Control of cellular responses to mechanical cues through YAP/TAZ regulation

Recruitment of Jub by α-catenin promotes Yki activity and Drosophila wing growth

(2019) Herve Alégot et al.   JOURNAL OF CELL SCIENCE

F-actin dynamics regulates mammalian organ growth and cell fate maintenance

(2019) Arianna Pocaterra et al.   JOURNAL OF HEPATOLOGY

A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK

(2019) Xiaodong Feng et al.   CANCER CELL

Angiomotin Regulates YAP Localization during Neural Differentiation of Human Pluripotent Stem Cells

(2019) Yefim Zaltsman et al.   Stem Cell Reports

Identification of the kinase STK25 as an upstream activator of LATS signaling

(2019) Sanghee Lim et al.   Nature Communications

FAK controls the mechanical activation of YAP, a transcriptional regulator required for durotaxis

(2018) Dariusz Lachowski et al.   FASEB JOURNAL

The Hippo pathway effector proteins YAP and TAZ have both distinct and overlapping functions in the cell

(2018) Steven W. Plouffe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tension-dependent regulation of mammalian Hippo signaling through LIMD1

(2018) Consuelo Ibar et al.   JOURNAL OF CELL SCIENCE

The Hippo Signaling Network and its Biological Functions

(2018) Jyoti R. Misra et al.   Annual Review of Genetics

Angiomotins stimulate LATS kinase autophosphorylation and act as scaffolds that promote Hippo signaling

(2018) Sebastian Mana-Capelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RAP2 mediates mechanoresponses of the Hippo pathway

(2018) Zhipeng Meng et al.   NATURE

VEGF–neuropilin-2 signaling promotes stem-like traits in breast cancer cells by TAZ-mediated repression of the Rac GAP β2-chimaerin

(2018) Ameer L. Elaimy et al.   Science Signaling

SRC tyrosine kinase activates the YAP/TAZ axis and thereby drives tumor growth and metastasis

(2018) John M. Lamar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ

(2018) Lei Chang et al.   NATURE

Focal adhesions: a personal perspective on a half century of progress

(2017) Keith Burridge   FEBS Journal

β1 integrin–dependent Rac/group I PAK signaling mediates YAP activation of Yes-associated protein 1 (YAP1) via NF2/merlin

(2017) Hiba Sabra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Active tension network model suggests an exotic mechanical state realized in epithelial tissues

(2017) Nicholas Noll et al.   Nature Physics

Common and Distinctive Functions of the Hippo Effectors Taz and Yap in Skeletal Muscle Stem Cell Function

(2017) Congshan Sun et al.   STEM CELLS

Integration of Cadherin Adhesion and Cytoskeleton at Adherens Junctions

(2017) René Marc Mège et al.   Cold Spring Harbor Perspectives in Biology

Mammalian Diaphanous 1 Mediates a Pathway for E-cadherin to Stabilize Epithelial Barriers through Junctional Contractility

(2017) Bipul R. Acharya et al.   Cell Reports

Agrin as a Mechanotransduction Signal Regulating YAP through the Hippo Pathway

(2017) Sayan Chakraborty et al.   Cell Reports

The Epithelial Circumferential Actin Belt Regulates YAP/TAZ through Nucleocytoplasmic Shuttling of Merlin

(2017) Kana T. Furukawa et al.   Cell Reports

Regulation of localization and function of the transcriptional co-activator YAP by angiomotin

(2017) Susana Moleirinho et al.   eLife

Induction of Expandable Tissue-Specific Stem/Progenitor Cells through Transient Expression of YAP/TAZ

(2016) Tito Panciera et al.   Cell Stem Cell

Mechanisms of Hippo pathway regulation

(2016) Zhipeng Meng et al.   GENES & DEVELOPMENT

αE-catenin inhibits a Src–YAP1 oncogenic module that couples tyrosine kinases and the effector of Hippo signaling pathway

(2016) Peng Li et al.   GENES & DEVELOPMENT

YAP Nuclear Localization in the Absence of Cell-Cell Contact Is Mediated by a Filamentous Actin-dependent, Myosin II- and Phospho-YAP-independent Pathway during Extracellular Matrix Mechanosensing

(2016) Arupratan Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Hippo Pathway Components by Gene Inactivation

(2016) Steven W. Plouffe et al.   MOLECULAR CELL

Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity

(2016) Alberto Elosegui-Artola et al.   NATURE CELL BIOLOGY

Differential growth triggers mechanical feedback that elevates Hippo signaling

(2016) Yuanwang Pan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An evolutionarily conserved negative feedback mechanism in the Hippo pathway reflects functional difference between LATS1 and LATS2

(2016) Gun-Soo Park et al.   Oncotarget

Yap1 Regulates Multiple Steps of Chondrocyte Differentiation during Skeletal Development and Bone Repair

(2016) Yujie Deng et al.   Cell Reports

Cytoskeletal to Nuclear Strain Transfer Regulates YAP Signaling in Mesenchymal Stem Cells

(2015) Tristan P. Driscoll et al.   BIOPHYSICAL JOURNAL

Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway

(2015) Youjun Li et al.   CELL RESEARCH

Dynamic Visualization of α-Catenin Reveals Rapid, Reversible Conformation Switching between Tension States

(2015) Tae-Jin Kim et al.   CURRENT BIOLOGY

Identification of Happyhour/MAP4K as Alternative Hpo/Mst-like Kinases in the Hippo Kinase Cascade

(2015) Yonggang Zheng et al.   DEVELOPMENTAL CELL

A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis

(2015) Toshiro Moroishi et al.   GENES & DEVELOPMENT

Nuclear F-actin Formation and Reorganization upon Cell Spreading

(2015) Matthias Plessner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adhesion to fibronectin regulates Hippo signaling via the FAK–Src–PI3K pathway

(2015) Nam-Gyun Kim et al.   JOURNAL OF CELL BIOLOGY

FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature

(2015) Amélie Sabine et al.   JOURNAL OF CLINICAL INVESTIGATION

The Hippo Pathway and YAP/TAZ–TEAD Protein–Protein Interaction as Targets for Regenerative Medicine and Cancer Treatment

(2015) Matteo Santucci et al.   JOURNAL OF MEDICINAL CHEMISTRY

YAP is essential for tissue tension to ensure vertebrate 3D body shape

(2015) Sean Porazinski et al.   NATURE

A gp130–Src–YAP module links inflammation to epithelial regeneration

(2015) Koji Taniguchi et al.   NATURE

Mechanical strain induces E-cadherin-dependent Yap1 and  -catenin activation to drive cell cycle entry

(2015) B. W. Benham-Pyle et al.   SCIENCE

Cyclic stretching of soft substrates induces spreading and growth

(2015) Yidan Cui et al.   Nature Communications

MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway

(2015) Zhipeng Meng et al.   Nature Communications

Localization of Hippo signalling complexes and Warts activation in vivo

(2015) Shuguo Sun et al.   Nature Communications

Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-Regulated Rho GTPase Signaling Circuitry

(2014) Xiaodong Feng et al.   CANCER CELL

Cytoskeletal Tension Inhibits Hippo Signaling through an Ajuba-Warts Complex

(2014) Cordelia Rauskolb et al.   CELL

Hippo Pathway Activity Influences Liver Cell Fate

(2014) Dean Yimlamai et al.   CELL

Regulation of YAP by Mechanical Strain through Jnk and Hippo Signaling

(2014) Veronica A. Codelia et al.   CURRENT BIOLOGY

Tension-Sensitive Actin Assembly Supports Contractility at the Epithelial Zonula Adherens

(2014) Joanne M. Leerberg et al.   CURRENT BIOLOGY

The Conserved Misshapen-Warts-Yorkie Pathway Acts in Enteroblasts to Regulate Intestinal Stem Cells in Drosophila

(2014) Qi Li et al.   DEVELOPMENTAL CELL

Angiomotins link F-actin architecture to Hippo pathway signaling

(2014) Sebastian Mana-Capelli et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanotransduction and extracellular matrix homeostasis

(2014) Jay D. Humphrey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dynamic contacts: rearranging adherens junctions to drive epithelial remodelling

(2014) Masatoshi Takeichi   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Shear Stress Induced by an Interstitial Level of Slow Flow Increases the Osteogenic Differentiation of Mesenchymal Stem Cells through TAZ Activation

(2014) Kyung Min Kim et al.   PLoS One

Force-dependent conformational switch of α-catenin controls vinculin binding

(2014) Mingxi Yao et al.   Nature Communications

Spatial Organization of Hippo Signaling at the Plasma Membrane Mediated by the Tumor Suppressor Merlin/NF2

(2013) Feng Yin et al.   CELL

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

(2013) Mariaceleste Aragona et al.   CELL

Fluid Shear Stress on Endothelial Cells Modulates Mechanical Tension across VE-Cadherin and PECAM-1

(2013) Daniel E. Conway et al.   CURRENT BIOLOGY

Polarity-Dependent Distribution of Angiomotin Localizes Hippo Signaling in Preimplantation Embryos

(2013) Yoshikazu Hirate et al.   CURRENT BIOLOGY

cAMP/PKA signalling reinforces the LATS–YAP pathway to fully suppress YAP in response to actin cytoskeletal changes

(2013) Minchul Kim et al.   EMBO JOURNAL

Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

Phosphorylation of Angiomotin by Lats1/2 Kinases Inhibits F-actin Binding, Cell Migration, and Angiogenesis

(2013) Xiaoming Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Actin-binding and Cell Proliferation Activities of Angiomotin Family Members Are Regulated by Hippo Pathway-mediated Phosphorylation

(2013) Siew Wee Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1

(2013) R. Fan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiomotin prevents pluripotent lineage differentiation in mouse embryos via Hippo pathway-dependent and -independent mechanisms

(2013) Chuen Yan Leung et al.   Nature Communications

Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase

(2013) Isabel Serrano et al.   Nature Communications

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

(2012) Fa-Xing Yu et al.   CELL

β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

(2012) Joseph Rosenbluh et al.   CELL

Identification of Serum-Derived Sphingosine-1-Phosphate as a Small Molecule Regulator of YAP

