Lipid-based mRNA vaccine delivery systems

Potentiation of pH-sensitive polymer-modified liposomes with cationic lipid inclusion as antigen delivery carriers for cancer immunotherapy

(2014) Yuta Yoshizaki et al.   BIOMATERIALS

A multivalent inhibitor of the DC-SIGN dependent uptake of HIV-1 and Dengue virus

(2014) Norbert Varga et al.   BIOMATERIALS

Glycosylation-Dependent Interactions of C-Type Lectin DC-SIGN with Colorectal Tumor-Associated Lewis Glycans Impair the Function and Differentiation of Monocyte-Derived Dendritic Cells

(2014) M. Nonaka et al.   JOURNAL OF IMMUNOLOGY

Effects of a Novel Archaeal Tetraether-Based Colipid on the In Vivo Gene Transfer Activity of Two Cationic Amphiphiles

(2014) Tony Le Gall et al.   MOLECULAR PHARMACEUTICS

mRNA-based therapeutics — developing a new class of drugs

(2014) Ugur Sahin et al.   NATURE REVIEWS DRUG DISCOVERY

Intranasal mRNA nanoparticle vaccination induces prophylactic and therapeutic anti-tumor immunity

(2014) Kyle K. L. Phua et al.   Scientific Reports

mRNA vaccine CV9103 and CV9104 for the treatment of prostate cancer

(2014) Steffen Rausch et al.   Human Vaccines & Immunotherapeutics

The Effects of β -Glucans on Dendritic Cells and Implications for Cancer Therapy

(2013) Sabrin H. Albeituni et al.   Anti-Cancer Agents in Medicinal Chemistry

The Headgroup Evolution of Cationic Lipids for Gene Delivery

(2013) Defu Zhi et al.   BIOCONJUGATE CHEMISTRY

Exogenous mRNA delivery and bioavailability in gene transfer mediated by piggyBac transposition

(2013) Solenne Bire et al.   BMC BIOTECHNOLOGY

Sonoporation: Mechanistic insights and ongoing challenges for gene transfer

(2013) Anthony Delalande et al.   GENE

The Dectin-2 family of C-type lectin-like receptors: an update

(2013) Bernhard Kerscher et al.   INTERNATIONAL IMMUNOLOGY

Structure of a Glycomimetic Ligand in the Carbohydrate Recognition Domain of C-type Lectin DC-SIGN. Structural Requirements for Selectivity and Ligand Design

(2013) Michel Thépaut et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

RNA Replicon Delivery via Lipid-Complexed PRINT Protein Particles

(2013) Jing Xu et al.   MOLECULAR PHARMACEUTICS

Challenges and advances towards the rational design of mRNA vaccines

(2013) Charlotte Pollard et al.   TRENDS IN MOLECULAR MEDICINE

Gene transfer by chemical vectors, and endocytosis routes of polyplexes, lipoplexes and lipopolyplexes in a myoblast cell line

(2012) Ludivine Billiet et al.   BIOMATERIALS

A long-lasting dendritic cell DNA vaccination system using lysinylated amphiphiles with mannose-mimicking head-groups

(2012) Ramishetti Srinivas et al.   BIOMATERIALS

DC-SIGN Antagonists, a Potential New Class of Anti-Infectives

(2012) M. Anderluh et al.   CURRENT MEDICINAL CHEMISTRY

The mannose receptor

(2012) Luisa Martinez-Pomares   JOURNAL OF LEUKOCYTE BIOLOGY

Type I IFN Counteracts the Induction of Antigen-Specific Immune Responses by Lipid-Based Delivery of mRNA Vaccines

(2012) Charlotte Pollard et al.   MOLECULAR THERAPY

Nonviral delivery of self-amplifying RNA vaccines

(2012) A. J. Geall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic Archaeosome Vaccines Containing Triglycosylarchaeols Can Provide Additive and Long-Lasting Immune Responses That Are Enhanced by Archaetidylserine

(2012) G. Dennis Sprott et al.   ARCHAEA-AN INTERNATIONAL MICROBIOLOGICAL JOURNAL

Selective uptake of naked vaccine RNA by dendritic cells is driven by macropinocytosis and abrogated upon DC maturation

(2011) M Diken et al.   GENE THERAPY

mRNA: delivering an antitumor message?

(2011) Sandra Van Lint et al.   Immunotherapy

Gene transfer by histidylated lipopolyplexes: A dehydration method allowing preservation of their physicochemical parameters and transfection efficiency

(2011) Federico Perche et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

In Vitroandin VivomRNA Delivery Using Lipid-Enveloped pH-Responsive Polymer Nanoparticles

(2011) Xingfang Su et al.   MOLECULAR PHARMACEUTICS

Enhancement of dendritic cells transfection in vivo and of vaccination against B16F10 melanoma with mannosylated histidylated lipopolyplexes loaded with tumor antigen messenger RNA

(2011) Federico Perche et al.   Nanomedicine-Nanotechnology Biology and Medicine

Second generation of fucose-based DC-SIGN ligands : affinity improvement and specificity versus Langerin

(2011) Manuel Andreini et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Glycomimetic Building Blocks: A Divergent Synthesis of Epimers of Shikimic Acid

(2011) Joseph C. Grim et al.   ORGANIC LETTERS

Protein expression from exogenous mRNA: Uptake by receptor-mediated endocytosis and trafficking via the lysosomal pathway

(2011) Christina Lorenz et al.   RNA Biology

Quinoxalinoneinhibitors of the lectin DC-SIGN

(2011) Shane L. Mangold et al.   Chemical Science

Intranodal Vaccination with Naked Antigen-Encoding RNA Elicits Potent Prophylactic and Therapeutic Antitumoral Immunity

(2010) S. Kreiter et al.   CANCER RESEARCH

Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA

(2010) Luigi Warren et al.   Cell Stem Cell

A general glycomimetic strategy yields non-carbohydrate inhibitors of DC-SIGN

(2010) Kathleen C. A. Garber et al.   CHEMICAL COMMUNICATIONS

Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo

(2010) A N Kuhn et al.   GENE THERAPY

Dectin-2 Recognition of α-Mannans and Induction of Th17 Cell Differentiation Is Essential for Host Defense against Candida albicans

(2010) Shinobu Saijo et al.   IMMUNITY

Caveolin-1 is ubiquitinated and targeted to intralumenal vesicles in endolysosomes for degradation

(2010) Arnold Hayer et al.   JOURNAL OF CELL BIOLOGY

Selective gene delivery in dendritic cells with mannosylated and histidylated lipopolyplexes

(2010) Federico Perche et al.   JOURNAL OF DRUG TARGETING

Messenger RNA-based Vaccines With Dual Activity Induce Balanced TLR-7 Dependent Adaptive Immune Responses and Provide Antitumor Activity

(2010) Mariola Fotin-Mleczek et al.   JOURNAL OF IMMUNOTHERAPY

Cationic Amphiphile with Shikimic Acid Headgroup Shows More Systemic Promise Than Its Mannosyl Analogue as DNA Vaccine Carrier in Dendritic Cell Based Genetic Immunization

(2010) Ramishetti Srinivas et al.   JOURNAL OF MEDICINAL CHEMISTRY

C-type lectin Langerin is a β-glucan receptor on human Langerhans cells that recognizes opportunistic and pathogenic fungi

(2010) Marein A.W.P. de Jong et al.   MOLECULAR IMMUNOLOGY

Intradermal Vaccinations With RNA Coding for TAA Generate CD8+ and CD4+ Immune Responses and Induce Clinical Benefit in Vaccinated Patients

(2010) Susanne M Rittig et al.   MOLECULAR THERAPY

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers

(2009) Patrick Midoux et al.   BRITISH JOURNAL OF PHARMACOLOGY

Development of new glycosylation methodologies for the synthesis of archaeal-derived glycolipid adjuvants

(2009) Dennis M. Whitfield et al.   CARBOHYDRATE RESEARCH

Dual Specificity of Langerin to Sulfated and Mannosylated Glycans via a Single C-type Carbohydrate Recognition Domain

(2009) Hiroaki Tateno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Injection of Protamine-protected mRNA: Results of a Phase 1/2 Vaccination Trial in Metastatic Melanoma Patients

(2009) Benjamin Weide et al.   JOURNAL OF IMMUNOTHERAPY

Influence of Ligand Valency on the Targeting of Immature Human Dendritic Cells by Mannosylated Liposomes

(2008) Socorro Espuelas et al.   BIOCONJUGATE CHEMISTRY

Nonviral Vectors for Gene Delivery

(2008) Meredith A. Mintzer et al.   CHEMICAL REVIEWS

Plasmid DNA- and messenger RNA-based anti-cancer vaccination

(2007) Benjamin Weide et al.   IMMUNOLOGY LETTERS