Article
Biochemistry & Molecular Biology
Lijuan Xiong, Bin Zhou, Jamie L. Young, Jianxiang Xu, Kupper Wintergerst, Lu Cai
Summary: This study examined the combined effect of low-dose cadmium (Cd) and a high-fat diet (HFD) on the testes of mice. The results showed that exposure to Cd or HFD alone caused testicular injury, but the combined exposure did not have toxic effects, possibly due to the activation of the JAK/STAT pathway to prevent apoptosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Environmental Sciences
Anouar Feriani, Mariano Bizzarri, Meriam Tir, Nouf Aldawood, Hussah Alobaid, Mohamed Salah Allagui, Waleed Dahmash, Nizar Tlili, Kais Mnafgui, Saleh Alwasel, Abdel Halim Harrath
Summary: The study revealed that a high-fat diet and permethrin treatment can induce cardiotoxicity, increase cardiovascular disease risk, and promote heart failure and fibrosis in rats. Changes in blood lipid levels, cardiac damage, inflammation, and fibrosis were observed as a result of HFD and PER exposure.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Jingxu Zhang, Hongyan Yu, Ruonan Pan, Gan Miao, Yu Wang, Ziyuan Li, Haiyi Yu, Lin Lu, Xiaoting Jin
Summary: This study demonstrates the proatherogenic effect of magnetite nanoparticles (MNPs) under high-fat dietary patterns, resulting in pathological changes including aortic wall thickening, fiber disorganization, and inflammation. MNPs are identified as a key component of atherogenic toxicity and disturb lipid metabolism, leading to lipid accumulation and metabolic disorder.
ENVIRONMENTAL TOXICOLOGY
(2023)
Review
Pharmacology & Pharmacy
Qiuyu Pang, Lu You, Xiangmin Meng, Yumeng Li, Tian Deng, Deyong Li, Bingmei Zhu
Summary: The JAK/STAT signaling pathway plays a crucial role in cell growth, differentiation, immune response, and hematopoietic system development. It has been found to have regulatory functions in various cardiovascular diseases, such as myocardial ischemia-reperfusion injury, acute myocardial infarction, hypertension, myocarditis, heart failure, angiogenesis, and fibrosis.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Muhammad Farooq, Huma Hameed, Marie-Therese Dimanche-Boitrel, Claire Piquet-Pellorce, Michel Samson, Jacques Le Seyec
Summary: The globally prevalent disease non-alcoholic steatohepatitis (NASH) is characterized by a steatotic and inflammatory liver. This study found that dietary intervention can partially reverse the fibrosis induced by a high-fat, high-cholesterol diet (HFHCD) in the livers of C57BL/6J mice.
Article
Food Science & Technology
Ryutaro Yoshida, Yoshihiko Yano, Namiko Hoshi, Norihiro Okamoto, Yunlong Sui, Atsushi Yamamoto, Naoki Asaji, Yuuki Shiomi, Eiichiro Yasutomi, Yuri Hatazawa, Hiroki Hayashi, Yoshihide Ueda, Yuzo Kodama
Summary: The study found that Type 4 resistant starch (RS4) can suppress steatosis and increase the levels of Bifidobacterium, Lactobacillus, and short chain fatty acids (SCFAs). RS4 may prevent steatosis by modulating the intestinal environment.
JOURNAL OF FOOD SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Ahmed I. Ashmawy, Hanan S. El-Abhar, Dalaal M. Abdallah, Mennatallah A. Ali
Summary: The phytochemical sulforaphane (SFN) has potential anti-obesity effects by reducing weight gain, blood glucose, and serum leptin levels, improving lipid profile, inhibiting lipogenesis-related enzymes, and regulating inflammatory pathways and autophagy. The combination of SFN with the antimalarial drug chloroquine (CQ) enhances the anti-obesity effects of SFN.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Cecilia M. Prele, Thomas Iosifidis, Robin J. McAnulty, David R. Pearce, Bahareh Badrian, Tylah Miles, Sarra E. Jamieson, Matthias Ernst, Philip J. Thompson, Geoffrey J. Laurent, Darryl A. Knight, Steven E. Mutsaers
Summary: Research has found that fibroblasts in idiopathic pulmonary fibrosis (IPF) have lower levels of SOCS1 mRNA compared to control fibroblasts, but the mechanism behind this down-regulation remains unknown. While SOCS1 may be important in the fibrotic process, it does not seem to play a significant role in regulating fibroblast function.
Review
Biochemistry & Molecular Biology
Juntang Yang, Chenxi Liang, Lulu Liu, Lan Wang, Guoying Yu
Summary: Pulmonary fibrosis is a metabolic disease characterized by excessive extracellular matrix deposition, and abnormal lipids have been observed in PF patients and mice models. High-fat diet, particularly the intake of saturated fatty acids and meat, is significantly associated with PF and lung fibrosis. However, the mechanisms underlying the connection between high-fat diet and PF are still unclear. This review highlights the diverse effects of epigenetic dysregulation induced by high-fat diet on fibrotic factors and discusses potential ways to improve patients' conditions and the prospect of targeted therapy based on epigenetic regulation.
Article
Biology
Abdullah S. Shatoor, Suliman Al Humayed
Summary: Astaxanthin has a protective effect against high-fat diet-induced cardiac damage and fibrosis in rats by modulating SIRT1 signaling pathway.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Agriculture, Multidisciplinary
Lirui Sun, Qing Liu, Yabin Zhang, Meilan Xue, Hongxue Yan, Xia Qiu, Yingjie Tian, Huaqi Zhang, Hui Liang
Summary: This study found that fucoidan has a protective effect against hyperuricemia-induced renal fibrosis. It reduces serum uric acid levels, improves kidney pathology, and inhibits the progression of renal fibrosis by suppressing the epithelial-to-mesenchymal transition and the activation of the JAK2/STAT3 signaling pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Il-Je Cho, Joung-Hoon Shin, Beom-Rak Choi, Hye-Rim Park, Jeong-Eun Park, Seong-Hwa Hong, Young-Sam Kwon, Won-Seok Oh, Sae-Kwang Ku
Summary: This study investigated the dose-dependent effect of a mixture of lemon balm and corn silk extracts on high-fat diet-induced metabolic disorders. The results showed that the mixture significantly inhibited body weight gain, adipocyte hypertrophy, and abnormal lipid accumulation in the blood. It also prevented pancreatic and liver injury, and protected the kidney. The prophylactic effect of the mixture was comparable to that of metformin.
Article
Nutrition & Dietetics
Thomas A. Aloysius, Veronika Tillander, Matteo Pedrelli, Simon N. Dankel, Rolf K. Berge, Bodil Bjorndal
Summary: Rest raw materials from chicken, such as chicken protein hydrolysate (CPH) and chicken oil (CO), have beneficial effects on health by reducing cholesterol levels and increasing fatty acid oxidation.
Article
Chemistry, Multidisciplinary
Yi-le Fu, Liang Tao, Fu-hua Peng, Ning-ze Zheng, Qing Lin, Shao-yi Cai, Qin Wang
Summary: The study revealed the crucial role of GJA1-20k in regulating gap junction formation and mitochondrial function in the pathogenesis of CH, providing a novel therapeutic strategy for patients with cardiomyocyte hypertrophy.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Biochemistry & Molecular Biology
Tilman Pfeffer, Charlotte Wetzel, Philip Kirschner, Maria Bartosova, Tanja Poth, Constantin Schwab, Gernot Poschet, Johanna Zemva, Ruben Bulkescher, Ivan Damgov, Christian Thiel, Sven F. F. Garbade, Kristina Klingbeil, Verena Peters, Claus Peter Schmitt
Summary: Supplementation of carnosine and anserine can effectively reduce diabetic nephropathy in rodents. However, the exact mechanism of their nephroprotective action in diabetes, whether it is through local protection or improved systemic glucose homeostasis, remains uncertain.
Article
Biochemistry & Molecular Biology
Hongqing Wen, Lei Wang, Kareem Morsy, Hamida Hamdi, Ayman E. El-Kenawy, Attalla F. El-kott
Summary: Chloroxine, a chemical used in the treatment of seborrheic dermatitis and dandruff, was found to inhibit HMG-CoA reductase and urease enzymes. In addition, chloroxine and methyl 3,4,5-trihydroxybenzoate also exhibited cytotoxic effects on lung cancer cells.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Immunology
Siyab Khan, Muhammad Rizwan, Adnan Zeb, Muhammad Alaa Eldeen, Said Hassan, Ashfaq Ur Rehman, Refaat A. Eid, Mohamed Samir A. Zaki, Ghadeer M. Albadrani, Ahmed E. Altyar, Nehal Ahmed Talaat Nouh, Mohamed M. Abdel-Daim, Amin Ullah
Summary: This study identified 6 antigenic proteins and designed a multi-epitope subunit vaccine, which showed strong immunogenicity and stability through simulation and validation. However, further confirmation of its safety and efficacy is needed.
Article
Microbiology
Ihsan Ullah, Sadia Sattar, Ijaz Ali, Arshad Farid, Amin Ullah, Refaat A. A. Eid, Mohamed Samir A. Zaki, Muhammad Alaa Eldeen, Iftikhar Ahmed, Irfan Ullah
Summary: Cystic echinococcosis (CE), or hydatid cyst disease (HCD), is highly endemic in Baluchistan, Pakistan, but no previous studies have been conducted in this region. This study collected and analyzed 23 human hydatid cyst samples, revealing the presence of multiple genotypes, with G1 and G3 being the most prevalent and the first report of G6/G7 in Baluchistan.
Article
Chemistry, Physical
Yadong Zhou, Bikash Karmakar, Fafu Dou, Attalla F. El-kott, Sally Negm, Eman M. El Nashar, Fatimah A. Al-Saeed, Eman T. Salem
Summary: This report introduces a sustainable method for synthesizing Ag nanoparticles decorated carboxymethyl lignin (CML) functionalized Fe3O4 nanocomposite (Fe3O4@CML/Ag) in situ, and demonstrates its chemical and biological applications. The structural and physicochemical characteristics of this novel material were evaluated using various analytical techniques. The nanomaterial showed excellent catalytic activity for the N-acylation of different amines under solvent-free conditions, and it could be reused multiple times. Additionally, the material exhibited promising antioxidant and anticancer properties, as confirmed by DPPH and MTT assays, respectively. The results suggest that this nanocomposite has potential applications in biomedicine.
Article
Polymer Science
Wei Zi, Bikash Karmakar, Attalla F. El-kott, Fatimah A. Al-Saeed, Sally Negm, Eman T. Salem
Summary: A biogenic synthesis of Ag NPs adorned Helleborus niger extract-modified graphene oxide nanohybrid material has been demonstrated. The Helleborus niger extract was functionalized on the surface of graphene oxide, and the polyphenolic groups of plant phytochemicals facilitated the green reduction of Ag ions and GO, resulting in the formation of Ag/H.niger@rGO nanocomposite.
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2023)
Article
Medicine, General & Internal
Mohamed Samir A. Zaki, Muhammad Alaa Eldeen, Waleed K. K. Abdulsahib, Ayed A. A. Shati, Youssef A. A. Alqahtani, Saleh M. M. Al-Qahtani, Hassan M. M. Otifi, Ashwag Asiri, Hesham M. M. Hassan, Hebatallah Emam Mohammed Ahmed, Samy A. A. Dawood, Amr Negm, Refaat A. A. Eid
Summary: Emerging research has found that the protein CEP55 may function as an oncogene in various human malignancies. However, there has been no comprehensive analysis conducted to investigate the role and behavior of CEP55 as an oncogene in different types of cancer. This study aims to provide a detailed analysis of CEP55, including its expression in different cancers, correlation with cancer stage, impact on patient survival, genetic alterations, methylation status, influence on immune cell infiltration, response to chemotherapeutic agents, and underlying molecular mechanisms. The findings suggest that CEP55 is upregulated in cancer tissues compared to normal controls and this upregulation is associated with poor prognosis in multiple forms of cancer. It also affects immune cell infiltration, chemokine levels, and response to anticancer drugs. Therefore, CEP55 could serve as a potential predictive marker and therapeutic target for cancer treatment.
Article
Biology
Mohamed A. Soltan, Muhammad Alaa Eldeen, Bayan H. Sajer, Reda F. A. Abdelhameed, Fawziah A. Al-Salmi, Eman Fayad, Ibrahim Jafri, Hebatallah Emam Mohammed Ahmed, Refaat A. Eid, Hesham M. Hassan, Mubarak Al-Shraim, Amr Negm, Ahmed E. Noreldin, Khaled M. Darwish
Summary: Cancer is a major cause of death globally, and there is a continuous effort to develop biomarkers and therapeutic agents for early diagnosis and treatment. A pan-cancer model analysis revealed that ECT2 could serve as a prognostic and immunological biomarker in various human cancers. Furthermore, potential inhibitors for ECT2 were identified through chemoinformatics, suggesting their potential as antitumor agents.
Article
Biochemistry & Molecular Biology
Rabia Basri, Saeed Ullah, Ajmal Khan, Suraj N. Mali, Oussama Abchir, Samir Chtita, Ahmed El-Gokha, Parham Taslimi, Ammena Y. Binsaleh, Attalla F. El-kott, Ahmed Al-Harrasi, Zahid Shafiq
Summary: In this study, the synthesis, alpha-glucosidase inhibition, structure activity relationship, pharmacokinetics, and docking analysis of novel chromone-based thiosemicarbazones were reported. The derivatives exhibited potent activity against alpha-glucosidase, with certain compounds showing higher inhibitory activity than the standard acarbose. Moreover, a statistically significant 2D-QSAR model was developed for further design of potent thiosemicarbazones as alpha-glucosidase inhibitors.
BIOORGANIC CHEMISTRY
(2023)
Article
Polymer Science
Yanmei Ma, Fuxiang He, Attalla F. El-kott, Ali S. Alshehri, Mohamed Abdellatif Zein, Ali M. Eldib
Summary: In this study, we demonstrated the structural features of gold nanoparticles prepared using a biogenic template on chitosan/gelatin mixed hydrogel, and evaluated their cytotoxicity and anti-leukemia effects on various leukemia cell lines.
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2023)
Article
Infectious Diseases
Muhammad Ajmal Khan, Atta Ur Rahman, Bakhtawar Khan, Samiah Hamad Al-Mijalli, Amal S. Alswat, Aftab Amin, Refaat A. Eid, Mohamed Samir A. Zaki, Sadia Butt, Jamshaid Ahmad, Eman Fayad, Amin Ullah
Summary: Urinary tract infections (UTIs) are common in the population of Khyber Pakhtunkhwa (KP), Pakistan, with Klebsiella pneumoniae being the most prevalent uropathogen. Imipenem was identified as the most effective antibiotic, while cefuroxime and ciprofloxacin showed the least effectiveness.
Article
Biochemistry & Molecular Biology
Mohamed A. Soltan, Ahmad A. Alhanshani, Ayed A. Shati, Youssef A. Alqahtani, Dalal Sulaiman Alshaya, Jawaher Alharthi, Sarah Awwadh Altalhi, Eman Fayad, Mohamed Samir A. Zaki, Refaat A. Eid
Summary: CDKN2A gene alteration is associated with human tumor development and affects immune components and tumor progression. This study found that CDKN2A gene is upregulated in tumor tissues and correlates with tumor stage, grade, metastasis, and clinical outcome. Additionally, CDKN2A experiences different forms of genetic alteration under tumor conditions, influencing immune components. Therefore, CDKN2A genetic alteration can serve as a prognostic and immunological biomarker in multiple human cancers.