Shedding light on the cell biology of extracellular vesicles

Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments

(2017) Francesc X. Guix et al.   Molecular Neurodegeneration

EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research

(2017) Jan Van Deun et al.   NATURE METHODS

Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23

(2017) Yao Wei et al.   Nature Communications

MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression

(2017) Yun Teng et al.   Nature Communications

Going live with tumor exosomes and microvesicles

(2017) Vincent Hyenne et al.   Cell Adhesion & Migration

The effects of glomerular and tubular renal progenitors and derived extracellular vesicles on recovery from acute kidney injury

(2017) Andrea Ranghino et al.   Stem Cell Research & Therapy

Enhanced exosome secretion in Down syndrome brain - a protective mechanism to alleviate neuronal endosomal abnormalities

(2017) Sébastien A. Gauthier et al.   Acta Neuropathologica Communications

Nanoscale Characterization of Carrier Dynamic and Surface Passivation in InGaN/GaN Multiple Quantum Wells on GaN Nanorods

(2016) Weijian Chen et al.   ACS Applied Materials & Interfaces

Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine

(2016) Stefano Fais et al.   ACS Nano

Impact of lysosome status on extracellular vesicle content and release

(2016) Erez Eitan et al.   AGEING RESEARCH REVIEWS

PRNP/prion protein regulates the secretion of exosomes modulating CAV1/caveolin-1-suppressed autophagy

(2016) Marcos V. S. Dias et al.   Autophagy

A new approach to follow a single extracellular vesicle–cell interaction using optical tweezers

(2016) Ilaria Prada et al.   BIOTECHNIQUES

Autophagy and the endo/exosomal pathways in health and disease

(2016) Margarita-Elena Papandreou et al.   Biotechnology Journal

Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket

(2016) Brandon Zimmerman et al.   CELL

PIKfyve inhibition increases exosome release and induces secretory autophagy

(2016) Nina Pettersen Hessvik et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Vesicle-MaNiA: extracellular vesicles in liquid biopsy and cancer

(2016) Veronica Torrano et al.   CURRENT OPINION IN PHARMACOLOGY

Secreted Glioblastoma Nanovesicles Contain Intracellular Signaling Proteins and Active Ras Incorporated in a Farnesylation-dependent Manner

(2016) Natalie Luhtala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cortactin promotes exosome secretion by controlling branched actin dynamics

(2016) Seema Sinha et al.   JOURNAL OF CELL BIOLOGY

Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER

(2016) Wolf Heusermann et al.   JOURNAL OF CELL BIOLOGY

Parkin Modulates Endosomal Organization and Function of the Endo-Lysosomal Pathway

(2016) Pingping Song et al.   JOURNAL OF NEUROSCIENCE

Extracellular Vesicles Exploit Viral Entry Routes for Cargo Delivery

(2016) Helena M. van Dongen et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation

(2016) Laura M. Desrochers et al.   Nature Communications

ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins

(2016) Carolina Villarroya-Beltri et al.   Nature Communications

KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes

(2016) Andrew J. McKenzie et al.   Cell Reports

Mesenchymal Stromal Cell-Derived Extracellular Vesicles Protect the Fetal Brain After Hypoxia-Ischemia

(2016) Daan R.M.G. Ophelders et al.   Stem Cells Translational Medicine

Autophagy and the endo/exosomal pathways in health and disease

(2016) Margarita-Elena Papandreou et al.   Biotechnology Journal

Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction

(2016) Matthew J Shurtleff et al.   eLife

Tetherin is an exosomal tether

(2016) James R Edgar et al.   eLife

Cells release subpopulations of exosomes with distinct molecular and biological properties

(2016) Eduard Willms et al.   Scientific Reports

In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior

(2015) Anoek Zomer et al.   CELL

Heparanase activates the syndecan-syntenin-ALIX exosome pathway

(2015) Bart Roucourt et al.   CELL RESEARCH

Extracellular vesicles shuffling intercellular messages: for good or for bad

(2015) Alessandra Lo Cicero et al.   CURRENT OPINION IN CELL BIOLOGY

Fibronectin on the Surface of Myeloma Cell-derived Exosomes Mediates Exosome-Cell Interactions

(2015) Anurag Purushothaman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rab27a controls HIV-1 assembly by regulating plasma membrane levels of phosphatidylinositol 4,5-bisphosphate

(2015) Pehuén Pereyra Gerber et al.   JOURNAL OF CELL BIOLOGY

RAL-1 controls multivesicular body biogenesis and exosome secretion

(2015) Vincent Hyenne et al.   JOURNAL OF CELL BIOLOGY

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

(2015) Sonia A. Melo et al.   NATURE

Unconventional protein secretion in plants: a critical assessment

(2015) David G. Robinson et al.   PROTOPLASMA

Extracellular vesicles – Their role in the packaging and spread of misfolded proteins associated with neurodegenerative diseases

(2015) Bradley M. Coleman et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Extracellular Vesicles in Cancer: Exosomes, Microvesicles and the Emerging Role of Large Oncosomes

(2015) Valentina R. Minciacchi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Organizing Polarized Delivery of Exosomes at Synapses

(2015) Maria Mittelbrunn et al.   TRAFFIC

Directional cell movement through tissues is controlled by exosome secretion

(2015) Bong Hwan Sung et al.   Nature Communications

Exosomes released by keratinocytes modulate melanocyte pigmentation

(2015) Alessandra Lo Cicero et al.   Nature Communications

Extracellular microvesicles and invadopodia mediate non-overlapping modes of tumor cell invasion

(2015) Alanna E. Sedgwick et al.   Scientific Reports

Active macropinocytosis induction by stimulation of epidermal growth factor receptor and oncogenic Ras expression potentiates cellular uptake efficacy of exosomes

(2015) Ikuhiko Nakase et al.   Scientific Reports

Apolipoprotein E Regulates Amyloid Formation within Endosomes of Pigment Cells

(2015) Guillaume van Niel et al.   Cell Reports

Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC

(2015) Benjamin Besse et al.   OncoImmunology

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration

(2014) Liang Ma et al.   CELL RESEARCH

Double-stranded DNA in exosomes: a novel biomarker in cancer detection

(2014) Basant Kumar Thakur et al.   CELL RESEARCH

The emerging role of exosomes in Wnt secretion and transport

(2014) Liang Zhang et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Exosomes and other extracellular vesicles in host-pathogen interactions

(2014) J. S. Schorey et al.   EMBO REPORTS

Syncytin proteins incorporated in placenta exosomes are important for cell uptake and show variation in abundance in serum exosomes from patients with preeclampsia

(2014) Amandine Vargas et al.   FASEB JOURNAL

Identification of Double-stranded Genomic DNA Spanning All Chromosomes with MutatedKRASandp53DNA in the Serum Exosomes of Patients with Pancreatic Cancer

(2014) Christoph Kahlert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosome Uptake through Clathrin-mediated Endocytosis and Macropinocytosis and Mediating miR-21 Delivery

(2014) Tian Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tetraspanins at a glance

(2014) S. Charrin et al.   JOURNAL OF CELL SCIENCE

Microvesicle-Shuttled miR-130b Reduces Fat Deposition in Recipient Primary Cultured Porcine Adipocytes by Inhibiting PPAR-γ Expression

(2014) Shifeng Pan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Dendritic Cell-Derived Exosomes as Immunotherapies in the Fight against Cancer

(2014) J. M. Pitt et al.   JOURNAL OF IMMUNOLOGY

Structure of an Rrp6–RNA exosome complex bound to poly(A) RNA

(2014) Elizabeth V. Wasmuth et al.   NATURE

Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease

(2014) Michael B. Dinkins et al.   NEUROBIOLOGY OF AGING

Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis

(2014) T. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Complex Ultrastructure of the Endolysosomal System

(2014) J. Klumperman et al.   Cold Spring Harbor Perspectives in Biology

Thecis-acting signals that target proteins to exosomes and microvesicles

(2013) Jr-Ming Yang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Exosomes as new vesicular lipid transporters involved in cell–cell communication and various pathophysiologies

(2013) Michel Record et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lysosome-related organelles: unusual compartments become mainstream

(2013) Michael S Marks et al.   CURRENT OPINION IN CELL BIOLOGY

Metastasis Suppressor Tetraspanin CD82/KAI1 Regulates Ubiquitylation of Epidermal Growth Factor Receptor

(2013) Elena Odintsova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Intracellular Interactome of Tetraspanin-enriched Microdomains Reveals Their Function as Sorting Machineries toward Exosomes

(2013) Daniel Perez-Hernandez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

(2013) Marina Colombo et al.   JOURNAL OF CELL SCIENCE

ARF1 regulates the Rho/MLC pathway to control EGF-dependent breast cancer cell invasion

(2013) Sabrina Schlienger et al.   MOLECULAR BIOLOGY OF THE CELL

Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury

(2013) Fatih Arslan et al.   Stem Cell Research

Hrs- and CD63-Dependent Competing Mechanisms Make Different Sized Endosomal Intraluminal Vesicles

(2013) James R. Edgar et al.   TRAFFIC

ALIX and the multivesicular endosome: ALIX in Wonderland

(2013) Christin Bissig et al.   TRENDS IN CELL BIOLOGY

Ongoing activation of sphingosine 1-phosphate receptors mediates maturation of exosomal multivesicular endosomes

(2013) Taketoshi Kajimoto et al.   Nature Communications

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

Exosomes for targeted siRNA delivery across biological barriers

(2012) Samir EL Andaloussi et al.   ADVANCED DRUG DELIVERY REVIEWS

Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers

(2012) C. D'Souza-Schorey et al.   GENES & DEVELOPMENT

Membrane Vesicle Release in Bacteria, Eukaryotes, and Archaea: a Conserved yet Underappreciated Aspect of Microbial Life

(2012) Brooke L. Deatherage et al.   INFECTION AND IMMUNITY

Toward tailored exosomes: The exosomal tetraspanin web contributes to target cell selection

(2012) Sanyukta Rana et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Two Distinct Populations of Exosomes Are Released from LIM1863 Colon Carcinoma Cell-derived Organoids

(2012) Bow J. Tauro et al.   MOLECULAR & CELLULAR PROTEOMICS

Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth

(2012) Arda Mizrak et al.   MOLECULAR THERAPY

Active Wnt proteins are secreted on exosomes

(2012) Julia Christina Gross et al.   NATURE CELL BIOLOGY

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functions

(2012) Esther N. M. Nolte-’t Hoen et al.   NUCLEIC ACIDS RESEARCH

RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells

(2012) B Li et al.   ONCOGENE

Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein

(2012) J. F. Nabhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rho GTPases and their roles in cancer metabolism

(2012) Kristin F. Wilson et al.   TRENDS IN MOLECULAR MEDICINE

miR-1289 and “Zipcode”-like Sequence Enrich mRNAs in Microvesicles

(2012) Mehmet Fatih Bolukbasi et al.   Molecular Therapy-Nucleic Acids

Interaction and uptake of exosomes by ovarian cancer cells

(2011) Cristina Escrevente et al.   BMC CANCER

The P4-ATPase TAT-5 Inhibits the Budding of Extracellular Vesicles in C. elegans Embryos

(2011) Ann M. Wehman et al.   CURRENT BIOLOGY

The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis

(2011) Guillaume van Niel et al.   DEVELOPMENTAL CELL

Biogenesis of the Posterior Pole Is Mediated by the Exosome/Microvesicle Protein-sorting Pathway

(2011) Beiyi Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteolipidic Composition of Exosomes Changes during Reticulocyte Maturation

(2011) Kévin Carayon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells

(2011) M. A. Antonyak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

(2011) María Mittelbrunn et al.   Nature Communications

Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein

(2010) Keiichi Tamai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cell Surface Tetraspanin Tspan8 Contributes to Molecular Pathways of Exosome-Induced Endothelial Cell Activation

(2010) I. Nazarenko et al.   CANCER RESEARCH

Activation-induced internalization differs for the tetraspanins CD9 and Tspan8: Impact on tumor cell motility

(2010) Sanyukta Rana et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C

(2010) Chieh Hsu et al.   JOURNAL OF CELL BIOLOGY

Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling

(2010) Arthit Chairoungdua et al.   JOURNAL OF CELL BIOLOGY

Visualizing of the cellular uptake and intracellular trafficking of exosomes by live-cell microscopy

(2010) Tian Tian et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Activation of Macrophages by P2X7-Induced Microvesicles from Myeloid Cells Is Mediated by Phospholipids and Is Partially Dependent on TLR4

(2010) L. M. Thomas et al.   JOURNAL OF IMMUNOLOGY

The immune functions of phosphatidylserine in membranes of dying cells and microvesicles

(2010) Benjamin Frey et al.   Seminars in Immunopathology

The majority of circulating platelet-derived microparticles fail to bind annexin V, lack phospholipid-dependent procoagulant activity and demonstrate greater expression of glycoprotein Ib

(2010) Thomas Exner et al.   THROMBOSIS AND HAEMOSTASIS

Cellular Internalization of Exosomes Occurs Through Phagocytosis

(2010) Du Feng et al.   TRAFFIC

TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways

(2009) Claudio Marcelo Fader et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages

(2009) C. Barres et al.   BLOOD

ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane Microvesicles

(2009) Vandhana Muralidharan-Chari et al.   CURRENT BIOLOGY

Acid sphingomyelinase activity triggers microparticle release from glial cells

(2009) Fabio Bianco et al.   EMBO JOURNAL

Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7–RILP–p150Gluedand late endosome positioning

(2009) Nuno Rocha et al.   JOURNAL OF CELL BIOLOGY

The enterocyte microvillus is a vesicle-generating organelle

(2009) Russell E. McConnell et al.   JOURNAL OF CELL BIOLOGY

Mesenchymal Stem Cell-Derived Microvesicles Protect Against Acute Tubular Injury

(2009) S. Bruno et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity

(2009) Derrick J. Gibbings et al.   NATURE CELL BIOLOGY

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Multivesicular Endosome Biogenesis in the Absence of ESCRTs

(2009) Susanne Stuffers et al.   TRAFFIC

MHC II in Dendritic Cells is Targeted to Lysosomes or T Cell-Induced Exosomes Via Distinct Multivesicular Body Pathways

(2009) Sonja I. Buschow et al.   TRAFFIC

Shedding microvesicles: artefacts no more

(2009) Emanuele Cocucci et al.   TRENDS IN CELL BIOLOGY

Exosomes are an effective vaccine against congenital toxoplasmosis in mice

(2009) Céline Beauvillain et al.   VACCINE

Effects of ceramide and other simple sphingolipids on membrane lateral structure

(2008) Félix M. Goñi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Activated T cells recruit exosomes secreted by dendritic cells via LFA-1

(2008) E. N. M. Nolte-'t Hoen et al.   BLOOD

ESCRT complexes and the biogenesis of multivesicular bodies

(2008) James H Hurley   CURRENT OPINION IN CELL BIOLOGY

The role of integrin binding sites in fibronectin matrix assembly in vivo

(2008) Michael Leiss et al.   CURRENT OPINION IN CELL BIOLOGY

Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

(2008) Khalid Al-Nedawi et al.   NATURE CELL BIOLOGY

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

Mast cells possess distinct secretory granule subsets whose exocytosis is regulated by different SNARE isoforms

(2008) N. Puri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE