Molecular and cellular mechanisms of glucagon-like peptide-1 receptor agonist-mediated attenuation of cardiac fibrosis

Endothelin-1 upregulation mediates aging-related cardiac fibrosis

(2015) Xianwei Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Heart failure and mortality outcomes in patients with type 2 diabetes taking alogliptin versus placebo in EXAMINE: a multicentre, randomised, double-blind trial

(2015) Faiez Zannad et al.   LANCET

Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis

(2015) Katrin Palumbo-Zerr et al.   NATURE MEDICINE

Stimulation of glucagon-like peptide-1 receptor through exendin-4 preserves myocardial performance and prevents cardiac remodeling in infarcted myocardium

(2014) Megan DeNicola et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Effects of glucagon-like peptide-1 agents on left ventricular function: Systematic review and meta-analysis

(2014) Rui Liu et al.   ANNALS OF MEDICINE

What Is Measured by Cardiac Fibrosis Biomarkers and Imaging?

(2014) Faiez Zannad   Circulation-Heart Failure

GLP-1 Receptor Localization in Monkey and Human Tissue: Novel Distribution Revealed With Extensively Validated Monoclonal Antibody

(2014) Charles Pyke et al.   ENDOCRINOLOGY

Diabetes, incretin hormones and cardioprotection

(2014) A Myat et al.   HEART

Glucagon like peptide-1 attenuates bleomycin-induced pulmonary fibrosis, involving the inactivation of NF-κB in mice

(2014) Si GOU et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Oxidative stress mediates the conversion of endothelial cells into myofibroblasts via a TGF-β1 and TGF-β2-dependent pathway

(2014) Ignacio Montorfano et al.   LABORATORY INVESTIGATION

Dipeptidyl peptidase inhibition prevents diastolic dysfunction and reduces myocardial fibrosis in a Mouse model of Western diet induced obesity

(2014) Brian Bostick et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Inactivation of the cardiomyocyte glucagon-like peptide-1 receptor (GLP-1R) unmasks cardiomyocyte-independent GLP-1R-mediated cardioprotection

(2014) John R. Ussher et al.   Molecular Metabolism

Metformin and liraglutide ameliorate high glucose-induced oxidative stress via inhibition of PKC-NAD(P)H oxidase pathway in human aortic endothelial cells

(2013) Battsetseg Batchuluun et al.   ATHEROSCLEROSIS

Glucagon-like Peptide-1 Receptor Agonist Liraglutide Inhibits Endothelin-1 in Endothelial Cell by Repressing Nuclear Factor-Kappa B Activation

(2013) Yao Dai et al.   CARDIOVASCULAR DRUGS AND THERAPY

HMGCoA reductase inhibition reverses myocardial fibrosis and diastolic dysfunction through AMP-activated protein kinase activation in a mouse model of metabolic syndrome

(2013) Nerea Hermida et al.   CARDIOVASCULAR RESEARCH

Identification and Characterization of GLP-1 Receptor-Expressing Cells Using a New Transgenic Mouse Model

(2013) P. Richards et al.   DIABETES

The GLP-1 receptor agonist liraglutide inhibits progression of vascular disease via effects on atherogenesis, plaque stability and endothelial function in an ApoE−/− mouse model

(2013) Tracey Gaspari et al.   Diabetes & Vascular Disease Research

Glucagon-like peptide-1 receptor agonist treatment reduces beta cell mass in normoglycaemic mice

(2013) J. H. Ellenbroek et al.   DIABETOLOGIA

Role of inflammation in the pathogenesis of heart failure with preserved ejection fraction and its potential as a therapeutic target

(2013) N. Glezeva et al.   HEART FAILURE REVIEWS

Conundrum of pathogenesis of diabetic cardiomyopathy: role of vascular endothelial dysfunction, reactive oxygen species, and mitochondria

(2013) Mandip Joshi et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The glucagon-like peptide 1 analog liraglutide reduces TNF-α-induced oxidative stress and inflammation in endothelial cells

(2012) Aya Shiraki et al.   ATHEROSCLEROSIS

Glucagon-like peptide-1 (GLP-1) induces M2 polarization of human macrophages via STAT3 activation

(2012) Daisuke Shiraishi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Glucagon-Like Peptide-1 Analog Reverses the Molecular Pathology and Cardiac Dysfunction of a Mouse Model of Obesity

(2012) Mohammad Hossein Noyan-Ashraf et al.   CIRCULATION

Glucagon-like peptide-1 inhibits adipose tissue macrophage infiltration and inflammation in an obese mouse model of diabetes

(2012) Y.-S. Lee et al.   DIABETOLOGIA

The Glucagon-Like Peptide-1 Receptor—or Not?

(2012) Charles Pyke et al.   ENDOCRINOLOGY

GLP-1 analog liraglutide protects against oxidative stress and albuminuria in streptozotocin-induced diabetic rats via protein kinase A-mediated inhibition of renal NAD(P)H oxidases

(2012) Hari Hendarto et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Myofibroblast-mediated mechanisms of pathological remodelling of the heart

(2012) Karl T. Weber et al.   Nature Reviews Cardiology

The role of cardiac fibroblasts in the transition from inflammation to fibrosis following myocardial infarction

(2012) Frans A. van Nieuwenhoven et al.   VASCULAR PHARMACOLOGY

A GLP-1 receptor agonist liraglutide inhibits endothelial cell dysfunction and vascular adhesion molecule expression in an ApoE-/- mouse model

(2011) Tracey Gaspari et al.   Diabetes & Vascular Disease Research

The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes

(2011) M. Shimoda et al.   DIABETOLOGIA

Angiotensin II induces inflammation leading to cardiac remodeling

(2011) Lixin Jia   Frontiers in Bioscience-Landmark

Exenatide Exerts a Potent Antiinflammatory Effect

(2011) Ajay Chaudhuri et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Exendin-4 Improves Blood Glucose Control in Both Young and Aging Normal Non-Diabetic Mice, Possible Contribution of Beta Cell Independent Effects

(2011) Rongrong Fan et al.   PLoS One

BAY 11-7082, a Nuclear Factor-κB Inhibitor, Reduces Inflammation and Apoptosis in a Rat Cardiac Ischemia-Reperfusion Injury Model

(2010) Yong Sook Kim et al.   International Heart Journal

GLP-1R Agonist Liraglutide Activates Cytoprotective Pathways and Improves Outcomes After Experimental Myocardial Infarction in Mice

(2009) M. H. Noyan-Ashraf et al.   DIABETES

Direct contribution of epithelium to organ fibrosis: epithelial-mesenchymal transition

(2009) Marcello Guarino et al.   HUMAN PATHOLOGY

Oxidative Stress Triggers Cardiac Fibrosis in the Heart of Diabetic Rats

(2007) Manuela Aragno et al.   ENDOCRINOLOGY

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY