Matricellular Proteins in Cardiac Adaptation and Disease

CD44 Is Critically Involved in Infarct Healing by Regulating the Inflammatory and Fibrotic Response

(2014) P. Huebener et al.   JOURNAL OF IMMUNOLOGY

MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure

(2011) Geert C. van Almen et al.   AGING CELL

Dynamic molecular and histopathological changes in the extracellular matrix and inflammation in the transition to heart failure in isolated volume overload

(2011) Yuan-wen Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

SPARC mediates early extracellular matrix remodeling following myocardial infarction

(2011) Sarah M. McCurdy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

SPARC regulates collagen interaction with cardiac fibroblast cell surfaces

(2011) Brett S. Harris et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The zebrafish heart regenerates after cryoinjury-induced myocardial infarction

(2011) Fabian Chablais et al.   BMC DEVELOPMENTAL BIOLOGY

The role of tenascin C in cardiovascular disease

(2011) Jonathan Golledge et al.   CARDIOVASCULAR RESEARCH

Angiotensin II increases periostin expression via Ras/p38 MAPK/CREB and ERK1/2/TGF-β1 pathways in cardiac fibroblasts

(2011) Li Li et al.   CARDIOVASCULAR RESEARCH

Syndecan-4 signalling inhibits apoptosis and controls NFAT activity during myocardial damage and remodelling

(2011) Frank Echtermeyer et al.   CARDIOVASCULAR RESEARCH

Cell–Matrix Interactions in the Pathobiology of Calcific Aortic Valve Disease

(2011) Jan-Hung Chen et al.   CIRCULATION RESEARCH

Syndecan-4 Prevents Cardiac Rupture and Dysfunction After Myocardial Infarction

(2011) Yutaka Matsui et al.   CIRCULATION RESEARCH

Relation of Peripheral Collagen Markers to Death and Hospitalization in Patients With Heart Failure and Preserved Ejection Fraction

(2011) Henry Krum et al.   Circulation-Heart Failure

TGF-β signaling in fibrosis

(2011) Anna Biernacka et al.   GROWTH FACTORS

Endogenous Thrombospondin 1 Protects the Pressure-Overloaded Myocardium by Modulating Fibroblast Phenotype and Matrix Metabolism

(2011) Ying Xia et al.   HYPERTENSION

Osteopontin: A potential biomarker for heart failure and reverse remodeling after left ventricular assist device support

(2011) Marguérite E.I. Schipper et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Osteopontin-Stimulated Expression of Matrix Metalloproteinase-9 Causes Cardiomyopathy in the mdx Model of Duchenne Muscular Dystrophy

(2011) S. Dahiya et al.   JOURNAL OF IMMUNOLOGY

Absence of thrombospondin-2 increases cardiomyocyte damage and matrix disruption in doxorubicin-induced cardiomyopathy

(2011) Geert C. van Almen et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

CCR5 Signaling Suppresses Inflammation and Reduces Adverse Remodeling of the Infarcted Heart, Mediating Recruitment of Regulatory T Cells

(2010) Marcin Dobaczewski et al.   AMERICAN JOURNAL OF PATHOLOGY

Tenascin-C may aggravate left ventricular remodeling and function after myocardial infarction in mice

(2010) Tomohiro Nishioka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mechanisms of novel cardioprotective functions of CCN2/CTGF in myocardial ischemia-reperfusion injury

(2010) M. Shakil Ahmed et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Tenascin-C deficiency attenuates TGF-β-mediated fibrosis following murine lung injury

(2010) William A. Carey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

WNT1-inducible signaling pathway protein-1 activates diverse cell survival pathways and blocks doxorubicin-induced cardiomyocyte death

(2010) Balachandar Venkatesan et al.   CELLULAR SIGNALLING

Matricellular Signaling Molecule CCN1 Attenuates Experimental Autoimmune Myocarditis by Acting as a Novel Immune Cell Migration Modulator

(2010) Madlen Rother et al.   CIRCULATION

Aging-Related Early Changes in Markers of Ventricular and Matrix Remodeling After Reperfused ST-Segment Elevation Myocardial Infarction in the Canine Model

(2010) Bodh I. Jugdutt et al.   CIRCULATION

Genetic Deficiency of Plasminogen Activator Inhibitor-1 Promotes Cardiac Fibrosis in Aged Mice

(2010) Asish K. Ghosh et al.   CIRCULATION

Thrombospondin-4 Regulates Vascular Inflammation and Atherogenesis

(2010) Ella G. Frolova et al.   CIRCULATION RESEARCH

Smad3 Signaling Critically Regulates Fibroblast Phenotype and Function in Healing Myocardial Infarction

(2010) Marcin Dobaczewski et al.   CIRCULATION RESEARCH

Potential Therapeutic Targets for Cardiac Fibrosis

(2010) Andrew Leask   CIRCULATION RESEARCH

Inactivation of SPARC enhances high-fat diet-induced obesity in mice

(2010) Jing Nie et al.   CONNECTIVE TISSUE RESEARCH

Osteopontin as a novel prognostic marker in stable ischaemic heart disease: a 3-year follow-up study

(2010) Panagiota Georgiadou et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Integrated protein network and microarray analysis to identify potential biomarkers after myocardial infarction

(2010) Yvan Devaux et al.   FUNCTIONAL & INTEGRATIVE GENOMICS

The role of inflammatory and fibrogenic pathways in heart failure associated with aging

(2010) Wei Chen et al.   HEART FAILURE REVIEWS

Role of osteopontin in heart failure associated with aging

(2010) Mahipal Singh et al.   HEART FAILURE REVIEWS

Syndecan-1

(2010) Nikolaos G. Frangogiannis   HYPERTENSION

Syndecan-1 Amplifies Angiotensin II–Induced Cardiac Fibrosis

(2010) Mark W.M. Schellings et al.   HYPERTENSION

Connective tissue growth factor induction in a pressure-overloaded heart ameliorated by the angiotensin II type 1 receptor blocker olmesartan

(2010) Mutsumi Iwamoto et al.   HYPERTENSION RESEARCH

Increased connective tissue growth factor associated with cardiac fibrosis in the mdx mouse model of dystrophic cardiomyopathy

(2010) Carol G. Au et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

SPARC Suppresses Apoptosis of Idiopathic Pulmonary Fibrosis Fibroblasts through Constitutive Activation of β-Catenin

(2010) Wenteh Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents

(2010) Daihiko Hakuno et al.   JOURNAL OF CLINICAL INVESTIGATION

CTGF directs fibroblast differentiation from human mesenchymal stem/stromal cells and defines connective tissue healing in a rodent injury model

(2010) Chang H. Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β

(2010) Polakit Teekakirikul et al.   JOURNAL OF CLINICAL INVESTIGATION

TGF-β1 and FAK Regulate Periostin Expression in PDL Fibroblasts

(2010) W. Wen et al.   JOURNAL OF DENTAL RESEARCH

Matricellular Protein CCN1 Activates a Proinflammatory Genetic Program in Murine Macrophages

(2010) T. Bai et al.   JOURNAL OF IMMUNOLOGY

The opposing effects of CCN2 and CCN5 on the development of cardiac hypertrophy and fibrosis

(2010) Pyoung Oh Yoon et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Involvement of NADPH oxidase in age-associated cardiac remodeling

(2010) Mingyi Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Transforming growth factor (TGF)-β signaling in cardiac remodeling

(2010) Marcin Dobaczewski et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Validation of Plasma Biomarkers in Degenerative Calcific Aortic Stenosis

(2010) Giovanni Ferrari et al.   JOURNAL OF SURGICAL RESEARCH

The Evolution of Thrombospondins and Their Ligand-Binding Activities

(2010) A. A. Bentley et al.   MOLECULAR BIOLOGY AND EVOLUTION

The Evolution of Extracellular Matrix

(2010) Suat Özbek et al.   MOLECULAR BIOLOGY OF THE CELL

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

(2010) Joon-Il Jun et al.   NATURE CELL BIOLOGY

SPARC: a key player in the pathologies associated with obesity and diabetes

(2010) Katarina Kos et al.   Nature Reviews Endocrinology

Roles of epithelial cell-derived periostin in TGF-  activation, collagen production, and collagen gel elasticity in asthma

(2010) S. S. Sidhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Attenuation of fibrosis in vitro and in vivo with SPARC siRNA

(2010) Jiu-Cun Wang et al.   ARTHRITIS RESEARCH & THERAPY

Spatiotemporal expression of periostin during skin development and incisional wound healing: lessons for human fibrotic scar formation

(2010) Hong-Ming Zhou et al.   Journal of Cell Communication and Signaling

CCN3 (NOV) Is a Negative Regulator of CCN2 (CTGF) and a Novel Endogenous Inhibitor of the Fibrotic Pathway in an in Vitro Model of Renal Disease

(2009) Bruce L. Riser et al.   AMERICAN JOURNAL OF PATHOLOGY

Adverse effects of high glucose and free fatty acid on cardiomyocytes are mediated by connective tissue growth factor

(2009) Xiaoyu Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Age-dependent alterations in fibrillar collagen content and myocardial diastolic function: role of SPARC in post-synthetic procollagen processing

(2009) Amy D. Bradshaw et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Connective Tissue Growth Factor Promotes Fibrosis Downstream of TGFβ and IL-6 in Chronic Cardiac Allograft Rejection

(2009) A. J. Booth et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Periostin Is a Novel Factor in Cardiac Remodeling After Experimental and Clinical Unloading of the Failing Heart

(2009) William E. Stansfield et al.   ANNALS OF THORACIC SURGERY

Periostin mediates vascular smooth muscle cell migration through the integrins ανβ3 and ανβ5 and focal adhesion kinase (FAK) pathway

(2009) Guohong Li et al.   ATHEROSCLEROSIS

The regulation of tenascin expression by tissue microenvironments

(2009) Richard P. Tucker et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Absence of Thrombospondin-2 Causes Age-Related Dilated Cardiomyopathy

(2009) Melissa Swinnen et al.   CIRCULATION

Pressure Overload–Induced Alterations in Fibrillar Collagen Content and Myocardial Diastolic Function

(2009) Amy D. Bradshaw et al.   CIRCULATION

Induction of the CXC Chemokine Interferon-γ-Inducible Protein 10 Regulates the Reparative Response Following Myocardial Infarction

(2009) Marcin Bujak et al.   CIRCULATION RESEARCH

Increased plasma levels of osteopontin are associated with activation of the renin–aldosterone system and with myocardial and coronary microvascular damage in dilated cardiomyopathy

(2009) Silvia Del Ry et al.   CYTOKINE

Periostin promotes a fibroblastic lineage pathway in atrioventricular valve progenitor cells

(2009) Russell A. Norris et al.   DEVELOPMENTAL DYNAMICS

Regulation of the Fibrosis and Angiogenesis Promoter SPARC/Osteonectin in Human Adipose Tissue by Weight Change, Leptin, Insulin, and Glucose

(2009) K. Kos et al.   DIABETES

Cardiomyopathy is associated with structural remodelling of heart valve extracellular matrix

(2009) Katja Schenke-Layland et al.   EUROPEAN HEART JOURNAL

Global deletion of thrombospondin-1 increases cardiac and skeletal muscle capillarity and exercise capacity in mice

(2009) Moh H. Malek et al.   EXPERIMENTAL PHYSIOLOGY

High prevalence of chronic myocarditis in dilated cardiomyopathy referred for left ventriculoplasty: expression of tenascin C as a possible marker for inflammation

(2009) Bin Tsukada et al.   HUMAN PATHOLOGY

Back to basics - how the evolution of the extracellular matrix underpinned vertebrate evolution

(2009) Julie Huxley-Jones et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

WISP1, a Pro-mitogenic, Pro-survival Factor, Mediates Tumor Necrosis Factor-α (TNF-α)-stimulated Cardiac Fibroblast Proliferation but Inhibits TNF-α-induced Cardiomyocyte Death

(2009) Kaliyamurthi Venkatachalam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Incremental Prognostic Values of Serum Tenascin-C Levels With Blood B-type Natriuretic Peptide Testing at Discharge in Patients With Dilated Cardiomyopathy and Decompensated Heart Failure

(2009) Naoki Fujimoto et al.   JOURNAL OF CARDIAC FAILURE

Osteopontin promotes fibrosis in dystrophic mouse muscle by modulating immune cell subsets and intramuscular TGF-β

(2009) Sylvia A. Vetrone et al.   JOURNAL OF CLINICAL INVESTIGATION

Osteopontin: Role in extracellular matrix deposition and myocardial remodeling post-MI

(2009) Mahipal Singh et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The extracellular matrix as a modulator of the inflammatory and reparative response following myocardial infarction

(2009) Marcin Dobaczewski et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Correlation between plasma osteopontin levels and aortic valve calcification: Potential insights into the pathogenesis of aortic valve calcification and stenosis

(2009) Pey-Jen Yu et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Thrombospondin-1 and CD47 regulate blood pressure and cardiac responses to vasoactive stress

(2009) Jeff S. Isenberg et al.   MATRIX BIOLOGY

Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease

(2009) Kim Midwood et al.   NATURE MEDICINE

Connective Tissue Growth Factor Overexpression in Cardiomyocytes Promotes Cardiac Hypertrophy and Protection against Pressure Overload

(2009) Anna N. Panek et al.   PLoS One

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

Modulation of matrix remodeling by SPARC in neoplastic progression

(2009) Alexandre Chlenski et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Decreased Expression of Thrombospondin-1 in Failing Hearts May Favor Ventricular Remodeling

(2009) M. Batlle et al.   TRANSPLANTATION PROCEEDINGS

The many facets of the matricelluar protein periostin during cardiac development, remodeling, and pathophysiology

(2009) Russell A. Norris et al.   Journal of Cell Communication and Signaling

Normal growth and development in mice over-expressing the CCN family member WISP3

(2009) Yukio Nakamura et al.   Journal of Cell Communication and Signaling

Connective tissue growth factor (CCN2, CTGF) and organ fibrosis: lessons from transgenic animals

(2009) David R. Brigstock   Journal of Cell Communication and Signaling

Periostin localizes to cells in normal skin, but is associated with the extracellular matrix during wound repair

(2009) Linda Jackson-Boeters et al.   Journal of Cell Communication and Signaling

The role of thrombospondins in wound healing, ischemia, and the foreign body reaction

(2009) Themis R. Kyriakides et al.   Journal of Cell Communication and Signaling

Thrombospondins in the heart: potential functions in cardiac remodeling

(2009) Mark W. M. Schellings et al.   Journal of Cell Communication and Signaling

Matricellular proteins: an overview

(2009) Paul Bornstein   Journal of Cell Communication and Signaling

The interaction of Thrombospondins with extracellular matrix proteins

(2009) Kemin Tan et al.   Journal of Cell Communication and Signaling

The role of SPARC in extracellular matrix assembly

(2009) Amy D. Bradshaw   Journal of Cell Communication and Signaling

The role of tenascin-C in tissue injury and tumorigenesis

(2009) Kim S. Midwood et al.   Journal of Cell Communication and Signaling

Connective tissue growth factor (CTGF, CCN2) gene regulation: a potent clinical bio-marker of fibroproliferative disease?

(2009) Andrew Leask et al.   Journal of Cell Communication and Signaling

Connective tissue growth factor and cardiac fibrosis

(2008) A. Daniels et al.   Acta Physiologica

Skeletal Abnormalities in Mice Lacking Extracellular Matrix Proteins, Thrombospondin-1, Thrombospondin-3, Thrombospondin-5, and Type IX Collagen

(2008) Karen L. Posey et al.   AMERICAN JOURNAL OF PATHOLOGY

Interleukin-1 Receptor Type I Signaling Critically Regulates Infarct Healing and Cardiac Remodeling

(2008) Marcin Bujak et al.   AMERICAN JOURNAL OF PATHOLOGY

Thrombospondin-2 Modulates Extracellular Matrix Remodeling during Physiological Angiogenesis

(2008) Marie M. Krady et al.   AMERICAN JOURNAL OF PATHOLOGY

Neonatal and Adult Cardiovascular Pathophysiological Remodeling and Repair

(2008) Russell A. Norris et al.   Annals of the New York Academy of Sciences

Thrombospondin-4 expression is rapidly upregulated by cardiac overload

(2008) Erja Mustonen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Abnormal skeletal and cardiac development, cardiomyopathy, muscle atrophy and cataracts in mice with a targeted disruption of the Nov (Ccn3) gene

(2008) Emma Heath et al.   BMC DEVELOPMENTAL BIOLOGY

Thrombospondins: from structure to therapeutics

(2008) C. B. Carlson et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Periostin Is Required for Maturation and Extracellular Matrix Stabilization of Noncardiomyocyte Lineages of the Heart

(2008) Paige Snider et al.   CIRCULATION RESEARCH

Genetic Manipulation of Periostin Expression in the Heart Does Not Affect Myocyte Content, Cell Cycle Activity, or Cardiac Repair

(2008) Angela Lorts et al.   CIRCULATION RESEARCH

miR-133 and miR-30 Regulate Connective Tissue Growth Factor

(2008) Rudy F. Duisters et al.   CIRCULATION RESEARCH

Osteopontin, a New Prognostic Biomarker in Patients With Chronic Heart Failure

(2008) Mark Rosenberg et al.   Circulation-Heart Failure

Regulation of Thrombospondin1 by Extracellular Proteases

(2008) M. Iruela-Arispe   CURRENT DRUG TARGETS

Periostin as a Heterofunctional Regulator of Cardiac Development and Disease

(2008) Simon Conway et al.   CURRENT GENOMICS

Osteopontin: Role in immune regulation and stress responses

(2008) Kathryn X. Wang et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Periostin regulates atrioventricular valve maturation

(2008) Russell A. Norris et al.   DEVELOPMENTAL BIOLOGY

Plasma connective tissue growth factor is a novel potential biomarker of cardiac dysfunction in patients with chronic heart failure

(2008) Norimichi Koitabashi et al.   EUROPEAN JOURNAL OF HEART FAILURE

Characterization of the inflammatory and fibrotic response in a mouse model of cardiac pressure overload

(2008) Ying Xia et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Noncollagenous bone matrix proteins as a part of calcific aortic valve disease regulation

(2008) Virva Pohjolainen et al.   HUMAN PATHOLOGY

Functions and mechanisms of action of CCN matricellular proteins

(2008) Chih-Chiun Chen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

SPARC Inhibits Adipogenesis by Its Enhancement of β-Catenin Signaling

(2008) Jing Nie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Interactions of Thrombospondin-1, -2, and -4 with CD47 and Effects on cGMP Signaling and Ischemic Injury Responses

(2008) Jeff S. Isenberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Haemocyte-derived SPARC is required for collagen-IV-dependent stability of basal laminae in Drosophila embryos

(2008) N. Martinek et al.   JOURNAL OF CELL SCIENCE

Periostin is essential for cardiac healingafter acute myocardial infarction

(2008) Masashi Shimazaki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Absence of SPARC results in increased cardiac rupture and dysfunction after acute myocardial infarction

(2008) Mark W.M. Schellings et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Adenovirus-mediated inhibition of SPARC attenuates liver fibrosis in rats

(2008) Alejandra M. Camino et al.   JOURNAL OF GENE MEDICINE

Epithelial Tenascin Predicts Obliterative Airway Disease

(2008) Outi E. Päiväniemi et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts

(2008) Baiqiu Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Endothelin-1 induces connective tissue growth factor expression in cardiomyocytes

(2008) Anna Grazia Recchia et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The differential amino acid requirement within osteopontin in α4 and α9 integrin-mediated cell binding and migration

(2008) Koyu Ito et al.   MATRIX BIOLOGY

Role of healing-specific-matricellular proteins and matrix metalloproteinases in age-related enhanced early remodeling after reperfused STEMI in dogs

(2008) Bodh I. Jugdutt et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The immune system and cardiac repair

(2008) N FRANGOGIANNIS   PHARMACOLOGICAL RESEARCH

Cardiac Remodeling in Obesity

(2008) E. Dale Abel et al.   PHYSIOLOGICAL REVIEWS

Mechano-regulated Tenascin-C orchestrates muscle repair

(2008) M. Fluck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Connective tissue growth factor: growth factor, matricellular organizer, fibrotic biomarker or molecular target for anti-fibrotic therapy in SSc?

(2008) D. Abraham   RHEUMATOLOGY

Functional role of periostin in development and wound repair: implications for connective tissue disease

(2008) Douglas W. Hamilton   Journal of Cell Communication and Signaling

Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling

(2007) J. S. Isenberg et al.   BLOOD