Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3
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Title
Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3
Authors
Keywords
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Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 118, Issue 10, Pages e2020401118
Publisher
Proceedings of the National Academy of Sciences
Online
2021-03-02
DOI
10.1073/pnas.2020401118
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Note: Only part of the references are listed.- The promise and challenge of therapeutic genome editing
- (2020) Jennifer A. Doudna NATURE
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- Fast and Efficient CRISPR/Cas9 Genome Editing In Vivo Enabled by Bioreducible Lipid and Messenger RNA Nanoparticles
- (2019) Ji Liu et al. ADVANCED MATERIALS
- Non-viral nanoparticles for CRISPR-based genome editing: is it just a simple adaption of what have been developed for nucleic acid delivery?
- (2019) Min Qiu et al. BIOMACROMOLECULES
- Inhibition of Angiopoietin-Like Protein 3 With a Monoclonal Antibody Reduces Triglycerides in Hypertriglyceridemia
- (2019) Zahid Ahmad et al. CIRCULATION
- Engineered materials for in vivo delivery of genome-editing machinery
- (2019) Sheng Tong et al. Nature Reviews Materials
- The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs
- (2019) Akin Akinc et al. Nature Nanotechnology
- Reduced Blood Lipid Levels With In Vivo CRISPR-Cas9 Base Editing of ANGPTL3
- (2018) Alexandra C. Chadwick et al. CIRCULATION
- A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates
- (2018) Staci Sabnis et al. MOLECULAR THERAPY
- Engineering the Delivery System for CRISPR-Based Genome Editing
- (2018) Zachary Glass et al. TRENDS IN BIOTECHNOLOGY
- A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing
- (2018) Jonathan D. Finn et al. Cell Reports
- ANGPTL3 Deficiency and Protection Against Coronary Artery Disease
- (2017) Nathan O. Stitziel et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Cardiovascular endocrinology: Is ANGPTL3 the next PCSK9?
- (2017) Kiran Musunuru et al. Nature Reviews Endocrinology
- Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides
- (2017) Mark J. Graham et al. NEW ENGLAND JOURNAL OF MEDICINE
- Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease
- (2017) Frederick E. Dewey et al. NEW ENGLAND JOURNAL OF MEDICINE
- Safety Evaluation of Lipid Nanoparticle–Formulated Modified mRNA in the Sprague-Dawley Rat and Cynomolgus Monkey
- (2017) Maja Sedic et al. VETERINARY PATHOLOGY
- Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA
- (2016) Jason B. Miller et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Non-viral delivery of genome-editing nucleases for gene therapy
- (2016) M Wang et al. GENE THERAPY
- Engineered Viruses as Genome Editing Devices
- (2016) Xiaoyu Chen et al. MOLECULAR THERAPY
- Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles
- (2016) Ming Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rapid and highly efficient mammalian cell engineering via Cas9 protein transfection
- (2015) Xiquan Liang et al. JOURNAL OF BIOTECHNOLOGY
- An Orthogonal Array Optimization of Lipid-like Nanoparticles for mRNA Delivery in Vivo
- (2015) Bin Li et al. NANO LETTERS
- Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs
- (2015) Kevin J. Kauffman et al. NANO LETTERS
- In vivo gene editing in dystrophic mouse muscle and muscle stem cells
- (2015) M. Tabebordbar et al. SCIENCE
- Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases
- (2014) S. Bae et al. BIOINFORMATICS
- CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling
- (2014) Randall J. Platt et al. CELL
- Development and Applications of CRISPR-Cas9 for Genome Engineering
- (2014) Patrick D. Hsu et al. CELL
- OutKnocker: a web tool for rapid and simple genotyping of designer nuclease edited cell lines
- (2014) Jonathan L. Schmid-Burgk et al. GENOME RESEARCH
- Non-viral vectors for gene-based therapy
- (2014) Hao Yin et al. NATURE REVIEWS GENETICS
- The new frontier of genome engineering with CRISPR-Cas9
- (2014) J. A. Doudna et al. SCIENCE
- Enhanced Intracellular siRNA Delivery using Bioreducible Lipid-Like Nanoparticles
- (2014) Ming Wang et al. Advanced Healthcare Materials
- A Combinatorial Library of Unsaturated Lipidoids for Efficient Intracellular Gene Delivery
- (2012) Ming Wang et al. ACS Synthetic Biology
- Transfection Efficiency of Cationic Lipids with Different Hydrophobic Domains in Gene Delivery
- (2010) DeFu Zhi et al. BIOCONJUGATE CHEMISTRY
- Stem Cells and Liver Regeneration
- (2009) Andrew W. Duncan et al. GASTROENTEROLOGY
- A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
- (2009) Linda Madisen et al. NATURE NEUROSCIENCE
- Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans
- (2008) Stefano Romeo et al. JOURNAL OF CLINICAL INVESTIGATION
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