Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 18, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/ijms18081683
Keywords
nucleic acid aptamer; nuclease degradation; rapid excretion; binding affinity; chemical modification
Funding
- Hong Kong General Research Fund [HKBU12102914]
- Faculty Research Grant of Hong Kong Baptist University [FRG2/12-13/027]
- Shanghai Institute of Organic Chemistry [SKLBNPC17344]
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Nucleic acid aptamers have minimal immunogenicity, high chemical synthesis production, low cost and high chemical stability when compared with antibodies. However, the susceptibility to nuclease degradation, rapid excretion through renal filtration and insufficient binding affinity hindered their development as drug candidates for therapeutic applications. In this review, we will discuss methods to conquer these challenges and highlight recent developments of chemical modifications and technological advances that may enable early aptamers to be translated into clinical therapeutics.
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