Of mice and men: models and mechanisms of diabetic cardiomyopathy

Multiple common comorbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress, and myocardial stiffening

(2018) Oana Sorop et al.   CARDIOVASCULAR RESEARCH

Type 2 diabetes mellitus and heart failure: a position statement from the Heart Failure Association of the European Society of Cardiology

(2018) Petar M. Seferović et al.   EUROPEAN JOURNAL OF HEART FAILURE

The proinflammatory effects of macrophage-derived NADPH oxidase function in autoimmune diabetes

(2018) Joseph M. Feduska et al.   FREE RADICAL BIOLOGY AND MEDICINE

Implications of Underlying Mechanisms for the Recognition and Management of Diabetic Cardiomyopathy

(2018) Thomas H. Marwick et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Combination of high-fat/high-fructose diet and low-dose streptozotocin to model long-term type-2 diabetes complications

(2018) David André Barrière et al.   Scientific Reports

Modeling the Western Diet for Preclinical Investigations

(2018) Korry J Hintze et al.   Advances in Nutrition

Long noncoding RNAs: A new player in the prevention and treatment of diabetic cardiomyopathy?

(2018) Chao Ma et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

OUP accepted manuscript

(2018)   EUROPEAN HEART JOURNAL

An integrative translational approach to study heart failure with preserved ejection fraction: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology

(2017) Andre P. Lourenço et al.   EUROPEAN JOURNAL OF HEART FAILURE

Autoreactive T cells in type 1 diabetes

(2017) Alberto Pugliese   JOURNAL OF CLINICAL INVESTIGATION

A murine model of type 2 diabetes mellitus developed using a combination of high fat diet and multiple low doses of streptozotocin treatment mimics the metabolic characteristics of type 2 diabetes mellitus in humans

(2017) Sayantan Nath et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induce Post-Translational Modifications of AKAP121, DRP1, and OPA1 That Promote Mitochondrial Fission

(2017) Kensuke Tsushima et al.   CIRCULATION RESEARCH

Posttranslational modulation of FoxO1 contributes to cardiac remodeling in post-ischemic heart failure

(2016) Ben Arpad Kappel et al.   ATHEROSCLEROSIS

Early reduced myocardial diastolic function in children and adolescents with type 1 diabetes mellitus a population-based study

(2016) Leif Brunvand et al.   BMC Cardiovascular Disorders

Inhibiting Insulin-Mediated β 2 -Adrenergic Receptor Activation Prevents Diabetes-Associated Cardiac DysfunctionClinical Perspective

(2016) Qingtong Wang et al.   CIRCULATION

Insulin Signaling and Heart Failure

(2016) Christian Riehle et al.   CIRCULATION RESEARCH

Type-2 diabetes increases autophagy in the human heart through promotion of Beclin-1 mediated pathway

(2016) Pujika Emani Munasinghe et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Diabetes-associated cardiac fibrosis: Cellular effectors, molecular mechanisms and therapeutic opportunities

(2016) Ilaria Russo et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Sequential changes of endoplasmic reticulum stress and apoptosis in myocardial fibrosis of diabetes mellitus-induced rats

(2016) QIONG YANG et al.   Molecular Medicine Reports

lncRNA H19/miR-675 axis regulates cardiomyocyte apoptosis by targeting VDAC1 in diabetic cardiomyopathy

(2016) Xiangquan Li et al.   Scientific Reports

Circulating long-non coding RNAs as biomarkers of left ventricular diastolic function and remodelling in patients with well-controlled type 2 diabetes

(2016) D. de Gonzalo-Calvo et al.   Scientific Reports

Type 2 diabetes, obesity, and sex difference affect the fate of glucose in the human heart

(2015) Linda R. Peterson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Autophagy and mitophagy in diabetic cardiomyopathy

(2015) Satoru Kobayashi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Histone deacetylase (HDAC) inhibition improves myocardial function and prevents cardiac remodeling in diabetic mice

(2015) Youfang Chen et al.   Cardiovascular Diabetology

Diastolic dysfunction in the diabetic continuum: association with insulin resistance, metabolic syndrome and type 2 diabetes

(2015) Ricardo Fontes-Carvalho et al.   Cardiovascular Diabetology

Adaptation of Hepatic Mitochondrial Function in Humans with Non-Alcoholic Fatty Liver Is Lost in Steatohepatitis

(2015) Chrysi Koliaki et al.   Cell Metabolism

Insulin induces IRS2-dependent and GRK2-mediated β2AR internalization to attenuate βAR signaling in cardiomyocytes

(2015) Qin Fu et al.   CELLULAR SIGNALLING

MicroRNA profiling unveils hyperglycaemic memory in the diabetic heart

(2015) Sarah Costantino et al.   EUROPEAN HEART JOURNAL

O-GlcNAcomic Profiling Identifies WidespreadO-Linked β-N-Acetylglucosamine Modification (O-GlcNAcylation) in Oxidative Phosphorylation System Regulating Cardiac Mitochondrial Function

(2015) Junfeng Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Irbesartan ameliorates diabetic cardiomyopathy by regulating protein kinase D and ER stress activation in a type 2 diabetes rat model

(2015) Xiangjuan Liu et al.   PHARMACOLOGICAL RESEARCH

Diabetes-associated dysregulation ofO-GlcNAcylation in rat cardiac mitochondria

(2015) Partha S. Banerjee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Post-translational modifications of the cardiac proteome in diabetes and heart failure

(2015) Adam R. Wende   Proteomics Clinical Applications

Obesity-induced lysine acetylation increases cardiac fatty acid oxidation and impairs insulin signalling

(2014) Osama Abo Alrob et al.   CARDIOVASCULAR RESEARCH

Myocardial Contractile Dysfunction Is Associated With Impaired Mitochondrial Function and Dynamics in Type 2 Diabetic but Not in Obese Patients

(2014) David Montaigne et al.   CIRCULATION

Insulin Regulation of Myocardial Autophagy

(2014) Christian Riehle et al.   CIRCULATION JOURNAL

Insulin Inhibits Cardiac Contractility by Inducing a Gi-Biased  2-Adrenergic Signaling in Hearts

(2014) Q. Fu et al.   DIABETES

Impairment of aldehyde dehydrogenase-2 by 4-hydroxy-2-nonenal adduct formation and cardiomyocyte hypertrophy in mice fed a high-fat diet and injected with low-dose streptozotocin

(2014) Vishal R Mali et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Resveratrol-enhanced autophagic flux ameliorates myocardial oxidative stress injury in diabetic mice

(2014) Bo Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Advanced Glycation End Products and Diabetic Complications

(2014) Varun Parkash Singh et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Noncoding RNAs and myocardial fibrosis

(2014) Thomas Thum   Nature Reviews Cardiology

Fructose-fed streptozotocin-injected rat: an alternative model for type 2 diabetes

(2014) Rachel D. Wilson et al.   Pharmacological Reports

Regulation of Cardiac Expression of the Diabetic Marker MicroRNA miR-29

(2014) Nicholas Arnold et al.   PLoS One

Glucagon-like peptide-1 receptor activation reverses cardiac remodeling via normalizing cardiac steatosis and oxidative stress in type 2 diabetes

(2013) Akio Monji et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Protein kinase RNA- like endoplasmic reticulum kinase (PERK) signaling pathway plays a major role in reactive oxygen species (ROS)- mediated endoplasmic reticulum stress- induced apoptosis in diabetic cardiomyopathy

(2013) Zhong-Wei Liu et al.   Cardiovascular Diabetology

Differential Expression of Dicer, miRNAs, and Inflammatory Markers in Diabetic Ins2+/− Akita Hearts

(2013) Vishalakshi Chavali et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Myocardial Adipose Triglyceride Lipase Overexpression Protects Diabetic Mice From the Development of Lipotoxic Cardiomyopathy

(2013) T. Pulinilkunnil et al.   DIABETES

Targeting the upregulation of reactive oxygen species subsequent to hyperglycemia prevents type 1 diabetic cardiomyopathy in mice

(2013) Karina Huynh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Advanced glycation end products: role in pathology of diabetic cardiomyopathy

(2013) Vijaya Lakshmi Bodiga et al.   HEART FAILURE REVIEWS

Insulin receptor substrate signaling suppresses neonatal autophagy in the heart

(2013) Christian Riehle et al.   JOURNAL OF CLINICAL INVESTIGATION

Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation

(2013) Jeffrey R. Erickson et al.   NATURE

Heme Oxygenase-1 Prevents Cardiac Dysfunction in Streptozotocin-Diabetic Mice by Reducing Inflammation, Oxidative Stress, Apoptosis and Enhancing Autophagy

(2013) Yanli Zhao et al.   PLoS One

Na+/Ca2+ exchanger-1 protects against systolic failure in the Akitains2 model of diabetic cardiomyopathy via a CXCR4/NF-κB pathway

(2012) Thomas J. LaRocca et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

TLR4 regulates cardiac lipid accumulation and diabetic heart disease in the nonobese diabetic mouse model of type 1 diabetes

(2012) Baojun Dong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Therapeutic effect of MG-132 on diabetic cardiomyopathy is associated with its suppression of proteasomal activities: roles of Nrf2 and NF-κB

(2012) Yuehui Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Polyphenols Resveratrol and S17834 Prevent the Structural and Functional Sequelae of Diet-Induced Metabolic Heart Disease in Mice

(2012) Fuzhong Qin et al.   CIRCULATION

Mechanisms of Lipotoxicity in the Cardiovascular System

(2012) Adam R. Wende et al.   CURRENT HYPERTENSION REPORTS

UCP3 Regulates Cardiac Efficiency and Mitochondrial Coupling in High Fat-Fed Mice but Not in Leptin-Deficient Mice

(2012) S. Boudina et al.   DIABETES

The hyperglycemia stimulated myocardial endoplasmic reticulum (ER) stress contributes to diabetic cardiomyopathy in the transgenic non-obese type 2 diabetic rats: A differential role of unfolded protein response (UPR) signaling proteins

(2012) Arun Prasath Lakshmanan et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Modification of STIM1 byO-linkedN-Acetylglucosamine (O-GlcNAc) Attenuates Store-operated Calcium Entry in Neonatal Cardiomyocytes

(2012) Xiaoyuan Zhu-Mauldin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic stress–induced activation of FoxO1 triggers diabetic cardiomyopathy in mice

(2012) Pavan K. Battiprolu et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic loss of insulin receptors worsens cardiac efficiency in diabetes

(2012) Heiko Bugger et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

(2012) Congcong He et al.   NATURE

PGC-1 Proteins and Heart Failure

(2012) Christian Riehle et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Advanced glycation end product cross-link breaker attenuates diabetes-induced cardiac dysfunction by improving sarcoplasmic reticulum calcium handling

(2012) Allyson L. Kranstuber et al.   Frontiers in Physiology

MicroRNAs Involved in the Mitogen-Activated Protein Kinase Cascades Pathway During Glucose-Induced Cardiomyocyte Hypertrophy

(2011) E. Shen et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of microRNAs in diabetes and its cardiovascular complications

(2011) S. Shantikumar et al.   CARDIOVASCULAR RESEARCH

G Protein–Coupled Receptor Kinase 2 Activity Impairs Cardiac Glucose Uptake and Promotes Insulin Resistance After Myocardial Ischemia

(2011) Michele Ciccarelli et al.   CIRCULATION

Improvement of Cardiac Functions by Chronic Metformin Treatment Is Associated With Enhanced Cardiac Autophagy in Diabetic OVE26 Mice

(2011) Z. Xie et al.   DIABETES

Mitochondrial respiratory control and early defects of oxidative phosphorylation in the failing human heart

(2011) Hélène Lemieux et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Myocardial autophagy activation and suppressed survival signaling is associated with insulin resistance in fructose-fed mice

(2011) Kimberley M. Mellor et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

MicroRNAs 103 and 107 regulate insulin sensitivity

(2011) Mirko Trajkovski et al.   NATURE

Increased propensity for cell death in diabetic human heart is mediated by mitochondrial-dependent pathways

(2010) Ethan J. Anderson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

MicroRNA-223 regulates Glut4 expression and cardiomyocyte glucose metabolism

(2010) Han Lu et al.   CARDIOVASCULAR RESEARCH

Mitochondria in the diabetic heart

(2010) H. Bugger et al.   CARDIOVASCULAR RESEARCH

Myocardial Steatosis and Biventricular Strain and Strain Rate Imaging in Patients With Type 2 Diabetes Mellitus

(2010) Arnold C.T. Ng et al.   CIRCULATION

Epigenetics

(2010) Mark E. Cooper et al.   CIRCULATION RESEARCH

Deficiency of Rac1 Blocks NADPH Oxidase Activation, Inhibits Endoplasmic Reticulum Stress, and Reduces Myocardial Remodeling in a Mouse Model of Type 1 Diabetes

(2010) Jianmin Li et al.   DIABETES

Elevated Expression of Liver X Receptor Alpha (LXRα) in Myocardium of Streptozotocin-Induced Diabetic Rats

(2010) Yongxia Cheng et al.   INFLAMMATION

Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents

(2010) Ippei Shimizu et al.   JOURNAL OF CLINICAL INVESTIGATION

Deficiency in AMP-activated protein kinase exaggerates high fat diet-induced cardiac hypertrophy and contractile dysfunction

(2010) Subat Turdi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

14-3-3 Protein Protects Against Cardiac Endoplasmic Reticulum Stress (ERS) and ERS-Initiated Apoptosis in Experimental Diabetes

(2010) Flori R. Sari et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

 -N-acetylglucosamine (O-GlcNAc) is part of the histone code

(2010) K. Sakabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A high-fat diet increases adiposity but maintains mitochondrial oxidative enzymes without affecting development of heart failure with pressure overload

(2009) David J. Chess et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function

(2009) Ratnadeep Basu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mechanisms for increased myocardial fatty acid utilization following short-term high-fat feeding

(2009) Jordan J. Wright et al.   CARDIOVASCULAR RESEARCH

Cardiac peroxisome proliferator-activated receptor-α activation causes increased fatty acid oxidation, reducing efficiency and post-ischaemic functional loss

(2009) Anne D. Hafstad et al.   CARDIOVASCULAR RESEARCH

The G protein coupled receptor kinase 2 plays an essential role in beta-adrenergic receptor-induced insulin resistance

(2009) Ersilia Cipolletta et al.   CARDIOVASCULAR RESEARCH

Contribution of Impaired Myocardial Insulin Signaling to Mitochondrial Dysfunction and Oxidative Stress in the Heart

(2009) Sihem Boudina et al.   CIRCULATION

Tumor necrosis factor-α decreases sarcoplasmic reticulum Ca2+-ATPase expressions via the promoter methylation in cardiomyocytes*

(2009) Yu-Hsun Kao et al.   CRITICAL CARE MEDICINE

Nutrient Stress Activates Inflammation and Reduces Glucose Metabolism by Suppressing AMP-Activated Protein Kinase in the Heart

(2009) H. J. Ko et al.   DIABETES

Location of Arterial Stiffening Differs in Those With Impaired Fasting Glucose Versus Diabetes: Implications for Left Ventricular Hypertrophy From the Multi-Ethnic Study of Atherosclerosis

(2009) P. Rerkpattanapipat et al.   DIABETES

Tissue-Specific Remodeling of the Mitochondrial Proteome in Type 1 Diabetic Akita Mice

(2009) H. Bugger et al.   DIABETES

Abnormal myocardial insulin signalling in type 2 diabetes and left-ventricular dysfunction

(2009) Stuart A. Cook et al.   EUROPEAN HEART JOURNAL

Blockage of receptor for advanced glycation end products prevents development of cardiac dysfunction in db/db type 2 diabetic mice

(2009) Jan M. Nielsen et al.   EUROPEAN JOURNAL OF HEART FAILURE

Diabetes- and angiotensin II-induced cardiac endoplasmic reticulum stress and cell death: metallothionein protection

(2009) Jiancheng Xu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

PET detection of the impact of dobutamine on myocardial glucose metabolism in women with type 1 diabetes mellitus

(2009) Pilar Herrero et al.   JOURNAL OF NUCLEAR CARDIOLOGY

Substrate-Specific Derangements in Mitochondrial Metabolism and Redox Balance in the Atrium of the Type 2 Diabetic Human Heart

(2009) Ethan J. Anderson et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Advanced Glycation End Products in the Development of Ischemic and Dilated Cardiomyopathy in Patients With Diabetes Mellitus Type 2

(2009) J. Nożyński et al.   TRANSPLANTATION PROCEEDINGS

Cardiac inflammation associated with a Western diet is mediated via activation of RAGE by AGEs

(2008) Christos Tikellis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Conditional increase in SERCA2a protein is able to reverse contractile dysfunction and abnormal calcium flux in established diabetic cardiomyopathy

(2008) Jorge Suarez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Reduced MMP-2 activity contributes to cardiac fibrosis in experimental diabetic cardiomyopathy

(2008) Sophie Linthout et al.   BASIC RESEARCH IN CARDIOLOGY

Comparisons of Diets Used in Animal Models of High-Fat Feeding

(2008) Craig H. Warden et al.   Cell Metabolism

Type 1 Diabetic Akita Mouse Hearts Are Insulin Sensitive but Manifest Structurally Abnormal Mitochondria That Remain Coupled Despite Increased Uncoupling Protein 3

(2008) H. Bugger et al.   DIABETES

Intracellular Angiotensin II Production in Diabetic Rats Is Correlated With Cardiomyocyte Apoptosis, Oxidative Stress, and Cardiac Fibrosis

(2008) V. P. Singh et al.   DIABETES

Short-Term Hyperglycemic Dysregulation in Patients With Type 1 Diabetes Does Not Change Myocardial Triglyceride Content or Myocardial Function

(2008) S. Hammer et al.   DIABETES CARE

Advanced glycation endproduct (AGE) accumulation and AGE receptor (RAGE) up-regulation contribute to the onset of diabetic cardiomyopathy

(2008) Heng Ma et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Myocardial Steatosis Is an Independent Predictor of Diastolic Dysfunction in Type 2 Diabetes Mellitus

(2008) Luuk J. Rijzewijk et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

(2008) Thomas Thum et al.   NATURE

Effects of Intensive Glucose Lowering in Type 2 Diabetes

(2008)   NEW ENGLAND JOURNAL OF MEDICINE