Review
Physiology
Natacha Fourny, Christophe Beauloye, Monique Bernard, Sandrine Horman, Martine Desrois, Luc Bertrand
Summary: Type 2 diabetes is linked to cardiovascular diseases, with significant sex differences in prevalence, pathophysiology, and outcomes. Women with diabetes have a higher risk of cardiovascular diseases, and there is a sexual dimorphism in the incidence and outcomes of cardiac dysfunction.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xi Zhang, Die Wang, Yafei Zheng, Yingxin Tu, Qingqing Xu, Haowei Jiang, Chen Li, Liangcai Zhao, Yuping Li, Hong Zheng, Hongchang Gao
Summary: The study reveals sexual dimorphism in T1D mice, with female mice showing greater changes in gut microbiota and male mice being more susceptible to T1D in terms of host metabolome. The correlation network analysis suggests that T1D-induced host metabolic changes may be regulated by the gut microbiota in a sex-specific manner, involving SCFAs metabolism, energy metabolism, amino acid metabolism, and choline metabolism.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Cardiac & Cardiovascular Systems
Christine Rootwelt-Norberg, Oyvind H. Lie, Monica Chivulescu, Anna Castrini, Sebastian Sarvari, Erik Lyseggen, Vibeke M. Almaas, Martin P. Bogsrud, Thor Edvardsen, Kristina H. Haugaa
Summary: Male AC patients were more likely to be probands and had a higher prevalence of VA than female patients, but the differences disappeared after adjusting for exercise dose. Importantly, disease progression was similar between male and female patients.
Article
Biochemistry & Molecular Biology
Marcus Negron, Jeffrey Kristensen, Van Thuan Nguyen, Lauren E. Gansereit, Frank J. Raucci, Julia L. Chariker, Aaron Heck, Imamulhaq Brula, Gabrielle Kitchen, Cassandra P. Awgulewitsch, Lin Zhong, Eric C. Rouchka, Simran Banga, Cristi L. Galindo
Summary: The study found that mice with the BDNF rs6265 polymorphism exhibited altered cardiac function, with gender-specific differences. Female mice showed cardiac hypertrophy in response to stress, while male mice displayed an inflammatory immune response. These results reveal sex-based differences in how the BDNF polymorphism modifies cardiac physiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Weikun Jia, Tao Bai, Jiang Zeng, Zijing Niu, Daogui Fan, Xin Xu, Meiling Luo, Peijian Wang, Qingliang Zou, Xiaozhen Dai
Summary: The combination therapy of metformin and atorvastatin showed superior protective effects against diabetic cardiomyopathy by inhibiting oxidative stress and inflammation, as well as reducing apoptosis of cardiomyocytes. This effect may be related to the activation of AMPK/SIRT1 signaling pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Juntao Yuan, Fang Li, Bingqing Cui, Junling Gao, Zhuoran Yu, Zhongbing Lu
Summary: Diabetic cardiomyopathy is a major cause of death in diabetic patients. The GCN2 inhibitor, GCN2iB, has been found to effectively protect T2D mice from cardiac dysfunction, making it a potential novel drug candidate for DCM therapy.
Article
Cardiac & Cardiovascular Systems
Jian Sun, Jiyu Xu, Yong Liu, Xiaoyi Xu, Shumin Zhang, Yankun Hao, Yitong Lin, Yue Han, Feiya Li, Hui Yuan
Summary: Diabetic cardiomyopathy (DCM) is a serious complication of diabetes. Recent studies have shown that spermine has a cardioprotective effect. In this study, proteomic and metabolomic analyses were used to identify the research targets of spermine treatment in a type II diabetic mouse model. The results showed that spermine can affect the production of metabolites by regulating the expression of specific proteins.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Nutrition & Dietetics
Hye-Yoom Kim, Jung-Joo Yoon, Hyeon-Kyoung Lee, Ai-Lin Tai, Yun-Jung Lee, Dae-Sung Kim, Dae-Gill Kang, Ho-Sub Lee
Summary: The study demonstrated that Bla.C extract effectively prevented diabetes-induced cardiovascular complications by reducing inflammation and cardiovascular fibrosis, and improving blood glucose metabolism.
Article
Endocrinology & Metabolism
Yiting Wang, Jue Zhang, Junlin Zhang, Yucheng Wu, Rui Zhang, Honghong Ren, Mark E. Cooper, Fang Liu
Summary: The study found that female patients with DKD had higher levels of certain indicators (such as blood pressure, cholesterol levels) compared to male patients, but there was no significant association observed between sex differences and ESKD.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Aila J. Ahola, Valma Harjutsalo, Carol Forsblom, Francois Pouwer, Per-Henrik Groop
Summary: The study found that diagnosed depression and antidepressant purchases are associated with the progression of diabetic nephropathy in type 1 diabetes patients, however, symptoms of depression themselves did not show a significant association with progression. Further research is needed to determine if successful treatment of depression can reduce the risk.
Review
Medicine, General & Internal
Angita Jain, Nadine Norton, Katelyn A. Bruno, Leslie T. Cooper, Paldeep S. Atwal, DeLisa Fairweather
Summary: Dilated cardiomyopathy (DCM) is a condition characterized by left ventricular dilatation and impaired systolic function, with diverse etiologies including genetic factors, infection, inflammation, and autoimmune diseases. Research indicates that DCM is more common in males than females, and there are differences in disease prevalence between the sexes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Hong-Kai Zhang, Chun-Yan Shi, Dong-Ting Liu, Hui-Qiang Gao, Qian-Qian Zhao, Nan Zhang, Lin Yang, Guo-Qi Li, Yue-Li Wang, Yu Du, Qing Li, Kai-Rui Bo, Baiyan Zhuang, Zhan-Ming Fan, Zhong-Hua Sun, Lei Xu
Summary: This study aimed to detect the dynamic changes in cardiac morphology, function, and diffuse myocardial fibrosis (DMF) associated with T1DM and T2DM mouse models. The findings showed that cardiac mechanical parameters had significant correlations with ECV values, which could provide imaging biomarkers for early diagnosis and intervention in diabetic cardiomyopathy.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fuyu Jin, Yaqian Li, Xiaojing Wang, Xinyu Yang, Tian Li, Hong Xu, Zhongqiu Wei, Heliang Liu
Summary: This study investigated the impact of sex on silicotic lesions and progressive fibrotic responses in silicosis. The results showed that there was no significant difference between male and female mice in terms of the area of silicon nodules and collagen deposition. Despite differences in the expression of certain factors, there was no overall difference in the progressive fibrosis between female and male mice in silicosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Shivani Singla, Chittaranjan Sahu, Gopabandhu Jena
Summary: The study found that hyperglycemic conditions exacerbated the pathological conditions in UC of male animals, while milder conditions developed in females.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Multidisciplinary Sciences
Minkwan Kim, Bongsung Kim, You-Jung Choi, Hyun-Jung Lee, Heesun Lee, Jun-Bean Park, Seung-Pyo Lee, Kyung-Do Han, Yong-Jin Kim, Hyung-Kwan Kim
Summary: The study revealed that women with HCM have a worse prognosis compared to men, primarily due to a higher incidence of new-onset HF admissions.
SCIENTIFIC REPORTS
(2021)