Review
Biochemistry & Molecular Biology
Nicola Marrano, Giuseppina Biondi, Anna Borrelli, Martina Rella, Tommaso Zambetta, Ludovico Di Gioia, Mariangela Caporusso, Giancarlo Logroscino, Sebastio Perrini, Francesco Giorgino, Annalisa Natalicchio
Summary: Type 2 diabetes and Alzheimer's disease are major health issues with a close relationship. Lipotoxicity may be the missing link connecting the pathogenesis of these two diseases. Obesity, the main cause of lipotoxicity, is a major risk factor for both conditions. This review provides a comprehensive overview of the common molecular pathways activated by lipotoxicity in type 2 diabetes and Alzheimer's disease, suggesting potential new therapeutic perspectives.
Review
Physiology
Jun Ren, Ne N. Wu, Shuyi Wang, James R. Sowers, Yingmei Zhang
Summary: The rise in heart failure prevalence is partly due to increasing rates of overweight and obesity. Evidence supports the existence of obesity cardiomyopathy as a unique disease entity that develops independently of other heart diseases. Clinical and experimental research have identified pathological changes in myocardial structure and function in obesity, highlighting various cellular and molecular mechanisms underlying this condition.
PHYSIOLOGICAL REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Natasha Z. Anita, Felicia Kwan, Si Won Ryoo, Chelsi Major-Orfao, William Z. Lin, Shiropa Noor, Krista L. Lanctot, Nathan Herrmann, Paul I. Oh, Baiju R. Shah, Jeremy Gilbert, Angela Assal, Ilana J. Halperin, Ameer Y. Taha, Walter Swardfager
Summary: Type 2 diabetes mellitus (T2DM) increases the risk of cognitive decline and dementia. Disruptions in the cytochrome P450-soluble epoxide hydrolase (CYP450-sEH) pathway have been reported in T2DM, obesity, and cognitive impairment. This study analyzes linoleic acid (LA)-derived CYP450-sEH oxylipins and their relationship with cognition in T2DM, considering potential differences between obese and nonobese individuals.
JOURNAL OF LIPID RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Kazufumi Nakamura, Toru Miyoshi, Masashi Yoshida, Satoshi Akagi, Yukihiro Saito, Kentaro Ejiri, Naoaki Matsuo, Keishi Ichikawa, Keiichiro Iwasaki, Takanori Naito, Yusuke Namba, Masatoki Yoshida, Hiroki Sugiyama, Hiroshi Ito
Summary: There is a strong correlation between diabetes mellitus and heart failure, with diabetes serving as an independent risk factor for heart failure. The link between diabetes and heart failure is not only due to complications such as ischemic heart disease, but also metabolic disorders like glucose toxicity and lipotoxicity caused by insulin resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Aaron Afonso-Ali, Esteban Porrini, Silvia Teixido-Trujillo, Jose Antonio Perez-Perez, Sergio Luis-Lima, Nieves Guadalupe Acosta-Gonzalez, Irene Sosa-Paz, Laura Diaz-Martin, Covadonga Rodriguez-Gonzalez, Ana Elena Rodriguez-Rodriguez
Summary: The pathogenesis of obesity-related-renal disease is not clear, and the interaction between menopause and renal disease in obese women is still unknown. In this study, obese male and female mice developed albuminuria, hyperfiltration, and glomerulomegaly, and these changes were more severe in obese ovariectomized females. Obesity induced inflammation and an unbalanced lipidic profile in renal tissue, and this pattern seems to be enhanced in obesity after menopause.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Carmen Rodriguez-Garcia, Cristina Sanchez-Quesada, Maria Jose Martinez-Ramirez, Jose J. Gaforio
Summary: Lipodystrophy syndromes are rare diseases that result in dysfunction of adipose tissue and abnormal accumulation of triglycerides. Both genetic and acquired factors may contribute to the development of lipodystrophy, and dietary fats can modulate gene activity. This article summarizes the main genes involved in lipodystrophy and reviews the effects of dietary fats on its development.
Review
Cardiac & Cardiovascular Systems
Florian A. Wenzl, Samuele Ambrosini, Shafeeq A. Mohammed, Simon Kraler, Thomas F. Luescher, Sarah Costantino, Francesco Paneni
Summary: Inflammatory processes play a crucial role in the development of metabolic cardiomyopathy, affecting cardiovascular health by influencing the function and structure of cardiac cells, exacerbating cardiovascular disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Editorial Material
Biochemistry & Molecular Biology
Jacqueline A. Seiglie, Devaki Nambiar, David Beran, J. Jaime Miranda
Summary: The increasing recognition of the impact of social determinants of health on diabetes risk and outcomes should influence health provision and diabetes research.
Article
Cardiac & Cardiovascular Systems
David A. Jenkins, Kaitlin H. Wade, David Carslake, Jack Bowden, Naveed Sattar, Ruth J. F. Loos, Nicholas J. Timpson, Matthew Sperrin, Martin K. Rutter
Summary: Observational data have shown that being overweight or obese is associated with a lower risk of death compared to being normal weight, a phenomenon known as the obesity paradox. However, Mendelian randomization analysis in this study revealed a positive linear causal effect of BMI on mortality risk, supporting the idea that intentional weight loss towards the normal BMI range could reduce mortality risk in the general population, including individuals with coronary heart disease.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cell Biology
Xiang Tao, Can Chen, Zheng Huang, Yu Lei, Muru Wang, Shuhui Wang, Dean Tian
Summary: A growing body of epidemiological evidence suggests that NAFLD is an independent risk factor for CKD, but the regulatory mechanism linking NAFLD and CKD remains unclear. This study found that hepatic PDE4D may act as a critical mediator between NAFLD and associated kidney injury by promoting the production and secretion of TGF-beta 1 into blood, which triggers kidney injury. Inhibition of PDE4D with roflumilast showed potential as a therapeutic strategy for NAFLD-associated CKD.
CELL DEATH & DISEASE
(2023)
Article
Gastroenterology & Hepatology
Amira Sayed Khan, Aziz Hichami, Babar Murtaza, Marie-Laure Louillat-Habermeyer, Christophe Ramseyer, Maryam Azadi, Semen Yesylevskyy, Floriane Mangin, Frederic Lirussi, Julia Leemput, Jean-Francois Merlin, Antonin Schmitt, Muhtadi Suliman, Jerome Bayardon, Saeed Semnanian, Sylvain Juge, Naim Akhtar Khan
Summary: Two high affinity agonists of tongue taste receptors (CD36/ GPR120) have been synthesized, acting as fat taste enhancers and triggering the activation of the tongue-gut satiation loop in male mice. These agents were found to reduce daily fat-rich food intake and body weight gain in diet-induced obese male mice.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Nilanjan Ghosh, Leena Chacko, Hiranmoy Bhattacharya, Jayalakshmi Vallamkondu, Sagnik Nag, Abhijit Dey, Tanushree Karmakar, P. Hemachandra Reddy, Ramesh Kandimalla, Saikat Dewanjee
Summary: Diabetes mellitus (DM) and cardiovascular complications often occur together, creating a challenging situation. The development of diabetic cardiomyopathy (DCM) involves complex pathophysiological pathways at the metabolic and molecular level, leading to structural and functional alterations of the heart. Glucagon-like peptide-1 (GLP-1) analogues and sodium-glucose cotransporter-2 (SGLT-2) inhibitors have shown promising results in improving cardiovascular outcomes in diabetes. This article highlights the pathways contributing to DCM and discusses potential future therapies.
Article
Cell Biology
Ying Zhang, Huijuan Yao, Chao Li, Wei Sun, Xiaofei Chen, Yan Cao, Yue Liu, Yan Liu, Jihui Chen, Jia Qi, Qiqiang Zhang, Hai Zhang, Ajing Xu, Jian Zhang
Summary: This study used network pharmacology methods to investigate the potential mechanism of Gandi capsule (GDC) in improving diabetic nephropathy (DN). The results suggested that GDC might ameliorate DN through the SIRT1/AMPK/HNF4A pathway, regulating lipid metabolism and improving renal function.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Cardiac & Cardiovascular Systems
Arnaud D. Kaze, Sebhat Erqou, Prasanna Santhanam, Alain G. Bertoni, Rexford S. Ahima, Gregg C. Fonarow, Justin B. Echouffo-Tcheugui
Summary: This study found that greater variability in adiposity indices in individuals with type 2 diabetes was associated with a higher risk of incident heart failure, independently of traditional risk factors and baseline adiposity levels.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Nutrition & Dietetics
Natalia Kopiczko, Anna Bobrus-Chociej, Ewa Harasim-Symbor, Eugeniusz Tarasow, Malgorzata Wojtkowska, Adrian Chabowski, Dariusz M. Lebensztejn
Summary: This study aimed to evaluate the serum FA concentration in children with obesity and NAFLD. The results showed that the total FA concentration was significantly higher in obese children and in obese children with NAFLD compared to controls. There was a significant positive correlation between total FA concentration and cholesterol, triacylglycerols, and insulin in children with NAFLD.
Article
Physiology
Jussara M. do Carmo, Alexandre A. da Silva, Sydney P. Moak, Fernanda S. da Silva, Frank T. Spradley, John E. Hall
Editorial Material
Peripheral Vascular Disease
John E. Hall, Michael E. Hall
Editorial Material
Cardiac & Cardiovascular Systems
Giuseppe Mancia, John E. Hall
CIRCULATION RESEARCH
(2019)
Article
Cardiac & Cardiovascular Systems
Thomas E. Lohmeier, John E. Hall
CIRCULATION RESEARCH
(2019)
Article
Physiology
Zhen Wang, Jussara M. do Carmo, Alexandre A. da Silva, Kandice C. Bailey, Nicola Aberdein, Sydney P. Moak, John E. Hall
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2019)
Review
Peripheral Vascular Disease
Alexandre A. da Silva, Jussara M. do Carmo, Zhen Wang, John E. Hall
CURRENT HYPERTENSION REPORTS
(2019)
Review
Cardiac & Cardiovascular Systems
Alexandre A. da Silva, Jussara M. do Carmo, Xuan Li, Zhen Wang, Alan J. Mouton, John E. Hall
CANADIAN JOURNAL OF CARDIOLOGY
(2020)
Review
Peripheral Vascular Disease
Zhen Wang, Jussara M. do Carmo, Alexandre A. da Silva, Yiling Fu, John E. Hall
CURRENT HYPERTENSION REPORTS
(2020)
Article
Peripheral Vascular Disease
Stephen P. Juraschek, Edgar R. Miller, Alexander R. Chang, Cheryl A. M. Anderson, John E. Hall, Lawrence J. Appel
Review
Cardiac & Cardiovascular Systems
Alan J. Mouton, Xuan Li, Michael E. Hall, John E. Hall
CIRCULATION RESEARCH
(2020)
Review
Endocrinology & Metabolism
Alexandre A. da Silva, Jussara M. do Carmo, John E. Hall
CURRENT DIABETES REPORTS
(2020)
Review
Cardiac & Cardiovascular Systems
John E. Hall, Alan J. Mouton, Alexandre A. da Silva, Ana C. M. Omoto, Zhen Wang, Xuan Li, Jussara M. do Carmo
Summary: Obesity contributes significantly to human primary hypertension risk, particularly in driving cardiovascular and kidney diseases, with kidney dysfunction and neurohormonal, renal, and inflammatory mechanisms playing key roles in the development of obesity-induced hypertension.
CARDIOVASCULAR RESEARCH
(2021)
Biographical-Item
Peripheral Vascular Disease
John E. Hall, L. Gabriel Navar, Allen W. Cowley, Richard L. Summers, Robert L. Hester
Editorial Material
Peripheral Vascular Disease
Michael E. Hall, John E. Hall
Article
Multidisciplinary Sciences
Chinni Yalamanchili, Amar G. Chittiboyina, Saqlain Haider, Yelkaira Vasquez, Shabana Khan, Jussara M. do Carmo, Alexandre A. da Silva, Mark Pinkerton, John E. Hall, Larry A. Walker, Ikhlas A. Khan