The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic
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Title
The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic
Authors
Keywords
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Journal
Nature Reviews Endocrinology
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-08-06
DOI
10.1038/s41574-020-0386-0
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Note: Only part of the references are listed.- Fibroblast growth factor (FGF)-21 based therapies: A magic bullet for nonalcoholic fatty liver disease (NAFLD)?
- (2020) Michael Ritchie et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice
- (2020) Susanne Keipert et al. Nature Communications
- Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation
- (2019) Yong Pan et al. JOURNAL OF CLINICAL INVESTIGATION
- Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues
- (2019) Leiluo Geng et al. Cell Reports
- The central fibroblast growth factor receptor/beta klotho system: Comprehensive mapping in Mus musculus and comparisons to nonhuman primate and human samples using an automated in situ hybridization platform
- (2019) Karin Hultman et al. JOURNAL OF COMPARATIVE NEUROLOGY
- Circulating FGF21 Levels in Human Health and Metabolic Disease
- (2019) Michaela Keuper et al. EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
- Exercise ameliorates the FGF21–adiponectin axis impairment in diet-induced obese mice
- (2019) Wenqi Yang et al. Endocrine Connections
- 140-LB: NGM313, a Novel Activator of b-Klotho/FGFR1c, Improves Insulin Resistance and Reduces Hepatic Fat in Obese, Nondiabetic Subjects
- (2019) ALEX DEPAOLI et al. DIABETES
- Going Back to the Biology of FGF21: New Insights
- (2019) Jo E. Lewis et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Improved FGF21 Sensitivity and Restored FGF21 Signaling Pathway in High-Fat Diet/Streptozotocin-Induced Diabetic Rats After Duodenal-Jejunal Bypass and Sleeve Gastrectomy
- (2019) Qiaoran Liu et al. Frontiers in Endocrinology
- Paracrine-endocrine FGF chimeras as potent therapeutics for metabolic diseases
- (2019) Longwei Zhao et al. EBioMedicine
- Increased Expression of FGF‐21 Negatively Affects Bone Homeostasis in Dystrophin/Utrophin Double Knockout Mice
- (2019) Hongshuai Li et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Whole-body and adipose tissue-specific mechanisms underlying the metabolic effects of fibroblast growth factor 21 in the Siberian hamster
- (2019) Jo E. Lewis et al. Molecular Metabolism
- A long-acting FGF21 alleviates hepatic steatosis and inflammation in a mouse model of non-alcoholic steatohepatitis partly through an FGF21-adiponectin-IL17A pathway
- (2018) Lichen Bao et al. BRITISH JOURNAL OF PHARMACOLOGY
- A 2A Receptor Activation Attenuates Hypertensive Cardiac Remodeling via Promoting Brown Adipose Tissue-Derived FGF21
- (2018) Cheng-Chao Ruan et al. Cell Metabolism
- FGF Family: From Drug Development to Clinical Application
- (2018) Qi Hui et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- FGF21 decreases body weight without reducing food intake or bone mineral density in high-fat fed obese rhesus macaque monkeys
- (2018) Birgitte Andersen et al. INTERNATIONAL JOURNAL OF OBESITY
- A biparatopic agonistic antibody that mimics fibroblast growth factor 21 ligand activity
- (2018) Sally Yu Shi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- BMS-986036, a PEGylated fibroblast growth factor 21 analogue, reduces fibrosis and Pro-C3 in a mouse model of non-alcoholic steatohepatitis
- (2018) Y. Luo et al. JOURNAL OF HEPATOLOGY
- Effects of a PEGylated fibroblast growth factor 21 variant on steatosis, inflammation, and fibrosis in a mouse model of nonalcoholic steatohepatitis
- (2018) B. Zinker et al. JOURNAL OF HEPATOLOGY
- Effects of central FGF21 infusion on the hypothalamus–pituitary–thyroid axis and energy metabolism in rats
- (2018) Umit Yilmaz et al. Journal of Physiological Sciences
- Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease
- (2018) Mohammad Zarei et al. Molecular Metabolism
- Agonistic β-Klotho antibody mimics fibroblast growth factor 21 (FGF21) functions
- (2018) Xiaoshan Min et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structures of β-klotho reveal a ‘zip code’-like mechanism for endocrine FGF signalling
- (2018) Sangwon Lee et al. NATURE
- Pegbelfermin (BMS-986036), a PEGylated fibroblast growth factor 21 analogue, in patients with non-alcoholic steatohepatitis: a randomised, double-blind, placebo-controlled, phase 2a trial
- (2018) Arun Sanyal et al. LANCET
- Pegbelfermin (BMS-986036), PEGylated FGF21, in Patients with Obesity and Type 2 Diabetes: Results from a Randomized Phase 2 Study
- (2018) Edgar D. Charles et al. Obesity
- Fibroblast activation protein is dispensable for control of glucose homeostasis and body weight in mice
- (2018) Brandon L. Panaro et al. Molecular Metabolism
- A Novel Fc-FGF21 With Improved Resistance to Proteolysis, Increased Affinity Toward β-Klotho, and Enhanced Efficacy in Mice and Cynomolgus Monkeys
- (2017) Shanaka Stanislaus et al. ENDOCRINOLOGY
- FGF21 Is an Insulin-Dependent Postprandial Hormone in Adult Humans
- (2017) Ricardo J Samms et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- FGF21 mimetic antibody stimulates UCP1-independent brown fat thermogenesis via FGFR1/βKlotho complex in non-adipocytes
- (2017) Mark Z. Chen et al. Molecular Metabolism
- FAP finds FGF21 easy to digest
- (2016) M. P. Gillum et al. BIOCHEMICAL JOURNAL
- FGF21 Regulates Sweet and Alcohol Preference
- (2016) Saswata Talukdar et al. Cell Metabolism
- A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects
- (2016) Saswata Talukdar et al. Cell Metabolism
- FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues
- (2016) Christian Schlein et al. Cell Metabolism
- FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver
- (2016) Stephanie von Holstein-Rathlou et al. Cell Metabolism
- FGF21 Improves the Adipocyte Dysfunction Related to Seipin Deficiency
- (2016) Lucile Dollet et al. DIABETES
- Overexpression of β-Klotho in Adipose Tissue Sensitizes Male Mice to Endogenous FGF21 and Provides Protection From Diet-Induced Obesity
- (2016) Ricardo J. Samms et al. ENDOCRINOLOGY
- Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice
- (2016) Qi Gong et al. HEPATOLOGY
- Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21
- (2016) Diana Ronai Dunshee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Fibroblast growth factor-21 restores insulin sensitivity but induces aberrant bone microstructure in obese insulin-resistant rats
- (2016) Narattaphol Charoenphandhu et al. JOURNAL OF BONE AND MINERAL METABOLISM
- PF-05231023, a long-acting FGF21 analogue, decreases body weight by reduction of food intake in non-human primates
- (2016) W. Clayton Thompson et al. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
- Fibroblast growth factor 21 attenuates hepatic fibrogenesis through TGF-β/smad2/3 and NF-κB signaling pathways
- (2016) Pengfei Xu et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes
- (2016) Annabel Y. Minard et al. Cell Reports
- Fibroblast activation protein (FAP) as a novel metabolic target
- (2016) Miguel Angel Sánchez-Garrido et al. Molecular Metabolism
- Fibroblast Growth Factor 21 Protects against Atherosclerosis via Fine-Tuning the Multiorgan Crosstalk
- (2016) Leigang Jin et al. Diabetes & Metabolism Journal
- Human FGF-21 Is a Substrate of Fibroblast Activation Protein
- (2016) Andrew L. Coppage et al. PLoS One
- FGF21 attenuates pathological myocardial remodeling following myocardial infarction through the adiponectin-dependent mechanism
- (2015) Yusuke Joki et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Circulating FGF21 proteolytic processing mediated by fibroblast activation protein
- (2015) E. Y. Zhen et al. BIOCHEMICAL JOURNAL
- A Liver-Bone Endocrine Relay by IGFBP1 Promotes Osteoclastogenesis and Mediates FGF21-Induced Bone Resorption
- (2015) Xunde Wang et al. Cell Metabolism
- Pharmacologic Effects of FGF21 Are Independent of the “Browning” of White Adipose Tissue
- (2015) Murielle M. Véniant et al. Cell Metabolism
- Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice
- (2015) Z. Lin et al. CIRCULATION
- Fibroblast growth factor 21 protects the heart from apoptosis in a diabetic mouse model via extracellular signal-regulated kinase 1/2-dependent signalling pathway
- (2015) Chi Zhang et al. DIABETOLOGIA
- Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice
- (2015) Nicholas Douris et al. ENDOCRINOLOGY
- FGF21 deletion exacerbates diabetic cardiomyopathy by aggravating cardiac lipid accumulation
- (2015) Xiaoqing Yan et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- FGF21 and the late adaptive response to starvation in humans
- (2015) Pouneh K. Fazeli et al. JOURNAL OF CLINICAL INVESTIGATION
- Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23
- (2015) Chiara Degirolamo et al. NATURE REVIEWS DRUG DISCOVERY
- Expression Atlas update—an integrated database of gene and protein expression in humans, animals and plants
- (2015) Robert Petryszak et al. NUCLEIC ACIDS RESEARCH
- FGF21-Mediated Improvements in Glucose Clearance Require Uncoupling Protein 1
- (2015) Michelle M. Kwon et al. Cell Reports
- Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1
- (2015) Ricardo J. Samms et al. Cell Reports
- FGF21 and Cardiac Physiopathology
- (2015) Anna Planavila et al. Frontiers in Endocrinology
- Sustained Brown Fat Stimulation and Insulin Sensitization by a Humanized Bispecific Antibody Agonist for Fibroblast Growth Factor Receptor 1/βKlotho Complex
- (2015) Ganesh Kolumam et al. EBioMedicine
- Ketogenic Diet Impairs FGF21 Signaling and Promotes Differential Inflammatory Responses in the Liver and White Adipose Tissue
- (2015) Mohamed Asrih et al. PLoS One
- Fibroblast growth factor 21 protects the heart from oxidative stress
- (2014) Anna Planavila et al. CARDIOVASCULAR RESEARCH
- FGF21 Acts Centrally to Induce Sympathetic Nerve Activity, Energy Expenditure, and Weight Loss
- (2014) Bryn M. Owen et al. Cell Metabolism
- FGF21 Maintains Glucose Homeostasis by Mediating the Cross Talk Between Liver and Brain During Prolonged Fasting
- (2014) Q. Liang et al. DIABETES
- Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding
- (2014) K. R. Markan et al. DIABETES
- Fibroblast growth factor 21 participates in adaptation to endoplasmic reticulum stress and attenuates obesity-induced hepatic metabolic stress
- (2014) Seong Hun Kim et al. DIABETOLOGIA
- Fibroblast Growth Factor 21 Limits Lipotoxicity by Promoting Hepatic Fatty Acid Activation in Mice on Methionine and Choline-Deficient Diets
- (2014) Ffolliott M. Fisher et al. GASTROENTEROLOGY
- Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1α-mediated antioxidant capacity in mice
- (2014) Dewei Ye et al. HEPATOLOGY
- Opposite alterations in FGF21 and FGF19 levels and disturbed expression of the receptor machinery for endocrine FGFs in obese patients
- (2014) J M Gallego-Escuredo et al. INTERNATIONAL JOURNAL OF OBESITY
- Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis
- (2014) Manoja K. Brahma et al. JOURNAL OF LIPID RESEARCH
- MicroRNA 34a Inhibits Beige and Brown Fat Formation in Obesity in Part by Suppressing Adipocyte Fibroblast Growth Factor 21 Signaling and SIRT1 Function
- (2014) T. Fu et al. MOLECULAR AND CELLULAR BIOLOGY
- A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity
- (2014) Daniel A Bachovchin et al. Nature Chemical Biology
- Understanding fibroblast activation protein (FAP): Substrates, activities, expression and targeting for cancer therapy
- (2014) Elizabeth J. Hamson et al. Proteomics Clinical Applications
- Adiponectin Mediates the Metabolic Effects of FGF21 on Glucose Homeostasis and Insulin Sensitivity in Mice
- (2013) Zhuofeng Lin et al. Cell Metabolism
- An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice
- (2013) William L. Holland et al. Cell Metabolism
- The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes
- (2013) Gregory Gaich et al. Cell Metabolism
- High Glucose Represses -Klotho Expression and Impairs Fibroblast Growth Factor 21 Action in Mouse Pancreatic Islets: Involvement of Peroxisome Proliferator-Activated Receptor Signaling
- (2013) W. Y. So et al. DIABETES
- Pegylated Fgf21 rapidly normalizes insulin-stimulated glucose utilization in diet-induced insulin resistant mice
- (2013) Raul C. Camacho et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Influence of growth hormone on circulating fibroblast growth factor 21 levels in humans
- (2013) J. Lundberg et al. JOURNAL OF INTERNAL MEDICINE
- FGF21 regulates metabolism and circadian behavior by acting on the nervous system
- (2013) Angie L Bookout et al. NATURE MEDICINE
- Rational Design of a Fibroblast Growth Factor 21-Based Clinical Candidate, LY2405319
- (2013) Alexei Kharitonenkov et al. PLoS One
- Fibroblast growth factor 21 protects against cardiac hypertrophy in mice
- (2013) A. Planavila et al. Nature Communications
- Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones
- (2012) Paul A. Dutchak et al. CELL
- Selective Insulin and Leptin Resistance in Metabolic Disorders
- (2012) A. Christine Könner et al. Cell Metabolism
- βKlotho Is Required for Fibroblast Growth Factor 21 Effects on Growth and Metabolism
- (2012) Xunshan Ding et al. Cell Metabolism
- TNF-α Represses β-Klotho Expression and Impairs FGF21 Action in Adipose Cells: Involvement of JNK1 in the FGF21 Pathway
- (2012) Julieta Díaz-Delfín et al. ENDOCRINOLOGY
- FGF21 Is Increased by Inflammatory Stimuli and Protects Leptin-Deficientob/obMice from the Toxicity of Sepsis
- (2012) Kenneth R. Feingold et al. ENDOCRINOLOGY
- FGF21 regulates PGC-1 and browning of white adipose tissues in adaptive thermogenesis
- (2012) f. M. Fisher et al. GENES & DEVELOPMENT
- High serum level of fibroblast growth factor 21 is an independent predictor of non-alcoholic fatty liver disease: A 3-year prospective study in China
- (2012) Huating Li et al. JOURNAL OF HEPATOLOGY
- FGF21 Promotes Metabolic Homeostasis via White Adipose and Leptin in Mice
- (2012) Murielle M. Véniant et al. PLoS One
- Rationale-Based Engineering of a Potent Long-Acting FGF21 Analog for the Treatment of Type 2 Diabetes
- (2012) Randy Hecht et al. PLoS One
- Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor
- (2012) W. Wei et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Treating Diabetes and Obesity with an FGF21-Mimetic Antibody Activating the Klotho/FGFR1c Receptor Complex
- (2012) I. N. Foltz et al. Science Translational Medicine
- The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue
- (2012) Andrew C. Adams et al. Molecular Metabolism
- Integrated Regulation of Hepatic Metabolism by Fibroblast Growth Factor 21 (FGF21)in Vivo
- (2011) ffolliott M. Fisher et al. ENDOCRINOLOGY
- Lack of Overt FGF21 Resistance in Two Mouse Models of Obesity and Insulin Resistance
- (2011) Clarence Hale et al. ENDOCRINOLOGY
- Growth Hormone Induces Hepatic Production of Fibroblast Growth Factor 21 through a Mechanism Dependent on Lipolysis in Adipocytes
- (2011) Wei Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Fibroblast Growth Factor 21 Induces Glucose Transporter-1 Expression through Activation of the Serum Response Factor/Ets-Like Protein-1 in Adipocytes
- (2011) Xuan Ge et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A critical appraisal of the prevalence and metabolic significance of brown adipose tissue in adult humans
- (2010) Paul Lee et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Fibroblast Growth Factor 21 Action in the Brain Increases Energy Expenditure and Insulin Sensitivity in Obese Rats
- (2010) D. A. Sarruf et al. DIABETES
- Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State
- (2010) f. M. Fisher et al. DIABETES
- Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse
- (2010) Klementina Fon Tacer et al. MOLECULAR ENDOCRINOLOGY
- Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models—association with liver and adipose tissue effects
- (2009) Jing Xu et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Fibroblast Growth Factor 21 Controls Glycemia via Regulation of Hepatic Glucose Flux and Insulin Sensitivity
- (2009) Eric D. Berglund et al. ENDOCRINOLOGY
- Fibroblast Growth Factor 21-Deficient Mice Demonstrate Impaired Adaptation to Ketosis
- (2009) Michael K. Badman et al. ENDOCRINOLOGY
- Fibroblast Growth Factor 21 Regulates Lipolysis in White Adipose Tissue But Is Not Required for Ketogenesis and Triglyceride Clearance in Liver
- (2009) Yuhei Hotta et al. ENDOCRINOLOGY
- Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 inob/obmice
- (2009) Xiaofan Li et al. FEBS LETTERS
- Different roles of N- and C- termini in the functional activity of FGF21
- (2009) Radmila Micanovic et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Circulating Fibroblast Growth Factor 21 Is Induced by Peroxisome Proliferator-Activated Receptor Agonists But Not Ketosis in Man
- (2009) Constantinos Christodoulides et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Cold-Activated Brown Adipose Tissue in Healthy Men
- (2009) Wouter D. van Marken Lichtenbelt et al. NEW ENGLAND JOURNAL OF MEDICINE
- FGF21 induces PGC-1 and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response
- (2009) M. J. Potthoff et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Circulating Metabolic Regulator FGF21 Is Induced by Prolonged Fasting and PPARα Activation in Man
- (2008) Cecilia Gälman et al. Cell Metabolism
- Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans
- (2008) X. Zhang et al. DIABETES
- Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice
- (2008) J. Xu et al. DIABETES
- Fibroblast Growth Factor 21 Corrects Obesity in Mice
- (2008) Tamer Coskun et al. ENDOCRINOLOGY
- FGF21 attenuates lipolysis in human adipocytes - A possible link to improved insulin sensitivity
- (2008) Peter Arner et al. FEBS LETTERS
- FGF21 N- and C-termini play different roles in receptor interaction and activation
- (2008) Junming Yie et al. FEBS LETTERS
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