Multifunctional nucleic acid nanostructures for gene therapies

A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo

(2018) Suping Li et al.   NATURE BIOTECHNOLOGY

Poly-sgRNA/siRNA ribonucleoprotein nanoparticles for targeted gene disruption

(2017) Jong Seong Ha et al.   JOURNAL OF CONTROLLED RELEASE

Delivery strategies of the CRISPR-Cas9 gene-editing system for therapeutic applications

(2017) Chang Liu et al.   JOURNAL OF CONTROLLED RELEASE

Fractal assembly of micrometre-scale DNA origami arrays with arbitrary patterns

(2017) Grigory Tikhomirov et al.   NATURE

Oligolysine-based coating protects DNA nanostructures from low-salt denaturation and nuclease degradation

(2017) Nandhini Ponnuswamy et al.   Nature Communications

Facile synthesis of size-tunable superparamagnetic/polymeric core/shell nanoparticles by metal-free atom transfer radical polymerization at ambient temperature

(2017) Xiaobing Wang et al.   RSC Advances

Library siRNA-generating RNA nanosponges for gene silencing by complementary rolling circle transcription

(2017) Sangwoo Han et al.   Scientific Reports

Multiple-Armed Tetrahedral DNA Nanostructures for Tumor-Targeting, Dual-Modality in Vivo Imaging

(2016) Dawei Jiang et al.   ACS Applied Materials & Interfaces

A Photosensitizer-Loaded DNA Origami Nanosystem for Photodynamic Therapy

(2016) Xiaoxi Zhuang et al.   ACS Nano

DNA-Nanostructure-Gold-Nanorod Hybrids for Enhanced In Vivo Optoacoustic Imaging and Photothermal Therapy

(2016) Yang Du et al.   ADVANCED MATERIALS

Transfer of Two-Dimensional Oligonucleotide Patterns onto Stereocontrolled Plasmonic Nanostructures through DNA-Origami-Based Nanoimprinting Lithography

(2016) Yinan Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multifunctional aptamer-based nanoparticles for targeted drug delivery to circumvent cancer resistance

(2016) Juan Liu et al.   BIOMATERIALS

Gene Therapy for “Bubble Boy” Disease

(2016) Jonathan Hoggatt   CELL

Optimized DNA “Nanosuitcases” for Encapsulation and Conditional Release of siRNA

(2016) Katherine E. Bujold et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A DNA dual lock-and-key strategy for cell-subtype-specific siRNA delivery

(2016) Kewei Ren et al.   Nature Communications

Dendrimeric siRNA for Efficient Gene Silencing

(2015) Cheol Am Hong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficient construction of stable gene nanoparticles through polymerase chain reaction with flexible branched primers for gene delivery

(2015) Jianbing Liu et al.   CHEMICAL COMMUNICATIONS

Nucleic Acid Therapeutics Using Polyplexes: A Journey of 50 Years (and Beyond)

(2015) Ulrich Lächelt et al.   CHEMICAL REVIEWS

Self-assembly of DNA Nanohydrogels with Controllable Size and Stimuli-Responsive Property for Targeted Gene Regulation Therapy

(2015) Juan Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Gene therapy returns to centre stage

(2015) Luigi Naldini   NATURE

$1-million price tag set for Glybera gene therapy

(2015) Chris Morrison   NATURE BIOTECHNOLOGY

DNA nanotechnology from the test tube to the cell

(2015) Yuan-Jyue Chen et al.   Nature Nanotechnology

Design of a platform technology for systemic delivery of siRNA to tumours using rolling circle transcription

(2015) Mihue Jang et al.   Nature Communications

DNA Origami as an In Vivo Drug Delivery Vehicle for Cancer Therapy

(2014) Qian Zhang et al.   ACS Nano

DNA Nanoflowers for Multiplexed Cellular Imaging and Traceable Targeted Drug Delivery

(2014) Rong Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development and Applications of CRISPR-Cas9 for Genome Engineering

(2014) Patrick D. Hsu et al.   CELL

Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos

(2014) Yuyu Niu et al.   CELL

Rolling circle amplification: a versatile tool for chemical biology, materials science and medicine

(2014) M. Monsur Ali et al.   CHEMICAL SOCIETY REVIEWS

Engineering adeno-associated viruses for clinical gene therapy

(2014) Melissa A. Kotterman et al.   NATURE REVIEWS GENETICS

Thermostable Branched DNA Nanostructures as Modular Primers for Polymerase Chain Reaction

(2013) Mark R. Hartman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development and Characterization of Gene Silencing DNA Cages

(2013) Johans J. Fakhoury et al.   BIOMACROMOLECULES

One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering

(2013) Haoyi Wang et al.   CELL

Noncanonical Self-Assembly of Multifunctional DNA Nanoflowers for Biomedical Applications

(2013) Guizhi Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Three-Dimensional Plasmonic Chiral Tetramers Assembled by DNA Origami

(2013) Xibo Shen et al.   NANO LETTERS

Efficient genome editing in zebrafish using a CRISPR-Cas system

(2013) Woong Y Hwang et al.   NATURE BIOTECHNOLOGY

Delivery materials for siRNA therapeutics

(2013) Rosemary Kanasty et al.   NATURE MATERIALS

Two DNA nanomachines map pH changes along intersecting endocytic pathways inside the same cell

(2013) Souvik Modi et al.   Nature Nanotechnology

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Rolling Circle Amplification-Based DNA Origami Nanostructrures for Intracellular Delivery of Immunostimulatory Drugs

(2013) Xiangyuan Ouyang et al.   Small

Small-Interfering RNA (siRNA)-Based Functional Micro- and Nanostructures for Efficient and Selective Gene Silencing

(2012) Soo Hyeon Lee et al.   ACCOUNTS OF CHEMICAL RESEARCH

Design and Development of Nanosized DNA Assemblies in Polypod-like Structures as Efficient Vehicles for Immunostimulatory CpG Motifs to Immune Cells

(2012) Kohta Mohri et al.   ACS Nano

DNA Origami Delivery System for Cancer Therapy with Tunable Release Properties

(2012) Yong-Xing Zhao et al.   ACS Nano

Visualization of the intracellular location and stability of DNA origami with a label-free fluorescent probe

(2012) Xibo Shen et al.   CHEMICAL COMMUNICATIONS

DNA Origami as a Carrier for Circumvention of Drug Resistance

(2012) Qiao Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Self-assembled RNA interference microsponges for efficient siRNA delivery

(2012) Jong Bum Lee et al.   NATURE MATERIALS

A mechanical metamaterial made from a DNA hydrogel

(2012) Jong Bum Lee et al.   Nature Nanotechnology

Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

(2012) Hyukjin Lee et al.   Nature Nanotechnology

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads

(2012) S. M. Douglas et al.   SCIENCE

Cellular Immunostimulation by CpG-Sequence-Coated DNA Origami Structures

(2011) Verena J. Schüller et al.   ACS Nano

Self-Assembled Multivalent DNA Nanostructures for Noninvasive Intracellular Delivery of Immunostimulatory CpG Oligonucleotides

(2011) Jiang Li et al.   ACS Nano

Encapsulation of Gold Nanoparticles in a DNA Origami Cage

(2011) Zhao Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Gene Silencing by siRNA Microhydrogels via Polymeric Nanoscale Condensation

(2011) Cheol Am Hong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rolling Up Gold Nanoparticle-Dressed DNA Origami into Three-Dimensional Plasmonic Chiral Nanostructures

(2011) Xibo Shen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A synthetic icosahedral DNA-based host–cargo complex for functional in vivo imaging

(2011) Dhiraj Bhatia et al.   Nature Communications

Orthogonal Protein Decoration of DNA Origami

(2010) Barbara Saccà et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nanomaterials Based on DNA

(2010) Nadrian C. Seeman   Annual Review of Biochemistry

Biodegradable CpG DNA hydrogels for sustained delivery of doxorubicin and immunostimulatory signals in tumor-bearing mice

(2010) Makiya Nishikawa et al.   BIOMATERIALS

Loading and selective release of cargo in DNA nanotubes with longitudinal variation

(2010) Pik Kwan Lo et al.   Nature Chemistry

On the Chirality of Self-Assembled DNA Octahedra

(2009) Yu He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Icosahedral DNA Nanocapsules by Modular Assembly

(2009) Dhiraj Bhatia et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

High-Resolution Structural Analysis of a DNA Nanostructure by cryoEM

(2009) Takayuki Kato et al.   NANO LETTERS

From molecular to macroscopic via the rational design of a self-assembled 3D DNA crystal

(2009) Jianping Zheng et al.   NATURE

A cell-free protein-producing gel

(2009) Nokyoung Park et al.   NATURE MATERIALS

Multifunctional nanoarchitectures from DNA-based ABC monomers

(2009) Jong B. Lee et al.   Nature Nanotechnology

A DNA nanomachine that maps spatial and temporal pH changes inside living cells

(2009) Souvik Modi et al.   Nature Nanotechnology

High-yield cell-free protein production from P-gel

(2009) Nokyoung Park et al.   Nature Protocols

Self-Assembly of a DNA Dodecahedron from 20 Trisoligonucleotides withC3h Linkers

(2008) Jan Zimmermann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cooperative Melting in Caged Dimers of Rigid Small Molecule-DNA Hybrids

(2008) Brian R. Stepp et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hierarchical self-assembly of DNA into symmetric supramolecular polyhedra

(2008) Yu He et al.   NATURE

Reconfigurable, braced, three-dimensional DNA nanostructures

(2008) Russell P. Goodman et al.   Nature Nanotechnology

Inorganic Nanoparticles as Carriers of Nucleic Acids into Cells

(2007) Viktoriya Sokolova et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION