of DNA into bovine preimplantation embryos by multiwall carbon nanotubes

(2016) Michele Munk et al.   Scientific Reports

Systemic Delivery of Anti-miRNA for Suppression of Triple Negative Breast Cancer Utilizing RNA Nanotechnology

(2015) Dan Shu et al.   ACS Nano

Cuboplexes: Topologically Active siRNA Delivery

(2015) Hojun Kim et al.   ACS Nano

Peptide Nanofiber Complexes with siRNA for Deep Brain Gene Silencing by Stereotactic Neurosurgery

(2015) Mariarosa Mazza et al.   ACS Nano

A Cell-Penetrating Foldamer with a Bioreducible Linkage for Intracellular Delivery of DNA

(2015) Céline Douat et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dendrimeric siRNA for Efficient Gene Silencing

(2015) Cheol Am Hong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Incorporation of a Non-Natural Arginine Analogue into a Cyclic Peptide Leads to Formation of Positively Charged Nanofibers Capable of Gene Transfection

(2015) Mao Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

High DNA-Binding Affinity and Gene-Transfection Efficacy of Bioreducible Cationic Nanomicelles with a Fluorinated Core

(2015) Long-Hai Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Self-Assembled Fluorodendrimers Combine the Features of Lipid and Polymeric Vectors in Gene Delivery

(2015) Hui Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Tailor-Made Specific Anion-Binding Motif in the Side Chain Transforms a Tetrapeptide into an Efficient Vector for Gene Delivery

(2015) Mao Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Unique Surface Modification of Silica Nanoparticles with Polyethylenimine (PEI) for siRNA Delivery Using Cerium Cation Coordination Chemistry

(2015) Yekaterina Kapilov-Buchman et al.   BIOCONJUGATE CHEMISTRY

A biodegradable adamantane polymer with ketal linkages in its backbone for gene therapy

(2015) Santanu Maity et al.   CHEMICAL COMMUNICATIONS

Carbon Nanomaterials for Biological Imaging and Nanomedicinal Therapy

(2015) Guosong Hong et al.   CHEMICAL REVIEWS

Clinical and Preclinical Pharmacokinetics and Pharmacodynamics of Mipomersen (Kynamro®): A Second-Generation Antisense Oligonucleotide Inhibitor of Apolipoprotein B

(2015) Richard S. Geary et al.   CLINICAL PHARMACOKINETICS

Delivery of siRNA via cationic Sterosomes to enhance osteogenic differentiation of mesenchymal stem cells

(2015) Zhong-Kai Cui et al.   JOURNAL OF CONTROLLED RELEASE

Protease-triggered siRNA delivery vehicles

(2015) David B. Rozema et al.   JOURNAL OF CONTROLLED RELEASE

Ribozyme–Spherical Nucleic Acids

(2015) Jessica L. Rouge et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rapid Synthesis of a Lipocationic Polyester Library via Ring-Opening Polymerization of Functional Valerolactones for Efficacious siRNA Delivery

(2015) Jing Hao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs

(2015) Kevin J. Kauffman et al.   NANO LETTERS

Gene therapy returns to centre stage

(2015) Luigi Naldini   NATURE

In vivo delivery of transcription factors with multifunctional oligonucleotides

(2015) Kunwoo Lee et al.   NATURE MATERIALS

Biodegradable silicon nanoneedles delivering nucleic acids intracellularly induce localized in vivo neovascularization

(2015) C. Chiappini et al.   NATURE MATERIALS

Functional correction in mouse models of muscular dystrophy using exon-skipping tricyclo-DNA oligomers

(2015) Aurélie Goyenvalle et al.   NATURE MEDICINE

Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference–based bone anabolic strategy

(2015) Chao Liang et al.   NATURE MEDICINE

Clinical experiences with systemically administered siRNA-based therapeutics in cancer

(2015) Jonathan E. Zuckerman et al.   NATURE REVIEWS DRUG DISCOVERY

siRNA-based spherical nucleic acids reverse impaired wound healing in diabetic mice by ganglioside GM3 synthase knockdown

(2015) Pratik S. Randeria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tunable assembly of amyloid-forming peptides into nanosheets as a retrovirus carrier

(2015) Bin Dai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microneedles: an innovative platform for gene delivery

(2015) Joanne McCaffrey et al.   Drug Delivery and Translational Research

The relationship between the diameter of chemically-functionalized multi-walled carbon nanotubes and their organ biodistribution profiles in vivo

(2014) Julie T-W. Wang et al.   BIOMATERIALS

Development and characterization of self-assembling nanoparticles using a bio-inspired amphipathic peptide for gene delivery

(2014) Helen O. McCarthy et al.   JOURNAL OF CONTROLLED RELEASE

Nanoscale Metal–Organic Frameworks for the Co-Delivery of Cisplatin and Pooled siRNAs to Enhance Therapeutic Efficacy in Drug-Resistant Ovarian Cancer Cells

(2014) Chunbai He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Liposomal Spherical Nucleic Acids

(2014) Resham J. Banga et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient delivery of RNAi prodrugs containing reversible charge-neutralizing phosphotriester backbone modifications

(2014) Bryan R Meade et al.   NATURE BIOTECHNOLOGY

mRNA-based therapeutics — developing a new class of drugs

(2014) Ugur Sahin et al.   NATURE REVIEWS DRUG DISCOVERY

Non-viral vectors for gene-based therapy

(2014) Hao Yin et al.   NATURE REVIEWS GENETICS

Systematic evaluation of antibody-mediated siRNA delivery using an industrial platform of THIOMAB–siRNA conjugates

(2014) Trinna L. Cuellar et al.   NUCLEIC ACIDS RESEARCH

Sequence motifs associated with hepatotoxicity of locked nucleic acid—modified antisense oligonucleotides

(2014) Andrew D. Burdick et al.   NUCLEIC ACIDS RESEARCH

Total Synthesis of a Functional Designer Eukaryotic Chromosome

(2014) N. Annaluru et al.   SCIENCE

Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity

(2014) Kathryn A. Whitehead et al.   Nature Communications

Ion Channel Models Based on Self-Assembling Cyclic Peptide Nanotubes

(2013) Javier Montenegro et al.   ACCOUNTS OF CHEMICAL RESEARCH

High Capacity Nanoporous Silicon Carrier for Systemic Delivery of Gene Silencing Therapeutics

(2013) Jianliang Shen et al.   ACS Nano

Dynamic Amphiphile Libraries To Screen for the “Fragrant” Delivery of siRNA into HeLa Cells and Human Primary Fibroblasts

(2013) Charlotte Gehin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals

(2013) Yiguang Wang et al.   NATURE MATERIALS

Peptide nanofibrils boost retroviral gene transfer and provide a rapid means for concentrating viruses

(2013) Maral Yolamanova et al.   Nature Nanotechnology

Regulatory evaluation of Glybera in Europe — two committees, one mission

(2013) Daniela Melchiorri et al.   NATURE REVIEWS DRUG DISCOVERY

Ammonium and Guanidinium Dendron-Carbon Nanotubes by Amidation and Click Chemistry and their Use for siRNA Delivery

(2013) Alessia Battigelli et al.   Small

An influenza virus-inspired polymer system for the timed release of siRNA

(2013) Nghia P Truong et al.   Nature Communications

Liposomal drug delivery systems: From concept to clinical applications

(2012) Theresa M. Allen et al.   ADVANCED DRUG DELIVERY REVIEWS

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

(2012) Muthusamy Jayaraman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Phenylboronate-Functionalized Polyion Complex Micelle for ATP-Triggered Release of siRNA

(2012) Mitsuru Naito et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Virus-mediated gene delivery for human gene therapy

(2012) Mauro Giacca et al.   JOURNAL OF CONTROLLED RELEASE

Spherical Nucleic Acids

(2012) Joshua I. Cutler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antisense 2′-Deoxy, 2′-Fluoroarabino Nucleic Acid (2′F-ANA) Oligonucleotides: In Vitro Gymnotic Silencers of Gene Expression Whose Potency Is Enhanced by Fatty Acids

(2012) Naira Souleimanian et al.   Molecular Therapy-Nucleic Acids

Cationic Polydiacetylene Micelles for Gene Delivery

(2011) Emmanuelle Morin et al.   BIOCONJUGATE CHEMISTRY

Slow Release and Delivery of Antisense Oligonucleotide Drug by Self-Assembled Peptide Amphiphile Nanofibers

(2011) Selma Bulut et al.   BIOMACROMOLECULES

Gene delivery with polycationic fullerene hexakis-adducts

(2011) David Sigwalt et al.   CHEMICAL COMMUNICATIONS

Design of multifunctional non-viral gene vectors to overcome physiological barriers: Dilemmas and strategies

(2011) Tao Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Gene therapy finds its niche

(2011) Cormac Sheridan   NATURE BIOTECHNOLOGY

Efficient gene transfer using the human JC virus-like particle that inhibits human colon adenocarcinoma growth in a nude mouse model

(2010) L-S Chen et al.   GENE THERAPY

Nanodiamond Vectors Functionalized with Polyethylenimine for siRNA Delivery

(2010) Mark Chen et al.   Journal of Physical Chemistry Letters

Highly Efficient Gene Silencing Activity of siRNA Embedded in a Nanostructured Gyroid Cubic Lipid Matrix

(2010) Cecília Leal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In vivo gene delivery by cationic tetraamino fullerene

(2010) R. Maeda-Mamiya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome

(2010) D. G. Gibson et al.   SCIENCE

Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction

(2010) J. B. Siegel et al.   SCIENCE

Polymer-Functionalized Nanodiamond Platforms as Vehicles for Gene Delivery

(2009) Xue-Qing Zhang et al.   ACS Nano

Viral Capsid DNA Aptamer Conjugates as Multivalent Cell-Targeting Vehicles

(2009) Gary J. Tong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The First Targeted Delivery of siRNA in Humans via a Self-Assembling, Cyclodextrin Polymer-Based Nanoparticle: From Concept to Clinic

(2009) Mark E. Davis   MOLECULAR PHARMACEUTICS

Efficient siRNA delivery into primary cells by a peptide transduction domain–dsRNA binding domain fusion protein

(2009) Akiko Eguchi et al.   NATURE BIOTECHNOLOGY

Are nucleosome positions in vivo primarily determined by histone–DNA sequence preferences?

(2009) Arnold Stein et al.   NUCLEIC ACIDS RESEARCH

Are In Vitro Tests Suitable for Regulatory Use?

(2009) Thomas Hartung et al.   TOXICOLOGICAL SCIENCES