Engineering organoids

3D bioprinting of high cell-density heterogeneous tissue models through spheroid fusion within self-healing hydrogels

(2021) Andrew C. Daly et al.   Nature Communications

Organoids to study immune functions, immunological diseases and immunotherapy

(2020) Wenrui Ye et al.   CANCER LETTERS

Cerebral organoid and mouse models reveal a RAB39b–PI3K–mTOR pathway-dependent dysregulation of cortical development leading to macrocephaly/autism phenotypes

(2020) Wei Zhang et al.   GENES & DEVELOPMENT

Fast and efficient generation of knock-in human organoids using homology-independent CRISPR–Cas9 precision genome editing

(2020) Benedetta Artegiani et al.   NATURE CELL BIOLOGY

Cell-type-specific signaling networks in heterocellular organoids

(2020) Xiao Qin et al.   NATURE METHODS

Aspiration-assisted bioprinting for precise positioning of biologics

(2020) Bugra Ayan et al.   Science Advances

Morphogenesis Guided by 3D Patterning of Growth Factors in Biological Matrices

(2020) Nicolas Broguiere et al.   ADVANCED MATERIALS

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

(2020) Vanessa Monteil et al.   CELL

Single-cell-resolution transcriptome map of human, chimpanzee, bonobo, and macaque brains

(2020) Ekaterina Khrameeva et al.   GENOME RESEARCH

Infection of bat and human intestinal organoids by SARS-CoV-2

(2020) Jie Zhou et al.   NATURE MEDICINE

SARS-CoV-2 productively infects human gut enterocytes

(2020) Mart M. Lamers et al.   SCIENCE

A Droplet Microfluidic System to Fabricate Hybrid Capsules Enabling Stem Cell Organoid Engineering

(2020) Haitao Liu et al.   Advanced Science

Synthetic alternatives to Matrigel

(2020) Elizabeth A. Aisenbrey et al.   Nature Reviews Materials

Human organoids: model systems for human biology and medicine

(2020) Jihoon Kim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

High-throughput automated organoid culture via stem-cell aggregation in microcavity arrays

(2020) Nathalie Brandenberg et al.   Nature Biomedical Engineering

Characterization of Human Colon Organoids From Inflammatory Bowel Disease Patients

(2020) Emilie d’Aldebert et al.   Frontiers in Cell and Developmental Biology

Using optogenetics to tackle systems-level questions of multicellular morphogenesis

(2020) Jonas Hartmann et al.   CURRENT OPINION IN CELL BIOLOGY

Homeostatic mini-intestines through scaffold-guided organoid morphogenesis

(2020) Mikhail Nikolaev et al.   NATURE

Phenotypic landscape of intestinal organoid regeneration

(2020) Ilya Lukonin et al.   NATURE

Effects of extracellular matrix viscoelasticity on cellular behaviour

(2020) Ovijit Chaudhuri et al.   NATURE

Recapitulating macro-scale tissue self-organization through organoid bioprinting

(2020) Jonathan A. Brassard et al.   NATURE MATERIALS

Progenitor identification and SARS-CoV-2 infection in human distal lung organoids

(2020) Ameen A. Salahudeen et al.   NATURE

Gene Regulatory Network Analysis and Engineering Directs Development and Vascularization of Multilineage Human Liver Organoids

(2020) Jeremy J. Velazquez et al.   Cell Systems

Long‐term expanding human airway organoids for disease modeling

(2019) Norman Sachs et al.   EMBO JOURNAL

Modeling G2019S-LRRK2 Sporadic Parkinson's Disease in 3D Midbrain Organoids

(2019) Hongwon Kim et al.   Stem Cell Reports

Increased Programmed Death-Ligand 1 is an Early Epithelial Cell Response to Helicobacter pylori Infection

(2019) Loryn Holokai et al.   PLoS Pathogens

Controlling Epithelial Polarity: A Human Enteroid Model for Host-Pathogen Interactions

(2019) Julia Y. Co et al.   Cell Reports

Flow-enhanced vascularization and maturation of kidney organoids in vitro

(2019) Kimberly A. Homan et al.   NATURE METHODS

Understanding the Mechanobiology of Early Mammalian Development through Bioengineered Models

(2019) Stefano Vianello et al.   DEVELOPMENTAL CELL

Cell membrane engineering with synthetic materials: Applications in cell spheroids, cellular glues and microtissue formation

(2019) Adérito J.R. Amaral et al.   Acta Biomaterialia

Synthetic genetic circuits for programmable biological functionalities

(2019) Peng-Fei Xia et al.   BIOTECHNOLOGY ADVANCES

Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids

(2019) Benedetta Artegiani et al.   Cell Stem Cell

Brain organoids: advances, applications and challenges

(2019) Xuyu Qian et al.   DEVELOPMENT

Self-organization and symmetry breaking in intestinal organoid development

(2019) Denise Serra et al.   NATURE

Specification of positional identity in forebrain organoids

(2019) Gustav Y. Cederquist et al.   NATURE BIOTECHNOLOGY

High-resolution 3D imaging of fixed and cleared organoids

(2019) Johanna F. Dekkers et al.   Nature Protocols

Authentic Modeling of Human Respiratory Virus Infection in Human Pluripotent Stem Cell-Derived Lung Organoids

(2019) M. Porotto et al.   mBio

A Cleared View on Retinal Organoids

(2019) Virginia Cora et al.   Cells

Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids

(2019) Rie Ouchi et al.   Cell Metabolism

Breakthrough Moments: Genome Editing and Organoids

(2019) Jatin Roper et al.   Cell Stem Cell

Engineering Stem Cell Self-organization to Build Better Organoids

(2019) Jonathan A. Brassard et al.   Cell Stem Cell

Disease modelling in human organoids

(2019) Madeline A. Lancaster et al.   Disease Models & Mechanisms

Individual brain organoids reproducibly form cell diversity of the human cerebral cortex

(2019) Silvia Velasco et al.   NATURE

Engineered signaling centers for the spatially controlled patterning of human pluripotent stem cells

(2019) Andrea Manfrin et al.   NATURE METHODS

Organoids-on-a-chip

(2019) Sunghee Estelle Park et al.   SCIENCE

Modeling microcephaly with cerebral organoids reveals a WDR62–CEP170–KIF2A pathway promoting cilium disassembly in neural progenitors

(2019) Wei Zhang et al.   Nature Communications

Generation and Characterization of Induced Pluripotent Stem Cells and Retinal Organoids From a Leber’s Congenital Amaurosis Patient With Novel RPE65 Mutations

(2019) Guilan Li et al.   Frontiers in Molecular Neuroscience

Engineered materials for organoid systems

(2019) Michael J. Kratochvil et al.   Nature Reviews Materials

Modeling breast cancer using CRISPR/Cas9-mediated engineering of human breast organoids

(2019) Johanna F Dekkers et al.   JNCI-Journal of the National Cancer Institute

Organoid single-cell genomic atlas uncovers human-specific features of brain development

(2019) Sabina Kanton et al.   NATURE

Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening

(2019) Minsuh Kim et al.   Nature Communications

Robust, Long-Term Culture of Endoderm-Derived Hepatic Organoids for Disease Modeling

(2019) Soheil Akbari et al.   Stem Cell Reports

3D bioengineered tissue model of the large intestine to study inflammatory bowel disease

(2019) Terrence T. Roh et al.   BIOMATERIALS

Emerging organoid models: leaping forward in cancer research

(2019) Han Fan et al.   Journal of Hematology & Oncology

Pancreatic cancer organoids recapitulate disease and allow personalized drug screening

(2019) Else Driehuis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Efficient Intestinal Organoid System of Direct Sorting to Evaluate Stem Cell Competition in Vitro

(2019) Yuki Fujimichi et al.   Scientific Reports

Cellular alterations identified in pluripotent stem cell-derived midbrain spheroids generated from a female patient with progressive external ophthalmoplegia and parkinsonism who carries a novel variation (p.Q811R) in the POLG1 gene

(2019) Margarita Chumarina et al.   Acta Neuropathologica Communications

Vascularized Liver Organoids Generated Using Induced Hepatic Tissue and Dynamic Liver-Specific Microenvironment as a Drug Testing Platform

(2018) Yoonhee Jin et al.   ADVANCED FUNCTIONAL MATERIALS

Defining Adult Stem Cells by Function, not by Phenotype

(2018) Hans Clevers et al.   Annual Review of Biochemistry

Understanding Biological Regulation Through Synthetic Biology

(2018) Caleb J. Bashor et al.   Annual Review of Biophysics

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

(2018) Norman Sachs et al.   CELL

Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression

(2018) Takashi Seino et al.   Cell Stem Cell

High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping

(2018) Stefan M. Czerniecki et al.   Cell Stem Cell

A Simplified Method for Generating Purkinje Cells from Human-Induced Pluripotent Stem Cells

(2018) Lauren M. Watson et al.   CEREBELLUM

DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome

(2018) Kate Joanne Howell et al.   GASTROENTEROLOGY

Single cell analysis of Crohn’s disease patient-derived small intestinal organoids reveals disease activity-dependent modification of stem cell properties

(2018) Kohei Suzuki et al.   JOURNAL OF GASTROENTEROLOGY

A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease

(2018) Joseph Park et al.   NATURE NEUROSCIENCE

Human brain organoids on a chip reveal the physics of folding

(2018) Eyal Karzbrun et al.   Nature Physics

Generation of human brain region–specific organoids using a miniaturized spinning bioreactor

(2018) Xuyu Qian et al.   Nature Protocols

Direct transfection of clonal organoids in Matrigel microbeads: a promising approach toward organoid-based genetic screens

(2018) Bastien Laperrousaz et al.   NUCLEIC ACIDS RESEARCH

Directed fusion of cardiac spheroids into larger heterocellular microtissues enables investigation of cardiac action potential propagation via cardiac fibroblasts

(2018) Tae Yun Kim et al.   PLoS One

Differentiated human airway organoids to assess infectivity of emerging influenza virus

(2018) Jie Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

(2018) Georgios Vlachogiannis et al.   SCIENCE

Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine

(2018) Yu Muta et al.   Nature Communications

A Roadmap for Human Liver Differentiation from Pluripotent Stem Cells

(2018) Lay Teng Ang et al.   Cell Reports

Tropism, replication competence, and innate immune responses of influenza virus: an analysis of human airway organoids and ex-vivo bronchus cultures

(2018) Kenrie P Y Hui et al.   Lancet Respiratory Medicine

Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients

(2018) Wen-Li Deng et al.   Stem Cell Reports

Modelling Cryptosporidium infection in human small intestinal and lung organoids

(2018) Inha Heo et al.   Nature Microbiology

Photoresponsive biomaterials for targeted drug delivery and 4D cell culture

(2018) Emily R. Ruskowitz et al.   Nature Reviews Materials

Growth of Epithelial Organoids in a Defined Hydrogel

(2018) Nicolas Broguiere et al.   ADVANCED MATERIALS

3D human liver tissue from pluripotent stem cells displays stable phenotype in vitro and supports compromised liver function in vivo

(2018) Hassan Rashidi et al.   ARCHIVES OF TOXICOLOGY

Human stomach-on-a-chip with luminal flow and peristaltic-like motility

(2018) Kang Kug Lee et al.   LAB ON A CHIP

Modeling amyloid beta and tau pathology in human cerebral organoids

(2018) Cesar Gonzalez et al.   MOLECULAR PSYCHIATRY

Progress and potential in organoid research

(2018) Giuliana Rossi et al.   NATURE REVIEWS GENETICS

Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids

(2018) Magdalena Kasendra et al.   Scientific Reports

Non-invasive electromechanical cell-based biosensors for improved investigation of 3D cardiac models

(2018) Guido Caluori et al.   BIOSENSORS & BIOELECTRONICS

Modeling liver cancer and therapy responsiveness using organoids derived from primary mouse liver tumors

(2018) Wanlu Cao et al.   CARCINOGENESIS

Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids

(2018) Huili Hu et al.   CELL

Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture

(2018) Weng Chuan Peng et al.   CELL

A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening

(2018) Helen H.N. Yan et al.   Cell Stem Cell

Reproducibility and staging of 3D human retinal organoids across multiple pluripotent stem cell lines

(2018) Elizabeth E. Capowski et al.   DEVELOPMENT

Vincristine Impairs Microtubules and Causes Neurotoxicity in Cerebral Organoids

(2018) Fangkun Liu et al.   NEUROSCIENCE

Synthetic mammalian pattern formation driven by differential diffusivity of Nodal and Lefty

