RNA in extracellular vesicles

Evidence and potential in vivo functions for biofluid miRNAs: From expression profiling to functional testing

(2016) Hina Iftikhar et al.   BIOESSAYS

Extracellular Vesicles and MicroRNAs: Their Role in Tumorigenicity and Therapy for Brain Tumors

(2016) Agnieszka Bronisz et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Emergence of exosomal miRNAs as a diagnostic biomarker for Alzheimer's disease

(2016) Vo Van Giau et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Mesenchymal Stem Cells Deliver Exogenous MicroRNA-let7c via Exosomes to Attenuate Renal Fibrosis

(2016) Bo Wang et al.   MOLECULAR THERAPY

Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2

(2016) William W. Du et al.   NUCLEIC ACIDS RESEARCH

Circular RNAs Co-Precipitate with Extracellular Vesicles: A Possible Mechanism for circRNA Clearance

(2016) Erika Lasda et al.   PLoS One

Investigation of Content, Stoichiometry and Transfer of miRNA from Human Neural Stem Cell Line Derived Exosomes

(2016) Lara Stevanato et al.   PLoS One

Cells release subpopulations of exosomes with distinct molecular and biological properties

(2016) Eduard Willms et al.   Scientific Reports

Long non-coding RNAs harboring miRNA seed regions are enriched in prostate cancer exosomes

(2016) Alireza Ahadi et al.   Scientific Reports

Circular RNAs in monkey muscle: age-dependent changes

(2015) Kotb Abdelmohsen et al.   Aging-US

Low pH increases the yield of exosome isolation

(2015) Jae-Jun Ban et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A novel serum microRNA panel to discriminate benign from malignant ovarian disease

(2015) Ream Langhe et al.   CANCER LETTERS

The RNA Binding Protein Quaking Regulates Formation of circRNAs

(2015) Simon J. Conn et al.   CELL

ADAR1 is required for differentiation and neural induction by regulating microRNA processing in a catalytically independent manner

(2015) Tian Chen et al.   CELL RESEARCH

Interactions between cancer cells and normal cells via miRNAs in extracellular vesicles

(2015) Nao Nishida-Aoki et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Expression of serum miR-200a, miR-200b, and miR-200c as candidate biomarkers in epithelial ovarian cancer and their association with clinicopathological features

(2015) M. Zuberi et al.   Clinical & Translational Oncology

Extracellular vesicles shuffling intercellular messages: for good or for bad

(2015) Alessandra Lo Cicero et al.   CURRENT OPINION IN CELL BIOLOGY

miRNA contents of cerebrospinal fluid extracellular vesicles in glioblastoma patients

(2015) Johnny C. Akers et al.   JOURNAL OF NEURO-ONCOLOGY

Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed

(2015) Agnieszka Rybak-Wolf et al.   MOLECULAR CELL

Interplay Between Exosomes, microRNAs and Toll-Like Receptors in Brain Disorders

(2015) Vera Paschon et al.   MOLECULAR NEUROBIOLOGY

Ambient particulate matter and microRNAs in extracellular vesicles: a pilot study of older individuals

(2015) Rodosthenis S. Rodosthenous et al.   Particle and Fibre Toxicology

Exosome Delivered Anticancer Drugs Across the Blood-Brain Barrier for Brain Cancer Therapy in Danio Rerio

(2015) Tianzhi Yang et al.   PHARMACEUTICAL RESEARCH

Free Extracellular miRNA Functionally Targets Cells by Transfecting Exosomes from Their Companion Cells

(2015) Krzysztof Bryniarski et al.   PLoS One

MicroRNA-200c and microRNA-141 as potential diagnostic and prognostic biomarkers for ovarian cancer

(2015) Ying-chun Gao et al.   TUMOR BIOLOGY

Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs

(2015) Donald G. Phinney et al.   Nature Communications

Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters

(2015) Charles P. Lai et al.   Nature Communications

Exosome-delivered microRNAs modulate the inflammatory response to endotoxin

(2015) Margaret Alexander et al.   Nature Communications

Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease

(2015) YaXing Gui et al.   Oncotarget

Exosomes derived from alcohol-treated hepatocytes horizontally transfer liver specific miRNA-122 and sensitize monocytes to LPS

(2015) Fatemeh Momen-Heravi et al.   Scientific Reports

Role and Function of MicroRNAs in Extracellular Vesicles in Cardiovascular Biology

(2015) Philipp Pfeifer et al.   Biomed Research International

Plasma Exosomal miRNAs in Persons with and without Alzheimer Disease: Altered Expression and Prospects for Biomarkers

(2015) Giovanni Lugli et al.   PLoS One

microRNA as Biomarkers and Regulator of Cardiovascular Development and Disease

(2014) Shinji Hagiwara et al.   CURRENT PHARMACEUTICAL DESIGN

The fusion of two worlds: Non-coding RNAs and extracellular vesicles - diagnostic and therapeutic implications (Review)

(2014) YUKIE SATO-KUWABARA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

circRNA Biogenesis Competes with Pre-mRNA Splicing

(2014) Reut Ashwal-Fluss et al.   MOLECULAR CELL

MicroRNA-193b is a regulator of amyloid precursor protein in the blood and cerebrospinal fluid derived exosomal microRNA-193b is a biomarker of Alzheimer’s disease

(2014) CHEN-GENG LIU et al.   Molecular Medicine Reports

A small noncoding RNA signature found in exosomes of GBM patient serum as a diagnostic tool

(2014) Lorea Manterola et al.   NEURO-ONCOLOGY

Exosomes in human semen carry a distinctive repertoire of small non-coding RNAs with potential regulatory functions

(2014) L. Vojtech et al.   NUCLEIC ACIDS RESEARCH

Quantitative and stoichiometric analysis of the microRNA content of exosomes

(2014) J. R. Chevillet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

circBase: a database for circular RNAs

(2014) Petar Glažar et al.   RNA

Endogenous RNAs Modulate MicroRNA Sorting to Exosomes and Transfer to Acceptor Cells

(2014) Mario Leonardo Squadrito et al.   Cell Reports

Exosomes secreted by human cells transport largely mRNA fragments that are enriched in the 3′-untranslated regions

(2013) Arsen O Batagov et al.   Biology Direct

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

(2013) Yanhua Tian et al.   BIOMATERIALS

Aging enhances release of exosomal cytokine mRNAs by Aβ1-42-stimulated macrophages

(2013) Masato Mitsuhashi et al.   FASEB JOURNAL

Neuronal Exosomal miRNA-dependent Translational Regulation of Astroglial Glutamate Transporter GLT1

(2013) Lydie Morel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antileukaemia Immunity: Effect of Exosomes against NB4 Acute Promyelocytic Leukaemia Cells

(2013) C Shen et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Natural RNA circles function as efficient microRNA sponges

(2013) Thomas B. Hansen et al.   NATURE

Circular RNAs are a large class of animal RNAs with regulatory potency

(2013) Sebastian Memczak et al.   NATURE

Argonaute proteins: functional insights and emerging roles

(2013) Gunter Meister   NATURE REVIEWS GENETICS

Diversifying microRNA sequence and function

(2013) Stefan L. Ameres et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

microRNAs are ligands of Toll-like receptors

(2013) X. Chen et al.   RNA

A Circuitous Route to Noncoding RNA

(2013) J. E. Wilusz et al.   SCIENCE

Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury

(2013) Fatih Arslan et al.   Stem Cell Research

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes

(2013) Takeshi Katsuda et al.   Scientific Reports

Cell-Type Specific Features of Circular RNA Expression

(2013) Julia Salzman et al.   PLoS Genetics

The detection of microRNA associated with Alzheimer's disease in biological fluids using next-generation sequencing technologies

(2013) Lesley Cheng et al.   Frontiers in Genetics

Synaptosomes secrete and uptake functionally active microRNAs via exocytosis and endocytosis pathways

(2012) Jie Xu et al.   JOURNAL OF NEUROCHEMISTRY

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

(2012) Shin-ichiro Ohno et al.   MOLECULAR THERAPY

Control of somatic tissue differentiation by the long non-coding RNA TINCR

(2012) Markus Kretz et al.   NATURE

Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs

(2012) Eduard Hergenreider et al.   NATURE CELL BIOLOGY

Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells

(2012) Shayne A. Bellingham et al.   NUCLEIC ACIDS RESEARCH

Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functions

(2012) Esther N. M. Nolte-’t Hoen et al.   NUCLEIC ACIDS RESEARCH

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

(2012) M. Fabbri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circular RNAs are abundant, conserved, and associated with ALU repeats

(2012) W. R. Jeck et al.   RNA

Exosomes: Vehicles for the Transfer of Toxic Proteins Associated with Neurodegenerative Diseases?

(2012) Shayne A. Bellingham et al.   Frontiers in Physiology

Proteomic Analysis of Two Types of Exosomes in Human Whole Saliva

(2011) Yuko Ogawa et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes

(2011) A. Montecalvo et al.   BLOOD

Exosomes From Human CD34 + Stem Cells Mediate Their Proangiogenic Paracrine Activity

(2011) Susmita Sahoo et al.   CIRCULATION RESEARCH

Human long non-coding RNAs promote pluripotency and neuronal differentiation by association with chromatin modifiers and transcription factors

(2011) Shi-Yan Ng et al.   EMBO JOURNAL

Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease

(2011) Sudad Saman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Gene silencing by microRNAs: contributions of translational repression and mRNA decay

(2011) Eric Huntzinger et al.   NATURE REVIEWS GENETICS

Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences

(2011) Leonora Balaj et al.   Nature Communications

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

(2011) María Mittelbrunn et al.   Nature Communications

Circulating MicroRNAs as Biomarkers and Potential Paracrine Mediators of Cardiovascular Disease

(2010) Shashi K. Gupta et al.   Circulation-Cardiovascular Genetics

The MicroRNA Spectrum in 12 Body Fluids

(2010) J. A. Weber et al.   CLINICAL CHEMISTRY

Microvesicles: mediators of extracellular communication during cancer progression

(2010) V. Muralidharan-Chari et al.   JOURNAL OF CELL SCIENCE

Cell-Produced  -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival

(2010) E. Emmanouilidou et al.   JOURNAL OF NEUROSCIENCE

Many ways to generate microRNA-like small RNAs: non-canonical pathways for microRNA production

(2010) Keita Miyoshi et al.   MOLECULAR GENETICS AND GENOMICS

Aging and microRNA expression in human skeletal muscle: a microarray and bioinformatics analysis

(2010) Micah J. Drummond et al.   PHYSIOLOGICAL GENOMICS

Noncoding RNA Gas5 Is a Growth Arrest- and Starvation-Associated Repressor of the Glucocorticoid Receptor

(2010) T. Kino et al.   Science Signaling

Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer

(2009) J Nilsson et al.   BRITISH JOURNAL OF CANCER

Origins and Mechanisms of miRNAs and siRNAs

(2009) Richard W. Carthew et al.   CELL

Exosomes from human saliva as a source of microRNA biomarkers

(2009) A Michael et al.   ORAL DISEASES

Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

(2009) Ahmad M. Khalil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aging differentially affects human skeletal muscle microRNA expression at rest and after an anabolic stimulus of resistance exercise and essential amino acids

(2008) Micah J. Drummond et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer

(2008) Douglas D. Taylor et al.   GYNECOLOGIC ONCOLOGY

Follicular dendritic cells control engulfment of apoptotic bodies by secreting Mfge8

(2008) Jan Kranich et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

Circulating microRNAs as stable blood-based markers for cancer detection

(2008) P. S. Mitchell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA