Fibrosis of the diabetic heart: Clinical significance, molecular mechanisms, and therapeutic opportunities
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Title
Fibrosis of the diabetic heart: Clinical significance, molecular mechanisms, and therapeutic opportunities
Authors
Keywords
Diabetes, Hyperglycemia, Fibrosis, Fibroblast, Inflammation, Oxidative stress, Lipotoxicity, Heart failure, Glucose-lowering agents
Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 176, Issue -, Pages 113904
Publisher
Elsevier BV
Online
2021-07-29
DOI
10.1016/j.addr.2021.113904
References
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- (2015) Brian Bostick et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- High-Density Lipoproteins Reduce Endothelial-to-Mesenchymal TransitionSignificance
- (2015) Frank Spillmann et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Inhibition of autophagy induces IL-1β release from ARPE-19 cells via ROS mediated NLRP3 inflammasome activation under high glucose stress
- (2015) Huanqi Shi et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- N-Acetyl Cysteine improves the diabetic cardiac function: possible role of fibrosis inhibition
- (2015) Cong Liu et al. BMC Cardiovascular Disorders
- Simvastatin alleviates cardiac fibrosis induced by infarction via up-regulation of TGF-β receptor III expression
- (2015) Fei Sun et al. BRITISH JOURNAL OF PHARMACOLOGY
- Histone deacetylase (HDAC) inhibition improves myocardial function and prevents cardiac remodeling in diabetic mice
- (2015) Youfang Chen et al. Cardiovascular Diabetology
- Response to Letter Regarding Article, “Heart Failure, Saxagliptin and Diabetes Mellitus: Observations From the SAVOR-TIMI 53 Randomized Trial”
- (2015) Benjamin M. Scirica et al. CIRCULATION
- Revisiting Cardiac Cellular CompositionNovelty and Significance
- (2015) Alexander R. Pinto et al. CIRCULATION RESEARCH
- Smad3 Signaling Promotes Fibrosis While Preserving Cardiac and Aortic Geometry in Obese Diabetic MiceCLINICAL PERSPECTIVE
- (2015) Anna Biernacka et al. Circulation-Heart Failure
- Inhibition of Dipeptidyl Peptidase-4 Impairs Ventricular Function and Promotes Cardiac Fibrosis in High Fat–Fed Diabetic Mice
- (2015) Erin E. Mulvihill et al. DIABETES
- miR-200b Mediates Endothelial-to-Mesenchymal Transition in Diabetic Cardiomyopathy
- (2015) Biao Feng et al. DIABETES
- Molecular and cellular mechanisms of glucagon-like peptide-1 receptor agonist-mediated attenuation of cardiac fibrosis
- (2015) Tracey Gaspari et al. Diabetes & Vascular Disease Research
- Mesenchymal stem cell-derived inflammatory fibroblasts promote monocyte transition into myeloid fibroblasts via an IL-6-dependent mechanism in the aging mouse heart
- (2015) Katarzyna A. Cieslik et al. FASEB JOURNAL
- Profibrotic Role for Interleukin-4 in Cardiac Remodeling and DysfunctionNovelty and Significance
- (2015) Hongmei Peng et al. HYPERTENSION
- Emerging roles for macrophages in cardiac injury: cytoprotection, repair, and regeneration
- (2015) Nikolaos G. Frangogiannis JOURNAL OF CLINICAL INVESTIGATION
- Altered parasympathetic nervous system regulation of the sinoatrial node in Akita diabetic mice
- (2015) Pooja S. Krishnaswamy et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Heart failure in diabetes: effects of anti-hyperglycaemic drug therapy
- (2015) Richard E Gilbert et al. LANCET
- Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy
- (2015) Guanghong Jia et al. Nature Reviews Endocrinology
- Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids
- (2015) Daniel F. Vatner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Updating Experimental Models of Diabetic Cardiomyopathy
- (2015) J. Fuentes-Antrás et al. Journal of Diabetes Research
- CXCR4 Antagonism Attenuates the Development of Diabetic Cardiac Fibrosis
- (2015) Po-Yin Chu et al. PLoS One
- Impact of Intensive Glycemic Control on the Incidence of Atrial Fibrillation and Associated Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus (from the Action to Control Cardiovascular Risk in Diabetes Study)
- (2014) Omid Fatemi et al. AMERICAN JOURNAL OF CARDIOLOGY
- Role for high-glucose-induced protein O-GlcNAcylation in stimulating cardiac fibroblast collagen synthesis
- (2014) Hugo Aguilar et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Rescue of cardiac leptin receptors in db/db mice prevents myocardial triglyceride accumulation
- (2014) Michael E. Hall et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- BMP-7 attenuates adverse cardiac remodeling mediated through M2 macrophages in prediabetic cardiomyopathy
- (2014) Princess Urbina et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Inhibition of PKC-θ preserves cardiac function and reduces fibrosis in streptozotocin-induced diabetic cardiomyopathy
- (2014) Zhao Li et al. BRITISH JOURNAL OF PHARMACOLOGY
- Micro-RNA 21Targets Dual Specific Phosphatase 8 to Promote Collagen Synthesis in High Glucose–Treated Primary Cardiac Fibroblasts
- (2014) Shulei Liu et al. CANADIAN JOURNAL OF CARDIOLOGY
- Hyperglycemia enhances function and differentiation of adult rat cardiac fibroblasts
- (2014) Patricia E. Shamhart et al. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
- High glucose induces Smad activation via the transcriptional coregulator p300 and contributes to cardiac fibrosis and hypertrophy
- (2014) Antoinette Bugyei-Twum et al. Cardiovascular Diabetology
- Glycemic control with empagliflozin, a novel selective SGLT2 inhibitor, ameliorates cardiovascular injury and cognitive dysfunction in obese and type 2 diabetic mice
- (2014) Bowen Lin et al. Cardiovascular Diabetology
- Investigating inherent functional differences between human cardiac fibroblasts cultured from nondiabetic and Type 2 diabetic donors
- (2014) Bryony Sedgwick et al. CARDIOVASCULAR PATHOLOGY
- Glucose fluctuations increase the incidence of atrial fibrillation in diabetic rats
- (2014) Shotaro Saito et al. CARDIOVASCULAR RESEARCH
- Developmental Heterogeneity of Cardiac Fibroblasts Does Not Predict Pathological Proliferation and Activation
- (2014) Shah R. Ali et al. CIRCULATION RESEARCH
- Interleukin-13 Deficiency Aggravates Healing and Remodeling in Male Mice After Experimental Myocardial Infarction
- (2014) Ulrich Hofmann et al. Circulation-Heart Failure
- Angiotensin 1–7 Ameliorates Diabetic Cardiomyopathy and Diastolic Dysfunction in db/db Mice by Reducing Lipotoxicity and Inflammation
- (2014) Jun Mori et al. Circulation-Heart Failure
- Treatment with brain natriuretic peptide prevents the development of cardiac dysfunction in obese diabetic db/db mice
- (2014) Eric Plante et al. DIABETOLOGIA
- Alagebrium (ALT-711) improves the anti-hypertensive efficacy of nifedipine in diabetic-hypertensive rats
- (2014) Bing Zhang et al. HYPERTENSION RESEARCH
- Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation
- (2014) Slava Epelman et al. IMMUNITY
- Cardiac miR-133a overexpression prevents early cardiac fibrosis in diabetes
- (2014) Shali Chen et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- P-wave characteristics and histological atrial abnormality
- (2014) Yan Huo et al. JOURNAL OF ELECTROCARDIOLOGY
- Chromatin Decondensation and T Cell Hyperresponsiveness in Diabetes-Associated Hyperglycemia
- (2014) Nuria Martinez et al. JOURNAL OF IMMUNOLOGY
- Cardiac fibroblasts protect cardiomyocytes against lethal ischemia–reperfusion injury
- (2014) Maryline Abrial et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Targeting cardiac fibroblasts to treat fibrosis of the heart: Focus on HDACs
- (2014) Katherine B. Schuetze et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Cardiovascular Phenotype in HFpEF Patients With or Without Diabetes
- (2014) Brian R. Lindman et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Dipeptidyl peptidase inhibition prevents diastolic dysfunction and reduces myocardial fibrosis in a Mouse model of Western diet induced obesity
- (2014) Brian Bostick et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Effects of high glucose on integrin activity and fibronectin matrix assembly by mesangial cells
- (2014) Charles G. Miller et al. MOLECULAR BIOLOGY OF THE CELL
- Tight blood glycaemic and blood pressure control in experimental diabetic nephropathy reduces extracellular matrix production without regression of fibrosis
- (2014) Bryan R. Conway et al. NEPHROLOGY
- Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure
- (2014) John J.V. McMurray et al. NEW ENGLAND JOURNAL OF MEDICINE
- NLRP3 Gene Silencing Ameliorates Diabetic Cardiomyopathy in a Type 2 Diabetes Rat Model
- (2014) Beibei Luo et al. PLoS One
- Erasers of Histone Acetylation: The Histone Deacetylase Enzymes
- (2014) E. Seto et al. Cold Spring Harbor Perspectives in Biology
- Aldosterone and Myocardial Extracellular Matrix Expansion in Type 2 Diabetes Mellitus
- (2013) Ajay D. Rao et al. AMERICAN JOURNAL OF CARDIOLOGY
- Lipid Droplet Accumulation Is Associated with an Increase in Hyperglycemia-Induced Renal Damage
- (2013) Eva Kiss et al. AMERICAN JOURNAL OF PATHOLOGY
- Thrombospondin-1 regulates adiposity and metabolic dysfunction in diet-induced obesity enhancing adipose inflammation and stimulating adipocyte proliferation
- (2013) Ping Kong et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Angiotensin receptor-mediated oxidative stress is associated with impaired cardiac redox signaling and mitochondrial function in insulin-resistant rats
- (2013) José Pablo Vázquez-Medina et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- HMGCoA reductase inhibition reverses myocardial fibrosis and diastolic dysfunction through AMP-activated protein kinase activation in a mouse model of metabolic syndrome
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- Differential Expression of Dicer, miRNAs, and Inflammatory Markers in Diabetic Ins2+/− Akita Hearts
- (2013) Vishalakshi Chavali et al. CELL BIOCHEMISTRY AND BIOPHYSICS
- Thrombospondin-1 Induction in the Diabetic Myocardium Stabilizes the Cardiac Matrix in Addition to Promoting Vascular Rarefaction Through Angiopoietin-2 Upregulation
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- Impact of interleukin-1β antibody (canakinumab) on glycaemic indicators in patients with type 2 diabetes mellitus: Results of secondary endpoints from a randomized, placebo-controlled trial
- (2013) J. Hensen et al. DIABETES & METABOLISM
- Obesity and Insulin Resistance Induce Early Development of Diastolic Dysfunction in Young Female Mice Fed a Western Diet
- (2013) Camila Manrique et al. ENDOCRINOLOGY
- Myocardial extracellular volume fraction quantified by cardiovascular magnetic resonance is increased in diabetes and associated with mortality and incident heart failure admission
- (2013) T. C. Wong et al. EUROPEAN HEART JOURNAL
- Aberrant differentiation of fibroblast progenitors contributes to fibrosis in the aged murine heart: role of elevated circulating insulin levels
- (2013) Katarzyna A. Cieslik et al. FASEB JOURNAL
- Fibrosis and cardiac function in obesity: a randomised controlled trial of aldosterone blockade
- (2013) Wojciech Kosmala et al. HEART
- Advanced glycation end products: role in pathology of diabetic cardiomyopathy
- (2013) Vijaya Lakshmi Bodiga et al. HEART FAILURE REVIEWS
- Assessment of cardiac inflammation and remodeling during the development of streptozotocin-induced diabetic cardiomyopathy in vivo: A time course analysis
- (2013) P.M. BECHER et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- High Fat Diet Causes Renal Fibrosis in LDLr-null Mice Through MAPK-NF-κB Pathway Mediated by Ox-LDL
- (2013) Yao Dai et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Diabetes increases mortality after myocardial infarction by oxidizing CaMKII
- (2013) Min Luo et al. JOURNAL OF CLINICAL INVESTIGATION
- Fibroblasts in myocardial infarction: A role in inflammation and repair
- (2013) Arti V. Shinde et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Type II diabetes promotes a myofibroblast phenotype in cardiac fibroblasts
- (2013) Vennece Fowlkes et al. LIFE SCIENCES
- Bone Marrow Progenitor Cell Therapy-Mediated Paracrine Regulation of Cardiac miRNA-155 Modulates Fibrotic Response in Diabetic Hearts
- (2013) Raj Kishore et al. PLoS One
- Mice Long-Term High-Fat Diet Feeding Recapitulates Human Cardiovascular Alterations: An Animal Model to Study the Early Phases of Diabetic Cardiomyopathy
- (2013) Sebastián D. Calligaris et al. PLoS One
- Cardiac Fibroblast-Dependent Extracellular Matrix Accumulation Is Associated with Diastolic Stiffness in Type 2 Diabetes
- (2013) Kirk R. Hutchinson et al. PLoS One
- Correction: Sitagliptin Reduces Cardiac Apoptosis, Hypertrophy and Fibrosis Primarily by Insulin-Dependent Mechanisms in Experimental type-II Diabetes. Potential Roles of GLP-1 Isoforms
- (2013) Belén Picatoste et al. PLoS One
- Impact of Obesity and Weight Loss on Cardiac Performance and Morphology in Adults
- (2013) Martin A. Alpert et al. PROGRESS IN CARDIOVASCULAR DISEASES
- The Accumulation of the Glycoxidation Product Nε-carboxymethyllysine in Cardiac Tissues with Age, Diabetes Mellitus and Coronary Heart Disease
- (2013) Shengda Hu et al. TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
- Myocardial Tissue Remodeling in Adolescent Obesity
- (2013) Ravi V. Shah et al. Journal of the American Heart Association
- Determinants of myocardial conduction velocity: implications for arrhythmogenesis
- (2013) James H. King et al. Frontiers in Physiology
- Conduction and refractory disorders in the diabetic atrium
- (2012) Masaya Watanabe et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- p38 MAPK alpha mediates cytokine-induced IL-6 and MMP-3 expression in human cardiac fibroblasts
- (2012) John K. Sinfield et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The use of animal models in diabetes research
- (2012) Aileen JF King BRITISH JOURNAL OF PHARMACOLOGY
- Alpha-lipoic acid attenuates cardiac fibrosis in Otsuka Long-Evans Tokushima Fatty rats
- (2012) Jung Eun Lee et al. Cardiovascular Diabetology
- Erythropoietin attenuates cardiac dysfunction by increasing myocardial angiogenesis and inhibiting interstitial fibrosis in diabetic rats
- (2012) Jing Lu et al. Cardiovascular Diabetology
- Cardiac fibrosis and dysfunction in experimental diabetic cardiomyopathy are ameliorated by alpha-lipoic acid
- (2012) Chun-jun Li et al. Cardiovascular Diabetology
- A pro-fibrotic role for interleukin-4 in cardiac pressure overload
- (2012) P. Kanellakis et al. CARDIOVASCULAR RESEARCH
- α11 integrin stimulates myofibroblast differentiation in diabetic cardiomyopathy
- (2012) Ilana Talior-Volodarsky et al. CARDIOVASCULAR RESEARCH
- Lipid Metabolism and Toxicity in the Heart
- (2012) Ira J. Goldberg et al. Cell Metabolism
- A Glucagon-Like Peptide-1 Analog Reverses the Molecular Pathology and Cardiac Dysfunction of a Mouse Model of Obesity
- (2012) Mohammad Hossein Noyan-Ashraf et al. CIRCULATION
- Interaction of diabetes and ACE2 in the pathogenesis of cardiovascular disease in experimental diabetes
- (2012) Chris Tikellis et al. CLINICAL SCIENCE
- A TRPC6-Dependent Pathway for Myofibroblast Transdifferentiation and Wound Healing In Vivo
- (2012) Jennifer Davis et al. DEVELOPMENTAL CELL
- Cannabinoid 1 Receptor Promotes Cardiac Dysfunction, Oxidative Stress, Inflammation, and Fibrosis in Diabetic Cardiomyopathy
- (2012) M. Rajesh et al. DIABETES
- Metformin Prevents the Development of Chronic Heart Failure in the SHHF Rat Model
- (2012) A. Cittadini et al. DIABETES
- Coenzyme Q10 attenuates diastolic dysfunction, cardiomyocyte hypertrophy and cardiac fibrosis in the db/db mouse model of type 2 diabetes
- (2012) K. Huynh et al. DIABETOLOGIA
- Long-term severe diabetes only leads to mild cardiac diastolic dysfunction in Zucker diabetic fatty rats
- (2012) Anneleen Daniels et al. EUROPEAN JOURNAL OF HEART FAILURE
- High glucose increases the expression of proinflammatory cytokines and secretion of TNFα and β-hexosaminidase in human mast cells
- (2012) Kanji Nagai et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Obesity results in progressive atrial structural and electrical remodeling: Implications for atrial fibrillation
- (2012) Hany S. Abed et al. HEART RHYTHM
- TRPV4 channels mediate cardiac fibroblast differentiation by integrating mechanical and soluble signals
- (2012) Ravi K. Adapala et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Diabetes and hypertension: the bad companions
- (2012) Ele Ferrannini et al. LANCET
- Lineage tracing and genetic ablation of ADAM12+ perivascular cells identify a major source of profibrotic cells during acute tissue injury
- (2012) Sophie Dulauroy et al. NATURE MEDICINE
- Matricellular Proteins in Cardiac Adaptation and Disease
- (2012) Nikolaos G. Frangogiannis PHYSIOLOGICAL REVIEWS
- Targeting Pericyte Differentiation as a Strategy to Modulate Kidney Fibrosis in Diabetic Nephropathy
- (2012) Benjamin D. Humphreys SEMINARS IN NEPHROLOGY
- Involvement of RhoA/ROCK in myocardial fibrosis in a rat model of type 2 diabetes
- (2011) Hong Zhou et al. ACTA PHARMACOLOGICA SINICA
- Intensive glycemic control has no impact on the risk of heart failure in type 2 diabetic patients: Evidence from a 37,229 patient meta-analysis
- (2011) Davide Castagno et al. AMERICAN HEART JOURNAL
- Effects of granulocyte-colony stimulating factor (G-CSF) on diabetic cardiomyopathy in Otsuka Long-Evans Tokushima Fatty rats
- (2011) Young-Hyo Lim et al. Cardiovascular Diabetology
- Myocardial Structure, Function, and Scar in Patients With Type 1 Diabetes Mellitus
- (2011) Evrim B. Turkbey et al. CIRCULATION
- Association of Imaging Markers of Myocardial Fibrosis With Metabolic and Functional Disturbances in Early Diabetic Cardiomyopathy
- (2011) Christine Jellis et al. Circulation-Cardiovascular Imaging
- Association Between Diffuse Myocardial Fibrosis by Cardiac Magnetic Resonance Contrast-Enhanced T 1 Mapping and Subclinical Myocardial Dysfunction in Diabetic Patients
- (2011) Arnold C.T. Ng et al. Circulation-Cardiovascular Imaging
- Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses high glucose-induced proliferation and collagen synthesis in rat cardiac fibroblasts
- (2011) Hong Zhou et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition
- (2011) O. Aisagbonhi et al. Disease Models & Mechanisms
- Effects of alagebrium, an advanced glycation endproduct breaker, on exercise tolerance and cardiac function in patients with chronic heart failure
- (2011) Jasper W.L. Hartog et al. EUROPEAN JOURNAL OF HEART FAILURE
- AMP-activated Protein Kinase Suppresses Matrix Metalloproteinase-9 Expression in Mouse Embryonic Fibroblasts
- (2011) Yuki Morizane et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Effects of DPP-4 inhibition on cardiac metabolism and function in mice
- (2011) M. Lenski et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
- (2011) Bolormaa Vandanmagsar et al. NATURE MEDICINE
- Effect of Simvastatin on Expression of Transforming Growth Factor-β and Collagen Type IV in Rat Mesangial Cells
- (2011) Yan-Bo Li et al. PHARMACOLOGY
- Simvastatin induces apoptosis by a Rho-dependent mechanism in cultured cardiac fibroblasts and myofibroblasts
- (2011) Miguel Copaja et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- A Randomized Study of the Beneficial Effects of Aldosterone Antagonism on LV Function, Structure, and Fibrosis Markers in Metabolic Syndrome
- (2011) Wojciech Kosmala et al. JACC-Cardiovascular Imaging
- Management of cardiac fibrosis in diabetic rats; the role of peroxisome proliferator activated receptor gamma (PPAR-gamma) and calcium channel blockers (CCBs)
- (2011) Hoda E Mohamad et al. Diabetology & Metabolic Syndrome
- A Novel Transcriptional Mechanism of Cell Type–Specific Regulation of Vascular Gene Expression by Glucose
- (2010) Priya Raman et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Metformin attenuates cardiac fibrosis by inhibiting the TGFβ1–Smad3 signalling pathway
- (2010) Han Xiao et al. CARDIOVASCULAR RESEARCH
- Endothelial Cell–Derived Endothelin-1 Promotes Cardiac Fibrosis in Diabetic Hearts Through Stimulation of Endothelial-to-Mesenchymal Transition
- (2010) Bambang Widyantoro et al. CIRCULATION
- TRPM7-Mediated Ca 2+ Signals Confer Fibrogenesis in Human Atrial Fibrillation
- (2010) Jianyang Du et al. CIRCULATION RESEARCH
- Smad3 Signaling Critically Regulates Fibroblast Phenotype and Function in Healing Myocardial Infarction
- (2010) Marcin Dobaczewski et al. CIRCULATION RESEARCH
- Angiotensin AT1 receptor activation mediates high glucose-induced epithelial-mesenchymal transition in renal proximal tubular cells
- (2010) Li Zhou et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Diabetic Nephropathy Is Accelerated by Farnesoid X Receptor Deficiency and Inhibited by Farnesoid X Receptor Activation in a Type 1 Diabetes Model
- (2010) X. X. Wang et al. DIABETES
- High Glucose-Induced Oxidative Stress Increases Transient Receptor Potential Channel Expression in Human Monocytes
- (2010) T. Wuensch et al. DIABETES
- Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice
- (2010) Michael G. Usher et al. JOURNAL OF CLINICAL INVESTIGATION
- Potentiation by candesartan of protective effects of pioglitazone against type 2 diabetic cardiovascular and renal complications in obese mice
- (2010) Masaya Fukuda et al. JOURNAL OF HYPERTENSION
- Immune-inflammatory dysregulation modulates the incidence of progressive fibrosis and diastolic stiffness in the aging heart
- (2010) Katarzyna A. Cieslik et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Ezetimibe Ameliorates Cardiovascular Complications and Hepatic Steatosis in Obese and Type 2 Diabetic db/db Mice
- (2010) M. Fukuda et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Epigenetic Histone Methylation Modulates Fibrotic Gene Expression
- (2010) G. Sun et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Obesogenic high fat western diet induces oxidative stress and apoptosis in rat heart
- (2010) Kalpana Ballal et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Cardiac and Renal Function are Progressively Impaired with Aging in Zucker Diabetic Fatty Type II Diabetic Rats
- (2010) John Baynes et al. Oxidative Medicine and Cellular Longevity
- Effects of high glucose and thiamine on the balance between matrix metalloproteinases and their tissue inhibitors in vascular cells
- (2009) Sonia Tarallo et al. ACTA DIABETOLOGICA
- Comparison of Patients With Heart Failure and Preserved Left Ventricular Ejection Fraction Among Those With Versus Without Diabetes Mellitus
- (2009) David Aguilar et al. AMERICAN JOURNAL OF CARDIOLOGY
- Myocardial lysyl oxidase regulation of cardiac remodeling in a murine model of diet-induced metabolic syndrome
- (2009) Sherma Zibadi et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Superoxide production by NAD(P)H oxidase and mitochondria is increased in genetically obese and hyperglycemic rat heart and aorta before the development of cardiac dysfunction. The role of glucose-6-phosphate dehydrogenase-derived NADPH
- (2009) Sabrina Serpillon et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Dominant-negative p38α mitogen-activated protein kinase prevents cardiac apoptosis and remodeling after streptozotocin-induced diabetes mellitus
- (2009) Rajarajan A. Thandavarayan et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function
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- Peroxisome proliferator-activated receptor-γ activation attenuates cardiac fibrosis in type 2 diabetic rats: the effect of rosiglitazone on myocardial expression of receptor for advanced glycation end products and of connective tissue growth factor
- (2009) Sang-Hyun Ihm et al. BASIC RESEARCH IN CARDIOLOGY
- Cardiac Fibroblast
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- Essential Role of TGF-β Signaling in Glucose-Induced Cell Hypertrophy
- (2009) Liyu Wu et al. DEVELOPMENTAL CELL
- Histological Course of Nonalcoholic Fatty Liver Disease in Japanese Patients: Tight glycemic control, rather than weight reduction, ameliorates liver fibrosis
- (2009) E. Hamaguchi et al. DIABETES CARE
- Intensive glucose control and macrovascular outcomes in type 2 diabetes
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- Angiotensin II increases collagen I expression via transforming growth factor-beta1 and extracellular signal-regulated kinase in cardiac fibroblasts
- (2009) Xiuren Gao et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Superoxide radicals increase transforming growth factor-β1 and collagen release from human lung fibroblasts via cellular influx through chloride channels
- (2009) Shufan Qi et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Pericytes and Perivascular Fibroblasts Are the Primary Source of Collagen-Producing Cells in Obstructive Fibrosis of the Kidney
- (2008) Shuei-Liong Lin et al. AMERICAN JOURNAL OF PATHOLOGY
- Cardiac overexpression of hormone-sensitive lipase inhibits myocardial steatosis and fibrosis in streptozotocin diabetic mice
- (2008) Masami Ueno et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Activation of the intracellular renin-angiotensin system in cardiac fibroblasts by high glucose: role in extracellular matrix production
- (2008) Vivek P. Singh et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Microvessel vascular smooth muscle cells contribute to collagen type I deposition through ERK1/2 MAP kinase, αvβ3-integrin, and TGF-β1 in response to ANG II and high glucose
- (2008) Souad Belmadani et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Agonists at PPAR-γ suppress angiotensin II-induced production of plasminogen activator inhibitor-1 and extracellular matrix in rat cardiac fibroblasts
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- Differential regulation of collagen types I and III expression in cardiac fibroblasts by AGEs through TRB3/MAPK signaling pathway
- (2008) M. Tang et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Intensive Glycemic Control and the Prevention of Cardiovascular Events: Implications of the ACCORD, ADVANCE, and VA Diabetes Trials
- (2008) Jay S. Skyler et al. CIRCULATION
- PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ-INDEPENDENT EFFECTS OF THIAZOLIDINEDIONES ON HUMAN CARDIAC MYOFIBROBLAST FUNCTION
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- Intracellular Angiotensin II Production in Diabetic Rats Is Correlated With Cardiomyocyte Apoptosis, Oxidative Stress, and Cardiac Fibrosis
- (2008) V. P. Singh et al. DIABETES
- Impact of diabetes on outcomes in patients with low and preserved ejection fraction heart failure: An analysis of the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) programme
- (2008) M. R. MacDonald et al. EUROPEAN HEART JOURNAL
- Atrial fibrillation progression and management: A 5-year prospective follow-up study
- (2008) Carlo Pappone et al. HEART RHYTHM
- Regulation of TGFβ1-mediated Collagen Formation by LOX-1
- (2008) Changping Hu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- AMP-activated Protein Kinase Inhibits Transforming Growth Factor-β-induced Smad3-dependent Transcription and Myofibroblast Transdifferentiation
- (2008) Rangnath Mishra et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- AGEs-RAGE System Mediates Atrial Structural Remodeling in the Diabetic Rat
- (2008) TAKESHI KATO et al. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
- Critical roles of (pro)renin receptor-bound prorenin in diabetes and hypertension: sallies into therapeutic approach
- (2008) Atsuhiro Ichihara et al. Journal of the American Society of Hypertension
- Telmisartan, Ramipril, or Both in Patients at High Risk for Vascular Events
- (2008) NEW ENGLAND JOURNAL OF MEDICINE
- Cardiac Remodeling in Obesity
- (2008) E. Dale Abel et al. PHYSIOLOGICAL REVIEWS
- Diastolic Stiffness of the Failing Diabetic Heart
- (2007) Loek van Heerebeek et al. CIRCULATION
- Oxidative Stress Triggers Cardiac Fibrosis in the Heart of Diabetic Rats
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