Review
Cardiac & Cardiovascular Systems
Amirala Bakhshian Nik, Santiago Alvarez-Argote, Caitlin C. O'Meara
Summary: IL4 and IL13 play a significant role in cardiac regeneration and repair following injury, leading to beneficial outcomes. However, there is still a lack of comprehensive understanding about their molecular and cellular actions in the heart.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Akihiko Kubota, Akira Suto, Kensuke Suga, Arifumi Iwata, Shigeru Tanaka, Kotaro Suzuki, Yoshio Kobayashi, Hiroshi Nakajima
Summary: The study reveals that IL-21 induces apoptosis of Ly6Clow macrophages, reducing survival rates after MI and delaying wound healing. Meanwhile, IL-21 secreted by CD4+ T cells plays a crucial role in this process.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Article
Surgery
Walker D. Short, Meredith Rae, Thomas Lu, Benjamin Padon, Tanuj J. Prajapati, Fayiz Faruk, Oluyinka O. Olutoye II, Ling Yu, Paul Bollyky, Sundeep G. Keswani, Swathi Balaji
Summary: This study investigates the role of endogenous interleukin-10 (IL-10) in postnatal dermal wound healing using a murine model. The results demonstrate that endogenous IL-10 expression does not affect wound healing rate, but leads to increased inflammatory cell infiltration and scar formation.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Jiao Jiao, Shujie He, Yiqiu Wang, Yuzhi Lu, Muyang Gu, Dan Li, Tingting Tang, Shaofang Nie, Min Zhang, Bingjie Lv, Jingyong Li, Ni Xia, Xiang Cheng
Summary: The study demonstrates that Bregs can limit ventricular remodeling after myocardial infarction by reducing CCR2-mediated monocyte recruitment and mobilization.
BASIC RESEARCH IN CARDIOLOGY
(2021)
Review
Endocrinology & Metabolism
Lisa K. Mullany, David M. Lonard, Bert W. O'Malley
Summary: Multicellular organisms have evolved complex mechanisms for tissue repair following injury, with steroid receptor coactivators (SRCs) playing a key role in cell signaling and wound healing. Stimulation of SRCs has been shown to promote cardiac protection and inhibit pathologic remodeling after myocardial infarction, suggesting a potential therapeutic target for drug development in wound healing.
Article
Pharmacology & Pharmacy
Yong Fu, Jun Shi, Hong Qian, Chaoyi Qin, Lulu Liu, Jiayu Shen, Hao Ma, Lang Ma, Bin Liao, Yingqiang Guo
Summary: This study investigated the therapeutic effect of peritoneal matrix-loaded pirfenidone nanodroplets (NDs) on myocardial infarction (MI) fibrosis. The results showed that the nanodroplets achieved a slow drug release and inhibited cardiac fibroblasts transformation and collagen synthesis. Combining the peritoneal matrix with pirfenidone nanodroplets showed excellent therapeutic effects on fibrosis in MI rats. This study confirmed the feasibility and synergistic effectiveness of the approach and highlighted the potential application of nanomedicine in other biomedical fields.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Immunology
Hector Giral, Vedran Franke, Minoo Moobed, Maja F. Mueller, Laura Luebking, Divya Maria James, Johannes Hartung, Kira Kuschnerus, Denitsa Meteva, Claudio Seppelt, Philipp Jakob, Roland Klingenberg, Nicolle Kraenkel, David Leistner, Tanja Zeller, Stefan Blankenberg, Friederike Zimmermann, Arash Haghikia, Thomas F. Luescher, Altuna Akalin, Ulf Landmesser, Adelheid Kratzer
Summary: This study found that in AMI patients, monocyte subpopulations exhibit attenuated rapid inflammasome activation, accompanied by a significant increase in TNFAIP3 and IRAKM expression. This unexpected response may be a protective phenotype occurring after an acute inflammatory wave in the ischemic area.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jianrui Song, Ryan A. Frieler, Steven E. Whitesall, Yutein Chung, Thomas M. Vigil, Lindsey A. Muir, Jun Ma, Frank Brombacher, Sascha N. Goonewardena, Carey N. Lumeng, Daniel R. Goldstein, Richard M. Mortensen
Summary: This study revealed the crucial role of myeloid IL4R alpha signaling in cardiac remodeling post-MI, showing that myeloid cells are the main target cell types of this signaling. Deficiency of myeloid IL4R alpha signaling resulted in impaired cardiac function post-MI due to dysregulated inflammation and insufficient fibrotic remodeling. These findings highlight the potential of activating myeloid-specific IL4R alpha signaling to improve remodeling post-MI, offering hope to MI patients and reducing side effects compared to whole body treatment.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Susanna Fiorelli, Andrea Anesi, Benedetta Porro, Nicola Cosentino, Jose P. Werba, Alessandro Di Minno, Chiara Maria Manega, Simone Barbieri, Gualtiero Colombo, Giancarlo Marenzi, Viviana Cavalca, Elena Tremoli, Sonia Eligini
Summary: The study focused on investigating the migration capacity of monocytes isolated from patients with acute myocardial infarction (AMI) at hospital presentation and its correlation with cellular lipid profile. It was found that AMI patients' monocytes exhibited increased migration and a distinct lipidomic profile compared to controls, with lactosylceramide levels positively correlating with migration and lactosylceramide synthase inhibition significantly reducing monocyte migration induced by fetal bovine serum. These results suggest a potential mechanism involving lactosylceramide in the development of atherothrombosis and AMI.
Article
Cardiac & Cardiovascular Systems
Naixin Wang, Weiwei Wang, Xiaoqi Wang, Ge Mang, Jianfeng Chen, Xiangyu Yan, Zhonghua Tong, Qiannan Yang, Mengdi Wang, Liangqi Chen, Ping Sun, Yupeng Yang, Jingxuan Cui, Mian Yang, Yafei Zhang, Dongni Wang, Jian Wu, Maomao Zhang, Bo Yu
Summary: Histone lactylation promotes early remote activation of reparative transcriptional response in monocytes, which is essential for establishing immune homeostasis and timely activation of the cardiac repair process post-MI.
CIRCULATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ingmar Soren Meyer, Xue Li, Carina Meyer, Oksana Voloshanenko, Susann Pohl, Michael Boutros, Hugo Albert Katus, Norbert Frey, Florian Leuschner
Summary: This study tested the therapeutic potential of the Wnt secretion inhibitor LGK-974 in a model of ischemia/reperfusion injury and found that LGK-974 can attenuate inflammatory response, improve heart function, and potentially be used for immunomodulatory approaches to improve cardiac remodeling after myocardial infarction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Tianbao Ye, Boshen Yang, Peng Wei, Kaifan Niu, Taixi Li, Di Wang, Yaping Zhang, Yu Chen, Chengxing Shen, Xiaoqing Wang, Xian Jin, Liang Liu
Summary: This study identifies Chil1 as a protective factor in myocardial infarction (MI) progression, which activates RAF/MEK1/ERK signaling pathway through binding to EGFR. Overexpression of Chil1 can reduce cardiac rupture, increase wall thickness, and improve cardiac function.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Elke Roeb
Summary: The liver is linked to metabolic-inflammatory diseases and plays a role in the pathogenesis of metabolic syndrome. IL-13 may have protective effects on the development of metabolic-dysfunction-associated steatohepatitis (MASH), but it can also contribute to the progression of MASH through gut barrier dysfunction and enhanced hepatic fibrosis. However, there is limited research on IL-13's effects on metabolic diseases and potential therapies. This review article summarizes and discusses the contradictory aspects of IL-13's effects on the liver and metabolic liver diseases based on recent literature.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Roxana Delia Zaharie, Calin Popa, Diana Schlanger, Dan Valean, Florin Zaharie
Summary: Wound healing process is influenced by various cytokines, chemokines, and growth factors, and interleukin-22 (IL-22) is a crucial cytokine for tissue regeneration. This systematic review examined the implications of IL-22 in wound healing caused by external factors. The findings suggest that IL-22 plays a central role in stimulating cell proliferation, migration, and differentiation during tissue repair. However, excessive IL-22 expression can have negative effects. Further research is needed to validate the roles of IL-22 in clinical practice and its potential implications in surgical healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Daile Jia, Siqin Chen, Peiyuan Bai, Chentao Luo, Jin Liu, Aijun Sun, Junbo Ge
Summary: This study reveals the importance of cardiac resident macrophages in the efficient clearance and degradation of apoptotic cardiomyocytes during myocardial infarction, which is crucial for inflammation resolution and tissue repair. The researchers identified Lgmn as a key gene involved in this process and demonstrated its functional significance through various experiments.
Article
Neurosciences
Chi Wang Ip, Ioannis U. Isaias, Burak B. Kusche-Tekin, Dennis Klein, Janos Groh, Aet O'Leary, Susanne Knorr, Takahiro Higuchi, James B. Koprich, Jonathan M. Brotchie, Klaus V. Toyka, Andreas Reif, Jens Volkmann
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2016)
Article
Neurosciences
Lisa Rauschenberger, Susanne Knorr, Yaser Al-Zuraiqi, Philip Tovote, Jens Volkmann, Chi Wang Ip
EXPERIMENTAL NEUROLOGY
(2020)
Article
Multidisciplinary Sciences
Lisa Rauschenberger, Susanne Knorr, Jens Volkmann, Chi Wang Ip
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2020)
Article
Neurosciences
Susanne Knorr, Lisa Rauschenberger, Uri Ramirez Pasos, Maximilian U. Friedrich, Robert L. Peach, Kathrin Grundmann-Hauser, Thomas Ott, Aet O'Leary, Andreas Reif, Philip Tovote, Jens Volkmann, Chi Wang Ip
Summary: The study induced dystonia-like symptoms in rats through peripheral nerve injury and investigated the central mechanisms of dystonia development. The nerve-injured rats developed long-lasting symptoms over 12 weeks and showed higher striatal dopaminergic turnover. Deep brain stimulation improved the symptoms, emphasizing the role of environmental factors in symptom development.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Multidisciplinary Sciences
Susanne Knorr, Lisa Rauschenberger, Tami Lang, Jens Volkmann, Chi Wang Ip
Summary: The induction of peripheral nerve injury is widely used in neuroscience to assess repair and pain mechanisms, while sciatic crush injury can trigger specific phenotypes in dystonia rodent models. Standardized methods for nerve crush induction and phenotypical characterization are crucial for consistent results.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Neurosciences
Susanne Knorr, Thomas Musacchio, Raik Paulat, Cordula Matthies, Heinz Endres, Nikolaus Wenger, Christoph Harms, Chi Wang Ip
Summary: Deep brain stimulation (DBS) is the preferred treatment for therapy-resistant movement disorders, but the mechanisms of action are still not well understood. Rodent models of PD and dystonia have been crucial in elucidating DBS effects, with advances in identifying impacts on motor networks, neuroprotection, and neuroinflammation. Continuous improvements in rodent DBS technologies contribute to experimental quality and understanding of DBS effects.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Neurosciences
Lisa Rauschenberger, Susanne Knorr, Antonio Pisani, Mark Hallett, Jens Volkmann, Wang Ip
Summary: The role of environmental factors in dystonia onset and development, especially in monogenic and adult-onset dystonia, remains a mystery in dystonia pathophysiology. Evidence suggests a gene-environment interaction, but the specific mechanisms are still unclear.
NEUROBIOLOGY OF DISEASE
(2021)