Review
Endocrinology & Metabolism
Wang-Soo Lee, Jaetaek Kim
Summary: Diabetic heart disease is a growing and important public health risk, with pathomechanisms involving metabolic derangements, oxidative stress, and other factors. Animal models play a crucial role in advancing understanding of these mechanisms.
DIABETES & METABOLISM JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Tom Kai Ming Wang, Duygu Kocyigit, Harry Choi, Chris M. Anthony, Nicholas Chan, Jennifer Bullen, Zoran B. Popovic, Samir R. Kapadia, Amar Krishnaswamy, Brian P. Griffin, Scott D. Flamm, W. H. Wilson Tang, Deborah H. Kwon
Summary: Quantitative cardiac magnetic resonance evaluation can provide important clinical risk stratification and guide therapeutic decision-making for patients with functional mitral regurgitation (FMR) and late gadolinium enhancement (LGE) in ischemic cardiomyopathy (ICM) and non-ICM (NICM).
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Review
Endocrinology & Metabolism
Jin Joo Park
Summary: Diabetes increases the risk of cardiovascular disease by affecting vascular homeostasis and myocardial function. Prognosis is worse in heart failure patients with diabetes compared to those without diabetes.
DIABETES & METABOLISM JOURNAL
(2021)
Article
Medicine, General & Internal
Bertram Pitt, Gerasimos Filippatos, Rajiv Agarwal, Stefan D. Anker, George L. Bakris, Peter Rossing, Amer Joseph, Peter Kolkhof, Christina Nowack, Patrick Schloemer, Luis M. Ruilope
Summary: Finerenone therapy improved cardiovascular outcomes in patients with type 2 diabetes and stage 2 to 4 CKD with moderately elevated albuminuria or stage 1 or 2 CKD with severely elevated albuminuria, compared to placebo. The risk of the primary outcome event was significantly lower in the finerenone group, primarily driven by a reduction in hospitalization for heart failure.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Physiology
Akram Tayanloo-Beik, Peyvand Parhizkar Roudsari, Mostafa Rezaei-Tavirani, Mahmood Biglar, Ozra Tabatabaei-Malazy, Babak Arjmand, Bagher Larijani
Summary: Diabetes and heart failure are significant global issues that impose substantial costs on healthcare systems and countries. There are common molecular mechanisms shared between type 2 diabetes and heart failure, such as oxidative stress and metabolic changes, which are key areas of focus for treatment.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Se Yong Jang, Jieun Jang, Dong Heon Yang, Hyun-Jai Cho, Soo Lim, Eun-Seok Jeon, Sang Eun Lee, Jae-Joong Kim, Seok-Min Kang, Sang Hong Baek, Myeong-Chan Cho, Dong-Ju Choi, Byung-Su Yoo, Kye Hun Kim, Sue K. Park, Hae-Young Lee
Summary: Patients with diabetes mellitus and heart failure have a higher risk of mortality. Insulin therapy was found to be associated with increased mortality in acute heart failure patients, especially in those with low levels of glycated hemoglobin.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Alan Kwan, Emmanuella Demosthenes, Gerran Salto, David Ouyang, Trevor Nguyen, Chike C. Nwabuo, Eric Luong, Amy Hoang, Ewa Osypiuk, Plamen Stantchev, Elizabeth H. Kim, Pranoti Hiremath, Debiao Li, Ramachandran Vasan, Vanessa Xanthakis, Susan Cheng
Summary: This study found that microstructural alterations in the heart are associated with increased risk of heart failure, particularly in women. These microstructural alterations may identify sex-specific pathways by which individuals progress from risk factors to clinical heart failure.
Review
Medicine, General & Internal
Israel Mazin, Fernando Chernomordik, Paul Fefer, Shlomi Matetzky, Roy Beigel
Summary: Over the past two decades, the number of patients diagnosed with diabetes mellitus has doubled. Despite advancements in cardiovascular disease treatment, patients with diabetes are still at a higher risk of dying from cardiovascular causes compared to non-diabetic individuals. However, recent breakthroughs in anti-diabetic therapies have shown cardiovascular benefits and reduced mortality rates.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Lore Schrutka, Philip Anner, Asan Agibetov, Benjamin Seirer, Fabian Dusik, Rene Rettl, Franz Duca, Daniel Dalos, Theresa-Marie Dachs, Christina Binder, Roza Badr-Eslam, Johannes Kastner, Dietrich Beitzke, Christian Loewe, Christian Hengstenberg, Guenther Laufer, Guenter Stix, Georg Dorffner, Diana Bonderman
Summary: A machine learning approach was used to develop an ECG-based tool from detailed electroanatomical mapping of patients with CA, which has proven helpful in suspecting CA without the aid of advanced imaging modalities.
Review
Medicine, General & Internal
Nelson A. Campos, Galo A. Palacios
Summary: Cardiac rehabilitation is crucial for diabetic patients as it helps reduce cardiovascular risk through both pharmacological and non-pharmacological treatments. Physical exercise plays a key role in controlling diabetes and preventing cardiovascular complications, along with glycemic and nutritional treatments.
Review
Medicine, General & Internal
Cristina Morelli, Gessica Ingrasciotta, Daniel Jacoby, Ahmad Masri, Iacopo Olivotto
Summary: The progress in science and technologies has allowed for the development of innovative drug molecules targeting the underlying pathophysiology of diseases. This has led to potential applications in heart muscle disease, heart failure, and skeletal muscle conditions. Several drugs, such as omecamtiv mecarbil, mavacamten, and aficamten, have shown promise in clinical trials, demonstrating efficacy in improving cardiac function and reducing heart failure-related events.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Hafeez Shaka, Zain El-Amir, Michael Aljadah, Farah Wani, Genero Velazquez, Asim Kichloo
Summary: The study found that there was no significant difference in in-hospital mortality between patients with DKA with or without DHF, but patients with DKA and DHF were more likely to develop NSTEMI or ARF during the same admission compared to those without DHF. Additionally, patients with DKA and DHF had higher hospital charges and longer length of hospital stay compared to patients without DHF.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2021)
Article
Cardiac & Cardiovascular Systems
Meng-Ting Shen, Yuan Li, Ying-Kun Guo, Li Jiang, Yue Gao, Rui Shi, Zhi-Gang Yang
Summary: Type 2 diabetes mellitus (T2DM) has an additive deleterious effect on left ventricular (LV) function in patients with non-ischemic dilated cardiomyopathy (NIDCM), and elevated blood glucose level is associated with reduced myocardial strain.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiao Li, Yubo Guo, Lu Lin, Yue Wang, Peijun Liu, Qian Wang, Wei Chen, Wenji Wang, Qing Xia, Ning Huang, Aydin Eresen, Zhuoli Zhang, Zhengyu Jin, Yining Wang
Summary: This study used contrast-free cardiac MRI combined with a radiomics model to assess myocardial scarring in patients with autoimmune rheumatic diseases. The results showed that the radiomics model and multivariable regression model had high accuracy and sensitivity in identifying myocardial scarring.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Endocrinology & Metabolism
Justin B. Echouffo-Tcheugui, Natalie Daya, Alexandra K. Lee, Olive Tang, Chiadi E. Ndumele, B. Gwen Windham, Amil M. Shah, Elizabeth Selvin
Summary: The study found that older individuals with diabetes and a history of severe hypoglycemia exhibited alterations in cardiac function, indicating an increased risk of future cardiovascular events.
Article
Cardiac & Cardiovascular Systems
Edward Y. Chan, Areeba Ali, Juan P. Umana, Duc T Nguyen, Dale J. Hamilton, Edward A. Graviss, Vinod Ravi, Thomas E. MacGillivray, Michael J. Reardon
Summary: Cardiac paraganglioma is a rare tumor that requires multidisciplinary management. Surgical resection yields acceptable mortality and survival rates, but complex procedures may be necessary for complete removal of the tumor and reconstruction.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Immunology
Sean A. Hebert, Dina N. Murad, Duc T. Nguyen, Edward A. Graviss, Horacio E. Adrogue, Arthur J. Matas, Hassan N. Ibrahim
Summary: The study suggests that kidney donors with impaired fasting glucose (IFG) and fasting plasma glucose (FPG) ≥126 mg/dL may not need to be routinely excluded from donation. Although they have a higher risk of diabetes and hypertension, it does not increase the risk of proteinuria or end-stage kidney disease (ESKD).
Article
Cardiac & Cardiovascular Systems
Asma Zainab, Duc T. Nguyen, Edward A. Graviss, Sahar Fatima, Faisal N. Masud, Thomas E. MacGillivray
Summary: This study developed and validated a risk score for postoperative respiratory failure after cardiac surgery, which stratified patients into low, medium, and high risk categories. Significant predictors of respiratory failure included factors such as body mass index, previous cardiac surgery, cardiopulmonary bypass, and presence of pulmonary disease.
ANNALS OF THORACIC SURGERY
(2022)
Article
Surgery
Mark J. Hobeika, Ashish Saharia, Constance M. Mobley, Terri Menser, Duc T. Nguyen, Edward A. Graviss, Robert R. McMillan, Hemangshu Podder, Joy V. Nolte Fong, Stephen L. Jones, Stephanie G. Yi, Mahmoud Elshawwaf, Ahmed O. Gaber, Rafik M. Ghobrial
Summary: This study demonstrates that outcomes of DCD liver transplantation can be similar to DBD liver transplantation in cohorts including high-acuity recipients, with a low rate of Ischemic-type biliary lesions. Essential considerations include strict donor selection criteria, minimizing ischemia time, and avoiding futile donor/recipient combinations.
CLINICAL TRANSPLANTATION
(2021)
Article
Education, Scientific Disciplines
Karen J. Dickinson, Barbara L. Bass, Edward A. Graviss, Duc T. Nguyen, Kevin Y. Pei
Summary: Independent resident operating is crucial for independent practice, but it is rare and not associated with increased complications or mortality. National data on this subject is outdated, highlighting the need for a national registry to understand the current impact of independent operating.
JOURNAL OF SURGICAL EDUCATION
(2021)
Article
Surgery
Yi Ying Law, Duc T. Nguyen, Leonora M. Meisenbach, Ray K. Chihara, Edward Y. Chan, Edward A. Graviss, Min P. Kim
Summary: The study demonstrated the significance of intraoperative use of EndoFLIP in diagnosing and treating achalasia by analyzing EndoFLIP values and intraoperative data.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Immunology
Danielle Ecabert, Christine Pham, Brett J. Pierce, William L. Musick, Duc T. Nguyen, Edward A. Graviss
Summary: In non-kidney transplant recipients, the study found that valganciclovir 450 mg three times weekly post-HD had similar rates of leukopenia, neutropenia, thrombocytopenia, and CMV infection compared to valganciclovir dosed per renal function.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Surgery
Johnny Hoang, Jill Krisl, Mozhgon Moaddab, Duc T. Nguyen, Edward A. Graviss, Imad Hussain, Mahwash Kassi, Rayan Yousefzai, Ju Kim, Barry Trachtenberg, Arvind Bhimaraj, Ashrith Guha
Summary: This study suggests that a single infusion of IVIG may have little to no benefit in reducing the incidence of new infections in patients with mild to moderate HGG.
CLINICAL TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Edward Y. Chan, Areeba Ali, M. Mujeeb Zubair, Duc T. Nguyen, Sergio H. Ibarra-Cortez, Edward A. Graviss, Oz M. Shapira, Vinod Ravi, Thomas E. MacGillivray, Michael J. Reardon
Summary: This study retrospectively analyzed the surgical outcomes of 122 patients with primary cardiac sarcoma. The results showed that the survival rate of cardiac sarcoma patients gradually decreased within 5 years, and there was no significant difference in mortality between different time periods. This suggests that cardiac sarcoma is a systemic disease, and current treatment methods have not significantly improved patient survival.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Respiratory System
Anuj S. Shah, Duc T. Nguyen, Ray Chihara, Edward Y. Chan, Edward A. Graviss, Min P. Kim
Summary: The study shows that self-assisted robotic technology in pulmonary lobectomy has low technical complications and acceptable morbidity, length of stay, and mortality. Compared to VATS lobectomy, this self-assisted robot technology has favorable outcomes.
JOURNAL OF THORACIC DISEASE
(2022)
Article
Immunology
Ashton A. Connor, Ashish Saharia, Constance M. Mobley, Mark J. Hobeika, David W. Victor, Sudha Kodali, Elizabeth W. Brombosz, Edward A. Graviss, Duc T. Nguyen, Linda W. Moore, A. Osama Gaber, R. Mark Ghobrial
Summary: The study retrospectively evaluated the outcomes of liver retransplantation and found that overall and graft survival rates were comparable to those of primary liver transplantation, indicating that modern liver retransplantation is a safer option for patients with liver graft failure.
Letter
Cardiac & Cardiovascular Systems
Maan Malahfji, Duc T. Nguyen, Edward A. Graviss, Dipan J. Shah
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Adaani E. Frost, Linda W. Moore, Miguel Valdivia e Alvarado, Chizoba Obi, Edward A. Graviss, Duc T. Nguyen, Ahmed Osama Gaber, Wadi N. Suki
Summary: This study reviewed the pre- and post-transplant status of 115 kidney transplant patients with echocardiographically-defined pulmonary hypertension. The results showed that although some patients showed improvement in pulmonary hypertension after transplantation, there was no clear association between the improvement and patient outcomes.
PULMONARY CIRCULATION
(2022)
Article
Cardiac & Cardiovascular Systems
Sandeep Sahay, Jiken Bhatt, Sarah Beshay, Ashrith Guha, Duc T. Nguyen, Edward A. Graviss, Sherif F. Nagueh
Summary: Combining echocardiographic parameters with REVEAL Lite 2.0 provides more accurate risk predictions for PAH.
PULMONARY CIRCULATION
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
C. V. Dinunno, C. Pham, B. Pierce, D. T. Nguyen, E. A. Graviss, H. J. Huang, A. Goodarzi, S. W. Yau, J. G. Youssef
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)