Article
Immunology
Zehua Ye, Yuqi Xia, Xiangjun Zhou, Bojun Li, Weimin Yu, Yuan Ruan, Haoyong Li, JinZhuo Ning, Lijia Chen, Ting Rao, Fan Cheng
Summary: This study aimed to investigate the role and mechanism of CXCR4 in calcium oxalate (CaOx) crystal deposition-induced renal fibrosis. The results showed that inhibition of CXCR4 could attenuate CaOx crystal-induced renal fibrosis and suppress autophagy and EMT pathways. Therefore, CXCR4 may be a potential target for preventing renal fibrosis in patients with nephrolithiasis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ning Zhang, Qunchao Ma, Yayu You, Xiangyang Xia, Cuiping Xie, Yuxue Huang, Zhuo Wang, Feiming Ye, Zhaosheng Yu, Xiaojie Xie
Summary: This study investigated the role of CXCR4 in heart failure with preserved ejection fraction (HFpEF) using a mouse model. The results showed that CXCR4+ macrophages play a crucial role in HFpEF, promoting inflammation and fibrosis in the heart. CXCR4 deficiency in macrophages improved cardiac function and reduced fibrosis in HFpEF mice. The findings suggest that targeting CXCR4 could be a potential therapeutic strategy for hypertension-induced HFpEF.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Hui Lin, Le Guan, Liping Meng, Hiroyasu Uzui, Hangyuan Guo
Summary: SGLT1 is upregulated in diabetic cardiac tissues and high-glucose-induced cardiac fibroblasts. Its overexpression promotes cardiac fibroblast proliferation and collagen synthesis, while its silencing significantly alleviates cardiac fibrosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yuanyuan Tian, Zhenyu Wang, Xiangyu Zheng, Wenjing Song, Lu Cai, Madhavi Rane, Yuguang Zhao
Summary: The study found that SDF-1 beta can prevent diabetes-induced cardiac dysfunction and fibrosis, partially dependent on KLF15. By activating the p38β MAPK signaling pathway, SDF-1 beta inhibits palmitate-induced cardiomyocyte fibrosis.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Omaima A. Ahmedy, Marwa W. Kamel, Dalia M. Abouelfadl, Marwa E. Shabana, Rabab H. Sayed
Summary: This study discovered the protective effects of berberine in bleomycin-induced pulmonary fibrosis in mice, and its mechanism involved the activation of adenosine A2a receptor and suppression of SDF-1/CXCR4 signaling pathway. Berberine improved lung fibrosis by modulating the purinergic system, inhibiting epithelial mesenchymal transition, and effectively suppressing inflammation and oxidative stress.
Article
Immunology
Qixian Sun, Xinrong Tao, Bing Li, Hangbing Cao, Haoming Chen, Yuanjie Zou, Huihui Tao, Min Mu, Wenyang Wang, Keyi Xu
Summary: AMD3100, a CXCR4 inhibitor, delays the progression of pulmonary inflammation and fibrosis in a silicosis mouse model caused by crystalline silica, suggesting its potential as a therapeutic drug for silicosis.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Yinhui Wang, Kun Yu, Chengcheng Zhao, Ling Zhou, Jia Cheng, Dao Wen Wang, Chunxia Zhao
Summary: The study revealed that Follistatin plays a cardioprotective role in attenuating diabetic cardiomyopathy by reducing cardiac fibrosis and reactive oxygen species production, and enhancing matrix metallopeptidase 9 activities.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Renata M. Lataro, Davi J. A. Moraes, Fabio N. Gava, Ana C. M. Omoto, Carlos A. A. Silva, Fernanda Brognara, Lais Alflen, Vania Brazao, Rafaela Pravato Colato, Jose' Clo'vis do Prado, Anthony P. Ford, Helio C. Salgado, Julian F. R. Paton
Summary: Despite advances in heart failure treatment, there is still no cure for this disease, which is associated with reduced cardiac function, autonomic dysregulation, inflammation, and sleep-disordered breathing. This study discovers that blocking purinergic receptors in the carotid body can improve various pathological processes of heart failure by inhibiting spontaneous burst discharges, normalizing chemoreceptor sensitivity, and improving cardiac function. The findings provide a potential therapeutic angle for heart failure and its complications.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Ajit Magadum, Neha Singh, Ann Anu Kurian, Mohammad Tofael Kabir Sharkar, Nishat Sultana, Elena Chepurko, Keerat Kaur, Magdalena M. Zak, Yoav Hadas, Djamel Lebeche, Susmita Sahoo, Roger Hajjar, Lior Zangi
Summary: Heart failure remains a major issue globally, with cardiac hypertrophy and fibrosis being key factors. The regulator Pip4k2c, associated with mTORC1, plays a role in these processes. Studies show that deleting Pip4k2c does not affect embryonic cardiac development, but leads to increased rates of CH, CF, and sudden death in adult mice. Upregulating Pip4k2c improves heart function, reverses CH and CF, and enhances survival through inhibiting TGF beta 1 via specific pathways. Loss-and-gain-of-function studies identify Pip4k2c as a potential therapeutic target for CF, CH, and HF, utilizing modRNA as an effective gene therapy approach.
Article
Cardiac & Cardiovascular Systems
Masum M. Mia, Dasan Mary Cibi, Siti Aishah Binte Abdul Ghani, Anamika Singh, Nicole Tee, Viswanathan Sivakumar, Hanumakumar Bogireddi, Stuart A. Cook, Junhao Mao, Manvendra K. Singh
Summary: Yap/Taz play an important regulatory role in MI-induced cardiac fibrosis by controlling fibroblast proliferation, transdifferentiation into myofibroblasts, and fibroinflammatory program.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yoshiko Hada, Haruhito A. Uchida, Ryoko Umebayashi, Masashi Yoshida, Jun Wada
Summary: Cilostazol can attenuate Angiotensin II-induced cardiac fibrosis by activating the cAMP-PKA pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Tianbao Ye, Zhiwen Yan, Cheng Chen, Di Wang, Aiting Wang, Taixi Li, Boshen Yang, Xianting Ding, Chengxing Shen
Summary: This study aimed to investigate the cardioprotective role of lactoferrin (Ltf) in myocardial infarction (MI) and its underlying mechanisms. Proteomic analysis revealed that Ltf was significantly upregulated in MI hearts but decreased in circulation, and its expression was positively correlated with cardiac function. Ltf administration attenuated cardiac fibrosis and remodeling, improved cardiac function, and reduced the incidence of heart failure post-MI.
Article
Endocrinology & Metabolism
Sang Hyun Song, Dawool Han, Kyeonghui Park, Jo Eun Um, Seonghun Kim, Minhee Ku, Jaemoon Yang, Tae-Hyun Yoo, Jong In Yook, Nam Hee Kim, Hyun Sil Kim
Summary: Diabetic nephropathy is a common complication of diabetes. The newly discovered cell death mechanism called ferroptosis, induced by TGF-beta, is involved in kidney damage in diabetic nephropathy. BMP7, a known antagonist of TGF-beta, can inhibit TGF-beta-induced fibrosis and play a role in the regeneration of pancreatic beta cells in diabetic animal models.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Siddharth Sunilkumar, Esma I. Yerlikaya, Allyson L. Toro, William P. Miller, Han Chen, Kebin Hu, Scot R. Kimball, Michael D. Dennis
Summary: Chronic hyperglycemia promotes the expression of REDD1 in the kidney, leading to oxidative stress and renal injury. Deletion of REDD1 reduces reactive oxygen species and prevents podocyte loss, indicating its role in diabetes-induced renal complications.
Article
Biochemistry & Molecular Biology
Tingting Li, Yuting Zhuang, Wanqi Yang, Yilin Xie, Wendi Shang, Shuang Su, Xue Dong, Jiaxu Wu, Wenmei Jiang, Yang Zhou, Ying Li, Xin Zhou, Mingyu Zhang, Yanjie Lu, Zhenwei Pan
Summary: METTL3 plays a critical role in cardiac fibrosis by regulating fibroblast proliferation, transition, and collagen accumulation. Silencing METTL3 can alleviate cardiac fibrosis, indicating its potential as a molecular target for manipulating fibrosis and associated cardiac diseases.
Article
Cardiac & Cardiovascular Systems
Anum Aslam, Sheneli Perera, Monique Watts, David Kaye, Jaime Layland, Stephen J. Nicholls, James Cameron, Sarah Zaman
Summary: More than a quarter of women treated with PCI for CAD had experienced a past pregnancy-related vascular complication, yet medical providers were not obtaining a history of these 'non-traditional' cardiovascular risk factors.
HEART LUNG AND CIRCULATION
(2021)
Article
Cardiac & Cardiovascular Systems
Sheneli Perera, Anum Aslam, Julia Stehli, David Kaye, Jamie Layland, Stephen J. Nicholls, James Cameron, Sarah Zaman
Summary: Gender differences were identified in healthy lifestyle adherence in patients treated with PCI for CAD. Women were less likely to smoke, be physically active, attend cardiac rehabilitation, and take statin therapy compared to men. Female gender independently predicted physical inactivity.
HEART LUNG AND CIRCULATION
(2021)
Article
Cardiac & Cardiovascular Systems
David McGiffin, Christina Kure, Janelle McLean, Silvana Marasco, Peter Bergin, James L. Hare, Angeline Leet, Hitesh Patel, Adam Zimmet, Julia Rix, Andrew Taylor, David Kaye
Summary: A total of 12 patients underwent HeartMate 3 biventricular VAD implantation with promising outcomes, as indicated by a survival rate of 91.7% at 18 months.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Letter
Cardiac & Cardiovascular Systems
Nir Uriel, Daniel Burkhoff, Gene Kim, Tracey Silverstein, Colleen Juricek, David M. Kaye, Gabriel Sayer
CIRCULATION-HEART FAILURE
(2021)
Letter
Peripheral Vascular Disease
Matthew Snelson, Rikeish R. Muralitharan, Evany Dinakis, Michael Nakai, Hamdi A. Jama, Waled A. Shihata, Chad Johnson, David M. Kaye, Charles R. Mackay, Louise M. Burrell, Melinda T. Coughlan, Francine Z. Marques
Article
Cardiac & Cardiovascular Systems
Wayne C. Zheng, Samer Noaman, Riley J. Batchelor, Laura Hanson, Jason Bloom, David Kaye, Stephen J. Duffy, Antony Walton, Vincent Pellegrino, James Shaw, Yang Yang, Craig French, Dion Stub, Nicholas Cox, William Chan
Summary: This study assessed the clinical characteristics and predictors of in-hospital mortality in patients presenting with out-of-hospital cardiac arrest (OHCA) and shockable rhythm selected for coronary angiography (CA). The findings showed that non-selection for CA, concomitant cardiogenic shock, poor initial resuscitation, greater burden of co-morbidities, and advanced age were key adverse prognostic indicators for patients with OHCA and shockable rhythm.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Shane Nanayakkara, David M. Kaye
Summary: Heart failure with preserved ejection fraction accounts for half of all cases of heart failure, leading to significant morbidity and mortality. Currently, there are no effective pharmacologic interventions. Device-based therapy, which aims to reduce left atrial pressure and pulmonary congestion, has become a focus of research. This review explores the pathophysiology, evidence base, benefits, and considerations of these devices in the treatment of heart failure with preserved ejection fraction.
HEART FAILURE REVIEWS
(2023)
Letter
Cardiac & Cardiovascular Systems
David M. Kaye, Donna Vizi, Sandra Graham, Bing Wang, Waled Shihata, Shane Nanayakkara, Justin Mariani, Manuja Premaratne
CIRCULATION-HEART FAILURE
(2022)
Article
Peripheral Vascular Disease
Evany Dinakis, Michael Nakai, Paul Gill, Rosilene Ribeiro, Stephanie Yiallourou, Yusuke Sata, Jane Muir, Melinda Carrington, Geoffrey A. Head, David M. Kaye, Francine Z. Marques
Summary: This study found that the diversity of the gut microbiome, levels of microbial metabolites, and specific bacteria were associated with blood pressure variability. Alistipesfinegoldii and Lactobacillus were associated with lower blood pressure variability, while Prevotella and Clostridium were associated with higher blood pressure variability.
Article
Cardiac & Cardiovascular Systems
Jennifer Zhou, Danny Liew, David M. Kaye, Sophia Zoungas, Dion Stub
Summary: This study evaluated the cost-effectiveness of adding Empagliflozin to standard therapy in patients with heart failure. The results showed that adding Empagliflozin is likely to be cost-effective compared to standard care alone in the Australian healthcare setting.
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2022)
Article
Computer Science, Interdisciplinary Applications
Avishka Wickramarachchi, Mehrdad Khamooshi, Aidan Burrell, Vincent A. Pellegrino, David M. Kaye, Shaun D. Gregory
Summary: This study investigated the impact of tip position of single-stage (SS) and multi-stage (MS) venoarterial extracorporeal membrane oxygenation (VA ECMO) drainage cannulae on the risk of thrombosis. Computational fluid dynamics was used to model flow dynamics, and several factors were measured to assess the risk of thrombosis. The results showed that the tip position of the drainage cannula had a significant impact on thrombosis risk.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Louise Segan, Shane Nanayakkara, Ella Spear, Anita Shirwaiker, David Chieng, Sandeep Prabhu, Hariharan Sugumar, Liang-Han Ling, David M. Kaye, Jonathan M. Kalman, Aleksandr Voskoboinik, Peter M. Kistler
Summary: This study evaluated clinical and transthoracic echocardiographic parameters to predict the risk of left atrial appendage thrombus (LAAT) in patients with atrial fibrillation (AF). A novel CLOTS-AF risk score was developed, which showed good predictive performance for identifying patients at increased risk of LAAT. This has important implications for guiding appropriate anticoagulation therapy and cardioversion.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Michael Seman, Andrew F. Stephens, Antony Walton, Stephen J. Duffy, David McGiffin, Shane Nanayakkara, David M. Kaye, Shaun D. Gregory, Dion Stub
Summary: This study aimed to characterize the influence of concomitant mitral regurgitation (MR) on the severity of aortic stenosis (AS) using clinical data and computational cardiovascular simulation. The results showed that AS patients with MR experienced a reduction in aortic pressure gradient, indicating the importance of accurately assessing the impact of MR on AS severity.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Orthopedics
Mark James Lambrechts, Jeremy Heard, Nicholas D'Antonio, John Bodnar, Gregory Schneider, Evan Bloom, Jose Canseco, Barrett Woods, Ian David Kaye, Mark Kurd, Jeffrey Rihn, Alan Hilibrand, Gregory Schroeder, Alexander Vaccaro, Christopher K. Epler
Summary: A retrospective cohort study was conducted to compare the radiographic outcomes of unilateral and bilateral cage placement in transforaminal lumbar interbody fusions (TLIF). The study found that bilateral cage placement was associated with better restoration of lumbar lordosis and higher fusion rates. However, unilateral cage placement was more effective in correcting endplate obliquity.
ASIAN SPINE JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Jason E. Bloom, William Chan, David M. Kaye, Dion Stub
Summary: Cardiogenic shock is a condition where inadequate cardiac output leads to tissue hypoxia and circulatory failure. Prompt hemodynamic support is crucial to reduce the risk of multiorgan dysfunction and preserve cellular metabolism, alongside treating the underlying disease process. Pharmacologic therapy, including vasopressors and inotropes, improves perfusion and stability, serving as a cornerstone in cardiogenic shock management. Despite the recent interest in mechanical circulatory support, pharmacologic hemodynamic support remains widely used, emphasizing the importance of understanding the pharmacology and hemodynamic effects, as well as future research directions.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)