Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA

Nanoparticles Containing Oxidized Cholesterol Deliver mRNA to the Liver Microenvironment at Clinically Relevant Doses

(2019) Kalina Paunovska et al.   ADVANCED MATERIALS

On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA

(2018) Jayesh A. Kulkarni et al.   ACS Nano

Analyzing 2000 in Vivo Drug Delivery Data Points Reveals Cholesterol Structure Impacts Nanoparticle Delivery

(2018) Kalina Paunovska et al.   ACS Nano

Structure of Lipid Nanoparticles Containing siRNA or mRNA by Dynamic Nuclear Polarization-Enhanced NMR Spectroscopy

(2018) Jasmine Viger-Gravel et al.   JOURNAL OF PHYSICAL CHEMISTRY B

A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates

(2018) Staci Sabnis et al.   MOLECULAR THERAPY

Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles

(2018) Marianna Yanez Arteta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Protocol for Real-time 3D Single Particle Tracking

(2018) Shangguo Hou et al.   Jove-Journal of Visualized Experiments

Dendrimer-Based Lipid Nanoparticles Deliver Therapeutic FAH mRNA to Normalize Liver Function and Extend Survival in a Mouse Model of Hepatorenal Tyrosinemia Type I

(2018) Qiang Cheng et al.   ADVANCED MATERIALS

Investigation of charge ratio variation in mRNA – DEAE-dextran polyplex delivery systems

(2018) C. Siewert et al.   BIOMATERIALS

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Robust real-time 3D single-particle tracking using a dynamically moving laser spot

(2017) Shangguo Hou et al.   OPTICS LETTERS

Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex

(2017) Brian M. Castellano et al.   SCIENCE

Tools for translation: non-viral materials for therapeutic mRNA delivery

(2017) Khalid A. Hajj et al.   Nature Reviews Materials

Classification and Segmentation of Nanoparticle Diffusion Trajectories in Cellular Micro Environments

(2017) Thorsten Wagner et al.   PLoS One

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

(2016) Xin Gong et al.   CELL

LDL–cholesterol transport to the endoplasmic reticulum

(2016) Simon G. Pfisterer et al.   CURRENT OPINION IN LIPIDOLOGY

Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2

(2016) Xiaochun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New Developments in Liposomal Drug Delivery

(2015) Bhushan S. Pattni et al.   CHEMICAL REVIEWS

An Orthogonal Array Optimization of Lipid-like Nanoparticles for mRNA Delivery in Vivo

(2015) Bin Li et al.   NANO LETTERS

Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs

(2015) Kevin J. Kauffman et al.   NANO LETTERS

The Structural Role of Cholesterol in Cell Membranes: From Condensed Bilayers to Lipid Rafts

(2014) Martin R. Krause et al.   ACCOUNTS OF CHEMICAL RESEARCH

5-Fluorouracil–lipid conjugate: Potential candidate for drug delivery through encapsulation in hydrophobic polyester-based nanoparticles

(2014) N. Ashwanikumar et al.   Acta Biomaterialia

A comparative calorimetric study of the effects of cholesterol and the plant sterols campesterol and brassicasterol on the thermotropic phase behavior of dipalmitoylphosphatidylcholine bilayer membranes

(2014) Matthew G.K. Benesch et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Membrane composition and dynamics: A target of bioactive virgin olive oil constituents

(2014) Sergio Lopez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mechanism of Macromolecular Structure Evolution in Self-Assembled Lipid Nanoparticles for siRNA Delivery

(2014) Marian E. Gindy et al.   LANGMUIR

mRNA-based therapeutics — developing a new class of drugs

(2014) Ugur Sahin et al.   NATURE REVIEWS DRUG DISCOVERY

Bidirectional cargo transport: moving beyond tug of war

(2014) William O. Hancock   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

(2013) Jerome Gilleron et al.   NATURE BIOTECHNOLOGY

Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

(2013) Gaurav Sahay et al.   NATURE BIOTECHNOLOGY

Nucleic Acid Delivery: The Missing Pieces of the Puzzle?

(2012) Juliane Nguyen et al.   ACCOUNTS OF CHEMICAL RESEARCH

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

(2012) Muthusamy Jayaraman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A comparison of the behavior of cholesterol, 7-dehydrocholesterol and ergosterol in phospholipid membranes

(2012) Changfeng Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Transfection efficiency boost of cholesterol-containing lipoplexes

(2012) Daniela Pozzi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The role of the helper lipid dioleoylphosphatidylethanolamine (DOPE) for DNA transfection cooperating with a cationic lipid bearing ethylenediamine

(2012) Shinichi Mochizuki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Plant sterols and cardiovascular disease: a systematic review and meta-analysis†

(2012) Bernd Genser et al.   EUROPEAN HEART JOURNAL

Lipid Nanoparticles Containing siRNA Synthesized by Microfluidic Mixing Exhibit an Electron-Dense Nanostructured Core

(2012) Alex K. K. Leung et al.   Journal of Physical Chemistry C

Regulation of cholesterol homeostasis

(2011) Leigh Goedeke et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Biosynthesis of Cholesterol and Other Sterols

(2011) W. David Nes   CHEMICAL REVIEWS

Ebola virus entry requires the cholesterol transporter Niemann–Pick C1

(2011) Jan E. Carette et al.   NATURE

Plant pentacyclic triterpenic acids as modulators of lipid membrane physical properties

(2010) Jesús Prades et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Modulation of signal transduction in cancer cells by phytosterols

(2010) Peter G. Bradford et al.   BIOFACTORS

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

(2010) Akin Akinc et al.   MOLECULAR THERAPY

The Role of Cholesterol and Structurally Related Molecules in Enhancing Transfection of Cationic Liposome−DNA Complexes

(2009) Alexandra Zidovska et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Cationic phospholipids: structure–transfection activity relationships

(2009) Rumiana Koynova et al.   Soft Matter

Differential Modulation of Membrane Structure and Fluctuations by Plant Sterols and Cholesterol

(2008) Aden Hodzic et al.   BIOPHYSICAL JOURNAL

High-speed varifocal imaging with a tunable acoustic gradient index of refraction lens

(2008) Alexandre Mermillod-Blondin et al.   OPTICS LETTERS

NPC1/NPC2 function as a tag team duo to mobilize cholesterol

(2008) K. Subramanian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of the intracellular dynamics of a non-degradative pathway accessed by polymer nanoparticles

(2007) Samuel K. Lai et al.   JOURNAL OF CONTROLLED RELEASE