Advances in therapeutic applications of extracellular vesicles

Multiplexed Profiling of Single Extracellular Vesicles

(2018) Kyungheon Lee et al.   ACS Nano

Sustained release of endothelial progenitor cell-derived extracellular vesicles from shear-thinning hydrogels improves angiogenesis and promotes function after myocardial infarction

(2018) Carol W Chen et al.   CARDIOVASCULAR RESEARCH

Cancer cells govern miR-2909 exosomal recruitment through its 3′-end post-transcriptional modification

(2018) Sameena Wani et al.   CELL BIOCHEMISTRY AND FUNCTION

New Technologies for Analysis of Extracellular Vesicles

(2018) Huilin Shao et al.   CHEMICAL REVIEWS

Low-level laser irradiation at a high power intensity increased human endothelial cell exosome secretion via Wnt signaling

(2018) Hesam Saghaei Bagheri et al.   LASERS IN MEDICAL SCIENCE

Optimized Cholesterol-siRNA Chemistry Improves Productive Loading onto Extracellular Vesicles

(2018) Reka Agnes Haraszti et al.   MOLECULAR THERAPY

Organoids with cancer stem cell-like properties secrete exosomes and HSP90 in a 3D nanoenvironment

(2018) Takanori Eguchi et al.   PLoS One

Anchor peptide captures, targets, and loads exosomes of diverse origins for diagnostics and therapy

(2018) Xianjun Gao et al.   Science Translational Medicine

Intricate relationships between naked viruses and extracellular vesicles in the crosstalk between pathogen and host

(2018) Susanne G. van der Grein et al.   Seminars in Immunopathology

Exosomes Derived from Hypoxia-Treated Human Adipose Mesenchymal Stem Cells Enhance Angiogenesis Through the PKA Signaling Pathway

(2018) Chunling Xue et al.   STEM CELLS AND DEVELOPMENT

Dendritic Cells Pulsed with Exosomes in Combination with PD-1 Antibody Increase the Efficacy of Sorafenib in Hepatocellular Carcinoma Model

(2018) Shengbin Shi et al.   Translational Oncology

ARMMs as a versatile platform for intracellular delivery of macromolecules

(2018) Qiyu Wang et al.   Nature Communications

Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment

(2018) Ryosuke Kojima et al.   Nature Communications

Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles

(2018) Eduardo Reátegui et al.   Nature Communications

Rapid isolation and enrichment of extracellular vesicle preparations using anion exchange chromatography

(2018) Nikki Heath et al.   Scientific Reports

Human Mesenchymal Stromal Cell-Derived Extracellular Vesicles Modify Microglial Response and Improve Clinical Outcomes in Experimental Spinal Cord Injury

(2018) Katherine A. Ruppert et al.   Scientific Reports

Mesenchymal stem cell-derived extracellular vesicles attenuate influenza virus-induced acute lung injury in a pig model

(2018) Mahesh Khatri et al.   Stem Cell Research & Therapy

Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis

(2018) Stella Cosenza et al.   Theranostics

Amnion Epithelial Cell-Derived Exosomes Restrict Lung Injury and Enhance Endogenous Lung Repair

(2018) Jean L. Tan et al.   Stem Cells Translational Medicine

Systematic Methodological Evaluation of a Multiplex Bead-Based Flow Cytometry Assay for Detection of Extracellular Vesicle Surface Signatures

(2018) Oscar P. B. Wiklander et al.   Frontiers in Immunology

Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles

(2018) Franz L. Ricklefs et al.   Science Advances

Lung mesenchymal stem cells-derived extracellular vesicles attenuate the inflammatory profile of Cystic Fibrosis epithelial cells

(2018) Aida Zulueta et al.   CELLULAR SIGNALLING

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

Small But Increasingly Mighty: Latest Advances in AAV Vector Research, Design, and Evolution

(2017) Dirk Grimm et al.   HUMAN GENE THERAPY

Cellular uptake of extracellular vesicles is mediated by clathrin-independent endocytosis and macropinocytosis

(2017) Helena Costa Verdera et al.   JOURNAL OF CONTROLLED RELEASE

Extracellular vesicles from mesenchymal stem cells activates VEGF receptors and accelerates recovery of hindlimb ischemia

(2017) Prakash Gangadaran et al.   JOURNAL OF CONTROLLED RELEASE

Exosomes derived from human amniotic epithelial cells accelerate wound healing and inhibit scar formation

(2017) Bin Zhao et al.   JOURNAL OF MOLECULAR HISTOLOGY

Mesenchymal stem cell–derived extracellular vesicles attenuate kidney inflammation

(2017) Alfonso Eirin et al.   KIDNEY INTERNATIONAL

Engineered Exosomes as Vehicles for Biologically Active Proteins

(2017) Ulrich Sterzenbach et al.   MOLECULAR THERAPY

Rescue of Hearing by Gene Delivery to Inner-Ear Hair Cells Using Exosome-Associated AAV

(2017) Bence György et al.   MOLECULAR THERAPY

Higher functionality of extracellular vesicles isolated using size-exclusion chromatography compared to ultracentrifugation

(2017) Emma A. Mol et al.   Nanomedicine-Nanotechnology Biology and Medicine

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression

(2017) Fengmei Pi et al.   Nature Nanotechnology

Why the need and how to approach the functional diversity of extracellular vesicles

(2017) Mercedes Tkach et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Mesenchymal Stem Cell-Derived Extracellular Vesicles Ameliorates Hippocampal Synaptic Impairment after Transient Global Ischemia

(2017) Mingyang Deng et al.   Frontiers in Cellular Neuroscience

Plasma membrane-derived extracellular microvesicles mediate non-canonical intercellular NOTCH signaling

(2017) Qiyu Wang et al.   Nature Communications

Exosomes from antigen-pulsed dendritic cells induce stronger antigen-specific immune responses than microvesicles in vivo

(2017) Casper J. E. Wahlund et al.   Scientific Reports

Extracellular Vesicle-functionalized Decalcified Bone Matrix Scaffolds with Enhanced Pro-angiogenic and Pro-bone Regeneration Activities

(2017) Hui Xie et al.   Scientific Reports

Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis

(2017) Stella Cosenza et al.   Scientific Reports

Concise Review: Developing Best-Practice Models for the Therapeutic Use of Extracellular Vesicles

(2017) Agnes T. Reiner et al.   Stem Cells Translational Medicine

Inferior In Vivo Osteogenesis and Superior Angiogeneis of Human Adipose-Derived Stem Cells Compared with Bone Marrow-Derived Stem Cells Cultured in Xeno-Free Conditions

(2017) Meadhbh A. Brennan et al.   Stem Cells Translational Medicine

Extracellular Vesicles from Bone Marrow-Derived Mesenchymal Stem Cells Improve Survival from Lethal Hepatic Failure in Mice

(2017) Hiroaki Haga et al.   Stem Cells Translational Medicine

Mesenchymal Stem and Progenitor Cells in Regeneration: Tissue Specificity and Regenerative Potential

(2017) Rokhsareh Rohban et al.   Stem Cells International

Exosome Mediated Delivery of miR-124 Promotes Neurogenesis after Ischemia

(2017) Jialei Yang et al.   Molecular Therapy-Nucleic Acids

Rapid magnetic isolation of extracellular vesicles via lipid-based nanoprobes

(2017) Yuan Wan et al.   Nature Biomedical Engineering

Reproducible and scalable purification of extracellular vesicles using combined bind-elute and size exclusion chromatography

(2017) Giulia Corso et al.   Scientific Reports

Oncogene Knockdown via Active Loading of Small RNAs into Extracellular Vesicles by Sonication

(2016) Tek N. Lamichhane et al.   Cellular and Molecular Bioengineering

Exosomes derived from endothelial progenitor cells attenuate vascular repair and accelerate reendothelialization by enhancing endothelial function

(2016) Xiaocong Li et al.   CYTOTHERAPY

Transfer of the Cystic Fibrosis Transmembrane Conductance Regulator to Human Cystic Fibrosis Cells Mediated by Extracellular Vesicles

(2016) Cyrielle Vituret et al.   HUMAN GENE THERAPY

NK Cell Regulatory Property is Involved in the Protective Role of MSC-Derived Extracellular Vesicles in Renal Ischemic Reperfusion Injury

(2016) Xiangyu Zou et al.   HUMAN GENE THERAPY

Exosomes Secreted by Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Repair Critical-Sized Bone Defects through Enhanced Angiogenesis and Osteogenesis in Osteoporotic Rats

(2016) Xin Qi et al.   International Journal of Biological Sciences

Extracellular Vesicles Exploit Viral Entry Routes for Cargo Delivery

(2016) Helena M. van Dongen et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Genetics of Parkinson's disease

(2016) Christina M. Lill   MOLECULAR AND CELLULAR PROBES

Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing

(2016) Marie-Cécile Didiot et al.   MOLECULAR THERAPY

Designed proteins induce the formation of nanocage-containing extracellular vesicles

(2016) Jörg Votteler et al.   NATURE

Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration

(2016) S. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

Development and regulation of exosome-based therapy products

(2016) Elena V. Batrakova et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module

(2016) Nambin Yim et al.   Nature Communications

Exosomal cancer immunotherapy is independent of MHC molecules on exosomes

(2016) Stefanie Hiltbrunner et al.   Oncotarget

The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting

(2016) Laura Santangelo et al.   Cell Reports

Mesenchymal Stem Cell-Derived Exosomes Promote Fracture Healing in a Mouse Model

(2016) Taisuke Furuta et al.   Stem Cells Translational Medicine

Cells release subpopulations of exosomes with distinct molecular and biological properties

(2016) Eduard Willms et al.   Scientific Reports

Engineering hybrid exosomes by membrane fusion with liposomes

(2016) Yuko T. Sato et al.   Scientific Reports

A novel affinity-based method for the isolation of highly purified extracellular vesicles

(2016) Wataru Nakai et al.   Scientific Reports

Low pH increases the yield of exosome isolation

(2015) Jae-Jun Ban et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Embryonic Stem Cell-Derived Exosomes Promote Endogenous Repair Mechanisms and Enhance Cardiac Function Following Myocardial Infarction

(2015) M. Khan et al.   CIRCULATION RESEARCH

Exosomes/microvesicles from induced pluripotent stem cells deliver cardioprotective miRNAs and prevent cardiomyocyte apoptosis in the ischemic myocardium

(2015) Yingjie Wang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Exosomes as drug delivery vehicles for Parkinson's disease therapy

(2015) Matthew J. Haney et al.   JOURNAL OF CONTROLLED RELEASE

Exosomes released from human induced pluripotent stem cells-derived MSCs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis

(2015) Jieyuan Zhang et al.   Journal of Translational Medicine

Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties

(2015) Joel Z. Nordin et al.   Nanomedicine-Nanotechnology Biology and Medicine

Chromatographically isolated CD63+CD81+extracellular vesicles from mesenchymal stromal cells rescue cognitive impairments after TBI

(2015) Dong-ki Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death

(2015) Stefania Raimondo et al.   Oncotarget

Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC

(2015) Benjamin Besse et al.   OncoImmunology

Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter

(2014) Charles P. Lai et al.   ACS Nano

Naturally enveloped AAV vectors for shielding neutralizing antibodies and robust gene delivery in vivo

(2014) Bence György et al.   BIOMATERIALS

Exosome Uptake through Clathrin-mediated Endocytosis and Macropinocytosis and Mediating miR-21 Delivery

(2014) Tian Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Benchtop isolation and characterization of functional exosomes by sequential filtration

(2014) Mitja L. Heinemann et al.   JOURNAL OF CHROMATOGRAPHY A

Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: A new approach for drug delivery

(2014) Luisa Pascucci et al.   JOURNAL OF CONTROLLED RELEASE

A review of therapeutic effects of mesenchymal stem cell secretions and induction of secretory modification by different culture methods

(2014) Marialaura Madrigal et al.   Journal of Translational Medicine

MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease

(2014) L Kordelas et al.   LEUKEMIA

Interspecies communication between plant and mouse gut host cells through edible plant derived exosome-like nanoparticles

(2014) Jingyao Mu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice

(2014) J. Mark Cooper et al.   MOVEMENT DISORDERS

Cells infected with herpes simplex virus 1 export to uninfected cells exosomes containing STING, viral mRNAs, and microRNAs

(2014) Maria Kalamvoki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pre-clinical studies of bone regeneration with human bone marrow stromal cells and biphasic calcium phosphate

(2014) Meadhbh Á Brennan et al.   Stem Cell Research & Therapy

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

(2013) Yanhua Tian et al.   BIOMATERIALS

Mesenchymal stromal cells for organ transplantation

(2013) Martin J. Hoogduijn et al.   Current Opinion in Organ Transplantation

Antigen-specific, antibody-coated, exosome-like nanovesicles deliver suppressor T-cell microRNA-150 to effector T cells to inhibit contact sensitivity

(2013) Krzysztof Bryniarski et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Exosome Uptake Depends on ERK1/2-Heat Shock Protein 27 Signaling and Lipid Raft-mediated Endocytosis Negatively Regulated by Caveolin-1

(2013) Katrin J. Svensson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles

(2013) Sander A.A. Kooijmans et al.   JOURNAL OF CONTROLLED RELEASE

IFNγ-stimulated dendritic cell exosomes as a potential therapeutic for remyelination

(2013) Aya D. Pusic et al.   JOURNAL OF NEUROIMMUNOLOGY

Targeted Drug Delivery to Intestinal Macrophages by Bioactive Nanovesicles Released from Grapefruit

(2013) Baomei Wang et al.   MOLECULAR THERAPY

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

Specific Transfection of Inflamed Brain by Macrophages: A New Therapeutic Strategy for Neurodegenerative Diseases

(2013) Matthew J. Haney et al.   PLoS One

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

Exosomes Mediate the Cytoprotective Action of Mesenchymal Stromal Cells on Hypoxia-Induced Pulmonary Hypertension

(2012) Changjin Lee et al.   CIRCULATION

Microfluidic filtration system to isolate extracellular vesicles from blood

(2012) Ryan T. Davies et al.   LAB ON A CHIP

Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes

(2012) Bow J. Tauro et al.   METHODS

Microvesicle-associated AAV Vector as a Novel Gene Delivery System

(2012) Casey A Maguire et al.   MOLECULAR THERAPY

Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth

(2012) Arda Mizrak et al.   MOLECULAR THERAPY

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

(2012) Shin-ichiro Ohno et al.   MOLECULAR THERAPY

Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes

(2012) Jessica Wahlgren et al.   NUCLEIC ACIDS RESEARCH

Human Embryonic Mesenchymal Stem Cell-Derived Conditioned Medium Rescues Kidney Function in Rats with Established Chronic Kidney Disease

(2012) Arianne van Koppen et al.   PLoS One

Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein

(2012) J. F. Nabhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of Tissues Following Mesenchymal Stromal Cell Therapy in Humans Indicates Limited Long-Term Engraftment and No Ectopic Tissue Formation

(2012) L. von Bahr et al.   STEM CELLS

Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Alleviate Liver Fibrosis

(2012) Tingfen Li et al.   STEM CELLS AND DEVELOPMENT

Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles

(2011) Bence György et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Outer Membrane Vesicles Induce Immune Responses to Virulence Proteins and Protect against Colonization by Enterotoxigenic Escherichia coli

(2011) Koushik Roy et al.   Clinical and Vaccine Immunology

Neutralizing antibodies against adeno-associated virus examined prospectively in pediatric patients with hemophilia

(2011) C Li et al.   GENE THERAPY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Fine-Tuned Expression of Programmed Death 1 Ligands in Mature Dendritic Cells Stimulated by CD40 Ligand Is Critical for the Induction of an Efficient Tumor Specific Immune Response

(2010) Tao Gu et al.   Cellular & Molecular Immunology

Huntington's disease: from molecular pathogenesis to clinical treatment

(2010) Christopher A Ross et al.   LANCET NEUROLOGY

Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell Migration

(2010) Yujing Zhang et al.   MOLECULAR CELL

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

(2010) Dongmei Sun et al.   MOLECULAR THERAPY

Exosomes Communicate Protective Messages during Oxidative Stress; Possible Role of Exosomal Shuttle RNA

(2010) Maria Eldh et al.   PLoS One

Functional delivery of viral miRNAs via exosomes

(2010) D. M. Pegtel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

(2010) Ruenn Chai Lai et al.   Stem Cell Research

Cellular Internalization of Exosomes Occurs Through Phagocytosis

(2010) Du Feng et al.   TRAFFIC

Tissue-Penetrating Delivery of Compounds and Nanoparticles into Tumors

(2009) Kazuki N. Sugahara et al.   CANCER CELL

B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes forin vivofunction

(2009) Melanie A. Ruffner et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

(2009) Isabella Parolini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mesenchymal Stem Cell-Derived Microvesicles Protect Against Acute Tubular Injury

(2009) S. Bruno et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cystic fibrosis

(2009) Brian P O'Sullivan et al.   LANCET

Tolerogenic dendritic cells for autoimmune disease and transplantation

(2008) A W Thomson et al.   ANNALS OF THE RHEUMATIC DISEASES

Exosome-Like Vesicles with Dipeptidyl Peptidase IV in Human Saliva

(2008) Yuko Ogawa et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Phase I Clinical Trial of Autologous Ascites-derived Exosomes Combined With GM-CSF for Colorectal Cancer

(2008) Shengming Dai et al.   MOLECULAR THERAPY

Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

(2008) Khalid Al-Nedawi et al.   NATURE CELL BIOLOGY

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

A microRNA-based gene dysregulation pathway in Huntington's disease

(2007) Rory Johnson et al.   NEUROBIOLOGY OF DISEASE