Neutralized Nanoparticle Composed of SS-Cleavable and pH-Activated Lipid-Like Material as a Long-Lasting and Liver-Specific Gene Delivery System

A Neutral Envelope-Type Nanoparticle Containing pH-Responsive and SS-Cleavable Lipid-Like Material as a Carrier for Plasmid DNA

(2013) Hidetaka Akita et al.   Advanced Healthcare Materials

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

(2012) Muthusamy Jayaraman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Particle Tracking Analysis for the Intracellular Trafficking of Nanoparticles Modified with African Swine Fever Virus Protein p54-derived Peptide

(2012) Hidetaka Akita et al.   MOLECULAR THERAPY

Functional Silica Nanoparticles for Redox-Triggered Drug/ssDNA Co-delivery

(2012) Xing Ma et al.   Advanced Healthcare Materials

KALA-modified multi-layered nanoparticles as gene carriers for MHC class-I mediated antigen presentation for a DNA vaccine

(2011) Sharif M. Shaheen et al.   BIOMATERIALS

AAV-mediated gene therapy for liver diseases: the prime candidate for clinical application?

(2011) Luc JW van der Laan et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Development of a suction device for stabilizing in vivo real-time imaging of murine tissues

(2011) Kazunori Shimizu et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

In situ quantitative monitoring of polyplexes and polyplex micelles in the blood circulation using intravital real-time confocal laser scanning microscopy

(2011) Takahiro Nomoto et al.   JOURNAL OF CONTROLLED RELEASE

Octaarginine- and pH sensitive fusogenic peptide-modified nanoparticles for liver gene delivery

(2011) Ikramy A. Khalil et al.   JOURNAL OF CONTROLLED RELEASE

Nanoparticles for ex vivo siRNA delivery to dendritic cells for cancer vaccines: Programmed endosomal escape and dissociation☆

(2010) Hidetaka Akita et al.   JOURNAL OF CONTROLLED RELEASE

Sustained Exogenous Expression of Therapeutic Levels of IFN-γ Ameliorates Atopic Dermatitis in NC/Nga Mice via Th1 Polarization

(2010) Kayoko Hattori et al.   JOURNAL OF IMMUNOLOGY

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

(2010) Akin Akinc et al.   MOLECULAR THERAPY

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

Hydrodynamic Gene Delivery and Its Applications in Pharmaceutical Research

(2010) Barbara Bonamassa et al.   PHARMACEUTICAL RESEARCH

The Role of Liver Sinusoidal Cells in Hepatocyte-Directed Gene Transfer

(2009) Frank Jacobs et al.   AMERICAN JOURNAL OF PATHOLOGY

Effect of the content of unmethylated CpG dinucleotides in plasmid DNA on the sustainability of transgene expression

(2009) Masaru Mitsui et al.   JOURNAL OF GENE MEDICINE

The size of endothelial fenestrae in human liver sinusoids: implications for hepatocyte-directed gene transfer

(2008) E Wisse et al.   GENE THERAPY

CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression

(2008) Stephen C Hyde et al.   NATURE BIOTECHNOLOGY