Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation

Lineage specific transcription factors and epigenetic regulators mediate TGFβ-dependent enhancer activation

(2018) Raquel Fueyo et al.   NUCLEIC ACIDS RESEARCH

The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability

(2017) Timothy S. Luongo et al.   NATURE

Redefining the identity of cardiac fibroblasts

(2017) Michelle D. Tallquist et al.   Nature Reviews Cardiology

Proteolytic control of the mitochondrial calcium uniporter complex

(2017) Chen-Wei Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MICU1 drives glycolysis and chemoresistance in ovarian cancer

(2017) Prabir K. Chakraborty et al.   Nature Communications

Tissue-Specific Mitochondrial Decoding of Cytoplasmic Ca 2+ Signals Is Controlled by the Stoichiometry of MICU1/2 and MCU

(2017) Melanie Paillard et al.   Cell Reports

α-Ketoglutarate Accelerates the Initial Differentiation of Primed Human Pluripotent Stem Cells

(2016) Tara TeSlaa et al.   Cell Metabolism

Type 2 Diabetes Dysregulates Glucose Metabolism in Cardiac Progenitor Cells

(2016) Joshua K. Salabei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular networks underlying myofibroblast fate and fibrosis

(2016) April Stempien-Otero et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition

(2016) Dipayan Chaudhuri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration

(2016) Anil Noronha Antony et al.   Nature Communications

Genetic lineage tracing defines myofibroblast origin and function in the injured heart

(2016) Onur Kanisicak et al.   Nature Communications

Glycolytic Reprogramming in Myofibroblast Differentiation and Lung Fibrosis

(2015) Na Xie et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Glycolysis-Mediated Changes in Acetyl-CoA and Histone Acetylation Control the Early Differentiation of Embryonic Stem Cells

(2015) Arieh Moussaieff et al.   Cell Metabolism

Metabolic Reprogramming Is Required for Myofibroblast Contractility and Differentiation

(2015) Karen Bernard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial calcium and the regulation of metabolism in the heart

(2015) George S.B. Williams et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Novel RAAS agonists and antagonists: clinical applications and controversies

(2015) Cesar A. Romero et al.   Nature Reviews Endocrinology

ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap

(2015) Tauno Metsalu et al.   NUCLEIC ACIDS RESEARCH

Glutamine Regulates Cardiac Progenitor Cell Metabolism and Proliferation

(2015) Joshua K. Salabei et al.   STEM CELLS

The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition

(2015) Timothy S. Luongo et al.   Cell Reports

MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter

(2014) K. J. Kamer et al.   EMBO REPORTS

Resident fibroblast lineages mediate pressure overload–induced cardiac fibrosis

(2014) Thomas Moore-Morris et al.   JOURNAL OF CLINICAL INVESTIGATION

Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer

(2014) M. I. Gross et al.   MOLECULAR CANCER THERAPEUTICS

MICU1 and MICU2 Finely Tune the Mitochondrial Ca2+ Uniporter by Exerting Opposite Effects on MCU Activity

(2014) Maria Patron et al.   MOLECULAR CELL

Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

(2014) Bryce W. Carey et al.   NATURE

Mesenchymal–endothelial transition contributes to cardiac neovascularization

(2014) Eric Ubil et al.   NATURE

The pentose phosphate pathway and cancer

(2014) Krushna C. Patra et al.   TRENDS IN BIOCHEMICAL SCIENCES

MICU1 Controls Both the Threshold and Cooperative Activation of the Mitochondrial Ca2+ Uniporter

(2013) György Csordás et al.   Cell Metabolism

Myofibroblasts: Trust your heart and let fate decide

(2013) Jennifer Davis et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Polycomb-Dependent H3K27me1 and H3K27me2 Regulate Active Transcription and Enhancer Fidelity

(2013) Karin J. Ferrari et al.   MOLECULAR CELL

The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter

(2013) Xin Pan et al.   NATURE CELL BIOLOGY

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

Mitochondrial calcium uptake

(2013) G. S. B. Williams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth

(2013) Lei Wang et al.   Nature Communications

Role of Mitochondrial Ca2+ in the Regulation of Cellular Energetics

(2012) Brian Glancy et al.   BIOCHEMISTRY

MICU1 Is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca2+ Uptake that Regulates Cell Survival

(2012) Karthik Mallilankaraman et al.   CELL

Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells

(2012) Anne Le et al.   Cell Metabolism

Genome-wide analysis reveals that Smad3 and JMJD3 HDM co-activate the neural developmental program

(2012) C. Estaras et al.   DEVELOPMENT

A TRPC6-Dependent Pathway for Myofibroblast Transdifferentiation and Wound Healing In Vivo

(2012) Jennifer Davis et al.   DEVELOPMENTAL CELL

TRPV4 channels mediate cardiac fibroblast differentiation by integrating mechanical and soluble signals

(2012) Ravi K. Adapala et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

(2011) T. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Expanded Palette of Genetically Encoded Ca2+ Indicators

(2011) Y. Zhao et al.   SCIENCE

TRPM7-Mediated Ca 2+ Signals Confer Fibrogenesis in Human Atrial Fibrillation

(2010) Jianyang Du et al.   CIRCULATION RESEARCH

A Novel and Efficient Model of Coronary Artery Ligation and Myocardial Infarction in the Mouse

(2010) Erhe Gao et al.   CIRCULATION RESEARCH

Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases

(2010) Christoph Loenarz et al.   TRENDS IN BIOCHEMICAL SCIENCES

The role of Ca2+ signaling in the coordination of mitochondrial ATP production with cardiac work

(2009) Robert S. Balaban   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Regulation of mitochondrial dehydrogenases by calcium ions

(2009) Richard M. Denton   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Myocardial remodeling after infarction: the role of myofibroblasts

(2009) Susanne W. M. van den Borne et al.   Nature Reviews Cardiology

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism