Inhibitory Effects of Momordicine I on High-Glucose-Induced Cell Proliferation and Collagen Synthesis in Rat Cardiac Fibroblasts

Ursolic acid ameliorates oxidative stress, inflammation and fibrosis in diabetic cardiomyopathy rats

(2018) Xu-tao Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Implications of Underlying Mechanisms for the Recognition and Management of Diabetic Cardiomyopathy

(2018) Thomas H. Marwick et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Recent Advances in Momordica charantia: Functional Components and Biological Activities

(2017) Shuo Jia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Matrine suppresses cardiac fibrosis by inhibiting the TGF‑β/Smad pathway in experimental diabetic cardiomyopathy

(2017) Yong Zhang et al.   Molecular Medicine Reports

Roles and Mechanisms of Herbal Medicine for Diabetic Cardiomyopathy: Current Status and Perspective

(2017) Jinfan Tian et al.   Oxidative Medicine and Cellular Longevity

Antioxidant and Antifibrotic Effect of a Herbal Formulation In Vitro and in the Experimental Andropause via Nrf2/HO-1 Signaling Pathway

(2017) Woong Jin Bae et al.   Oxidative Medicine and Cellular Longevity

Momordica charantia extracts ameliorate insulin resistance by regulating the expression of SOCS-3 and JNK in type 2 diabetes mellitus rats

(2017) Chunyu Ma et al.   PHARMACEUTICAL BIOLOGY

Studies on the antidiabetic activities of Momordica charantia fruit juice in streptozotocin-induced diabetic rats

(2017) Mona F. Mahmoud et al.   PHARMACEUTICAL BIOLOGY

Nrf2 exerts cell-autonomous antifibrotic effects: compromised function in systemic sclerosis and therapeutic rescue with a novel heterocyclic chalcone derivative

(2017) Jun Wei et al.   Translational Research

Transforming growth factor β and its role in heart disease

(2017) Guangwang Liu et al.   Experimental and Therapeutic Medicine

Effect of Momordica charantia protein on proliferation, apoptosis and the AKT signal transduction pathway in the human endometrial carcinoma Ishikawa H cell line in vitro

(2017) Hang-Zhi Gu et al.   Oncology Letters

An Overview of Herbal Products and Secondary Metabolites Used for Management of Type Two Diabetes

(2017) Ajda Ota et al.   Frontiers in Pharmacology

Tanshinone IIA Induces Heme Oxygenase 1 Expression and Inhibits Cyclic Strain-Induced Interleukin 8 Expression in Vascular Endothelial Cells

(2016) Shaowei Zhuang et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Nuclear Factor–Erythroid-2–Related Factor 2 in Aging and Lung Fibrosis

(2016) Shobha M. Swamy et al.   AMERICAN JOURNAL OF PATHOLOGY

Resveratrol ameliorates myocardial fibrosis by inhibiting ROS/ERK/TGF-β/periostin pathway in STZ-induced diabetic mice

(2016) Han Wu et al.   BMC Cardiovascular Disorders

Cardiac Fibrosis

(2016) Joshua G. Travers et al.   CIRCULATION RESEARCH

Diabetic Cardiomyopathy: The Case for a Role of Fructose in Disease Etiology

(2016) Lea M.D. Delbridge et al.   DIABETES

Sulforaphane mitigates muscle fibrosis in mdx mice via Nrf2-mediated inhibition of TGF-β/Smad signaling

(2016) Chengcao Sun et al.   JOURNAL OF APPLIED PHYSIOLOGY

The protective role of vitamin D3 in a murine model of asthma via the suppression of TGF-β/Smad signaling and activation of the Nrf2/HO-1 pathway

(2016) Zhihui Wang et al.   Molecular Medicine Reports

Neferine inhibits proliferation and collagen synthesis induced by high glucose in cardiac fibroblasts and reduces cardiac fibrosis in diabetic mice

(2016) Xue Liu et al.   Oncotarget

Activation of SIRT3 by resveratrol ameliorates cardiac fibrosis and improves cardiac function via the TGF-β/Smad3 pathway

(2015) Tongshuai Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

N-Acetyl Cysteine improves the diabetic cardiac function: possible role of fibrosis inhibition

(2015) Cong Liu et al.   BMC Cardiovascular Disorders

Pectic polysaccharide from the green fruits of Momordica charantia (Karela): structural characterization and study of immunoenhancing and antioxidant properties

(2015) Bibhash C. Panda et al.   CARBOHYDRATE RESEARCH

Exogenous Hydrogen Sulfide Attenuates Cardiac Fibrosis Through Reactive Oxygen Species Signal Pathways in Experimental Diabetes Mellitus Models

(2015) Dan Zheng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Lycopene inhibits cyclic strain-induced endothelin-1 expression through the suppression of reactive oxygen species generation and induction of heme oxygenase-1 in human umbilical vein endothelial cells

(2015) Li-Chin Sung et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Preventive effects of bitter melon (Momordica charantia) against insulin resistance and diabetes are associated with the inhibition of NF-κB and JNK pathways in high-fat-fed OLETF rats

(2015) Soo Jin Yang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The cytotoxicology of momordicins I and II on Spodoptera litura cultured cell line SL-1

(2015) Huan Liu et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Good and bad sides of TGFβ-signaling in myocardial infarction

(2015) Gerhild Euler   Frontiers in Physiology

Effects of tanshinone IIA on the transforming growth factor β1/Smad signaling pathway in rat cardiac fibroblasts

(2014) Jin-Hui Tang et al.   INDIAN JOURNAL OF PHARMACOLOGY

A Novel Insulin Receptor-Binding Protein from Momordica charantia Enhances Glucose Uptake and Glucose Clearance in Vitro and in Vivo through Triggering Insulin Receptor Signaling Pathway

(2014) Hsin-Yi Lo et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Shensong Yangxin Capsule prevents diabetic myocardial fibrosis by inhibiting TGF-β1/Smad signaling

(2014) Nannan Shen et al.   JOURNAL OF ETHNOPHARMACOLOGY

Transport in Caco-2 Cell Monolayers of Antidiabetic Cucurbitane Triterpenoids from Momordica charantia Fruits

(2014) Shi-Biao Wu et al.   PLANTA MEDICA

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Prevention of diabetes-induced cardiovascular complications upon treatment with antioxidants

(2013) Yan-Jun Xu et al.   HEART FAILURE REVIEWS

Diabetic cardiomyopathy: pathophysiology and clinical features

(2012) Takayuki Miki et al.   HEART FAILURE REVIEWS

Saponins from the traditional medicinal plant Momordica charantia stimulate insulin secretion in vitro

(2011) Amy C. Keller et al.   PHYTOMEDICINE

Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism

(2011) D. Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cucurbitane-Type Triterpenoids fromMomordica charantia

(2010) Jun Ma et al.   PLANTA MEDICA

MAGNOLOL DEPRESSES UROTENSIN-II-INDUCED CELL PROLIFERATION IN RAT CARDIAC FIBROBLASTS

(2009) Jer-Young Liou et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Urotensin II Induces Rat Cardiomyocyte Hypertrophy via the Transient Oxidization of Src Homology 2-Containing Tyrosine Phosphatase and Transactivation of Epidermal Growth Factor Receptor

(2009) J.-C. Liu et al.   MOLECULAR PHARMACOLOGY

Antidiabetic Activities of Triterpenoids Isolated from Bitter Melon Associated with Activation of the AMPK Pathway

(2008) Min-Jia Tan et al.   CHEMISTRY & BIOLOGY

Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes

(2008) Xiaoqing He et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY