Gene Therapy Based on Nucleic Acid Nanostructure

Environment-Recognizing DNA-Computation Circuits for the Intracellular Transport of Molecular Payloads for mRNA Imaging

(2020) Huihui Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Double Rolling Circle Amplification Generates Physically Cross-Linked DNA Network for Stem Cell Fishing

(2020) Chi Yao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engineering adeno-associated virus vectors for gene therapy

(2020) Chengwen Li et al.   NATURE REVIEWS GENETICS

Cryopreservation of DNA Origami Nanostructures

(2020) Yang Xin et al.   Small

Site‐Specific Synthesis of Silica Nanostructures on DNA Origami Templates

(2020) Yingxu Shang et al.   ADVANCED MATERIALS

Transformation of Biomass DNA into Biodegradable Materials from Gels to Plastics for Reducing Petrochemical Consumption

(2020) Dong Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CRISPR-Cas12a delivery by DNA-mediated bioresponsive editing for cholesterol regulation

(2020) Wujin Sun et al.   Science Advances

Treating Disease at the RNA Level with Oligonucleotides

(2019) Arthur A. Levin   NEW ENGLAND JOURNAL OF MEDICINE

Self-Assembled and Size-Controllable Oligonucleotide Nanospheres for Effective Antisense Gene Delivery through an Endocytosis-Independent Pathway

(2019) Jie Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The next generation of CRISPR–Cas technologies and applications

(2019) Adrian Pickar-Oliver et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bundling mRNA Strands to Prepare Nano-Assemblies with Enhanced Stability Towards RNase for In Vivo Delivery

(2019) Naoto Yoshinaga et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Nanobody-Conjugated DNA Nanoplatform for Targeted Platinum-Drug Delivery

(2019) Tiantian Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rationally Engineered Nucleic Acid Architectures for Biosensing Applications

(2019) Mingshu Xiao et al.   CHEMICAL REVIEWS

A Self-Assembled Platform Based on Branched DNA for sgRNA/Cas9/Antisense Delivery

(2019) Jianbing Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Precise Organization of Metal and Metal Oxide Nanoclusters into Arbitrary Patterns on DNA Origami

(2019) Na Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engineered materials for in vivo delivery of genome-editing machinery

(2019) Sheng Tong et al.   Nature Reviews Materials

Programming DNA Nanoassembly for Enhanced Photodynamic Therapy

(2019) Min Pan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Self-Assembled Double-Bundle DNA Tetrahedron for Efficient Antisense Delivery

(2018) Juanjuan Yang et al.   ACS Applied Materials & Interfaces

A Crosslinked Nucleic Acid Nanogel for Effective siRNA Delivery and Antitumor Therapy

(2018) Fei Ding et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A DNA-Based Nanocarrier for Efficient Gene Delivery and Combined Cancer Therapy

(2018) Jianbing Liu et al.   NANO LETTERS

A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo

(2018) Suping Li et al.   NATURE BIOTECHNOLOGY

A Tailored DNA Nanoplatform for Synergistic RNAi-/Chemotherapy of Multidrug-Resistant Tumors

(2018) Jianbing Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Poly-sgRNA/siRNA ribonucleoprotein nanoparticles for targeted gene disruption

(2017) Jong Seong Ha et al.   JOURNAL OF CONTROLLED RELEASE

Biotechnological mass production of DNA origami

(2017) Florian Praetorius et al.   NATURE

Overcoming cellular barriers for RNA therapeutics

(2017) Steven F Dowdy   NATURE BIOTECHNOLOGY

Library siRNA-generating RNA nanosponges for gene silencing by complementary rolling circle transcription

(2017) Sangwoo Han et al.   Scientific Reports

Tools for translation: non-viral materials for therapeutic mRNA delivery

(2017) Khalid A. Hajj et al.   Nature Reviews Materials

DNA nanotechnology

(2017) Nadrian C. Seeman et al.   Nature Reviews Materials

DNA-Nanostructure-Gold-Nanorod Hybrids for Enhanced In Vivo Optoacoustic Imaging and Photothermal Therapy

(2016) Yang Du et al.   ADVANCED MATERIALS

Reciprocal Self-Assembly of Peptide-DNA Conjugates into a Programmable Sub-10-nm Supramolecular Deoxyribonucleoprotein

(2016) Mahnseok Kye et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Optimized DNA “Nanosuitcases” for Encapsulation and Conditional Release of siRNA

(2016) Katherine E. Bujold et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A DNA dual lock-and-key strategy for cell-subtype-specific siRNA delivery

(2016) Kewei Ren et al.   Nature Communications

Self-Assembled DNA Nanoclews for the Efficient Delivery of CRISPR-Cas9 for Genome Editing

(2015) Wujin Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficient construction of stable gene nanoparticles through polymerase chain reaction with flexible branched primers for gene delivery

(2015) Jianbing Liu et al.   CHEMICAL COMMUNICATIONS

Nucleic Acid Therapeutics Using Polyplexes: A Journey of 50 Years (and Beyond)

(2015) Ulrich Lächelt et al.   CHEMICAL REVIEWS

Self-assembly of DNA Nanohydrogels with Controllable Size and Stimuli-Responsive Property for Targeted Gene Regulation Therapy

(2015) Juan Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient Production of Single-Stranded Phage DNA as Scaffolds for DNA Origami

(2015) Benjamin Kick et al.   NANO LETTERS

Gene therapy returns to centre stage

(2015) Luigi Naldini   NATURE

$1-million price tag set for Glybera gene therapy

(2015) Chris Morrison   NATURE BIOTECHNOLOGY

Clinical experiences with systemically administered siRNA-based therapeutics in cancer

(2015) Jonathan E. Zuckerman et al.   NATURE REVIEWS DRUG DISCOVERY

Design of a platform technology for systemic delivery of siRNA to tumours using rolling circle transcription

(2015) Mihue Jang et al.   Nature Communications

DNA Origami as an In Vivo Drug Delivery Vehicle for Cancer Therapy

(2014) Qian Zhang et al.   ACS Nano

DNA Nanoflowers for Multiplexed Cellular Imaging and Traceable Targeted Drug Delivery

(2014) Rong Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development and Applications of CRISPR-Cas9 for Genome Engineering

(2014) Patrick D. Hsu et al.   CELL

Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos

(2014) Yuyu Niu et al.   CELL

Rolling circle amplification: a versatile tool for chemical biology, materials science and medicine

(2014) M. Monsur Ali et al.   CHEMICAL SOCIETY REVIEWS

Cocoon-Like Self-Degradable DNA Nanoclew for Anticancer Drug Delivery

(2014) Wujin Sun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Non-viral vectors for gene-based therapy

(2014) Hao Yin et al.   NATURE REVIEWS GENETICS

Engineering of Switchable Aptamer Micelle Flares for Molecular Imaging in Living Cells

(2013) Cuichen Wu et al.   ACS Nano

One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering

(2013) Haoyi Wang et al.   CELL

Efficient genome editing in zebrafish using a CRISPR-Cas system

(2013) Woong Y Hwang et al.   NATURE BIOTECHNOLOGY

Delivery materials for siRNA therapeutics

(2013) Rosemary Kanasty et al.   NATURE MATERIALS

Enzymatic production of 'monoclonal stoichiometric' single-stranded DNA oligonucleotides

(2013) Cosimo Ducani et al.   NATURE METHODS

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

DNA Origami Delivery System for Cancer Therapy with Tunable Release Properties

(2012) Yong-Xing Zhao et al.   ACS Nano

Liposomal drug delivery systems: From concept to clinical applications

(2012) Theresa M. Allen et al.   ADVANCED DRUG DELIVERY REVIEWS

DNA Origami as a Carrier for Circumvention of Drug Resistance

(2012) Qiao Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Self-assembled RNA interference microsponges for efficient siRNA delivery

(2012) Jong Bum Lee et al.   NATURE MATERIALS

A mechanical metamaterial made from a DNA hydrogel

(2012) Jong Bum Lee et al.   Nature Nanotechnology

Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

(2012) Hyukjin Lee et al.   Nature Nanotechnology

RNA therapeutics: beyond RNA interference and antisense oligonucleotides

(2012) Ryszard Kole et al.   NATURE REVIEWS DRUG DISCOVERY

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads

(2012) S. M. Douglas et al.   SCIENCE

DNA Origami with Complex Curvatures in Three-Dimensional Space

(2011) D. Han et al.   SCIENCE

A synthetic icosahedral DNA-based host–cargo complex for functional in vivo imaging

(2011) Dhiraj Bhatia et al.   Nature Communications

Biomedical applications of dendrimers: a tutorial

(2010) Meredith A. Mintzer et al.   CHEMICAL SOCIETY REVIEWS

Folding and cutting DNA into reconfigurable topological nanostructures

(2010) Dongran Han et al.   Nature Nanotechnology

Polymerase Chain Reaction Based Scaffold Preparation for the Production of Thin, Branched DNA Origami Nanostructures of Arbitrary Sizes

(2009) Elisabeth Pound et al.   NANO LETTERS

From molecular to macroscopic via the rational design of a self-assembled 3D DNA crystal

(2009) Jianping Zheng et al.   NATURE

A cell-free protein-producing gel

(2009) Nokyoung Park et al.   NATURE MATERIALS

Folding DNA into Twisted and Curved Nanoscale Shapes

(2009) H. Dietz et al.   SCIENCE

Self-Assembly of a DNA Dodecahedron from 20 Trisoligonucleotides withC3h Linkers

(2008) Jan Zimmermann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

DNA Polymerase-Catalyzed DNA Network Growth

(2008) Sascha Keller et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hierarchical self-assembly of DNA into symmetric supramolecular polyhedra

(2008) Yu He et al.   NATURE

Inorganic Nanoparticles as Carriers of Nucleic Acids into Cells

(2007) Viktoriya Sokolova et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION