Melatonin alleviates cardiac fibrosis via inhibiting lncRNA MALAT1/miR‐141‐mediated NLRP3 inflammasome and TGF‐β1/Smads signaling in diabetic cardiomyopathy

Inflammation and NLRP3 Inflammasome Activation Initiated in Response to Pressure Overload by Ca 2+ /Calmodulin-Dependent Protein Kinase II δ Signaling in Cardiomyocytes Are Essential for Adverse Cardiac Remodeling

(2019) Takeshi Suetomi et al.   CIRCULATION

Dual Role of Triptolide in Interrupting the NLRP3 Inflammasome Pathway to Attenuate Cardiac Fibrosis

(2019) Xi-Chun Pan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin protects against streptozotocin-induced diabetic cardiomyopathy through themammalian target of rapamycin (mTOR) signaling pathway

(2019) yasemin kandemir et al.   Advances in Clinical and Experimental Medicine

A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injury

(2019) Ram Kuwar et al.   Journal of Neuroinflammation

The lncRNA Neat1 promotes activation of inflammasomes in macrophages

(2019) Pengfei Zhang et al.   Nature Communications

Vaspin prevents myocardial injury in rats model of diabetic cardiomyopathy by enhancing autophagy and inhibiting inflammation

(2019) Xuelian Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Melatonin protects diabetic heart against ischemia-reperfusion injury, role of membrane receptor-dependent cGMP-PKG activation

(2018) Li-ming Yu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Functional Classification and Experimental Dissection of Long Noncoding RNAs

(2018) Florian Kopp et al.   CELL

Melatonin therapy for diabetic cardiomyopathy: A mechanism involving Syk-mitochondrial complex I-SERCA pathway

(2018) Hao Zhou et al.   CELLULAR SIGNALLING

Anti-Inflammatory Effects of Melatonin in Obesity and Hypertension

(2018) Natalia Jorgelina Prado et al.   CURRENT HYPERTENSION REPORTS

Melatonin in Synaptic Impairments of Alzheimer’s Disease

(2018) Yan Shi et al.   JOURNAL OF ALZHEIMERS DISEASE

Melatonin prevents Drp1-mediated mitochondrial fission in diabetic hearts through SIRT1-PGC1α pathway

(2018) Mingge Ding et al.   JOURNAL OF PINEAL RESEARCH

NLRP3: A Novel Mediator in Cardiovascular Disease

(2018) Wenyi Zhou et al.   Journal of Immunology Research

Melatonin activates Parkin translocation and rescues the impaired mitophagy activity of diabetic cardiomyopathy through Mst1 inhibition

(2018) Shanjie Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Inhibition of JNK and p38 MAPK-mediated inflammation and apoptosis by ivabradine improves cardiac function in streptozotocin-induced diabetic cardiomyopathy

(2018) Guangfeng Zuo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Melatonin Induces Osteoblastic Differentiation of Mesenchymal Stem Cells and Promotes Fracture Healing in a Rat Model of Femoral Fracture via Neuropeptide Y/Neuropeptide Y Receptor Y1 Signaling

(2018) Penghong Dong et al.   PHARMACOLOGY

PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation

(2018) Jueqi Chen et al.   NATURE

Long noncoding RNA MALAT1 regulates renal tubular epithelial pyroptosis by modulated miR-23c targeting of ELAVL1 in diabetic nephropathy

(2017) Xue Li et al.   EXPERIMENTAL CELL RESEARCH

Melatonin protects against diabetic cardiomyopathy through Mst1/Sirt3 signaling

(2017) Mingming Zhang et al.   JOURNAL OF PINEAL RESEARCH

Melatonin prevents endothelial cell pyroptosis via regulation of long noncoding RNA MEG3/miR-223/NLRP3 axis

(2017) Yong Zhang et al.   JOURNAL OF PINEAL RESEARCH

Cardiac Fibrosis

(2016) Joshua G. Travers et al.   CIRCULATION RESEARCH

The long noncoding RNA MALAT1 regulates the lipopolysaccharide-induced inflammatory response through its interaction with NF-κB

(2016) Gui Zhao et al.   FEBS LETTERS

Involvement of long noncoding RNA MALAT1 in the pathogenesis of diabetic cardiomyopathy

(2016) Mengyao Zhang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Down-regulation of lncRNA MALAT1 reduces cardiomyocyte apoptosis and improves left ventricular function in diabetic rats

(2016) Mengyao Zhang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Diabetes-associated cardiac fibrosis: Cellular effectors, molecular mechanisms and therapeutic opportunities

(2016) Ilaria Russo et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Elevated heart rate and nondipping heart rate as potential targets for melatonin: a review

(2016) Fedor Simko et al.   JOURNAL OF PINEAL RESEARCH

Melatonin: the dawning of a treatment for fibrosis?

(2016) Wei Hu et al.   JOURNAL OF PINEAL RESEARCH

The nuclear melatonin receptor RORαis a novel endogenous defender against myocardial ischemia/reperfusion injury

(2016) Ben He et al.   JOURNAL OF PINEAL RESEARCH

Diabetic Cardiomyopathy: Catabolism Driving Metabolism

(2015) Z. V. Wang et al.   CIRCULATION

Melatonin ameliorates metabolic risk factors, modulates apoptotic proteins, and protects the rat heart against diabetes-induced apoptosis

(2015) Ali H. Amin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibition of MEF2A prevents hyperglycemia-induced extracellular matrix accumulation by blocking Akt and TGF-β1/Smad activation in cardiac fibroblasts

(2015) Xueying Chen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Investigating inherent functional differences between human cardiac fibroblasts cultured from nondiabetic and Type 2 diabetic donors

(2014) Bryony Sedgwick et al.   CARDIOVASCULAR PATHOLOGY

miR-141 regulates TGF-β1-induced epithelial-mesenchymal transition through repression of HIPK2 expression in renal tubular epithelial cells

(2014) YUANHANG HUANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Peripheral and Central Effects of Melatonin on Blood Pressure Regulation

(2014) Olga Pechanova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Myocardial fibroblast–matrix interactions and potential therapeutic targets

(2014) Edie C. Goldsmith et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

NLRP3 Gene Silencing Ameliorates Diabetic Cardiomyopathy in a Type 2 Diabetes Rat Model

(2014) Beibei Luo et al.   PLoS One

Rosuvastatin Alleviates Diabetic Cardiomyopathy by Inhibiting NLRP3 Inflammasome and MAPK Pathways in a Type 2 Diabetes Rat Model

(2013) Beibei Luo et al.   CARDIOVASCULAR DRUGS AND THERAPY

Type II diabetes promotes a myofibroblast phenotype in cardiac fibroblasts

(2013) Vennece Fowlkes et al.   LIFE SCIENCES

Cardiac Fibroblast-Dependent Extracellular Matrix Accumulation Is Associated with Diastolic Stiffness in Type 2 Diabetes

(2013) Kirk R. Hutchinson et al.   PLoS One

The inflammasome activating caspase 1 mediates fibrosis and myofibroblast differentiation in systemic sclerosis

(2011) Carol M. Artlett et al.   ARTHRITIS AND RHEUMATISM

A survey of molecular details in the human pineal gland in the light of phylogeny, structure, function and chronobiological diseases

(2011) Jörg H. Stehle et al.   JOURNAL OF PINEAL RESEARCH

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Melatonin ameliorates high fat diet-induced diabetes and stimulates glycogen synthesis via a PKCζ-Akt-GSK3β pathway in hepatic cells

(2009) Jiunn-Min Shieh et al.   JOURNAL OF PINEAL RESEARCH

Interleukin-1 beta regulates proximal tubular cell transforming growth factor beta-1 signalling

(2009) D. D. Luo et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Effects of Intensive Glucose Lowering in Type 2 Diabetes

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

Expression of neuropeptide Y and its receptors Y1 and Y2 in the rat heart and its supplying autonomic and spinal sensory ganglia in experimentally induced diabetes

(2007) M. Chottová Dvoráková et al.   NEUROSCIENCE

Effects of pinealectomy and exogenous melatonin on ghrelin and peptide YY in gastrointestinal system and neuropeptide Y in hypothalamic arcuate nucleus: Immunohistochemical studies in male rats

(2007) Mehmet Aydin et al.   REGULATORY PEPTIDES