Article
Food Science & Technology
Mustafa Fevzi Karagoz, A. Gulcin Sagdicoglu Celep
Summary: Energy restriction, a non-genetic intervention, increases life expectancy by stimulating NAD+ and AMP levels, activating SIRT enzymes and AMPK. These enzymes regulate various mechanisms, including enhancing resistance to oxidative stress, inducing apoptosis, and suppressing tumor growth. Energy restriction also stimulates autophagy, mitophagy, and mitochondrial biogenesis, while regulating lipid metabolism and inflammatory response through genetic pathways.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Review
Biochemistry & Molecular Biology
Masaki Kobayashi, Yusuke Deguchi, Yuka Nozaki, Yoshikazu Higami
Summary: PGC-1 alpha plays a crucial role in regulating mitochondrial function and adipocyte-specific functions in white adipose tissue, with its function being affected by metabolic changes such as obesity and caloric restriction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Yaoxing Dou, Gaoxiang Ai, Ronglei Huang, Ziwei Huang, Yucui Li, Yuhong Liu, Jianhui Xie, Jiannan Chen, Ziren Su
Summary: The study found that OBB effectively improved hyperglycemia, dyslipidemia, and insulin resistance, enhanced oral glucose tolerance, and maintained glucose metabolism homeostasis, partially through promoting the activation of the PI3K/Akt and AMPK pathways mediated by HO-1. These data suggest that OBB, as a novel HO-1 agonist, has the potential to be a promising candidate drug for diabetes management, and support the therapeutic role of HO-1 induction in diabetes, paving the way for translational research.
Article
Gastroenterology & Hepatology
Shao-Wei Li, Terumi Takahara, Weitao Que, Masayuki Fujino, Wen-Zhi Guo, Shin-Ichi Hirano, Li-Ping Ye, Xiao-Kang Li
Summary: Hydrogen-rich water (HRW) protects mice with nonalcoholic fatty liver disease by increasing the expression of Sirt1 in hepatocytes, which leads to the suppression of abnormal fat metabolism. In a NASH mouse model, HRW reduces the expression of inflammatory cytokines, alleviates tissue damage, and reverses preexisting hepatic fibrosis.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Food Science & Technology
Rasha A. Mansouri, Adel M. Ahmed, Huda F. Alshaibi, Esam M. Aboubakr
Summary: Capsaicin has hypoglycemic, hypolipidemic, antioxidant, anti-inflammatory, and anti-apoptotic effects, which can attenuate the development of myocardial damage in diabetic patients.
Article
Plant Sciences
Jing Ni, Yuanmin Li, Yawei Xu, Rong Guo
Summary: Salidroside has been found to significantly improve diabetes-induced cardiac dysfunction, hypertrophy, and fibrosis by up-regulating HO-1 expression through activation of the AKT signaling pathway. This demonstrates the cardio-protective effect of salidroside in diabetic mice, which is dependent on AKT signaling activation.
Article
Pharmacology & Pharmacy
Agnieszka Stelmaszyk, Przemyslaw Mikolajczak, Marzena Dworacka
Summary: SIRT1, as a key deacetylase enzyme, plays a critical role in preventing metabolic memory and reducing complications in diabetic patients. Modifying the expression and activity of SIRT1 may be beneficial for individuals with diabetes.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Nimisha Lingappa, Harvey N. Mayrovitz
Summary: Intermittent fasting is a widely practiced diet trend with high success rate. By increasing the levels of SIRT proteins in the body, intermittent fasting brings numerous health benefits and has a significant impact on age-related disease processes.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Maria G. Detsika, Elias A. Lianos
Summary: Heme oxygenase-1 has a new cytoprotective role by regulating the complement control protein, which helps prevent kidney injury. Targeting HO-1 induction in specific cells could be a novel approach to attenuate complement-dependent kidney diseases.
Review
Biochemistry & Molecular Biology
Valeria Consoli, Valeria Sorrenti, Salvo Grosso, Luca Vanella
Summary: Heme-oxygenase (HO-1) plays a crucial role in maintaining cellular oxidative damage and has implications in cancer research and antioxidant activity.
Review
Biochemistry & Molecular Biology
Virginia Athanassiadou, Stella Plavoukou, Eirini Grapsa, Maria G. Detsika
Summary: The protein heme oxygenase-1 plays a key role in kidney disease and affects immune pathways and responses, as demonstrated by animal models and patient studies.
Article
Multidisciplinary Sciences
Zhen Liang, Zhaoshi Zheng, Qi Guo, Meng Tian, Jing Yang, Xiu Liu, Xiaojuan Zhu, Songyan Liu
Summary: This study investigates the role of hypoxia-inducible factor (HIF)-1 alpha/heme oxygenase (HO)-1 in hippocampal neuron ferroptosis during epilepsy. The results suggest that there are metabolic differences between epilepsy patients and healthy individuals, with increased oxidative stress, heightened bilirubin, and augmented iron metabolism in epileptic blood. The active HIF-1 pathway in epileptic pathogenesis and perturbations in HIF-1 alpha signaling are reinforced by the analysis. The study implicates that HIF-1 alpha/HO-1 potentially regulates hippocampal neuronal ferroptosis, iron metabolism, and oxidative stress, thereby promoting the propagation of epilepsy.
Article
Biochemistry & Molecular Biology
Alena Jiraskova, Jan Skrha, Libor Vitek
Summary: This study assessed serum bilirubin concentrations and microsatellite variations in UGT1A1 and HMOX1 genes in patients with type 2 diabetes mellitus (T2DM). Results showed that T2DM patients had lower serum bilirubin concentrations compared to controls, and the prevalence of phenotypic Gilbert syndrome and (TA)(7/7) UGT1A1 genotype was lower in male T2DM patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Wei-Jin Fang, Xiao-Mei Li, Xin-Ke Zhou, Yan Xiong
Summary: The study found that resveratrol improves mitochondrial function and protects the heart by activating SIRT1 and deacetylating PGC-1 alpha. Additionally, resveratrol can reverse the pathogenic role of ADMA in diabetic cardiomyopathy and restore altered PGC-1 alpha expression and acetylation. Exogenous ADMA reproduces cardiac and mitochondrial dysfunction, which can be prevented by resveratrol pretreatment.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Anne Grunenwald, Lubka T. Roumenina, Marie Frimat
Summary: The incidence of kidney disease is increasing, posing a significant burden on healthcare systems and underscoring the need for new therapeutic targets. The HO system, specifically HO-1, has shown promise in protecting against various kidney injuries, but despite preclinical data, clinical translation has not yet been achieved. Future research may focus on identifying potential therapeutic interventions targeting HO-1 in kidney diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Maayan Waldman, Keren Cohen, Dor Yadin, Vadim Nudelman, Dan Gorfil, Michal Laniado-Schwartzman, Ran Kornwoski, Dan Aravot, Nader G. Abraham, Michael Arad, Edith Hochhauser
CARDIOVASCULAR DIABETOLOGY
(2018)
Correction
Cardiac & Cardiovascular Systems
Maayan Waldman, Keren Cohen, Dor Yadin, Vadim Nudelman, Dan Gorfil, Michal Laniado-Schwartzman, Ran Kornwoski, Dan Aravot, Nader G. Abraham, Michael Arad, Edith Hochhauser
CARDIOVASCULAR DIABETOLOGY
(2018)
Article
Oncology
Maayan Waldman, Vadim Nudelman, Asher Shainberg, Nader G. Abraham, Ran Komwoski, Dan Aravot, Michael Arad, Edith Hochhauser
EXPERIMENTAL CELL RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Maayan Waldman, Michael Arad, Nader G. Abraham, Edith Hochhauser
ANTIOXIDANTS & REDOX SIGNALING
(2020)
Article
Cardiac & Cardiovascular Systems
M. Arow, M. Waldman, D. Yadin, V. Nudelman, A. Shainberg, N. G. Abraham, D. Freimark, R. Kornowski, D. Aravot, E. Hochhauser, M. Arad
CARDIOVASCULAR DIABETOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Michael Arad, Maayan Waldman, Nader G. Abraham, Edith Hochhauser
PROSTAGLANDINS & OTHER LIPID MEDIATORS
(2020)
Article
Oncology
Heba Abd Alkhaleq, Ran Kornowski, Maayan Waldman, Ester Levy, Romy Zemel, Vadim Nudelman, Asher Shainberg, Ruth Miskin, Edith Hochhauser
EXPERIMENTAL CELL RESEARCH
(2020)
Article
Cardiac & Cardiovascular Systems
Michal Herman-Edelstein, Tali Guetta, Amir Barnea, Maayan Waldman, Naomi Ben-Dor, Yaron Barak, Ran Kornowski, Michael Arad, Edith Hochhauser, Dan Aravot
Summary: This study found that ACE2 expression is increased in diabetic hearts and positively correlated with glycosylated hemoglobin, body mass index, and activation of the renin angiotensin system, indicating that patients with uncontrolled diabetes or obesity with RAS activation have higher ACE2 expression and are at higher risk for severe infection. Additionally, there was no correlation between plasma free ACE2 and cardiac tissue ACE2 expression. Transmembrane serine protease 2, metalloprotease ADAM10, and ADAM17, which facilitate viral-ACE2 complex entry and degradation, were increased in diabetic hearts.
CARDIOVASCULAR DIABETOLOGY
(2021)
Correction
Cardiac & Cardiovascular Systems
Michal Herman-Edelstein, Tali Guetta, Amir Barnea, Maayan Waldman, Naomi Ben-Dor, Yaron D. Barac, Ran Kornowski, Michael Arad, Edith Hochhauser, Dan Aravot
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shin-Hsueh Shen, Shailendra P. Singh, Marco Raffaele, Maayan Waldman, Edith Hochhauser, Juancarlos Ospino, Michael Arad, Stephen J. Peterson
Summary: PGC1-alpha and HO expression in adipose tissues play a crucial role in improving obesity-related vascular dysfunction.
Article
Pharmacology & Pharmacy
Dor Yadin, Zachary Petrover, Asher Shainberg, Ronny Alcalai, Maayan Waldman, Jon Seidman, Christine E. Seidman, Nader G. Abraham, Edith Hochhauser, Michael Arad
Summary: Danon disease is a lethal genetic syndrome primarily affecting the heart, skeletal muscle, and central nervous system. Deficiency in the LAMP2 protein, caused by mutations in the LAMP2 gene, leads to defective lysosomal function and autophagy arrest. A mouse model mimicking the cardiac phenotype of Danon disease was constructed and used to study the mechanisms and potential therapies. It was found that activating autophagy exacerbated the disease, while inhibiting autophagy had a mitigating effect. Therefore, it is suggested that activation of autophagy should be avoided in Danon patients.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Cell Biology
Maayan Waldman, Shailendra P. Singh, Hsin-Hsueh Shen, Ragin Alex, Rita Rezzani, Gaia Favero, Edith Hochhauser, Ran Kornowski, Michael Arad, Stephen J. Peterson
Summary: This study investigates the interaction between adipose tissue-specific NOV/CCN3 and cardiometabolic function. Inhibiting NOV expression improves adipose tissue function, cardiac metabolism, and mitochondrial function in obese mice, resulting in improved glucose tolerance, decreased inflammation, and improved cardiovascular function.
Meeting Abstract
Cardiac & Cardiovascular Systems
Maayan Waldman, Stephen J. Peterson, Ran Kornowski, Nader G. Abraham
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
M. Waldman, K. Cohen, V. Nudelman, D. Gorfil, M. Laniado-Schwartzman, R. Kornwoski, N. G. Abraham, D. Aravot, A. Shainberg, M. Arad, E. Hochhauser
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2017)