Article
Multidisciplinary Sciences
Maarten Hulsmans, Maximilian J. Schloss, I-Hsiu Lee, Aneesh Bapat, Yoshiko Iwamoto, Claudio Vinegoni, Alexandre Paccalet, Masahiro Yamazoe, Jana Grune, Steffen Pabel, Noor Momin, Hana Seung, Nina Kumowski, Fadi E. Pulous, Daniel Keller, Constanze Bening, Ursula Green, Jochen K. Lennerz, Richard N. Mitchell, Andrew Lewis, Barbara Casadei, Oriol Iborra-Egea, Antoni Bayes-Genis, Samuel Sossalla, Chin Siang Ong, Richard N. Pierson, Jon C. Aster, David Rohde, Gregory R. Wojtkiewicz, Ralph Weissleder, Filip K. Swirski, George Tellides, George Tolis, Serguei Melnitchouk, David J. Milan, Patrick T. Ellinor, Kamila Naxerova, Matthias Nahrendorf
Summary: This study deciphered the role of immune and stromal cells in atrial fibrillation and identified SPP1(+) macrophages as potential targets for immunotherapy in atrial fibrillation.
Review
Cardiac & Cardiovascular Systems
Hongyang Shu, Jia Cheng, Na Li, Zixuan Zhang, Jiali Nie, Yizhong Peng, Yan Wang, Dao Wen Wang, Ning Zhou
Summary: The prevalence of obesity and AF is rapidly increasing worldwide, with higher obesity rates among AF patients. Epidemiological data shows a potential correlation between obesity and AF, but results are inconsistent. Obesity-related factors such as hypertension, diabetes, and sleep apnea contribute to AF. Obesity can also induce atrial enlargement, inflammation, fibrosis, and electrical abnormalities, promoting AF. Weight loss has been shown to reduce the risk and improve the prognosis of AF, possibly due to its anti-fibrosis and anti-inflammatory effects. However, fluctuations in weight can offset the benefits of weight loss. Therefore, weight management interventions should be incorporated in the treatment of AF patients.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Multidisciplinary Sciences
Michiel R. L. Tubeeckx, Steven Laga, Christel Jacobs, Marina Stroe, Steven Van Cruchten, Bo Goovaerts, Jens Van Fraeyenhove, Hielko Miljoen, Guido R. Y. De Meyer, Gilles W. De Keulenaer, Hein Heidbuchel, Vincent F. M. Segers
Summary: This paper presents a model of sterile pericarditis-induced atrial myopathy in Aachener minipigs, which has clinical relevance, necessary features, and reproducibility.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Cardiac & Cardiovascular Systems
Olga Shaihov-Teper, Eilon Ram, Nimer Ballan, Rafael Y. Brzezinski, Nili Naftali-Shani, Rula Masoud, Tamar Ziv, Nir Lewis, Yeshai Schary, La-Paz Levin-Kotler, David Volvovitch, Elchanan M. Zuroff, Sergei Amunts, Neta Regev-Rudzki, Leonid Sternik, Ehud Raanani, Lior Gepstein, Jonathan Leor
Summary: This study revealed, for the first time, a distinctive proinflammatory, profibrotic, and proarrhythmic signature of epicardial fat-derived extracellular vesicles in patients with atrial fibrillation, uncovering another pathway by which epicardial fat promotes the development of atrial myopathy and fibrillation.
Review
Physiology
Kensuke Ihara, Tetsuo Sasano
Summary: Atrial fibrillation (AF) is a common arrhythmia associated with high mortality and disability due to stroke. Inflammation plays a crucial role in the formation of AF substrate and its perpetuation. Understanding the relationship between AF and inflammation, as well as the potential of inflammatory molecules as therapeutic targets, could lead to the development of new treatment strategies for AF.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
Serena Cabaro, Maddalena Conte, Donato Moschetta, Laura Petraglia, Vincenza Valerio, Serena Romano, Michele Francesco Di Tolla, Pasquale Campana, Giuseppe Comentale, Emanuele Pilato, Vittoria D'Esposito, Annabella Di Mauro, Monica Cantile, Paolo Poggio, Valentina Parisi, Dario Leosco, Pietro Formisano
Summary: The study explored the link between epicardial adipose tissue (EAT)-secreted interleukin (IL)-1 beta, atrial remodeling, and post-operative atrial fibrillation (POAF) in patients with coronary artery disease (CAD). Results showed that EAT-mediated IL-1 beta secretion was significantly higher in patients with POAF compared to those without POAF, suggesting a potential role of EAT in both POAF occurrence and atrial fibrotic remodeling.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Andrew S. Tseng, Marlene Girardo, Christine Firth, Shubhang Bhatt, David Liedl, Paul Wennberg, Win-Kuang Shen, Leslie T. Cooper, Fadi E. Shamoun
Summary: The study examines the relationship between peripheral arterial disease (PAD) and incident atrial fibrillation (AF), finding that PAD patients are at increased risk for developing AF, ischemic stroke, and all-cause mortality. Patients with abnormal ankle-brachial index (ABI), especially those with severe PAD and cardiac structural abnormalities, may benefit from routine monitoring for AF and management of cardiovascular risk factors.
MAYO CLINIC PROCEEDINGS
(2021)
Review
Cell Biology
Abhijit Takawale, Martin Aguilar, Yasmina Bouchrit, Roddy Hiram
Summary: This article explores the association between thyroid disease and atrial fibrillation, highlighting the impact of thyroid hormone dysregulation on the development of atrial arrhythmogenic substrate. It also reviews the available therapeutic strategies for treating atrial fibrillation in the context of thyroid disease.
Review
Biology
Georgios Leventopoulos, Rafail Koros, Christoforos Travlos, Angelos Perperis, Panagiotis Chronopoulos, Evropi Tsoni, Eleni-Evangelia Koufou, Athanasios Papageorgiou, Anastasios Apostolos, Panagiotis Kaouris, Periklis Davlouros, Grigorios Tsigkas
Summary: Atrial fibrillation (AF) is a common arrhythmia in older individuals. The mechanism of AF involves trigger activation and arrhythmia perpetuation, with the pulmonary veins as the most common triggers. Electrical isolation of the pulmonary veins through ablation is the key treatment for AF. Various factors and comorbidities lead to myocardial stretch and the formation of a fibrotic substrate, promoting AF perpetuation. Multiple mechanisms are employed in the clinical practice for the interventions and medical treatments of AF.
Article
Cardiac & Cardiovascular Systems
Laura Petraglia, Maddalena Conte, Giuseppe Comentale, Serena Cabaro, Pasquale Campana, Carmela Russo, Ilaria Amaranto, Dario Bruzzese, Pietro Formisano, Emanuele Pilato, Nicola Ferrara, Dario Leosco, Valentina Parisi
Summary: This study aimed to evaluate the association between inflammatory mediators produced by EAT and the occurrence of POAF. The results showed that higher levels of IL-6 and MCP-1 in EAT were significantly associated with POAF, and statin therapy may play a role in preventing POAF. These findings suggest a potential targeted use of these drugs in the perioperative period.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Medicine, Research & Experimental
Chang Yi Li, Jing Rui Zhang, Wan Ning Hu, Song Nan Li
Summary: Atrial fibrillation (AF) is closely linked with fibrosis, which is a key factor in structural changes that impact the occurrence and persistence of AF. Despite the complexity of this process, advancements in technology now allow for non-invasive evaluation of fibrosis, facilitating the selection of personalized treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Andrea Lorenzo Poggi, Benedicte Gaborit, Thomas Hellmut Schindler, Luca Liberale, Fabrizio Montecucco, Federico Carbone
Summary: Obesity is a heterogeneous condition that may have a closer link with cardiovascular disease burden and atrial fibrillation. Dysfunction of epicardial adipose tissue (EAT) due to ectopic fat deposition is associated with atrial remodelling and may play a significant role in the development and recurrence of atrial fibrillation. This study provides an updated understanding of the relationship between dysfunctional EAT, LA remodelling, and atrial fibrillation onset and recurrence.
Article
Medicine, Research & Experimental
Sandrine Parent, Ramana Vaka, Yousef Risha, Clarissa Ngo, Pushpinder Kanda, Stanley Nattel, Saad Khan, David Courtman, Duncan J. Stewart, Darryl R. Davis
Summary: This study found that extracellular vesicles isolated from cells of atrial fibrillation patients can prevent postoperative AF by reducing inflammation and fibrosis, providing a new effective strategy for prevention.
Article
Medicine, Research & Experimental
Hongting Hao, Sen Yan, Xinbo Zhao, Xuejie Han, Ning Fang, Yun Zhang, Chenguang Dai, Wenpeng Li, Hui Yu, Yunlong Gao, Dingyu Wang, Qiang Gao, Yu Duan, Yue Yuan, Yue Li
Summary: Atrial fibrosis plays a critical role in the development of atrial fibrillation. The promotion of atrial fibrosis through inhibition of GPD1L by miR-210-3p in extracellular vesicles is identified. Preventing pathological crosstalk between atrial myocytes and fibroblasts may offer a novel approach to ameliorate atrial fibrosis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Maddalena Conte, Laura Petraglia, Serena Cabaro, Vincenza Valerio, Paolo Poggio, Emanuele Pilato, Emilio Attena, Vincenzo Russo, Adele Ferro, Pietro Formisano, Dario Leosco, Valentina Parisi
Summary: Atrial fibrillation (AF) is a common cardiac arrhythmia associated with age and increased risk of stroke, heart failure, and cardiovascular mortality. Recent evidence suggests that epicardial adipose tissue (EAT), the visceral fat depot of the heart, plays a significant role in AF development through various mechanisms such as inflammation, fibrosis, oxidative stress, and fat infiltration. EAT is a local source of inflammatory mediators that contribute to atrial collagen deposition and fibrosis, as well as alter atrial electrophysiological properties. Imaging methods can be used to measure EAT and predict the presence, severity, and recurrence of AF. Additionally, EAT is emerging as a potential therapeutic target for AF.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Hidekazu Kondo, Shintaro Kira, Takahiro Oniki, Koro Gotoh, Akira Fukui, Ichitaro Abe, Yuki Ikebe, Kyoko Kawano, Shotaro Saito, Kohei Aoki, Norihiro Okada, Yasuko Nagano, Hidefumi Akioka, Tetsuji Shinohara, Kumiko Akiyoshi, Takayuki Masaki, Yasushi Teshima, Kunio Yufu, Mikiko Nakagawa, Naohiko Takahashi
CARDIOVASCULAR RESEARCH
(2019)
Article
Cardiac & Cardiovascular Systems
Hidefumi Akioka, Kunio Yufu, Yasushi Teshima, Kyoko Kawano, Yumi Ishii, Ichitaro Abe, Hidekazu Kondo, Shotaro Saito, Akira Fukui, Norihiro Okada, Yasuko Nagano, Tetsuji Shinohara, Mikiko Nakagawa, Masahide Hara, Naohiko Takahashi
Article
Cardiac & Cardiovascular Systems
Ichitaro Abe, Yasushi Teshima, Hidekazu Kondo, Haruka Kaku, Shintaro Kira, Yuki Ikebe, Shotaro Saito, Akira Fukui, Tetsuji Shinohara, Kunio Yufu, Mikiko Nakagawa, Naoki Hijiya, Masatsugu Moriyama, Tatsuo Shimada, Shinji Miyamoto, Naohiko Takahashi
Article
Cardiac & Cardiovascular Systems
Mami Fujinami, Hidekazu Kondo, Kunio Yufu, Tetsuji Shinohara, Yumi Ishii, Yasushi Teshima, Mikiko Nakagawa, Naohiko Takahashi
JOURNAL OF CARDIOLOGY
(2018)
Editorial Material
Cardiac & Cardiovascular Systems
Yumi Ishii, Hidefumi Akioka, Kunio Yufu, Kyoko Kawano, Miho Miyoshi, Takaaki Imamura, Reika Ayabe, Hidekazu Kondo, Shotaro Saito, Akira Fukui, Norihiro Okada, Tetsuji Shinohara, Yasushi Teshima, Mikiko Nakagawa, Naohiko Takahashi
CIRCULATION JOURNAL
(2019)
Article
Cardiac & Cardiovascular Systems
Kunio Yufu, Hidekazu Kondo, Tetsuji Shinohara, Yumi Ishii, Seiichiro Yoshimura, Ichitaro Abe, Shotaro Saito, Akira Fukui, Norihiro Okada, Hidefumi Akioka, Yasushi Teshima, Mikiko Nakagawa, Naohiko Takahashi
Article
Medicine, General & Internal
Miho Miyoshi, Hidekazu Kondo, Tetsuji Shinohara, Kunio Yufu, Mikiko Nakagawa, Naohiko Takahashi
Editorial Material
Cardiac & Cardiovascular Systems
Hidekazu Kondo, Naohiko Takahashi
CARDIOVASCULAR RESEARCH
(2019)
Article
Cardiac & Cardiovascular Systems
Yuki Ebata, Mikiko Nakagawa, Hidekazu Kondo, Kaori Ezaki, Hiroko Miyazaki, Tetsuji Shinohara, Yasushi Teshima, Kunio Yufu, Naohiko Takahashi
JOURNAL OF CARDIOLOGY
(2020)
Meeting Abstract
Cardiac & Cardiovascular Systems
Nadia Akawi, Antonio Checa, Ioannis Akoumianakis, Marios Margaritis, Christos P. Kotanidis, Evangelia Daskalakis, Hidekazu Kondo, Keith M. Channon, Craig Wheelock, Charalambos Antoniades
Meeting Abstract
Cardiac & Cardiovascular Systems
Y. Ishii, K. Yufu, S. Kira, M. Miyoshi, I. Abe, T. Oniki, H. Kondo, S. Saito, A. Fukui, N. Okada, H. Akioka, T. Shinohara, Y. Teshima, M. Nakagawa, N. Takahashi
EUROPEAN HEART JOURNAL
(2019)
Meeting Abstract
Cardiac & Cardiovascular Systems
I. Abe, T. Terabayashi, Y. Teshima, Y. Ishii, M. Miyoshi, S. Kira, H. Kondo, S. Saito, K. Yufu, N. Takahashi, T. Ishizaki
EUROPEAN HEART JOURNAL
(2019)
Meeting Abstract
Cardiac & Cardiovascular Systems
H. Kondo, S. Kira, T. Oniki, S. Saito, Y. Teshima, N. Takahashi
EUROPEAN HEART JOURNAL
(2018)
Meeting Abstract
Cardiac & Cardiovascular Systems
H. Kondo, I. Abe, A. Fukui, Y. Teshima, N. Takahashi
EUROPEAN HEART JOURNAL
(2018)