Nanoescapology: progress toward understanding the endosomal escape of polymeric nanoparticles

Progress and perspective of inorganic nanoparticle-based siRNA delivery systems

(2016) Ying Jiang et al.   Expert Opinion on Drug Delivery

Probing Endosomal Escape Using pHlexi Nanoparticles

(2016) Nachnicha Kongkatigumjorn et al.   MACROMOLECULAR BIOSCIENCE

Quantifying Nanoparticle Internalization Using a High Throughput Internalization Assay

(2016) Sarah K. Mann et al.   PHARMACEUTICAL RESEARCH

Fusion of Enveloped Viruses in Endosomes

(2016) Judith M. White et al.   TRAFFIC

HD Flow Cytometry: An Improved Way to Quantify Cellular Interactions with Nanoparticles

(2016) Laura I. Selby et al.   Advanced Healthcare Materials

Structure-Invertible Nanoparticles for Triggered Co-Delivery of Nucleic Acids and Hydrophobic Drugs for Combination Cancer Therapy

(2015) Kai Wang et al.   ADVANCED FUNCTIONAL MATERIALS

Triblock Copolymer Nanovesicles for pH-Responsive Targeted Delivery and Controlled Release of siRNA to Cancer Cells

(2015) Elena Gallon et al.   BIOMACROMOLECULES

Quaternary Complexes Modified from pDNA and Poly-l-Lysine Complexes to Enhance pH-Buffering Effect and Suppress Cytotoxicity

(2015) Yukinobu Kodama et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Discovery and Characterization of a Peptide That Enhances Endosomal Escape of Delivered Proteins in Vitro and in Vivo

(2015) Margie Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

siRNA Inhibition of Endocytic Pathways to Characterize the Cellular Uptake Mechanisms of Folate-Functionalized Glycol Chitosan Nanogels

(2015) Paula Pereira et al.   MOLECULAR PHARMACEUTICS

Effect of the amino acid composition of cyclic peptides on their self-assembly in lipid bilayers

(2015) Maarten Danial et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Controlled Endolysosomal Release of Agents by pH-responsive Polymer Blend Particles

(2015) Xi Zhan et al.   PHARMACEUTICAL RESEARCH

Self-assembling dual component nanoparticles with endosomal escape capability

(2015) Adelene S. M. Wong et al.   Soft Matter

Nanoparticle–Cell Interactions: Molecular Structure of the Protein Corona and Cellular Outcomes

(2014) Candace C. Fleischer et al.   ACCOUNTS OF CHEMICAL RESEARCH

Nanoparticles for Imaging, Sensing, and Therapeutic Intervention

(2014) Lara K. Bogart et al.   ACS Nano

Endosomal Escape: A Bottleneck in Intracellular Delivery

(2014) Harshad K. Shete et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Multifunctional Cationic Lipid-Based Nanoparticles Facilitate Endosomal Escape and Reduction-Triggered Cytosolic siRNA Release

(2014) Maneesh Gujrati et al.   MOLECULAR PHARMACEUTICS

Intracellular delivery of nanomaterials: How to catch endosomal escape in the act

(2014) Thomas F. Martens et al.   Nano Today

Etchable plasmonic nanoparticle probes to image and quantify cellular internalization

(2014) Gary B. Braun et al.   NATURE MATERIALS

Protein delivery into live cells by incubation with an endosomolytic agent

(2014) Alfredo Erazo-Oliveras et al.   NATURE METHODS

In vitro interaction of colloidal nanoparticles with mammalian cells: What have we learned thus far?

(2014) Moritz Nazarenus et al.   Beilstein Journal of Nanotechnology

pH-Responsive Nanoparticle Vaccines for Dual-Delivery of Antigens and Immunostimulatory Oligonucleotides

(2013) John T. Wilson et al.   ACS Nano

Direct Delivery of Functional Proteins and Enzymes to the Cytosol Using Nanoparticle-Stabilized Nanocapsules

(2013) Rui Tang et al.   ACS Nano

Peptide-Tunable Drug Cytotoxicity via One-Step Assembled Polymer Nanoparticles

(2013) Kang Liang et al.   ADVANCED MATERIALS

A Programmable Sensor to Probe the Internalization of Proteins and Nanoparticles in Live Cells

(2013) Haiyin Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synergistic Antitumor Activity from Two-Stage Delivery of Targeted Toxins and Endosome-Disrupting Nanoparticles

(2013) Xingfang Su et al.   BIOMACROMOLECULES

Intracellular trafficking and cellular uptake mechanism of mPEG-PLGA-PLL and mPEG-PLGA-PLL-Gal nanoparticles for targeted delivery to hepatomas

(2013) Peifeng Liu et al.   BIOMATERIALS

Use of LysoTracker dyes: A flow cytometric study of autophagy

(2013) Shaheen Chikte et al.   CYTOMETRY PART A

Stimuli-responsive nanocarriers for drug delivery

(2013) Simona Mura et al.   NATURE MATERIALS

Delivery materials for siRNA therapeutics

(2013) Rosemary Kanasty et al.   NATURE MATERIALS

Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface

(2013) Anna Salvati et al.   Nature Nanotechnology

Nanoparticle vaccines

(2013) Liang Zhao et al.   VACCINE

Targeting Dendritic Cells: The Role of Specific Receptors in the Internalization of Polymer Capsules

(2013) Justine D. Mintern et al.   Advanced Healthcare Materials

Ex Vivo Red Blood Cell Hemolysis Assay for the Evaluation of pH-responsive Endosomolytic Agents for Cytosolic Delivery of Biomacromolecular Drugs

(2013) Brian C. Evans et al.   Jove-Journal of Visualized Experiments

Polymeric Multilayer Capsule-Mediated Vaccination Induces Protective Immunity Against Cancer and Viral Infection

(2012) Bruno G. De Geest et al.   ACS Nano

Smart Multilayered Assembly for Biocompatible siRNA Delivery Featuring Dissolvable Silica, Endosome-Disrupting Polycation, and Detachable PEG

(2012) Tomoya Suma et al.   ACS Nano

Quantum dots as a platform for nanoparticle drug delivery vehicle design

(2012) Christine E. Probst et al.   ADVANCED DRUG DELIVERY REVIEWS

The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems

(2012) Alexandre Albanese et al.   Annual Review of Biomedical Engineering

Poly(ethylene oxide) Grafted with Short Polyethylenimine Gives DNA Polyplexes with Superior Colloidal Stability, Low Cytotoxicity, and Potent In Vitro Gene Transfection under Serum Conditions

(2012) Meng Zheng et al.   BIOMACROMOLECULES

Internalization of C60 fullerenes into cancer cells with accumulation in the nucleus via the nuclear pore complex

(2012) Mustafa Raoof et al.   BIOMATERIALS

Self-assembly nanomicelles based on cationic mPEG-PLA-b-Polyarginine(R15) triblock copolymer for siRNA delivery

(2012) Zhi-Xia Zhao et al.   BIOMATERIALS

pH-sensitive poly(histidine)-PEG/DSPE-PEG co-polymer micelles for cytosolic drug delivery

(2012) Hong Wu et al.   BIOMATERIALS

Endocytosis at the nanoscale

(2012) Irene Canton et al.   CHEMICAL SOCIETY REVIEWS

Arginine Topology Controls Escape of Minimally Cationic Proteins from Early Endosomes to the Cytoplasm

(2012) Jacob S. Appelbaum et al.   CHEMISTRY & BIOLOGY

The Possible “Proton Sponge ” Effect of Polyethylenimine (PEI) Does Not Include Change in Lysosomal pH

(2012) Rikke V Benjaminsen et al.   MOLECULAR THERAPY

Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

(2012) Hyukjin Lee et al.   Nature Nanotechnology

Insights into the endosomal escape mechanism via investigation of dendrimer–membrane interactions

(2012) Wen-de Tian et al.   Soft Matter

Overcoming Endosomal Barrier by Amphotericin B-Loaded Dual pH-Responsive PDMA-b-PDPA Micelleplexes for siRNA Delivery

(2011) Haijun Yu et al.   ACS Nano

Switching the Targeting Pathways of a Therapeutic Antibody by Nanodesign

(2011) Sanjib Bhattacharyya et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tunable, Ultrasensitive pH-Responsive Nanoparticles Targeting Specific Endocytic Organelles in Living Cells

(2011) Kejin Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A HA2-Fusion tag limits the endosomal release of its protein cargo despite causing endosomal lysis

(2011) Ya-Jung Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Intracellular Trafficking of Polyamidoamine–Poly(ethylene glycol) Block Copolymers in DNA Delivery

(2011) Daniel K. Bonner et al.   BIOCONJUGATE CHEMISTRY

Endosomal escape and the knockdown efficiency of liposomal-siRNA by the fusogenic peptide shGALA

(2011) Yu Sakurai et al.   BIOMATERIALS

In Vitroandin VivomRNA Delivery Using Lipid-Enveloped pH-Responsive Polymer Nanoparticles

(2011) Xingfang Su et al.   MOLECULAR PHARMACEUTICS

Endocytosis and intracellular transport of nanoparticles: Present knowledge and need for future studies

(2011) Tore-Geir Iversen et al.   Nano Today

Cellular Uptake, Intracellular Trafficking, and Cytotoxicity of Nanomaterials

(2011) Feng Zhao et al.   Small

Effects of Cell Culture Media on the Dynamic Formation of Protein−Nanoparticle Complexes and Influence on the Cellular Response

(2010) Gabriele Maiorano et al.   ACS Nano

DNA and carbon nanotubes as medicine

(2010) William Cheung et al.   ADVANCED DRUG DELIVERY REVIEWS

pH-Responsive Polymeric Micelle Carriers for siRNA Drugs

(2010) A. J. Convertine et al.   BIOMACROMOLECULES

Endosome-disruptive peptides for improving cytosolic delivery of bioactive macromolecules

(2010) Ikuhiko Nakase et al.   BIOPOLYMERS

Challenges facing colloidal delivery systems: From synthesis to the clinic

(2010) Angus P.R. Johnston et al.   CURRENT OPINION IN COLLOID & INTERFACE SCIENCE

Revisiting caveolin trafficking: the end of the caveosome: Figure 1.

(2010) Robert G. Parton et al.   JOURNAL OF CELL BIOLOGY

Caveolin-1 is ubiquitinated and targeted to intralumenal vesicles in endolysosomes for degradation

(2010) Arnold Hayer et al.   JOURNAL OF CELL BIOLOGY

Endocytosis of nanomedicines

(2010) Gaurav Sahay et al.   JOURNAL OF CONTROLLED RELEASE

Endosomal escape pathways for delivery of biologicals

(2010) Amir K. Varkouhi et al.   JOURNAL OF CONTROLLED RELEASE

Efficient Delivery of Payload into Tumor Cells in a Controlled Manner by TAT and Thiolytic Cleavable PEG Co-Modified Liposomes

(2010) Rui Kuai et al.   MOLECULAR PHARMACEUTICS

pH-Responsive Nanoparticles for Drug Delivery

(2010) Weiwei Gao et al.   MOLECULAR PHARMACEUTICS

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Nanomaterial cytotoxicity is composition, size, and cell type dependent

(2010) Syed K Sohaebuddin et al.   Particle and Fibre Toxicology

Polycation cytotoxicity: a delicate matter for nucleic acid therapy—focus on polyethylenimine

(2010) Ladan Parhamifar et al.   Soft Matter

Mechanisms of Endocytosis

(2009) Gary J. Doherty et al.   Annual Review of Biochemistry

Internally Cationic Polyamidoamine PAMAM-OH Dendrimers for siRNA Delivery: Effect of the Degree of Quaternization and Cancer Targeting

(2009) Mahesh L. Patil et al.   BIOMACROMOLECULES

Cationic Poly(amidoamine) Dendrimer Induces Lysosomal Apoptotic Pathway at Therapeutically Relevant Concentrations

(2009) Thommey P. Thomas et al.   BIOMACROMOLECULES

Cytosolic Delivery Mediated via Electrostatic Surface Binding of Protein, Virus, or siRNA Cargos to pH-Responsive Core−Shell Gel Particles

(2009) Yuhua Hu et al.   BIOMACROMOLECULES

Biohybrid Polymer Capsules

(2009) Stijn F. M. van Dongen et al.   CHEMICAL REVIEWS

Nanoparticle-based targeted drug delivery

(2009) Rajesh Singh et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Fluorescent proteins for live cell imaging: Opportunities, limitations, and challenges

(2009) Jörg Wiedenmann et al.   IUBMB LIFE

Lysosomes as “Suicide Bags” in Cell Death: Myth or Reality?

(2009) Boris Turk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficient polyethylenimine-mediated gene delivery proceeds via a caveolar pathway in HeLa cells

(2009) Nathan P. Gabrielson et al.   JOURNAL OF CONTROLLED RELEASE

Missing pieces in understanding the intracellular trafficking of polycation/DNA complexes

(2009) You-Yeon Won et al.   JOURNAL OF CONTROLLED RELEASE

A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo

(2009) Hiroto Hatakeyama et al.   JOURNAL OF CONTROLLED RELEASE

The efficiency of nuclear plasmid DNA delivery is a critical determinant of transgene expression at the single cell level

(2009) Dominic J. Glover et al.   JOURNAL OF GENE MEDICINE

Functions of Tat: the versatile protein of human immunodeficiency virus type 1

(2009) B. Romani et al.   JOURNAL OF GENERAL VIROLOGY

Cationic Nanoparticles Induce Nanoscale Disruption in Living Cell Plasma Membranes

(2009) Jiumei Chen et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Understanding biophysicochemical interactions at the nano–bio interface

(2009) Andre E. Nel et al.   NATURE MATERIALS

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sensors and regulators of intracellular pH

(2009) Joseph R. Casey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Controlled Degradation of DNA Capsules with Engineered Restriction-Enzyme Cut Sites

(2009) Angus P. R. Johnston et al.   Small

Controlling Cellular Uptake by Surface Chemistry, Size, and Surface Topology at the Nanoscale

(2009) Marzia Massignani et al.   Small

Mechanisms of Quantum Dot Nanoparticle Cellular Uptake

(2009) Leshuai W. Zhang et al.   TOXICOLOGICAL SCIENCES

Targeting of Porous Hybrid Silica Nanoparticles to Cancer Cells

(2008) Jessica M. Rosenholm et al.   ACS Nano

Guanidinium group: A versatile moiety inducing transport and multicompartmentalization in complementary membranes

(2008) Alexandros Pantos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Proteomics of the lysosome

(2008) Torben Lübke et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The conjugation of diphtheria toxin T domain to poly(ethylenimine) based vectors for enhanced endosomal escape during gene transfection

(2008) Shinji Kakimoto et al.   BIOMATERIALS

Structure of the Alamethicin Pore Reconstructed by X-Ray Diffraction Analysis

(2008) Shuo Qian et al.   BIOPHYSICAL JOURNAL

Non-cytotoxic polymer vesicles for rapid and efficient intracellular delivery

(2008) Hannah Lomas et al.   FARADAY DISCUSSIONS

Octaarginine- and Octalysine-modified Nanoparticles Have Different Modes of Endosomal Escape

(2008) Ayman El-Sayed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transferrin Receptor-Targeted Lipid Nanoparticles for Delivery of an Antisense Oligodeoxyribonucleotide against Bcl-2

(2008) Xiaojuan Yang et al.   MOLECULAR PHARMACEUTICS

Wide Varieties of Cationic Nanoparticles Induce Defects in Supported Lipid Bilayers

(2008) Pascale R. Leroueil et al.   NANO LETTERS

Phagosome maturation: going through the acid test

(2008) Jason M. Kinchen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts

(2008) M. Lundqvist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein therapeutics: a summary and pharmacological classification

(2007) Benjamin Leader et al.   NATURE REVIEWS DRUG DISCOVERY