(2012) Eric Miller et al.   CHEMISTRY & BIOLOGY

The Tumor Suppressor Merlin Controls Growth in Its Open State, and Phosphorylation Converts It to a Less-Active More-Closed State

(2012) Ifat Sher et al.   DEVELOPMENTAL CELL

Regulation of the Hippo-YAP pathway by protease-activated receptors (PARs)

(2012) J.-S. Mo et al.   GENES & DEVELOPMENT

Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis

(2012) B. Zhao et al.   GENES & DEVELOPMENT

Rap2A links intestinal cell polarity to brush border formation

(2012) Martijn Gloerich et al.   NATURE CELL BIOLOGY

Transduction of mechanical and cytoskeletal cues by YAP and TAZ

(2012) Georg Halder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

 E-catenin is an autoinhibited molecule that coactivates vinculin

(2012) H.-J. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch

(2012) N. Borghi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collective and single cell behavior in epithelial contact inhibition

(2012) A. Puliafito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Yap1 Acts Downstream of α-Catenin to Control Epidermal Proliferation

(2011) Karin Schlegelmilch et al.   CELL

Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila

(2011) B. G. Fernandez et al.   DEVELOPMENT

Hippo pathway regulation by cell morphology and stress fibers

(2011) K.-I. Wada et al.   DEVELOPMENT

Modulating F-actin organization induces organ growth by affecting the Hippo pathway

(2011) Leticia Sansores-Garcia et al.   EMBO JOURNAL

Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein

(2011) B. Zhao et al.   GENES & DEVELOPMENT

Hippo Pathway-independent Restriction of TAZ and YAP by Angiomotin

(2011) Siew Wee Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor

(2011) Murugan Paramasivam et al.   MOLECULAR BIOLOGY OF THE CELL

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Balancing forces: architectural control of mechanotransduction

(2011) Christopher C. DuFort et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components

(2011) N.-G. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Catenin Is a Tumor Suppressor That Controls Cell Accumulation by Regulating the Localization and Activity of the Transcriptional Coactivator Yap1

(2011) M. R. Silvis et al.   Science Signaling

Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis

(2010) Xiaofeng Zhao et al.   ADVANCED DRUG DELIVERY REVIEWS

Effect of Fluid Shear Stress on Cardiomyogenic Differentiation of Rat Bone Marrow Mesenchymal Stem Cells

(2010) Yan Huang et al.   ARCHIVES OF MEDICAL RESEARCH

Strength Dependence of Cadherin-Mediated Adhesions

(2010) Benoit Ladoux et al.   BIOPHYSICAL JOURNAL

The NF2 Tumor Suppressor, Merlin, Regulates Epidermal Development through the Establishment of a Junctional Polarity Complex

(2010) Andrew B. Gladden et al.   DEVELOPMENTAL CELL

The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation

(2010) I. Lian et al.   GENES & DEVELOPMENT

Angiomotin-like Proteins Associate with and Negatively Regulate YAP1

(2010) Wenqi Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II–dependent manner

(2010) Quint le Duc et al.   JOURNAL OF CELL BIOLOGY

α-Catenin as a tension transducer that induces adherens junction development

(2010) Shigenobu Yonemura et al.   NATURE CELL BIOLOGY

Adherens junctions: from molecules to morphogenesis

(2010) Tony J. C. Harris et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Shear stress induces osteogenic differentiation of human mesenchymal stem cells

(2010) Gregory Yourek et al.   Regenerative Medicine

Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture

(2010) P. M. Gilbert et al.   SCIENCE

Integrins and Extracellular Matrix in Mechanotransduction

(2010) M. A. Schwartz   Cold Spring Harbor Perspectives in Biology

Vinculin Nucleates Actin Polymerization and Modifies Actin Filament Structure

(2009) Kuo-Kuang Wen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adhesive and Signaling Functions of Cadherins and Catenins in Vertebrate Development

(2009) E. Stepniak et al.   Cold Spring Harbor Perspectives in Biology

Discovering the Molecular Components of Intercellular Junctions--A Historical View

(2009) W. W. Franke   Cold Spring Harbor Perspectives in Biology

Human angiomotin-like 1 associates with an angiomotin protein complex through its coiled-coil domain and induces the remodeling of the actin cytoskeleton

(2009) Valérie Gagné et al.   CELL MOTILITY AND THE CYTOSKELETON

YAP regulates neural progenitor cell number via the TEA domain transcription factor

(2008) X. Cao et al.   GENES & DEVELOPMENT

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT

A two-tiered mechanism for stabilization and immobilization of E-cadherin

(2008) Matthieu Cavey et al.   NATURE

Talin depletion reveals independence of initial cell spreading from integrin activation and traction

(2008) Xian Zhang et al.   NATURE CELL BIOLOGY

Mechanotransduction gone awry

(2008) Diana E. Jaalouk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Morphogenetic Cell Movements: Diversity from Modular Mechanical Properties

(2008) D. J. Montell   SCIENCE

Differential roles of p80- and p130-angiomotin in the switch between migration and stabilization of endothelial cells

(2007) Mira Ernkvist et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH