Article
Pharmacology & Pharmacy
Meifang Wu, Yanguang Guo, Ying Wu, Kaizu Xu, Liming Lin
Summary: Sacubitril/valsartan has a significant improvement on cardiac function and fibrosis in rats after experimental myocardial infarction, by inhibiting collagen synthesis in myocardial fibroblasts through the suppression of the TGF/Smads signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Food Science & Technology
So Yamamoto, Tomoko Kayama, Moeko Noguchi-Shinohara, Tsuyoshi Hamaguchi, Masahito Yamada, Keiko Abe, Shoko Kobayashi
Summary: Rosmarinic acid (RA) inhibits the accumulation of Aβ and phosphorylated tau, improves cognitive function, and suppresses hippocampal inflammation in the 3xTg-AD mouse model. Additionally, RA exerts anti-inflammatory effects by downregulating the JNK signaling pathway, suggesting a potential mechanism for inhibiting the progression of pathology and cognitive deficits.
NPJ SCIENCE OF FOOD
(2021)
Review
Cell Biology
Haiying Wang, Ran Zhang, Xinjie Wu, Yafen Chen, Wei Ji, Jingsuo Wang, Yawen Zhang, Yong Xia, Yiqun Tang, Jinxiang Yuan
Summary: Diabetic nephropathy is a serious kidney complication of diabetes that can lead to kidney failure. The role of the Wnt signaling pathway in regulating the development of diabetic nephropathy is significant.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Rajvir Singh, Ravinder K. Kaundal, Baoyin Zhao, Rihab Bouchareb, Djamel Lebeche
Summary: This study reveals the role of resistin in cardiac fibrosis, promoting fibroblast-to-myofibroblast differentiation through JAK/STAT3 and JNK/c-Jun pathways, independent of TGF beta 1. Resistin-null mice showed improvements in cardiac function and reduction in tissue fibrosis, indicating the potential stimulation of cardiac fibrosis by resistin.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Food Science & Technology
Peiying Shi, Tianyu Du, Fei Meng, Shihui Xie, Shuo Han, Jiali Yang, Yi Zhang, Yang Sun, Jietao Gong, Hong Yao
Summary: This study aims to reveal the effect and mechanism of ethanol extract of propolis (EEP) against diabetic cardiomyopathy (DCM). The results showed that EEP improved blood glucose regulation ability, cardiac function, and reduced myocardial oxidative stress in streptozotocin-induced diabetic rats. Additionally, EEP increased cell survival rate, decreased lactate dehydrogenase and malondialdehyde levels, and increased antioxidant enzyme levels in high glucose-injured H9c2 cells. EEP also affected the expression of genes and signaling pathways related to DCM.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Chin-Feng Tsai, Shun-Fa Yang, Chien-Hsien Lo, Hsiao-Ju Chu, Kwo-Chang Ueng
Summary: The study revealed that hypoxia-induced atrial fibrotic response primarily occurs via the ROS/JNK pathway, leading to upregulation of HIF-1 alpha and c-Jun/ATF2 phosphorylation. This mechanism could offer a novel therapeutic strategy against atrial fibrillation by targeting the suppression of ROS/JNK signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yu Chen, Ping Li, Yueting Peng, Xiaoxue Xie, Yixi Zhang, Ying Jiang, Tingting Li, Xiang Qin, Shun Li, Hong Yang, Chunhui Wu, Chuan Zheng, Jie Zhu, Fengming You, Yiyao Liu
Summary: The study demonstrates that the soft substrate-induced ROS/JNK signaling increases cell apoptosis and protective autophagy by promoting the interaction of Bcl-2 and Beclin-1 and suppressing the interaction of Bcl-2 and Beclin-1, respectively, in human breast cancer cells.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Joseph Adu-Amankwaah, Aisha Bushi, Rubin Tan, Adebayo Oluwafemi Adekunle, Gabriel Komla Adzika, Marie Louise Ndzie Noah, Iqra Nadeem, Seyram Yao Adzraku, Stephane Koda, Richard Mprah, Jie Cui, Kexue Li, Prosperl Ivette Wowui, Hong Sun
Summary: The lack of estrogen (E2) leads to overexpression of the enzyme ADAM17 during stress, resulting in cardiac injury and inflammation. The study found that E2 can reduce ADAM17 expression by regulating the GPER-1/PI3K pathway, thereby alleviating cardiac injury and inflammation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Fang-fang Ren, Lin Zhao, Xian-yun Jiang, Jing-jing Zhang, Jia-min Gou, Xiao-yu Yu, Shu-jin Wu, Lei Li
Summary: Apoptosis, or programmed cell death, plays a critical role in the development of heart failure. Sphingosylphosphorylcholine (SPC), a bioactive sphingolipid, has been shown to inhibit apoptosis in myofibroblasts, non-muscle cells in the heart. In this study, the researchers investigated the role of the SPC receptor, calmodulin (CaM), in cardiomyocyte apoptosis and the associated signaling pathways. They found that SPC administration improved survival rate, cardiac hypertrophy, and cardiac fibrosis in mice with pressure overload-induced heart failure. In cardiomyocytes, SPC treatment inhibited cardiomyocyte hypertrophy, fibroblast-to-myofibroblast transition, and cell apoptosis. This was accompanied by reduced levels of pro-apoptotic proteins and phosphorylation of CaM, JNK, and p38, as well as increased levels of a cardiomyocyte-protective protein. The protective effect of SPC was annulled by a compound that increased CaM function. The researchers also demonstrated that SPC-mediated inhibition of cardiomyocyte apoptosis involved the regulation of p38 and JNK phosphorylation, which was downstream of CaM. These findings provide new evidence for SPC regulation of cardiomyocyte apoptosis and suggest it as a potential therapeutic target for cardiac remodeling following stress overload.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Cell Biology
Jia Li, Chenghui Yan, Yilong Wang, Can Chen, Haibo Yu, Dan Liu, Kai Huang, Yaling Han
Summary: Pathological cardiac hypertrophy is a major risk factor for heart failure, characterized by abnormal remodeling of cardiomyocytes in response to pressure overload or other stress stimuli. The study reveals that GCN5 plays a significant role in promoting cardiac hypertrophy through excessive activation of the TAK1-JNK/p38 signaling pathway.
CELL DEATH & DISEASE
(2022)
Article
Pharmacology & Pharmacy
Jing Liu, Xuehui Zheng, Chen Zhang, Chunmei Zhang, Peili Bu
Summary: The study demonstrated that ARNI alleviated myocardial fibrosis by inhibiting the Wnt/beta-catenin signaling pathway and overexpressing sFRP-1, thereby improving cardiac function.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Tianbao Ye, Zhiwen Yan, Cheng Chen, Di Wang, Aiting Wang, Taixi Li, Boshen Yang, Xianting Ding, Chengxing Shen
Summary: This study aimed to investigate the cardioprotective role of lactoferrin (Ltf) in myocardial infarction (MI) and its underlying mechanisms. Proteomic analysis revealed that Ltf was significantly upregulated in MI hearts but decreased in circulation, and its expression was positively correlated with cardiac function. Ltf administration attenuated cardiac fibrosis and remodeling, improved cardiac function, and reduced the incidence of heart failure post-MI.
Article
Multidisciplinary Sciences
Shiran Yu, Xuefei Dong, Min Yang, Qingtao Yu, Jie Xiong, Jing Chen, Bo Dong, Qing Su
Summary: The PRR-YAP pathway is believed to play a crucial role in the pathogenesis of DCM by promoting pathological injuries through triggering oxidative stress and myocardial fibrosis, as revealed in experiments involving Wistar rats and neonatal rat cardiac fibroblasts in vivo and in vitro.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Jia-Min Li, Fang-Fang Chen, Guo-Hua Li, Jia-Liang Zhu, Yu Zhou, Xin-Yi Wei, Fei Zheng, Li-Li Wang, Wei Zhang, Ming Zhong, Ming-Ming Zhang, Wen-Yuan Ding
Summary: The study reveals that overexpression of sKL can mitigate diabetic cardiomyopathy by ameliorating insulin resistance, inflammation, fibrosis, and improving cardiac function.
Article
Nutrition & Dietetics
Lichun Qiao, Ziwei Guo, Haobiao Liu, Jiaxin Liu, Xue Lin, Huan Deng, Xuan Liu, Yan Zhao, Xiang Xiao, Jian Lei, Jing Han
Summary: This study reveals the mechanisms underlying liver fibrosis induced by selenium deficiency and the preventive effects of nano-selenium supplementation on liver fibrosis. It demonstrates the crucial roles of mitochondrial energy metabolism and mitophagy in these processes.
Article
Environmental Sciences
Xianjie Jia, Ying Yu, Wanning Xia, Shahir Masri, Mojgan Sami, Zhixiong Hu, Zhaoxia Yu, Jun Wu
ENVIRONMENTAL RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Pinfang Kang, Jiahui Wang, Dian Fang, Tingting Fang, Ying Yu, Weiping Zhang, Lin Shen, Zhenghong Li, Hongju Wang, Hongwei Ye, Qin Gao
FREE RADICAL BIOLOGY AND MEDICINE
(2020)
Article
Clinical Neurology
Ying Yu, Jie Gao, Shasha Wang, Heng Lv, Liping Xiao, Hengyuan Shi, Xianjie Jia
Summary: The study found that ALDH2 polymorphisms and alcohol consumption have a significant impact on cognitive function in ischemic stroke patients, with individuals with the ALDH2 wild-type genotype more likely to have higher cognitive scores. Higher alcohol consumption was associated with a higher risk of cognitive impairment, and there was a synergistic effect between ALDH2 polymorphisms and alcohol consumption. Specifically, the ALDH2*2 mutant allele and higher alcohol intake were linked to cognitive impairment and swallowing function after ischemic stroke. Targeting ALDH2 may be beneficial for cognitive rehabilitation post-stroke.
BEHAVIOURAL NEUROLOGY
(2021)
Correction
Endocrinology & Metabolism
Ruiping Cao, Dian Fang, Jiahui Wang, Ying Yu, Hongwei Ye, Pinfang Kang, Zhenghong Li, Hongju Wang, Qin Gao
JOURNAL OF DIABETES RESEARCH
(2021)
