Lipid nanoparticle delivery systems for siRNA-based therapeutics

Abstract LB-289: A phase I dose escalation study of TKM-080301, a RNAi therapeutic directed against PLK1, in patients with advanced solid tumors.

(2014) Ramesh K. Ramanathan et al.   CANCER RESEARCH

VEGFA and tumour angiogenesis

(2013) L. Claesson-Welsh et al.   JOURNAL OF INTERNAL MEDICINE

Liposomal drug delivery systems: From concept to clinical applications

(2012) Theresa M. Allen et al.   ADVANCED DRUG DELIVERY REVIEWS

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

(2012) Muthusamy Jayaraman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficacy and Safety of Pegylated Liposomal Doxorubicin in Combination With Bortezomib for Multiple Myeloma: Effects of Adverse Prognostic Factors on Outcome

(2012) Joan Bladé et al.   Clinical Lymphoma Myeloma & Leukemia

Lipid Nanoparticles Containing siRNA Synthesized by Microfluidic Mixing Exhibit an Electron-Dense Nanostructured Core

(2012) Alex K. K. Leung et al.   Journal of Physical Chemistry C

Bottom-Up Design and Synthesis of Limit Size Lipid Nanoparticle Systems with Aqueous and Triglyceride Cores Using Millisecond Microfluidic Mixing

(2012) Igor V. Zhigaltsev et al.   LANGMUIR

Action and Reaction: The Biological Response to siRNA and Its Delivery Vehicles

(2012) Rosemary L Kanasty et al.   MOLECULAR THERAPY

Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA

(2012) Nathan M Belliveau et al.   Molecular Therapy-Nucleic Acids

The Role of Proprotein Convertase Subtilisin/Kexin Type 9 in Hyperlipidemia

(2011) Michel Farnier   American Journal of Cardiovascular Drugs

Clinical aspects of PCSK9

(2011) Bertrand Cariou et al.   ATHEROSCLEROSIS

Lipid nanoparticle siRNA systems for silencing the androgen receptor in human prostate cancer in vivo

(2011) Justin B. Lee et al.   INTERNATIONAL JOURNAL OF CANCER

Selective Therapeutic Targeting of the Anaplastic Lymphoma Kinase With Liposomal siRNA Induces Apoptosis and Inhibits Angiogenesis in Neuroblastoma

(2011) Daniela Di Paolo et al.   MOLECULAR THERAPY

Influence of Cationic Lipid Composition on Gene Silencing Properties of Lipid Nanoparticle Formulations of siRNA in Antigen-Presenting Cells

(2011) Genc Basha et al.   MOLECULAR THERAPY

siRNAs: Potential therapeutic agents against Hepatitis C Virus

(2011) Usman A Ashfaq et al.   Virology Journal

RNA interference-based therapeutics for human immunodeficiency virus HIV-1 treatment: synthetic siRNA or vector-based shRNA?

(2010) Sandesh Subramanya et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Strategies for proprotein convertase subtilisin kexin 9 modulation: a perspective on recent patents

(2010) Marianne Abifadel et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

From “Banghasomes” to liposomes: A memoir of Alec Bangham, 1921–2010

(2010) David W. Deamer   FASEB JOURNAL

Development of a weak-base docetaxel derivative that can be loaded into lipid nanoparticles

(2010) Igor V. Zhigaltsev et al.   JOURNAL OF CONTROLLED RELEASE

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

(2010) Akin Akinc et al.   MOLECULAR THERAPY

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus

(2010) J. DeVincenzo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA interference-based gene therapy for successful treatment of rheumatoid arthritis

(2009) Gabriel Courties et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Physiologic upper limit of pore size in the blood-tumor barrier of malignant solid tumors

(2009) Hemant Sarin et al.   Journal of Translational Medicine

Chemical Modification of siRNAs for In Vivo Use

(2008) Mark A. Behlke   OLIGONUCLEOTIDES