MicroRNA therapeutics

Thelet-7microRNA reduces tumor growth in mouse models of lung cancer

(2010) Aurora Esquela-Kerscher et al.   CELL CYCLE

MicroRNAs and cancer: An overview

(2010) Pedro P. Medina et al.   CELL CYCLE

Mammalian microRNAs: experimental evaluation of novel and previously annotated genes

(2010) H. R. Chiang et al.   GENES & DEVELOPMENT

Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver

(2010) Dirk Grimm et al.   JOURNAL OF CLINICAL INVESTIGATION

Cellular MicroRNAs 200b and 429 Regulate the Epstein-Barr Virus Switch between Latency and Lytic Replication

(2010) A. L. Ellis-Connell et al.   JOURNAL OF VIROLOGY

OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma

(2010) Pedro P. Medina et al.   NATURE

Mammalian microRNAs predominantly act to decrease target mRNA levels

(2010) Huili Guo et al.   NATURE

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

The human cytomegalovirus microRNA miR-UL112 acts synergistically with a cellular microRNA to escape immune elimination

(2010) Daphna Nachmani et al.   NATURE IMMUNOLOGY

MicroRNA-132–mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis

(2010) Sudarshan Anand et al.   NATURE MEDICINE

A Direct Comparison of Anti-microRNA Oligonucleotide Potency

(2010) Kim A. Lennox et al.   PHARMACEUTICAL RESEARCH

Double-Detargeted Oncolytic Adenovirus Shows Replication Arrest in Liver Cells and Retains Neuroendocrine Cell Killing Ability

(2010) Justyna Leja et al.   PLoS One

Lipid-like materials for low-dose, in vivo gene silencing

(2010) K. T. Love et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Micromanipulating cancer: microRNA-based therapeutics?

(2010) Fabio Petrocca et al.   RNA Biology

Target RNA-Directed Trimming and Tailing of Small Silencing RNAs

(2010) S. L. Ameres et al.   SCIENCE

A Collection of Target Mimics for Comprehensive Analysis of MicroRNA Function in Arabidopsis thaliana

(2010) Marco Todesco et al.   PLoS Genetics

Five Questions about Viruses and MicroRNAs

(2010) Bryan R. Cullen   PLoS Pathogens

In vivo delivery of a microRNA-regulated transgene induces antigen-specific regulatory T cells and promotes immunologic tolerance

(2009) A. Annoni et al.   BLOOD

Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model

(2009) Janaiah Kota et al.   CELL

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Regulation of KSHV Lytic Switch Protein Expression by a Virus-Encoded MicroRNA: An Evolutionary Adaptation that Fine-Tunes Lytic Reactivation

(2009) Priya Bellare et al.   Cell Host & Microbe

The role of RNAi and microRNAs in animal virus replication and antiviral immunity

(2009) J. L. Umbach et al.   GENES & DEVELOPMENT

Low-level shRNA Cytotoxicity Can Contribute to MYC-induced Hepatocellular Carcinoma in Adult Mice

(2009) Shelly Beer et al.   MOLECULAR THERAPY

Viral and cellular messenger RNA targets of viral microRNAs

(2009) Bryan R. Cullen   NATURE

Mutations in the seed region of human miR-96 are responsible for nonsyndromic progressive hearing loss

(2009) Ángeles Mencía et al.   NATURE GENETICS

An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice

(2009) Morag A Lewis et al.   NATURE GENETICS

Transgenic microRNA inhibition with spatiotemporal specificity in intact organisms

(2009) Carlos M Loya et al.   NATURE METHODS

Vectors expressing efficient RNA decoys achieve the long-term suppression of specific microRNA activity in mammalian cells

(2009) Takeshi Haraguchi et al.   NUCLEIC ACIDS RESEARCH

Regression of murine lung tumors by the let-7 microRNA

(2009) P Trang et al.   ONCOGENE

Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection

(2009) R. E. Lanford et al.   SCIENCE

Position-Dependent Function for a Tandem MicroRNA miR-122-Binding Site Located in the Hepatitis C Virus RNA Genome

(2008) Catherine L. Jopling et al.   Cell Host & Microbe

Prevention of interferon-stimulated gene expression using microRNA-designed hairpins

(2008) M Bauer et al.   GENE THERAPY

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

Engineered lentiviral vector targeting astrocytesIn vivo

(2008) Angélique Colin et al.   GLIA

MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators

(2008) G. Gabriely et al.   MOLECULAR AND CELLULAR BIOLOGY

Artificial MicroRNAs as siRNA Shuttles: Improved Safety as Compared to shRNAs In vitro and In vivo

(2008) Ryan L Boudreau et al.   MOLECULAR THERAPY

The impact of microRNAs on protein output

(2008) Daehyun Baek et al.   NATURE

Widespread changes in protein synthesis induced by microRNAs

(2008) Matthias Selbach et al.   NATURE

LNA-mediated microRNA silencing in non-human primates

(2008) Joacim Elmén et al.   NATURE

The miR-15a–miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities

(2008) Désirée Bonci et al.   NATURE MEDICINE

Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: Implications for the therapeutic development of RNAi

(2008) J. L. McBride et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A system for Cre-regulated RNA interference in vivo

(2008) P. Stern et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of non-small cell lung tumor development by the let-7 microRNA family

(2008) M. S. Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of immediate-early viral gene expression by herpesvirus-coded microRNAs: Implications for latency

(2008) E. Murphy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coexpression of Argonaute-2 enhances RNA interference toward perfect match binding sites

(2008) S. Diederichs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Minimizing variables among hairpin-based RNAi vectors reveals the potency of shRNAs

(2008) R. L. Boudreau et al.   RNA