(2018) Ryoji Sekine et al.   Nature Communications

Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa

(2018) Adriana Buskin et al.   Nature Communications

Validation of Current Good Manufacturing Practice Compliant Human Pluripotent Stem Cell-Derived Hepatocytes for Cell-Based Therapy

(2018) Samuel J.I. Blackford et al.   Stem Cells Translational Medicine

Multilineage communication regulates human liver bud development from pluripotency

(2017) J. Gray Camp et al.   NATURE

Wnt/β-catenin promotes gastric fundus specification in mice and humans

(2017) Kyle W. McCracken et al.   NATURE

Assembly of functionally integrated human forebrain spheroids

(2017) Fikri Birey et al.   NATURE

Guided self-organization and cortical plate formation in human brain organoids

(2017) Madeline A Lancaster et al.   NATURE BIOTECHNOLOGY

Synthetic hydrogels for human intestinal organoid generation and colonic wound repair

(2017) Ricardo Cruz-Acuña et al.   NATURE CELL BIOLOGY

A three-dimensional model of human lung development and disease from pluripotent stem cells

(2017) Ya-Wen Chen et al.   NATURE CELL BIOLOGY

Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease

(2017) Nelly M. Cruz et al.   NATURE MATERIALS

Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

(2017) Laura Broutier et al.   NATURE MEDICINE

Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids

(2017) Fotios Sampaziotis et al.   NATURE MEDICINE

Fused cerebral organoids model interactions between brain regions

(2017) Joshua A Bagley et al.   NATURE METHODS

The use of brain organoids to investigate neural development and disease

(2017) Elizabeth Di Lullo et al.   NATURE REVIEWS NEUROSCIENCE

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

(2017) Yu Shrike Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disease Modeling in Stem Cell-Derived 3D Organoid Systems

(2017) Devanjali Dutta et al.   TRENDS IN MOLECULAR MEDICINE

Multiscale microenvironmental perturbation of pluripotent stem cell fate and self-organization

(2017) Yoji Tabata et al.   Scientific Reports

Fundamentals of Laser-Based Hydrogel Degradation and Applications in Cell and Tissue Engineering

(2017) Shantanu Pradhan et al.   Advanced Healthcare Materials

Massive and Reproducible Production of Liver Buds Entirely from Human Pluripotent Stem Cells

(2017) Takanori Takebe et al.   Cell Reports

Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids

(2017) Marko Z Nikolić et al.   eLife

Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells

(2017) Anna S. Monzel et al.   Stem Cell Reports

Label-Free and Regenerative Electrochemical Microfluidic Biosensors for Continual Monitoring of Cell Secretomes

(2017) Su Ryon Shin et al.   Advanced Science

Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip

(2017) Samira Musah et al.   Nature Biomedical Engineering

Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform

(2017) Aleksander Skardal et al.   Scientific Reports

Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in vitro

(2016) Sofia B. Leite et al.   BIOMATERIALS

Design and demonstration of a pumpless 14 compartment microphysiological system

(2016) Paula G. Miller et al.   BIOTECHNOLOGY AND BIOENGINEERING

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors

(2016) Leonardo Morsut et al.   CELL

A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds

(2016) Alejandra Bruna et al.   CELL

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Identification and Correction of Mechanisms Underlying Inherited Blindness in Human iPSC-Derived Optic Cups

(2016) David A. Parfitt et al.   Cell Stem Cell

Enhancing a Wnt-Telomere Feedback Loop Restores Intestinal Stem Cell Function in a Human Organotypic Model of Dyskeratosis Congenita

(2016) Dong-Hun Woo et al.   Cell Stem Cell

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

(2016) Junghyun Jo et al.   Cell Stem Cell

Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3

(2016) Jason Dang et al.   Cell Stem Cell

A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis

(2016) Masayuki Fujii et al.   Cell Stem Cell

Development-on-chip:in vitroneural tube patterning with a microfluidic device

(2016) Christopher J. Demers et al.   DEVELOPMENT

Derivation of a robust mouse mammary organoid system for studying tissue dynamics

(2016) Paul R. Jamieson et al.   DEVELOPMENT

In vitropatterning of pluripotent stem cell-derived intestine recapitulatesin vivohuman development

(2016) Yu-Hwai Tsai et al.   DEVELOPMENT

Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling

(2016) Meike Hohwieler et al.   GUT

Designer matrices for intestinal stem cell and organoid culture

(2016) Nikolce Gjorevski et al.   NATURE

Organoids as an in vitro model of human development and disease

(2016) Aliya Fatehullah et al.   NATURE CELL BIOLOGY

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system

(2016) Michael J Workman et al.   NATURE MEDICINE

Organoid culture systems for prostate epithelial and cancer tissue

(2016) Jarno Drost et al.   Nature Protocols

Real-time monitoring of metabolic function in liver-on-chip microdevices tracks the dynamics of mitochondrial dysfunction

(2016) Danny Bavli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Replication of human noroviruses in stem cell-derived human enteroids

(2016) K. Ettayebi et al.   SCIENCE

Zika virus impairs growth in human neurospheres and brain organoids

(2016) P. P. Garcez et al.   SCIENCE

Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6

(2016) Patrick Guye et al.   Nature Communications

Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids

(2016) Thierry Jardé et al.   Nature Communications

Platinum nanopetal-based potassium sensors for acute cell death monitoring

(2016) Irene Taurino et al.   RSC Advances

Feedback, Lineages and Self-Organizing Morphogenesis

(2016) Sameeran Kunche et al.   PLoS Computational Biology

Rapid Induction of Cerebral Organoids From Human Induced Pluripotent Stem Cells Using a Chemically Defined Hydrogel and Defined Cell Culture Medium

(2016) Beth A. Lindborg et al.   Stem Cells Translational Medicine

A bioengineered niche promotes in vivo engraftment and maturation of pluripotent stem cell derived human lung organoids

(2016) Briana R Dye et al.   eLife

Retinal Organoids from Pluripotent Stem Cells Efficiently Recapitulate Retinogenesis

(2016) Manuela Völkner et al.   Stem Cell Reports

Multi-analyte biosensor interface for real-time monitoring of 3D microtissue spheroids in hanging-drop networks

(2016) Patrick M. Misun et al.   Microsystems & Nanoengineering

In Vitro Polarization of Colonoids to Create an Intestinal Stem Cell Compartment

(2016) Peter J. Attayek et al.   PLoS One

Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer’s Disease Phenotypes

(2016) Waseem K. Raja et al.   PLoS One

Scaffold Free Bio-orthogonal Assembly of 3-Dimensional Cardiac Tissue via Cell Surface Engineering

(2016) Dmitry Rogozhnikov et al.   Scientific Reports

Spheroid and Tissue Assembly via Click Chemistry in Microfluidic Flow

(2015) Paul J. O’Brien et al.   BIOCONJUGATE CHEMISTRY

Controlled 3D culture in Matrigel microbeads to analyze clonal acinar development

(2015) Monika E. Dolega et al.   BIOMATERIALS

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

(2015) Meritxell Huch et al.   CELL

FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders

(2015) Jessica Mariani et al.   CELL

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

(2015) Sylvia F. Boj et al.   CELL

Chemodetection and Destruction of Host Urea Allows Helicobacter pylori to Locate the Epithelium

(2015) Julie Y. Huang et al.   Cell Host & Microbe

Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells

(2015) Anita A. Kurmann et al.   Cell Stem Cell

Quantification of regenerative potential in primary human mammary epithelial cells

(2015) J. R. Linnemann et al.   DEVELOPMENT

Intestinal organoids: A model of intestinal fibrosis for evaluating anti-fibrotic drugs

(2015) Eva S. Rodansky et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

In Vitro Expansion of Human Gastric Epithelial Stem Cells and Their Responses to Bacterial Infection

(2015) Sina Bartfeld et al.   GASTROENTEROLOGY

Interaction of Salmonella enterica Serovar Typhimurium with Intestinal Organoids Derived from Human Induced Pluripotent Stem Cells

(2015) Jessica L. Forbester et al.   INFECTION AND IMMUNITY

Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology

(2015) Nicholas C. Zachos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The use of murine-derived fundic organoids in studies of gastric physiology

(2015) Michael A. Schumacher et al.   JOURNAL OF PHYSIOLOGY-LONDON

Sequential cancer mutations in cultured human intestinal stem cells

(2015) Jarno Drost et al.   NATURE

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

(2015) Minoru Takasato et al.   NATURE

Directed differentiation of cholangiocytes from human pluripotent stem cells

(2015) Mina Ogawa et al.   NATURE BIOTECHNOLOGY

Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation

(2015) Fotios Sampaziotis et al.   NATURE BIOTECHNOLOGY

Nephron organoids derived from human pluripotent stem cells model kidney development and injury

(2015) Ryuji Morizane et al.   NATURE BIOTECHNOLOGY

Generation of stomach tissue from mouse embryonic stem cells

(2015) Taka-aki K. Noguchi et al.   NATURE CELL BIOLOGY

Hydrogels with tunable stress relaxation regulate stem cell fate and activity

(2015) Ovijit Chaudhuri et al.   NATURE MATERIALS

Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell– and patient-derived tumor organoids

(2015) Ling Huang et al.   NATURE MEDICINE

Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids

(2015) Mami Matano et al.   NATURE MEDICINE

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

(2015) Anca M Paşca et al.   NATURE METHODS

Human cerebral organoids recapitulate gene expression programs of fetal neocortex development

(2015) J. Gray Camp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency

(2015) M. J. Ciancanelli et al.   SCIENCE

Plasticity of Hopx+ type I alveolar cells to regenerate type II cells in the lung

(2015) Rajan Jain et al.   Nature Communications

Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue

(2015) Hideya Sakaguchi et al.   Nature Communications

Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids

(2015) Benjamin S. Freedman et al.   Nature Communications

Self-Organization of Polarized Cerebellar Tissue in 3D Culture of Human Pluripotent Stem Cells

(2015) Keiko Muguruma et al.   Cell Reports

CD44 Plays a Functional Role in Helicobacter pylori-induced Epithelial Cell Proliferation

(2015) Nina Bertaux-Skeirik et al.   PLoS Pathogens

In vitro generation of human pluripotent stem cell derived lung organoids

(2015) Briana R Dye et al.   eLife

Defined Conditions for the Isolation and Expansion of Basal Prostate Progenitor Cells of Mouse and Human Origin

(2015) Thomas Höfner et al.   Stem Cell Reports

Microfluidics platform for measurement of volume changes in immobilized intestinal enteroids

(2014) Byung-Ju Jin et al.   Biomicrofluidics

Organoid Cultures Derived from Patients with Advanced Prostate Cancer

(2014) Dong Gao et al.   CELL

Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures

(2014) Wouter R. Karthaus et al.   CELL

Persistence and Toxin Production by Clostridium difficile within Human Intestinal Organoids Result in Disruption of Epithelial Paracellular Barrier Function

(2014) Jhansi L. Leslie et al.   INFECTION AND IMMUNITY

A small intestinal organoid model of non-invasive enteric pathogen–epithelial cell interactions

(2014) S S Wilson et al.   Mucosal Immunology

Modelling human development and disease in pluripotent stem-cell-derived gastric organoids

(2014) Kyle W. McCracken et al.   NATURE

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture

(2014) Xingnan Li et al.   NATURE MEDICINE

Type I Collagen as an Extracellular Matrix for the In Vitro Growth of Human Small Intestinal Epithelium

(2014) Ziyad Jabaji et al.   PLoS One

IL-6/STAT3 promotes regeneration of airway ciliated cells from basal stem cells

(2014) T. Tadokoro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From confluent human iPS cells to self-forming neural retina and retinal pigmented epithelium

(2014) S. Reichman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

3D niche microarrays for systems-level analyses of cell fate

(2014) A. Ranga et al.   Nature Communications

Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs

(2014) Xiufeng Zhong et al.   Nature Communications

Remote Control of Tissue Interactions via Engineered Photo-switchable Cell Surfaces

(2014) Wei Luo et al.   Scientific Reports

Transplantation of Embryonic and Induced Pluripotent Stem Cell-Derived 3D Retinal Sheets into Retinal Degenerative Mice

(2014) Juthaporn Assawachananont et al.   Stem Cell Reports

Hydrogels for Two-Photon Polymerization: A Toolbox for Mimicking the Extracellular Matrix

(2013) Jan Torgersen et al.   ADVANCED FUNCTIONAL MATERIALS

Use of Magnetic Forces to Promote Stem Cell Aggregation During Differentiation, and Cartilage Tissue Modeling

(2013) D. Fayol et al.   ADVANCED MATERIALS

Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium

(2013) Daniel E. Stange et al.   CELL

Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients

(2013) Gerald Schwank et al.   Cell Stem Cell

Redefining the In Vivo Origin of Metanephric Nephron Progenitors Enables Generation of Complex Kidney Structures from Pluripotent Stem Cells

(2013) Atsuhiro Taguchi et al.   Cell Stem Cell

Artificial three-dimensional niches deconstruct pancreas development in vitro

(2013) C. Greggio et al.   DEVELOPMENT

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

(2013) Meritxell Huch et al.   EMBO JOURNAL

Reduced Ciliary Polycystin-2 in Induced Pluripotent Stem Cells from Polycystic Kidney Disease Patients with PKD1 Mutations

(2013) B. S. Freedman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

(2013) Meritxell Huch et al.   NATURE

Vascularized and functional human liver from an iPSC-derived organ bud transplant

(2013) Takanori Takebe et al.   NATURE

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney

(2013) M. Takasato et al.   NATURE CELL BIOLOGY

In situ cell manipulation through enzymatic hydrogel photopatterning

(2013) Katarzyna A. Mosiewicz et al.   NATURE MATERIALS

A functional CFTR assay using primary cystic fibrosis intestinal organoids

(2013) Johanna F Dekkers et al.   NATURE MEDICINE

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex

(2013) T. Kadoshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs

(2012) Tokushige Nakano et al.   Cell Stem Cell

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Generation of functional thyroid from embryonic stem cells

(2012) Francesco Antonica et al.   NATURE

Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein

(2012) Amy P Wong et al.   NATURE BIOTECHNOLOGY

Stem Cell-Derived Human Intestinal Organoids as an Infection Model for Rotaviruses

(2012) S. R. Finkbeiner et al.   mBio

The effect of matrix stiffness on the differentiation of mesenchymal stem cells in response to TGF-β

(2011) Jennifer S. Park et al.   BIOMATERIALS

Growth and differentiation of primary and passaged equine bronchial epithelial cells under conventional and air-liquid-interface culture conditions

(2011) Getu Abraham et al.   BMC Veterinary Research

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

(2011) T. R. Cox et al.   Disease Models & Mechanisms

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Role of shear stress and stretch in vascular mechanobiology

(2011) D. Lu et al.   Journal of the Royal Society Interface

Collagen VI is a basement membrane component that regulates epithelial cell–fibronectin interactions

(2011) Jean-François Groulx et al.   MATRIX BIOLOGY

Self-organizing optic-cup morphogenesis in three-dimensional culture

(2011) Mototsugu Eiraku et al.   NATURE

Spatially controlled simultaneous patterning of multiple growth factors in three-dimensional hydrogels

(2011) Ryan G. Wylie et al.   NATURE MATERIALS

Isolation and in vitro expansion of human colonic stem cells

(2011) Peter Jung et al.   NATURE MEDICINE

Micro Total Bioassay System for Ingested Substances: Assessment of Intestinal Absorption, Hepatic Metabolism, and Bioactivity

(2010) Yuki Imura et al.   ANALYTICAL CHEMISTRY

Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

(2010) Nick Barker et al.   Cell Stem Cell

Mechanical control of tissue and organ development

(2010) T. Mammoto et al.   DEVELOPMENT

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

(2010) Jason R. Spence et al.   NATURE

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

The effects of mechanical forces on intestinal physiology and pathology

(2009) Christopher P. Gayer et al.   CELLULAR SIGNALLING

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche

(2009) Akifumi Ootani et al.   NATURE MEDICINE

Genetic diseases of connective tissues: cellular and extracellular effects of ECM mutations

(2009) John F. Bateman et al.   NATURE REVIEWS GENETICS

Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties

(2009) April M. Kloxin et al.   SCIENCE

Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

(2008) Mototsugu Eiraku et al.   Cell Stem Cell