Compromised DNA repair is responsible for diabetes‐associated fibrosis

Neurodegeneration in diabetic retinopathy: does it really matter?

(2018) Rafael Simó et al.   DIABETOLOGIA

DNA repair deficiency sensitizes lung cancer cells to NAD+ biosynthesis blockade

(2018) Mehdi Touat et al.   JOURNAL OF CLINICAL INVESTIGATION

Monogenic Diseases of DNA Repair

(2018)   NEW ENGLAND JOURNAL OF MEDICINE

Breathlessness and Restrictive Lung Disease: An Important Diabetes-Related Feature in Patients with Type 2 Diabetes

(2018) Stefan Kopf et al.   RESPIRATION

Targeting Senescent Cells in Fibrosis: Pathology, Paradox, and Practical Considerations

(2018) Marissa J. Schafer et al.   Current Rheumatology Reports

Obesity and type-2 diabetes as inducers of premature cellular senescence and ageing

(2018) Dominick G. A. Burton et al.   BIOGERONTOLOGY

Diabetic Pulmopathy: A New Clinical Challenge for Diabetology

(2018) Stefan Kopf et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Diabetes mellitus and radiation induced lung injury after thoracic stereotactic body radiotherapy

(2018) Noah S. Kalman et al.   RADIOTHERAPY AND ONCOLOGY

Diabetes induces fibrotic changes in the lung through the activation of TGF-β signaling pathways

(2018) Girish Talakatta et al.   Scientific Reports

Homeostatic nuclear RAGE–ATM interaction is essential for efficient DNA repair

(2017) Varun Kumar et al.   NUCLEIC ACIDS RESEARCH

A conserved NAD + binding pocket that regulates protein-protein interactions during aging

(2017) Jun Li et al.   SCIENCE

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

Association of kidney fibrosis with urinary peptides: a path towards non-invasive liquid biopsies?

(2017) Pedro Magalhães et al.   Scientific Reports

d -Ribose as a Contributor to Glycated Haemoglobin

(2017) Xixi Chen et al.   EBioMedicine

Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells

(2016) Brandon M. Hall et al.   Aging-US

Diabetes and Kidney Disease: Role of Oxidative Stress

(2016) Jay C. Jha et al.   ANTIOXIDANTS & REDOX SIGNALING

Diabetes-associated cardiac fibrosis: Cellular effectors, molecular mechanisms and therapeutic opportunities

(2016) Ilaria Russo et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Hyperglycemic Stress and Carbon Stress in Diabetic Glucotoxicity

(2016) Xiaoting Luo et al.   Aging and Disease

Multilineage transduction of resident lung cells in vivo by AAV2/8 for α1-antitrypsin gene therapy

(2016) Julia G Payne et al.   Molecular Therapy-Methods & Clinical Development

Increased reactive oxygen species production during reductive stress: The roles of mitochondrial glutathione and thioredoxin reductases

(2015) Paavo Korge et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes

(2015) Shweta Bhatt et al.   Cell Metabolism

Role of RAGE in Alzheimer’s Disease

(2015) Zhiyou Cai et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity

(2015) Allyson K. Palmer et al.   DIABETES

ATM and ATR signaling at a glance

(2015) P. Awasthi et al.   JOURNAL OF CELL SCIENCE

A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses

(2015) Jianning Lu et al.   Nature Communications

Mice with Pulmonary Fibrosis Driven by Telomere Dysfunction

(2015) Juan M. Povedano et al.   Cell Reports

DNA Damage, DNA Repair, Aging, and Neurodegeneration

(2015) Scott Maynard et al.   Cold Spring Harbor Perspectives in Medicine

The Oxygen-Rich Postnatal Environment Induces Cardiomyocyte Cell-Cycle Arrest through DNA Damage Response

(2014) Bao N. Puente et al.   CELL

DNA Damage Response and Metabolic Disease

(2014) Ippei Shimizu et al.   Cell Metabolism

High levels of γ-H2AX foci and cell membrane oxidation in adolescents with type 1 diabetes

(2014) Caterina Giovannini et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Positron emission tomography probe demonstrates a striking concentration of ribose salvage in the liver

(2014) P. M. Clark et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative DNA damage induces the ATM-mediated transcriptional suppression of the Wnt inhibitor WIF-1 in systemic sclerosis and fibrosis

(2014) S. Svegliati et al.   Science Signaling

Normal Roles for Dietary Fructose in Carbohydrate Metabolism

(2014) Maren Laughlin   Nutrients

Pathogenesis of Chronic Hyperglycemia: From Reductive Stress to Oxidative Stress

(2014) Liang-Jun Yan   Journal of Diabetes Research

Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function

(2014) Jackelyn M. Kembro et al.   Frontiers in Physiology

Telomerase and Telomere Length in Pulmonary Fibrosis

(2013) Tianju Liu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Redox-Optimized ROS Balance and the relationship between mitochondrial respiration and ROS

(2013) Sonia Cortassa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Integrating Mitochondrial Energetics, Redox and ROS Metabolic Networks: A Two-Compartment Model

(2013) Jackelyn M. Kembro et al.   BIOPHYSICAL JOURNAL

Type 2 Diabetes and Congenital Hyperinsulinism Cause DNA Double-Strand Breaks and p53 Activity in β Cells

(2013) Sharona Tornovsky-Babeay et al.   Cell Metabolism

Inhibition of RAGE signaling through the intracellular delivery of inhibitor peptides by PEI cationization

(2013) ENDY WIDYA PUTRANTO et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

Pitfalls in Hemoglobin A1c Measurement: When Results may be Misleading

(2013) Michael S. Radin   JOURNAL OF GENERAL INTERNAL MEDICINE

Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes

(2013) Carles Cantó et al.   MOLECULAR ASPECTS OF MEDICINE

SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons

(2013) Matthew M Dobbin et al.   NATURE NEUROSCIENCE

Premature lung aging and cellular senescence in the pathogenesis of idiopathic pulmonary fibrosis and COPD/emphysema

(2013) Marco Chilosi et al.   Translational Research

Oxidative stress and pulmonary fibrosis

(2012) Paul Cheresh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

RAGE in tissue homeostasis, repair and regeneration

(2012) Guglielmo Sorci et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Management of Metabolic Effects Associated With Anticancer Agents Targeting the PI3K-Akt-mTOR Pathway

(2012) Naifa L. Busaidy et al.   JOURNAL OF CLINICAL ONCOLOGY

Regulation of DNA-End Resection by hnRNPU-like Proteins Promotes DNA Double-Strand Break Signaling and Repair

(2012) Sophie E. Polo et al.   MOLECULAR CELL

Association between DNA strand breakage and oxidative, inflammatory and endothelial biomarkers in type 2 diabetes

(2012) Etiane Tatsch et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Telomerase Mutations and the Pulmonary Fibrosis–Bone Marrow Failure Syndrome Complex

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

Linking mitochondrial bioenergetics to insulin resistance via redox biology

(2012) Kelsey H. Fisher-Wellman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Diseases Associated with Defective Responses to DNA Damage

(2012) M. O'Driscoll   Cold Spring Harbor Perspectives in Biology

RAGE regulates autophagy and apoptosis following oxidative injury

(2011) Rui Kang et al.   Autophagy

Psoriasin (S100A7) increases the expression of ROS and VEGF and acts through RAGE to promote endothelial cell proliferation

(2011) Emman Shubbar et al.   BREAST CANCER RESEARCH AND TREATMENT

Rising Rates of All Types of Diabetes in South Asian and Non-South Asian Children and Young People Aged 0-29 Years in West Yorkshire, U.K., 1991-2006

(2011) K. L. Harron et al.   DIABETES CARE

Pulmonary fibrosis: a possible diabetic complication

(2011) Junling Yang et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

In vivo monitoring of cystic fibrosis-like lung disease in mice by volumetric computed tomography

(2011) M. O. Wielputz et al.   EUROPEAN RESPIRATORY JOURNAL

Redox-optimized ROS balance: A unifying hypothesis

(2010) M.A. Aon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Diabetes, insulin, and development of acute lung injury

(2010) Shyoko Honiden et al.   CRITICAL CARE MEDICINE

High-Efficiency Transduction of Fibroblasts and Mesenchymal Stem Cells by Tyrosine-Mutant AAV2 Vectors for Their Potential Use in Cellular Therapy

(2010) Mengxin Li et al.   HUMAN GENE THERAPY

Diabetes Mellitus and Breast Cancer Outcomes: A Systematic Review and Meta-Analysis

(2010) Kimberly S. Peairs et al.   JOURNAL OF CLINICAL ONCOLOGY

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE

Hyperglycemia-Induced Reactive Oxygen Species Increase Expression of the Receptor for Advanced Glycation End Products (RAGE) and RAGE Ligands

(2009) D. Yao et al.   DIABETES

RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation

(2009) Louis J Sparvero et al.   Journal of Translational Medicine

Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks

(2009) Bunsyo Shiotani et al.   MOLECULAR CELL

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

(2009) Florence Debacq-Chainiaux et al.   Nature Protocols

Epigenetic mechanisms that underpin metabolic and cardiovascular diseases

(2009) Peter D. Gluckman et al.   Nature Reviews Endocrinology

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

Comparison of nonhomologous end joining and homologous recombination in human cells

(2008) Z MAO et al.   DNA REPAIR

Renal toxicity mediated by glucose degradation products in a rat model of advanced renal failure

(2008) S. Müller-Krebs et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome

(2008) Kjersti M Aagaard-Tillery et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

AAV Vector–mediated RNAi of Mutant Huntingtin Expression Is Neuroprotective in a Novel Genetic Rat Model of Huntington's Disease

(2008) Nicholas R Franich et al.   MOLECULAR THERAPY

ATR: an essential regulator of genome integrity

(2008) Karlene A. Cimprich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY