Article
Cardiac & Cardiovascular Systems
Naoko Yamaguchi, Junhua Xiao, Deven Narke, Devin Shaheen, Xianming Lin, Erik Offerman, Alireza Khodadadi-Jamayran, Akshay Shekhar, Alex Choy, Sojin Y. Wass, David R. Van Wagoner, Mina K. Chung, David S. Park
Summary: This study revealed that ETV1 is downregulated in the left atrium during cardiac pressure overload, contributing to both electrical and structural remodeling.
Review
Biochemistry & Molecular Biology
Xiaonan Sun, Jalen Alford, Hongyu Qiu
Summary: Mitochondrial remodeling is crucial for maintaining normal cellular function and dysregulation can lead to complex diseases. Understanding the molecular basis and regulatory network of mitochondrial remodeling is important for elucidating the pathogenesis of cardiac diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Julliane Vasconcelos Joviano-Santos, Artur Santos-Miranda, Danilo Roman-Campos
Summary: There is a significant association between neurodegenerative diseases and cardiac impairment, but current research primarily focuses on the mechanical aspects of the heart rather than electrical disturbances. Many studies have shown important alterations in the electrocardiogram of patients with these diseases and animal models, with limited descriptions of excitability disruptions in cardiomyocytes.
Review
Pharmacology & Pharmacy
Fatemeh Zahedipour, Alexandra E. Butler, Ali H. Eid, Amirhossein Sahebkar
Summary: This article discusses the impact of statins on angiogenesis, with a particular focus on angiogenesis in stroke and cardiovascular disease. Statins have pleiotropic effects, including both proangiogenic and antiangiogenic characteristics. These properties could offer new therapeutic applications.
DRUG DISCOVERY TODAY
(2022)
Article
Cardiac & Cardiovascular Systems
Vivek Jani, M. Imran Aslam, Axel J. Fenwick, Weikang Ma, Henry Gong, Gregory Milburn, Devin Nissen, Ilton M. Cubero M. Salazar, Olivia Hanselman, Monica Mukherjee, Marc K. Halushka, Kenneth B. Margulies, Kenneth S. Campbell, Thomas C. Irving, David A. Kass, Steven Hsu
Summary: Right ventricular contractile dysfunction commonly occurs in patients with heart failure with reduced ejection fraction and pulmonary hypertension. Standard clinical indices may not reflect aspects of underlying myocyte dysfunction. This study investigates the mechanical properties of RV myocytes in HFrEF-PH patients and identifies potential underlying mechanisms.
Review
Medicine, Research & Experimental
Ekaterina Podyacheva, Maria Danilchuk, Yana Toropova
Summary: Doxorubicin is an effective antineoplastic agent used to treat various types of cancers, but its use is limited by cardiotoxicity. Recent studies have shown that endothelial-mesenchymal transition and endothelial damage play a crucial role in DOX-induced cardiotoxicity.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tilman Emrich, Veronica Bordonaro, U. Joseph Schoepf, Aniela Petrescu, Gabrielle Young, Moritz Halfmann, Theresia Schoeler, Josua Decker, Ibukun Abidoye, Anna Lena Emrich, Karl-Friedrich Kreitner, Kai Helge Schmidt, Akos Varga-Szemes, Aurelio Secinaro
Summary: The study aimed to test the feasibility of T2 mapping for detecting left-to-right shunts. Results indicated that the T2 ratio can serve as an imaging biomarker capable of detecting or ruling out left-to-right shunts.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Review
Cell Biology
Stefan Dhein, Aida Salameh
Summary: The heart relies on gap junction channels to maintain cell-cell coupling for efficient and rapid electrical conduction. Connexin expression and gap junction localization play crucial roles in modulating cardiac electrical properties, ultimately affecting cardiac stability and function.
Article
Cardiac & Cardiovascular Systems
Catherine G. Ireland, Rachel L. Damico, Todd M. Kolb, Stephen C. Mathai, Monica Mukherjee, Stefan L. Zimmerman, Ami A. Shah, Fredrick M. Wigley, Brian A. Houston, Paul M. Hassoun, David A. Kass, Ryan J. Tedford, Steven Hsu
Summary: The study found that measuring RV contractile reserve during exercise by changes in RV Ees and dilation can better predict occult RV dysfunction, with RV ejection fraction during exercise proving to be a robust surrogate. This parameter was found to predict clinical outcomes more effectively than resting measures of RV function.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Peripheral Vascular Disease
Yongfa Huang, Chuxiang Lei, Wenjun Xie, Li Yan, Yanru Wang, Su Yuan, Jing Wang, Yan Zhao, Zhaojian Wang, Xiaoying Yang, Xiaohan Qin, Quan Fang, Ligang Fang, Xiaoxiao Guo
Summary: The study identified that in a rat model of pulmonary arterial hypertension, the development of RV failure can be divided into stages of normal, compensated, and decompensated. In the decompensated stage, diastolic SR Ca2+ leakage via oxidized RyR2 was found to facilitate the progression of RV failure. Dantrolene was proven to inhibit this Ca2+ leakage, delaying right cardiac dysfunction and improving the survival rate of animals with pulmonary arterial hypertension.
Article
Medicine, General & Internal
Marina Ioffe, Anjelika Kremer, Irena Nachimov, Michael Swartzon, Dan Justo
Summary: The study investigated the association between stopping statins and 1-year mortality in the general population of the oldest-old, revealing that stopping statins may be safe in this age group. However, in patients with ischemic heart disease, stopping statins appeared to be associated with lower 1-year mortality rates, although this association was not statistically significant. Further research is needed to verify these findings, particularly in older adults who continue to use statins.
Article
Biology
Yue Zhang, Jennifer Adams, Vicky Y. Wang, Lucas Horwitz, Mehrzad Tartibi, Ashley E. Morgan, Jiwon Kim, Arthur W. Wallace, Jonathan W. Weinsaft, Liang Ge, Mark B. Ratcliffe
Summary: This study successfully demonstrated the construction of a biventricular FE mechanics model using hexahedral elements, airbags, and an FMI interface coupled with lumped-parameter circulation models. By simulating PAC and VCO, and calculating LV ESPVR, the study provided insights into the cardiovascular conditions of both healthy volunteers and IHD patients. The results indicate that this co-simulation approach can be applied to study cardiovascular pathologies and device therapies.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Lindsay Kraus, Brianna Beavens
Summary: Cardiovascular diseases are a leading global cause of death, lacking a cure. Epigenetics and chromatin remodeling have emerged as promising interventions. Recent advancements in bioinformatics and gene therapy have particularly advanced the field of chromatin remodeling, specifically for the treatment of heart failure. Understanding changes to chromatin architecture has revealed potential methods for altering the progression of cardiac diseases through genomic sequencing, targeting cardiac genes, utilizing RNA molecules, and employing chromatin remodeler complexes. This understanding may lead to individualized pharmaceutical interventions and biomarkers for major disease states, ultimately paving the way for future therapeutic approaches.
Review
Cardiac & Cardiovascular Systems
Myriam Carpenito, Diego Fanti, Simona Mega, Giovanni Benfari, Maria Caterina Bono, Andrea Rossi, Flavio Luciano Ribichini, Francesco Grigioni
Summary: In traditional cardiovascular medicine, the focus on the left ventricle has overshadowed the importance of the left atrium. Recent advances have shown that the left atrium plays a crucial role in various cardiovascular diseases, impacting symptoms, prognosis, and potential therapeutic targets.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Miguel Valderrabano, Stephanie C. Fuentes C. Rojas, Adi Lador, Apoor Patel, Paul A. Schurmann, Carlos Tapias, Diego Rodriguez, Luis Carlos Saenz, Maan Malahjfi, Dipan J. J. Shah, Nilesh Mathuria, Amish S. S. Dave
Summary: Venous ethanol ablation (VEA) through a multiballoon, multivein approach can provide effective substrate ablation for patients with ablation-refractory ventricular tachycardia (VT) in the setting of structural heart disease, covering a broad range of left ventricular locations.
Article
Cardiac & Cardiovascular Systems
Larisa Emelyanova, Zain Ashary, Milanka Cosic, Ulugbek Negmadjanov, Gracious Ross, Farhan Rizvi, Susan Olet, David Kress, Jasbir Sra, A. Jamil Tajik, Ekhson L. Holmuhamedov, Yang Shi, Arshad Jahangir
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2016)
Meeting Abstract
Cardiac & Cardiovascular Systems
Farhan Rizvi, Ramail Siddiqui, Alessandra DeFranco, Larisa Emelyanova, Alisher Holmuhamedov, Gracious Ross, Ekhson Holmuhamedov, David Kress, A. Jamil Tajik, Arshad Jahangir
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2016)
Meeting Abstract
Cardiac & Cardiovascular Systems
Milanka Petrovic, Zarko Godic, Alisher Holmuhamedov, Kelsey Kraft, Ulugbek Negmadjanov, Larisa Emelyanova, Farhan Rizvi, Gracious Ross, David C. Kress, Ekhson Holmuhamedov, A. Jamil Tajik, Arshad Jahangir
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2016)
Meeting Abstract
Cardiac & Cardiovascular Systems
Farhan Rizvi, Alessandra DeFranco, Ramail Siddiqui, Alisher Holmuhamedov, Larisa Emelyanova, Gracious Ross, Ekhson Holmuhamedov, Paul Werner, A. Jamil Tajik, Arshad Jahangir
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2016)
Meeting Abstract
Cardiac & Cardiovascular Systems
Larisa Emelyanova, Mingyuan Liu, Guangyuan Yang, Elizabeth Stoeckl, Milanka Petrovic, Ekhson Holmuhamedov, Farhan Rizvi, Gracious Ross, Frank X. Downey, A. Jamil Tajik, Arshad Jahangir
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2016)
Meeting Abstract
Cardiac & Cardiovascular Systems
Larisa Emelyanova, Milanka Petrovic, Ekhson Holmuhamedov, Farhan Rizvi, Gracious Ross, David C. Kress, A. Jamil Tajik, Arshad Jahangir
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2016)
Article
Pharmacology & Pharmacy
Marina Chulkina, Ulugbek Negmadjanov, Ekaterina Lebedeva, Aleksey Pichugin, Dmitriy Mazurov, Ravshan Ataullakhanov, Ekhson Holmuhamedov
EUROPEAN JOURNAL OF PHARMACOLOGY
(2017)
Article
Geriatrics & Gerontology
Larisa Emelyanova, Claudia Preston, Anu Gupta, Maria Viqar, Ulugbek Negmadjanov, Stacie Edwards, Kelsey Kraft, Kameswari Devana, Ekhson Holmuhamedov, Daniel O'Hair, Jamil Tajik, Arshad Jahangir
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2018)
Article
Biology
Gracious R. Ross, Tanvir Bajwa, Stacie Edwards, Larisa Emelyanova, Farhan Rizvi, Ekhson L. Holmuhamedov, Paul Werner, Francis X. Downey, A. Jamil Tajik, Arshad Jahangir
Article
Cardiac & Cardiovascular Systems
Farhan Rizvi, Ramail Siddiqui, Alessandra DeFranco, Peter Homar, Larisa Emelyanova, Ekhson Holmuhamedov, Gracious Ross, A. Jamil Tajik, Arshad Jahangir
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2018)
Article
Multidisciplinary Sciences
Ulugbek Negmadjanov, Zarko Godic, Farhan Rizvi, Larisa Emelyanova, Gracious Ross, John Richards, Ekhson L. Holmuhamedov, Arshad Jahangir
Article
Multidisciplinary Sciences
Anastasia Zotova, Alexey Pichugin, Anastasia Atemasova, Ekaterina Knyazhanskaya, Elena Lopatukhina, Nikita Mitkin, Ekhson Holmuhamedov, Marina Gottikh, Dmitry Kuprashs, Alexander Filatov, Dmitriy Mazurov
SCIENTIFIC REPORTS
(2019)
Meeting Abstract
Biochemistry & Molecular Biology
Gracious R. Ross, Kelsey Kraft, Larisa Emelyanova, Farhan Rizvi, Ekhson L. Holmuhamedov, Paul Werner, Jamil Tajik, Arshad Jahangir
Meeting Abstract
Cardiac & Cardiovascular Systems
Larisa Emelyanova, Mingyuan Liu, Guangyuan Yang, Elizabeth Stoeckl, Ekhson Holmuhamedov, Farhan Rizvi, Gracious Ross, Francis X. Downey, A. Jamil Tajik, Arshad Jahangir