mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability

Nanomaterial Delivery Systems for mRNA Vaccines

(2021) Michael D. Buschmann et al.   Vaccines

Self-assembled mRNA vaccines

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Apolipoprotein E Binding Drives Structural and Compositional Rearrangement of mRNA-Containing Lipid Nanoparticles

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Encapsulation state of messenger RNA inside lipid nanoparticles

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The dawn of mRNA vaccines: The COVID-19 case

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Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

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Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA

(2020) Siddharth Patel et al.   Nature Communications

The promise of mRNA vaccines: a biotech and industrial perspective

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Deconvoluting Lipid Nanoparticle Structure for Messenger RNA Delivery

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Self‐Degradable Lipid‐Like Materials Based on “Hydrolysis accelerated by the intra‐Particle Enrichment of Reactant (HyPER)” for Messenger RNA Delivery

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A Thermostable mRNA Vaccine against COVID-19

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An Alphavirus-derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates

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Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice

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Long-term storage of lipid-like nanoparticles for mRNA delivery

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Analytical characterization of liposomes and other lipid nanoparticles for drug delivery

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Addressing the Cold Reality of mRNA Vaccine Stability

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COVID-19 vaccines poised for launch, but impact on pandemic unclear

(2020) Elie Dolgin   NATURE BIOTECHNOLOGY

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

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HPLC methods for purity evaluation of man-made single-stranded RNAs

(2019) Anastassia Kanavarioti   Scientific Reports

Formulation of Biocompatible Targeted ECO/siRNA Nanoparticles with Long-Term Stability for Clinical Translation of RNAi

(2019) Nadia R. Ayat et al.   Nucleic Acid Therapeutics

Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines

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Visualization of early events in mRNA vaccine delivery in non-human primates via PET–CT and near-infrared imaging

(2019) Kevin E. Lindsay et al.   Nature Biomedical Engineering

Three decades of messenger RNA vaccine development

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Establishing Preferred Product Characterization for the Evaluation of RNA Vaccine Antigens

(2019) Cristina Poveda et al.   Vaccines

Quantitative analysis of cholesterol oxidation products and desmosterol in parenteral liposomal pharmaceutical formulations

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mRNA structure regulates protein expression through changes in functional half-life

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On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA

(2018) Jayesh A. Kulkarni et al.   ACS Nano

Structure of Lipid Nanoparticles Containing siRNA or mRNA by Dynamic Nuclear Polarization-Enhanced NMR Spectroscopy

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Self-Amplifying RNA Vaccines Give Equivalent Protection against Influenza to mRNA Vaccines but at Much Lower Doses

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mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles

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Development of an Alcohol Dilution–Lyophilization Method for Preparing Lipid Nanoparticles Containing Encapsulated siRNA

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Induction of an IFN-Mediated Antiviral Response by a Self-Amplifying RNA Vaccine: Implications for Vaccine Design

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Efficient Targeting and Activation of Antigen-Presenting Cells In Vivo after Modified mRNA Vaccine Administration in Rhesus Macaques

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A thermostable messenger RNA based vaccine against rabies

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Critical considerations for developing nucleic acid macromolecule based drug products

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Achieving long-term stability of lipid nanoparticles: examining the effect of pH, temperature, and lyophilization

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Materials for non-viral intracellular delivery of messenger RNA therapeutics

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siRNA-lipid nanoparticles with long-term storage stability facilitate potent gene-silencing in vivo

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Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

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Microfluidic Mixing: A General Method for Encapsulating Macromolecules in Lipid Nanoparticle Systems

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Characterization of Titratable Amphiphiles in Lipid Membranes by Fluorescence Spectroscopy

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Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals

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Freeze-drying of live virus vaccines: A review

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Understanding Nucleic Acid–Ion Interactions

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Pseudouridine in a new era of RNA modifications

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mRNA-based therapeutics — developing a new class of drugs

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An efficient method for long-term room temperature storage of RNA

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Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

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Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection

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Quantification of RNA integrity and its use for measurement of transcript number

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Degradation of mRNAs that lack a stop codon: a decade of nonstop progress

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GC content around splice sites affects splicing through pre-mRNA secondary structures

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Impact of freezing on pH of buffered solutions and consequences for monoclonal antibody aggregation

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The Many Pathways of RNA Degradation

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Immunize and disappear—Safety-optimized mRNA vaccination with a panel of 29 allergens

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